Professional Bio
Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective thereapies at present.
Research Bio
Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal hematopoesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survivial, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecue Bc12a1. His current work encompasses embryogenesis in gentically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.
2013 Apr
Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM, Thompson EA, Ko TC. "Overexpression of Evi-1 oncoprotein represses TGF-? signaling in colorectal cancer." Molecular carcinogenesis. 2013 Apr 0; 52(4):255-64. Epub 2011 Dec 07. |
2012 Jul
Bresnick EH, Katsumura KR, Lee HY, Johnson KD, Perkins AS. "Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies." Nucleic acids research. 2012 Jul 0; 40(13):5819-31. Epub 2012 Apr 05. |
2011 Oct 6
Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. "PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function." Blood. 2011 Oct 6; 118(14):3853-61. Epub 2011 Jun 10. |
2011
Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda KA, Wheeler JC, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. "Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide." Biochemistry. 2011 50(48):10431-41. Epub 2011 Nov 10. |
2008 Mar 25
Qiu Y, Lynch J, Guo L, Yatsula B, Perkins AS, Michalak M. "Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors." Biochemistry. 2008 Mar 25; 47(12):3697-704. Epub 2008 Feb 28. |
