Archibald S. Perkins, M.D., Ph.D.

Archibald S. Perkins, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 276-3399
Fax: (585) 756-4468

Lab Information

Cancer research, using mouse models to investigate molecular mechanisms in acute myeloid leukemia and myelodysplastic syndrome, with focus on the function of the zinc finger oncoprotein EVI1.

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Professional Bio

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective thereapies at present.

Research Bio

Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal hematopoesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survivial, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecue Bc12a1. His current work encompasses embryogenesis in gentically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.

Awards & Honors (Local)

Phi Beta Kappa 1979
Sigma Xi 1979

Recent Journal Articles

Showing the 5 most recent journal articles. 45 available »

2014 Mar
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. "Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia." Bone.. 2014 Mar; 60:148-61. Epub 2013 Dec 04.
2014 Feb 1
Glass C, Wilson M, Gonzalez R, Zhang Y, Perkins AS. "The role of EVI1 in myeloid malignancies." Blood cells, molecules & diseases.. 2014 Feb 1; Epub 2014 Feb 01.
2014
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG. "Mice carrying a hypomorphic evi1 allele are embryonic viable but exhibit severe congenital heart defects." PloS one. 2014 9(2):e89397. Epub 2014 Feb 27.
2013 Oct 17
Zhang Y, Owens K, Hatem L, Glass CH, Karuppaiah K, Camargo F, Perkins AS. "Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia." Blood.. 2013 Oct 17; 122(16):2888-92. Epub 2013 Sep 10.
2013 Apr
Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM, Thompson EA, Ko TC. "Overexpression of Evi-1 oncoprotein represses TGF-? signaling in colorectal cancer." Molecular carcinogenesis.. 2013 Apr; 52(4):255-64. Epub 2011 Dec 07.

Current Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary

Specialties

Hematology - American Board of Pathology
Anatomic Pathology - American Board of Pathology

Education

PhD | Human Genetics | Columbia Univ, College of Physicians & Surgeons1987
MD | Medicine | Columbia Univ, College of Physicians & Surgeons1986
BA | Chemistry | Williams College1979

Post-Doctoral Training & Residency

Fellowship in Genetics at National Cancer Institute07/01/1988 - 06/30/1992
Residency in Pathology at Brigham & Women's Hospital07/01/1986 - 06/30/1988