cortical basal ganglia neurocircuits

Research Overview

Dr. Haber's laboratory investigates the neural network that underlies incentive-based learning and decision-making leading to the development of action plans. The cortico-basal ganglia system is at the center of this circuit and comprises a diverse group of structures involved in reward and motivation, cognition, and motor control.  The consequence of basal ganglia dysfunction is emphasized in the range of diseases that involve it, including mental health disorders such as obsessive-compulsive disorder, drug abuse and addiction, and schizophrenia, and motor control disorders including Parkinson’s disease. One set of experiments in Dr. Haber's laboratory address the hypothesis that the cortico-basal ganglia network processes information through both parallel and integrative circuits.  A second set of studies focus on the pathway trajectories from different prefrontal areas to their targets.  A third set of experiments focus on which pathways and terminals fields are likely to be involved in the therapeutic effects of during deep brain stimulation (DBS).  A fourth set of studies address the changes in terminal fields and white matter tracts during postnatal development. Basal ganglia structures

Projects

DBSModels
Developmental

2) Rules for prefrontal cortical pathways: how they really get their targets: 2.1 Rules for the ventral prefrontal cortex Rules

vmPFC cortical & subcortical pathways. OFC cortical & subcortical pathways; 2.2 Monkey and Human ventral prefrontal fibers use the same organizational rules DTI; 2.3 The cingulate bundle carries more than you think Cingulate; 2.4 Internal capsule: an organized gateway for connections Internal capsule.

pathways

3) Terminals and pathways effected during deep brain stimulation (DBS) DBSreview

Overview of deep brain stimulation. : 3.1 DBS at the internal capsule site, what it gets and what it doesn’t get DBS Model of electrode in internal capsule.

connectivities

4)Postnatal development of cortical conectivities and pathways: 4.1 vmPFC cortico-striatal connections during postnatal development

Recent Publications

Jbabdi S, Lehman J, Haber SN*, Behrens, TEJ*. Human and monkey ventral prefrontal fibers use the same organizational principles to reach their targets: tracing versus tractography, J. Neurosci., 2013, 33(7):3190-3201. *equal contributon.

Mailly P, Aliane V, Groenewegen HJ, Haber SN, Deniau JM. The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units  J. Neurosci., 2013. 33(13):5718-5727.

Tziortzi AC, Haber SN, Searle G, Tsoumpas C, Long C, Shotbolt P, Douaud G, Jbabdi S, Behrens T, Rabiner EA, Jenkinson M, Gunn RN.  Connectivity-based functional analysis of dopamine release in the striatum using Diffusion Weighted MRI and Positron Emission Tomography.  Cerebral cortex, (5):1165-77. doi: 10.1093/cercor/bhs397. Epub 2013 Jan 2.

Contact Us

Suzanne N. Haber, Ph.D.

University of Rochester
School of Medicine and Dentistry
Box 711
601 Elmwood Avenue
Rochester, NY 14642

Telephone: 585 275-4538
Fax: 585-273-2652

Suzanne_Haber@
urmc.rochester.edu

haber

Lab Members

 

Sarah

Sarah Heilbronner, PhD
Post-doctoral Fellow

SFN 2012 Poster

URMC Page

ziad

Eun Young Choi, PhD

Post-doctoral Fellow

Julia

Julia Lehman, MD
Research Assistant Professor

SFN 2012 Poster

 

ziad

Ziad Safadi, PhD

Senior Research Associate

SFN 2012 Poster

 

borkowska

Anna Borkowska-Belanger
Technical Associate

 

Alison

Alison Kochersberger
Technical Associate

 

mariah

Mariah Meyer

Undergraduate

 

Naba Ali

Naba Ali

Undergraduate

 

lisa

Lisa Swetz
Administrative Assistant

Positions Available

Postdoctoral Fellow

Position Description and Requirements