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Suzanne N. Haber, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-2144

Office: (585) 275-4538

Fax: (585) 273-2652

Research Labs

Lab: (585) 275-6959

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Biography

Research

The Haber lab focuses on the neural network that underlies incentive learning and decision-making that leads to the development of action plans. The cortico-basal ganglia-thalamic system is central to this network and comprises a diverse group of structures involved in reward and motivation, cognition, and motor control. Pathology of this network is implicated in several mental health disorders including drug addition, obsessive-compulsive disorder, and schizophrenia.

One set of questions centers around which pathways are stimulated during deep brain stimulation (DBS). DBS, a proven therapy for intractable tremor and Parkinson disease, is now being actively investigated for depression and obsessive compulsive disorder (OCD), with encouraging results. The electrodes target specific points in the cortico-basal ganglia circuit by placing the electrodes in the internal capsule, ventral striatum (VS), or subcortical white matter. Several ascending and descending fiber bundles pass through these sites, each of which may differentially modulate these behaviors and, thus, the impact on different symptoms. We use 3-D reconstructions of cortical and subcortical pathways and terminal fields to model the electrode and DBS stimulation sites to evaluate how clinical outcome depends on electrode placement.

A second set of experiments address the hypothesis that the cortico-basal ganglia connections are critical for integrating information across functional domains. These complex neuronal networks work in concert with the cortex to moderate behavioral changes and provides the anatomical substrate for plasticity during learning. Specific questions include: 1) what is the organization of cortical and thalamic connections that mediate information flow through the basal ganglia? 2) How are pathways involved in reward processing and cognition integrated into the basal ganglia pathways of action? 3) What is the interface between the descending cortico-basal ganglia system and the midbrain dopamine system?

A third set of experiments is directed towards understanding postnatal changes in the cortico-basal ganglia system associated with specific developmental milestones. A particular focus is on the refinement of cortico-and amygdalo-BG network, including connections, cell types, transmitter systems, and receptors that are consistent with the high level of plasticity during early learning.

Credentials

Faculty Appointments

Education

1968
BA | Kent St University
Psychology

1978
Ph.D. | Stanford University
Neuro- & Bio-Behavioral Science

1980
Postdoctoral | University of Minnesota
Anatomy

1982
Postdoctoral | Massachusetts Institute of Technology
Anatomy

Awards

2012 - Present
Elected on Council: American College of Neuropsychopharmacology

2011 - Present
Margaret L. Wendt Foundation Investigator

2011
NARSAD Distinguished Investigator Award

2011
Special Lecture: Society for Neuroscience Annual Meeting

2009 - Present
Director, Silvio Conte O. Center, Neurocircuitry underlying DBS effects in OCD

2008
Elected to the NARSAD Scientific Board

2007
Elected Fellow of American College of Neuropsychopharmacology

2003 - Present
Elected, member of American College of Neuropsychopharmacology

1989 - 1997
NIMH Merit Award

1985 - 1990
NIH Research Career Development Award

1980 - 1982
National Institute of Drug Abuse Fellowship Award

1979 - 1980
Pharmaceutical Manufacturers Association Foundation Fellowship Award

1978
Doctoral thesis and oral presentation passed with Distinction

1977 - 1978
Scottish Rite Schizophrenia Research Program: Dissertation Fellowship Award

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Publications

Journal Articles

3/8/2017
Coizet V, Heilbronner SR, Carcenac C, Mailly P, Lehman JF, Savasta M, David O, Deniau JM, Groenewegen HJ, Haber SN. "Organization of the Anterior Limb of the Internal Capsule in the Rat." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 Mar 8; 37(10):2539-2554. Epub 2017 Feb 03.

2/1/2017
Choi EY, Tanimura Y, Vage PR, Yates EH, Haber SN. "Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum." NeuroImage.. 2017 Feb 1; 146:821-832. Epub 2016 Sep 17.

11/2016
Dougherty DD, Chou T, Corse AK, Arulpragasam AR, Widge AS, Cusin C, Evans KC, Greenberg BD, Haber SN, Deckersbach T. "Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder." Journal of neurosurgery.. 2016 Nov 0; 125(5):1087-1093. Epub 2016 Feb 19.

Books & Chapters

2012
Chapter Title: Neural circuits affected by deep brain stimulation for psychiatric disorders
Book Title: Deep Brain Stimulation: A New Frontier in Psychiatry
Author List: Haber, S. N., and Greenberg, B.D.
Edited By: Edited by Denys, Feenstra, and Schuurman
Published By: Springer Press2012

2011
Chapter Title: Neuroanatomy of reward: a view from the ventral striatum
Book Title: Neurobiology of Sensation and Reward
Author List: Haber, S.N.
Edited By: Edited by JA Gottfried
Published By: CRC Press2011

2010
Chapter Title: Convergence of limbic, cognitive, and motor cortico-striatal circuits with dopamine pathways in the primate brain
Book Title: Dopamine Handbook
Author List: Haber, S.N.
Edited By: Edited by L.Iversen, I. Iversen, S. Dunnett and A. Bjorklund
Published By: Oxford University Press2010

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Videos

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Obsessive-compulsive disorder and deep brain stimulation