Biostatistics, Bioinformatics and Computational Biology Core
Director: Hulin Wu, Ph.D.
This core is an interdisciplinary core of biostatisticians, modelers, biocomputing scientists, software tool developers and bioinformaticians with expertise in various HIV/AIDS research areas. In addition to providing novel and standard statistical methods, this core seeks to support and collaborate with Investigators in the areas of grant proposal, study design and manuscript/abstract preparation. This core additionally provides training through seminars and hands-on lab specific training and consultation.
Provides biostatistics support for design and analysis of HIV/AIDS-related in vitro and in vivo lab experiments, clinical studies, prevention/behavior studies and epidemiological and translational studies.
Biomathematical Modeling Unit
Supports and promotes new multidisciplinary collaborations by providing modeling support to further HIV/AIDS-related research and to expand existing modeling efforts. Modeling expertise and projects include the following.
PK/PD modeling of antiretroviral therapies
HIV viral dynamics in AIDS clinical studies
HIV viral fitness modeling for in vitro experiments
AIDS epidemics modeling
HIV RNA structure and sequence modeling
Pathway modeling, cellular signaling and regulatory network modeling
High-throughput data modeling and analysis
Provides translational data management and informatics services for HIV/AIDS-related research and studies, including the development of databases and data management, biocomputing and bioinformatics tools, and computational algorithms. Tools available include the following.