March 27, 2015
A University of Rochester team found a way to make chemotherapy more effective, by stopping a cellular quality-control mechanism, according to a study published today in Nature Communications.
The mechanism is known as NMD (nonsense-mediated mRNA decay), and scientists found that exposing breast cancer cells to a molecule that inhibits NMD prior to treatment with doxorubicin, a drug used to treat leukemia, breast, bone, lung and other cancers, hastens cell death.
The research team, led by Lynne E. Maquat, Ph.D., director of the Center for RNA Biology at the University of Rochester, acknowledges that the work is in the early stages and a long way from being applied in humans. But, they believe their data provide insights that could lead to new treatment strategies for cancer patients in the future.
March 26, 2015
Lynne E. Maquat, Ph.D. received the 2015 Gairdner International Award for the discovery and mechanistic studies of nonsense-mediated mRNA decay, a cellular quality control mechanism that derails the production of unwanted proteins in the body that can disrupt normal processes and initiate disease. She is one of five scientists honored with the award, which is given every year to recognize the achievement of medical researchers whose work contributes significantly to improving the quality of human life.
The J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics at the University of Rochester Medical Center, Maquat is known around the world for her work on nonsense-mediated mRNA decay, which is critically important in both normal and disease states. She is considered the uncontested pioneer on the subject and in 2011 was elected to the National Academy of Sciences for her exceptional research, which has been published in more than 130 peer-reviewed scientific articles.
Maquat is the first scientist from upstate New York to receive the Gairdner International Award, which is recognized for its rigorous peer-led selection process. A panel of active Canadian scientists reviews all nominations and passes their recommendations to a board of two dozen senior scientists from across Canada, the United States, Europe, Australia and Japan. After in-depth study and review, board members cast votes for the nominees whose achievements rise above all others in their field. According to the Gairdner Foundation, of the 313 winners to date, 82 have gone on to receive a Nobel Prize in Physiology or Medicine, a testament to the quality of the awardees.
The award was also highlighted in the Opinion pages of Saturday’s Democrat and Chronicle in the
Thumbs up, thumbs downsection:
Thumbs up: For Dr. Lynne Maquat, who is one of five biomedical researchers from around the world to win this year's Gairdner International Award. The University of Rochester Medical Center scientist has joined a prestigious group. Since 1959, more than a quarter of the Gairdner International winners have gone on to win a Nobel Prize, too.
March 20, 2015
B&B Graduate Students 'Bootleg' Their Way to the Top
The Biochemistry and Biophysics department is pleased to announce that a number of the department's gradaute students have undertaken a very creative project. Specifically, six of our graduate students have been writing, producing, and voice acting in a serial podcast about bootleggers smuggling rum across Lake Ontario in 1921.
You can access the first three episodes on iTunes, or you can find them on the Pocket Radio Theater web site, or on their Facebook page. While contingent on their individual research workloads, their plan is to release more episodes on a monthly basis for a total of around 20.
Check out the creative endeavors of your departmental colleagues!
March 6, 2015
Department Announces Fred Sherman Student Award
The Department of Biochemistry & Biophysics are very pleased to announce a new student award within the Biochemistry and Molecular Biology program, to be given at our annual Awards Ceremony in May.
The Fred Sherman Award will honor the memory of our former colleague, and will annually recognize a student in the BMB program who exemplifies the imagination, the excellence in the pursuit of scientific knowledge, and the commitment to the scientific community that were characteristic of Fred Sherman.
This award will compliment the William F. Neuman Award, given annually to a BSCB student to recognize academic, scientific and personal qualities which exemplify the imagination, enthusiasm and excellence in the pursuit of scientific knowledge which were characteristic of the life of Dr. William F. Neuman.
February 1, 2015
MSTP Announces 40th Anniversary Celebration!
The Medical Scientist Training Program (MSTP) is excited to announce a celebration of the 40th anniversary of the MSTP NIH training grant on Friday, October 9, 2015.
The keynote speaker will be an MSTP alumni from the Class of 1980: Edward Rubin, MD, PhD, Director, DOE Joint Genome Institute.
EddyRubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Division in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI ’s involvement in the Human Genome Project (HGP).
For more information and schedule of events for the day, please visit the MSTP 40th Anniversary page.
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