Skip to content
David C. Linehan, M.D.

David C. Linehan, M.D.

Surgical Oncology, Surgery, Cancer

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Locations

Surgery

90 Crittenden Boulevard
Rochester, NY 14642

Surgical Oncology

90 Crittenden Boulevard
Rochester, NY 14642

Surgical Oncology

160 Sawgrass Drive, Suite 120
Rochester, NY 14620

About Me

Professional Background

Dr. Linehan is CEO of the University of Rochester Medical Center (URMC), dean of the School of Medicine and Dentistry (SMD), and senior vice president for Health Sciences at the University of Rochester. Before that, he chaired URMC’s Department of Surgery for 10 years. A surgical oncologist and an a...
Dr. Linehan is CEO of the University of Rochester Medical Center (URMC), dean of the School of Medicine and Dentistry (SMD), and senior vice president for Health Sciences at the University of Rochester. Before that, he chaired URMC’s Department of Surgery for 10 years. A surgical oncologist and an accomplished researcher, Dr. Linehan is recognized for bringing new therapies to patients with difficult-to-treat cancers, and for his compassionate approach to care. He is also internationally renowned for his research into new immunotherapy treatments for pancreatic cancer; his laboratory has been continuously funded by the National Cancer Institute for nearly two decades. He specializes in treating cancers and benign surgical conditions of the liver, pancreas, gallbladder, and bile ducts.

Dr. Linehan attended Dartmouth College, graduated from the University of Massachusetts Medical School, then completed his internship and residency at Deaconess-Harvard Surgical Service. He was a research fellow at Brigham and Women's Hospital and the Kristin Ann Carr Fellow in Surgical Oncology at Memorial Sloan-Kettering Cancer Center. He went on to become a professor of Surgery at Washington University and chief of Hepatobiliary, Pancreatic and Gastrointestinal Surgery.

Faculty Appointments

Professor - Department of Surgery, Oncology (SMD)

Seymour I. Schwartz Professorship in Surgery - Department of Surgery (SMD)

Credentials

Residency & Fellowship

Fellowship, Surgical Oncology, Memorial Sloan-Kettering Cancer Center. 1997 - 1999

Fellowship, Surgery (General Surgery), Beth Israel Deaconess Medical Center-Main Campus. 1996 - 1997

Fellowship, Brigham & Womens Hospital. 1993 - 1995

Residency, Surgery (General Surgery), Beth Israel Deaconess Medical Center-Main Campus. 1991 - 1996

Internship, Surgery (General Surgery), Beth Israel Deaconess Medical Center-Main Campus. 1990 - 1991

Education

MD | University of Massachusetts Medical School. 1990

Awards

Inaugural Gerry O'Sullivan Memorial Lecturer Award. 2012

CTRF Superhero Cancer Researcher Award. 2006

Evarts A. Graham Teaching Award. 2004

Young Investigator Award. 1999

Publications

Journal Articles

CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models.

Ye J, Gavras NW, Keeley DC, Hughson AL, Hannon G, Vrooman TG, Lesch ML, Johnston CJ, Lord EM, Belt BA, Linehan DC, Eyles J, Gerber SA

Journal for immunotherapy of cancer.. 2023 May 11 (5)Epub 1900 01 01.

Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity.

Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM

Cancer research.. 2022 December 2 Epub 12/02/2022.

Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer.

Uccello TP, Lecsh ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA

International journal of radiation oncology, biology, physics.. 2022 October 3 Epub 10/03/2022.

Neoadjuvant chemotherapy is associated with altered immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer.

Dias Costa A, Väyrynen SA, Chawla A, Zhang J, Väyrynen JP, Lau MC, Williams HL, Yuan C, Morales-Oyarvide V, Elganainy D, Singh H, Cleary JM, Perez K, Ng K, Freed-Pastor W, Mancias JD, Dougan SK, Wang J, Rubinson DA, Dunne RF, Kozak MM, Brais L, Reilly E, Clancy T, Linehan DC, Chang DT, Hezel AF, Koong AC, Aguirre A, Wolpin BM, Nowak JA

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2022 September 21 Epub 09/21/2022.

Predictors of opioid-free discharge after laparoscopic cholecystectomy.

Melucci AD, Dave YA, Lynch OF, Hsu S, Erlick MR, Linehan DC, Moalem J,

American journal of surgery.. 2022 August 3 Epub 08/03/2022.

Immunologic Strategies in Pancreatic Cancer: Making Tumors .

Ullman NA, Burchard PR, Dunne RF, Linehan DC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2022 July 15 :JCO2102616. Epub 07/15/2022.

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.

Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Journal for immunotherapy of cancer.. 2022 July 10 (7)Epub 1900 01 01.

Intrathecal Morphine and Effect on Opioid Consumption and Functional Recovery after Pancreaticoduodenectomy.

Burchard PR, Melucci AD, Lynch O, Loria AA, Dave Y, Strawderman M, Schoeniger LO, Galka E, Moalem J, Linehan DC

Journal of the American College of Surgeons.. 2022 May 4 Epub 05/04/2022.

Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors .

Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG

Journal of medicinal chemistry.. 2022 April 11 Epub 04/11/2022.

Early postoperative ERAS compliance predicts decreased length of stay and complications following liver resection.

Burchard PR, Dave YA, Loria AP, Parikh NB, Pineda-Solis K, Ruffolo LI, Strawderman M, Schoeniger LO, Galka E, Tomiyama K, Orloff MS, Carpizo DR, Linehan DC, Hernandez-Alejandro R

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2022 January 25 Epub 01/25/2022.

Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy.

Uccello TP, Kintzel SA, Mills BN, Murphy JD, Garrett-Larsen J, Battaglia NG, Rodriguez CJ, Drage MG, Ye J, Love TMT, Johnston CJ, Repasky EA, Qiu H, Linehan DC, Lord EM, Gerber SA

Advances in radiation oncology.. 2022 7 (2):100867. Epub 12/09/2021.

Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.

Mills BN, Qiu H, Drage MG, Chen C, Mathew JS, Garrett-Larsen J, Ye J, Uccello TP, Murphy JD, Belt BA, Lord EM, Katz AW, Linehan DC, Gerber SA

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2021 December 3 Epub 12/03/2021.

GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity.

Ruffolo LI, Jackson KM, Kuhlers PC, Dale BS, Figueroa Guilliani NM, Ullman NA, Burchard PR, Qin SS, Juviler PG, Keilson JM, Morrison AB, Georger M, Jewell R, Calvi LM, Nywening TM, O'Dell MR, Hezel AF, De Las Casas L, Lesinski GB, Yeh JJ, Hernandez-Alejandro R, Belt BA, Linehan DC

Gut.. 2021 August 19 Epub 08/19/2021.

Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model.

Qin SS, Han BJ, Williams A, Jackson KM, Jewell R, Chacon AC, Lord EM, Linehan DC, Kim M, Reuben A, Gerber SA, Prieto PA

Cancers.. 2021 May 1113 (10)Epub 05/11/2021.

Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.

Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D

Journal of cachexia, sarcopenia and muscle.. 2021 May 7 Epub 05/07/2021.

HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.

Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 April 26 Epub 04/26/2021.

Picomets: Assessing single and few cell metastases in melanoma sentinel lymph node biopsies.

Jackso K, Ruffolo L, Kozakiewicz L, Qin SS, Chacon AC, Jewell R, Belt B, Scott GA, Linehan DC, Galka E, Prieto PA

Surgery.. 2021 April 23 Epub 04/23/2021.

Early Prediction of Length of Stay After Pancreaticoduodenectomy.

Pineda-Solis K, Burchard PR, Ruffolo LI, Schoeniger LO, Linehan DC, Moalem J, Galka E

The Journal of surgical research.. 2020 December 22 Epub 12/22/2020.

Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer.

Väyrynen SA, Zhang J, Yuan C, Väyrynen JP, Dias Costa A, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais LK, Reilly E, Rahma OE, Clancy TE, Wang J, Linehan DC, Aguirre A, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2020 December 1 Epub 12/01/2020.

Preclinical Imaging Using Single Track Location Shear Wave Elastography: Monitoring the Progression of Murine Pancreatic Tumor Liver Metastasis In Vivo.

Ahmed R, Ye J, Gerber SA, Linehan DC, Doyley MM

IEEE transactions on medical imaging.. 2020 July 39 (7):2426-2439. Epub 02/03/2020.

Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma.

Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA

Immunological investigations.. 2020 June 4 :1-16. Epub 06/04/2020.

The clonal evolution of metastatic colorectal cancer.

Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, Hawkins WG, Strasberg SM, Linehan DC, Lim KH, Lockhart AC, Mardis ER, Wilson RK, Ley TJ, Maher CA, Fields RC

Science advances.. 2020 June 6 (24):eaay9691. Epub 06/10/2020.

We Orient Residents to Surgical Life: Why Not Their Families Too?

DeCaporale-Ryan LN, Salloum R, Linehan DC

Journal of surgical education.. 2020 March 13 Epub 03/13/2020.

Shear Wave Elastography Can Differentiate between Radiation-Responsive and Non-responsive Pancreatic Tumors: An ex Vivo Study with Murine Models.

Wang H, Mills B, Mislati R, Ahmed R, Gerber SA, Linehan D, Doyley MM

Ultrasound in medicine & biology.. 2020 February 46 (2):393-404. Epub 11/11/2019.

Dual Energy X-ray Absorptiometry (DEXA) as a longitudinal outcome measure of cancer-related muscle wasting in mice.

Cole CL, Beck CA, Robinson D, Ye J, Mills B, Gerber SA, Schwarz EM, Linehan D

PloS one.. 2020 15 (6):e0230695. Epub 06/19/2020.

Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer.

Rashid NU, Peng XL, Jin C, Moffitt RA, Volmar KE, Belt BA, Panni RZ, Nywening TM, Herrera SG, Moore KJ, Hennessey SG, Morrison AB, Kawalerski R, Nayyar A, Chang AE, Schmidt B, Kim HJ, Linehan DC, Yeh JJ

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2019 November 21 Epub 11/21/2019.

Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.

Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Cancer immunology research.. 2019 November 12 Epub 11/12/2019.

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.

Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SA

Cell reports.. 2019 October 829 (2):406-421.e5. Epub 1900 01 01.

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

Noel M, O'Reilly EM, Wolpin BM, Ryan DP, Bullock AJ, Britten CD, Linehan DC, Belt BA, Gamelin EC, Ganguly B, Yin D, Joh T, Jacobs IA, Taylor CT, Lowery MA

Investigational new drugs.. 2019 July 12 Epub 07/12/2019.

Narcotic Free Cervical Endocrine Surgery: A Shift in Paradigm.

Ruffolo LI, Jackson KM, Juviler P, Kaur R, Chennell T, Glover DM, Linehan DC, Moalem J

Annals of surgery.. 2019 July 6 Epub 07/06/2019.

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.

Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM

Genetics in medicine : official journal of the American College of Medical Genetics.. 2019 January 21 (1):213-223. Epub 07/02/2018.

Targeting both tumour-associated CXCR2 neutrophils and CCR2 macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma.

Nywening TM, Belt BA, Cullinan DR, Panni RZ, Han BJ, Sanford DE, Jacobs RC, Ye J, Patel AA, Gillanders WE, Fields RC, DeNardo DG, Hawkins WG, Goedegebuure P, Linehan DC

Gut.. 2018 June 67 (6):1112-1123. Epub 12/01/2017.

Have Recent Modifications of Operating Room Attire Policies Decreased Surgical Site Infections? An American College of Surgeons NSQIP Review of 6,517 Patients.

Farach SM, Kelly KN, Farkas RL, Ruan DT, Matroniano A, Linehan DC, Moalem J

Journal of the American College of Surgeons.. 2018 May 226 (5):804-813. Epub 02/28/2018.

Intermediate-term survival and quality of life outcomes in patients with advanced colorectal liver metastases undergoing associating liver partition and portal vein ligation for staged hepatectomy.

Wanis KN, Ardiles V, Alvarez FA, Tun-Abraham ME, Linehan D, de Santibañes E, Hernandez-Alejandro R

Surgery.. 2018 April 163 (4):691-697. Epub 12/06/2017.

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance.

Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG

Nature communications.. 2018 March 289 (1):1250. Epub 03/28/2018.

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma.

Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM

JAMA oncology.. 2018 March 84 (3):e173420. Epub 03/08/2018.

Recruitment of CCR2 tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer.

Grossman JG, Nywening TM, Belt BA, Panni RZ, Krasnick BA, DeNardo DG, Hawkins WG, Goedegebuure SP, Linehan DC, Fields RC

Oncoimmunology.. 2018 7 (9):e1470729. Epub 08/01/2018.

Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival.

Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM

British journal of cancer.. 2017 December 5117 (12):1874-1882. Epub 10/05/2017.

Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia.

Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG

Current opinion in supportive and palliative care.. 2017 December 11 (4):278-286. Epub 1900 01 01.

Comment: Fancier and More Expensive Do Mean Better: An Argument for Computed Tomography Staging of Patients With Colorectal Liver Metastases.

Fowler KJ, Linehan DC, Menias CO

Annals of surgical oncology.. 2017 December 24 (Suppl 3):605-606. Epub 11/22/2017.

Staging for Intrahepatic Cholangiocarcinoma: Are We Getting Close to Understanding the True Tumor Biology?

Tomiyama K, Hernandez-Alejandro R, Linehan DC

JAMA surgery.. 2017 May 17152 (5):e170108. Epub 05/17/2017.

Interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: long-term follow-up.

Ohman KA, Liu J, Linehan DC, Tan MC, Tan BR, Fields RC, Strasberg SM, Hawkins WG

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2017 May 19 (5):449-457. Epub 02/03/2017.

Hepatectomy for Early Hepatocellular Carcinoma: Not If, but When and How?

Hernandez-Alejandro R, Levstik MA, Linehan DC

JAMA surgery.. 2017 March 15152 (3):e165042. Epub 03/15/2017.

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes.

Connolly KA, Belt BA, Figueroa NM, Murthy A, Patel A, Kim M, Lord EM, Linehan DC, Gerber SA

Oncotarget.. 2016 December 277 (52):86522-86535. Epub 1900 01 01.

Interaction of Postoperative Morbidity and Receipt of Adjuvant Therapy on Long-Term Survival After Resection for Gastric Adenocarcinoma: Results From the U.S. Gastric Cancer Collaborative.

Jin LX, Sanford DE, Squires MH, Moses LE, Yan Y, Poultsides GA, Votanopoulos KI, Weber SM, Bloomston M, Pawlik TM, Hawkins WG, Linehan DC, Schmidt C, Worhunsky DJ, Acher AW, Cardona K, Cho CS, Kooby DA, Levine EA, Winslow E, Saunders N, Spolverato G, Colditz GA, Maithel SK, Fields RC

Annals of surgical oncology.. 2016 August 23 (8):2398-408. Epub 03/22/2016.

Wound Infections After Pancreaticoduodenectomy.

Schoeniger LO, Linehan DC

JAMA surgery.. 2016 May 1151 (5):440. Epub 1900 01 01.

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DC

The Lancet. Oncology.. 2016 May 17 (5):651-62. Epub 04/04/2016.

Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging.

Owen JW, Fowler KJ, Doyle MB, Saad NE, Linehan DC, Chapman WC

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2016 March 18 (3):296-303. Epub 03/14/2016.

Induction Chemotherapy Followed by Concurrent Full-dose Gemcitabine and Intensity-modulated Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma.

Badiyan SN, Olsen JR, Lee AY, Yano M, Menias CO, Khwaja S, Wang-Gillam A, Strasberg SM, Hawkins WG, Linehan DC, Myerson RJ, Parikh PJ

American journal of clinical oncology.. 2016 February 39 (1):1-7. Epub 1900 01 01.

Factors Associated With Recurrence and Survival in Lymph Node-negative Gastric Adenocarcinoma: A 7-Institution Study of the US Gastric Cancer Collaborative.

Jin LX, Moses LE, Squires MH, Poultsides GA, Votanopoulos K, Weber SM, Bloomston M, Pawlik TM, Hawkins WG, Linehan DC, Strasberg SM, Schmidt C, Worhunsky DJ, Acher AW, Cardona K, Cho CS, Kooby DA, Levine E, Winslow ER, Saunders ND, Spolverato G, Maithel SK, Fields RC

Annals of surgery.. 2015 December 262 (6):999-1005. Epub 1900 01 01.

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.

Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Barrett MT, Anagnostou V, Parpart-Li S, Murphy D, Kay Li Q, Hruban CA, Scharpf R, White JR, O'Dwyer PJ, Allen PJ, Eshleman JR, Thompson CB, Klimstra DS, Linehan DC, Maitra A, Hruban RH, Diaz LA, Von Hoff DD, Johansen JS, Drebin JA, Velculescu VE

Nature communications.. 2015 July 76 :7686. Epub 07/07/2015.

A phase II study of adjuvant gemcitabine plus docetaxel followed by concurrent chemoradation in resected pancreaticobiliary carcinoma.

Cho M, Wang-Gillam A, Myerson R, Gao F, Strasberg S, Picus J, Sorscher S, Fournier C, Nagaraj G, Parikh P, Suresh R, Linehan D, Tan BR

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2015 July 17 (7):587-93. Epub 03/20/2015.

Lingering Questions on Choledochal Cysts.

Linehan D, Galka E

JAMA surgery.. 2015 June 150 (6):584. Epub 1900 01 01.

Natural history of preoperative subcentimeter pulmonary nodules in patients with resectable pancreatic adenocarcinoma: a retrospective cohort study.

Chang ST, Nguyen DC, Raptis C, Menias CO, Zhou G, Wang-Gillam A, Linehan DC, Hawkins WG, Strasberg SM, Fields RC

Annals of surgery.. 2015 May 261 (5):970-5. Epub 1900 01 01.

Imaging approach to hepatocellular carcinoma, cholangiocarcinoma, and metastatic colorectal cancer.

Fowler KJ, Saad NE, Linehan D

Surgical oncology clinics of North America.. 2015 January 24 (1):19-40. Epub 10/11/2014.

Comparison of implanted fiducial markers and self-expandable metallic stents for pancreatic image guided radiation therapy localization.

Pepin E, Olsen L, Badiyan S, Murad F, Mullady D, Wang-Gillam A, Linehan D, Parikh P, Olsen J

Practical radiation oncology.. 2015 5 (3):e193-9. Epub 10/03/2014.

Correction: Synergistic Effects of Concurrent Blockade of PI3K and MEK Pathways in Pancreatic Cancer Preclinical Models.

Zhong H, Sanchez C, Spitrzer D, Plambeck-Suess S, Gibbs J, Hawkins WG, Denardo D, Gao F, Pufahl RA, Lockhart AC, Xu M, Linehan D, Weber J, Wang-Gillam A

PloS one.. 2015 10 (4):e0127365. Epub 04/27/2015.

Severe nutritional risk predicts decreased long-term survival in geriatric patients undergoing pancreaticoduodenectomy for benign disease.

Sanford DE, Sanford AM, Fields RC, Hawkins WG, Strasberg SM, Linehan DC

Journal of the American College of Surgeons.. 2014 December 219 (6):1149-56. Epub 06/30/2014.

Association of discharge home with home health care and 30-day readmission after pancreatectomy.

Sanford DE, Olsen MA, Bommarito KM, Shah M, Fields RC, Hawkins WG, Jaques DP, Linehan DC

Journal of the American College of Surgeons.. 2014 November 219 (5):875-86.e1. Epub 07/18/2014.

Histological features and severity of oxaliplatin-induced liver injury and clinical associations.

Nalbantoglu I, Tan BR, Linehan DC, Gao F, Brunt EM

Journal of digestive diseases.. 2014 October 15 (10):553-60. Epub 1900 01 01.

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, Wang-Gillam A, Goedegebuure SP, Linehan DC, DeNardo DG

Cancer research.. 2014 September 1574 (18):5057-69. Epub 07/31/2014.

Variations in definition and method of retrieval of complications influence outcomes statistics after pancreatoduodenectomy: comparison of NSQIP with non-NSQIP methods.

Sanford DE, Woolsey CA, Hall BL, Linehan DC, Hawkins WG, Fields RC, Strasberg SM

Journal of the American College of Surgeons.. 2014 September 219 (3):407-15. Epub 04/18/2014.

Hepatobiliary cancers, version 2.2014.

Benson AB, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar H

Journal of the National Comprehensive Cancer Network : JNCCN.. 2014 August 12 (8):1152-82. Epub 1900 01 01.

A new operative approach for type I choledochal cysts.

Jin LX, Fields RC, Hawkins WG, Linehan DC, Strasberg SM

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2014 May 18 (5):1049-53. Epub 11/13/2013.

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.

Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, Denardo DG, Goedegebuure SP, Linehan DC

Cancer immunology, immunotherapy : CII.. 2014 May 63 (5):513-28. Epub 03/21/2014.

Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas.

Strasberg SM, Gao F, Sanford D, Linehan DC, Hawkins WG, Fields R, Carpenter DH, Brunt EM, Phillips C

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2014 February 16 (2):150-6. Epub 04/22/2013.

Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs).

Hashim YM, Trinkaus KM, Linehan DC, Strasberg SS, Fields RC, Cao D, Hawkins WG

Annals of surgery.. 2014 February 259 (2):197-203. Epub 1900 01 01.

Cost benefit analysis of mesh reinforcement of stapled left pancreatectomy.

Idrees K, Edler JR, Linehan DC, Strasberg SM, Jacques D, Hamilton NA, Fields RC, Lambert D, Kymes S, Hawkins WG

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2013 November 15 (11):893-8. Epub 02/20/2013.

Down-regulation of PLC?2-?-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

Capietto AH, Kim S, Sanford DE, Linehan DC, Hikida M, Kumosaki T, Novack DV, Faccio R

The Journal of experimental medicine.. 2013 October 21210 (11):2257-71. Epub 10/14/2013.

Targeting tumor-infiltrating macrophages to combat cancer.

Panni RZ, Linehan DC, DeNardo DG

Immunotherapy.. 2013 October 5 (10):1075-87. Epub 1900 01 01.

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.

Sanford DE, Belt BA, Panni RZ, Mayer A, Deshpande AD, Carpenter D, Mitchem JB, Plambeck-Suess SM, Worley LA, Goetz BD, Wang-Gillam A, Eberlein TJ, Denardo DG, Goedegebuure SP, Linehan DC

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2013 July 119 (13):3404-15. Epub 05/07/2013.

Colorectal liver metastases: state of the art imaging.

Fowler KJ, Linehan DC, Menias CO

Annals of surgical oncology.. 2013 April 20 (4):1185-93. Epub 11/01/2012.

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG

Cancer research.. 2013 February 173 (3):1128-41. Epub 12/05/2012.

Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.

Zhong H, Sanchez C, Spitzer D, Spitrzer D, Plambeck-Suess S, Gibbs J, Hawkins WG, Denardo D, Gao F, Pufahl RA, Lockhart AC, Xu M, Linehan D, Weber J, Wang-Gillam A

PloS one.. 2013 8 (10):e77243. Epub 10/09/2013.

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.

Porembka MR, Mitchem JB, Belt BA, Hsieh CS, Lee HM, Herndon J, Gillanders WE, Linehan DC, Goedegebuure P

Cancer immunology, immunotherapy : CII.. 2012 September 61 (9):1373-85. Epub 01/04/2012.

Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure.

Mitchem JB, Hamilton N, Gao F, Hawkins WG, Linehan DC, Strasberg SM

Journal of the American College of Surgeons.. 2012 January 214 (1):46-52. Epub 1900 01 01.

The right way to do a Whipple procedure: comment on 'Stenting and the rate of pancreatic fistula following pancreaticoduodenectomy'

Linehan, DC.

Archives of Surgery. 2012; 147(1): 41.

Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreas.

Porembka MR, Hawkins WG, Linehan DC, Gao F, Ma C, Brunt EM, Strasberg SM

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2011 September 13 (9):633-42. Epub 1900 01 01.

A technique of gastrojejunostomy to reduce delayed gastric emptying after pancreatoduodenectomy.

Khan AS, Hawkins WG, Linehan DC, Strasberg SM

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2011 August 15 (8):1468-71. Epub 02/24/2011.

Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer.

Goedegebuure P, Mitchem JB, Porembka MR, Tan MC, Belt BA, Wang-Gillam A, Gillanders WE, Hawkins WG, Linehan DC

Current cancer drug targets.. 2011 July 11 (6):734-51. Epub 1900 01 01.

RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.

Subramaniam D, Ramalingam S, Linehan DC, Dieckgraefe BK, Postier RG, Houchen CW, Jensen RA, Anant S

PloS one.. 2011 February 116 (2):e16958. Epub 02/11/2011.

Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease.

Pai RK, Beck AH, Mitchem J, Linehan DC, Chang DT, Norton JA, Pai RK

The American journal of surgical pathology.. 2011 February 35 (2):228-34. Epub 1900 01 01.

Choosing 'The Best'

Linehan, DC; Jaques D.

Archives of Surgery. 2011; 146(5): 604-5.

Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer.

Gnerlich JL, Mitchem JB, Weir JS, Sankpal NV, Kashiwagi H, Belt BA, Porembka MR, Herndon JM, Eberlein TJ, Goedegebuure P, Linehan DC

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 October 1185 (7):4063-71. Epub 08/30/2010.

Bile duct injuries in the era of laparoscopic cholecystectomies.

Wu YV, Linehan DC

The Surgical clinics of North America.. 2010 August 90 (4):787-802. Epub 1900 01 01.

Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.

Fox AC, Robertson CM, Belt B, Clark AT, Chang KC, Leathersich AM, Dominguez JA, Perrone EE, Dunne WM, Hotchkiss RS, Buchman TG, Linehan DC, Coopersmith CM

Critical care medicine.. 2010 March 38 (3):886-93. Epub 1900 01 01.

Re: ABO blood group and the risk of pancreatic cancer.

Dandona M, Gao F, Linehan DC, Wang-Gillam A

Journal of the National Cancer Institute.. 2010 January 20102 (2):135-7; author reply 137. Epub 12/17/2009.

Benign and Malignant Bilary Tract Disease

Logan S and Linehan DC.

Journal of the ACS. 2010; .

Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer.

Johnston FM, Tan MC, Tan BR, Porembka MR, Brunt EM, Linehan DC, Simon PO, Plambeck-Suess S, Eberlein TJ, Hellstrom KE, Hellstrom I, Hawkins WG, Goedegebuure P

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2009 November 115 (21):6511-8. Epub 10/20/2009.

The accordion severity grading system of surgical complications.

Strasberg SM, Linehan DC, Hawkins WG

Annals of surgery.. 2009 August 250 (2):177-86. Epub 1900 01 01.

Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement.

Callery MP, Chang KJ, Fishman EK, Talamonti MS, William Traverso L, Linehan DC

Annals of surgical oncology.. 2009 July 16 (7):1727-33. Epub 04/24/2009.

Saline-linked surface radiofrequency ablation: a safe and effective method of surface ablation of hepatic metastatic colorectal cancer.

Gnerlich JL, Ritter JH, Linehan DC, Hawkins WG, Strasberg SM

Annals of surgery.. 2009 July 250 (1):96-102. Epub 1900 01 01.

Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issues.

Rupp CC, Linehan DC

Journal of surgical oncology.. 2009 March 1599 (4):207-14. Epub 1900 01 01.

Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.

Tan MC, Goedegebuure PS, Belt BA, Flaherty B, Sankpal N, Gillanders WE, Eberlein TJ, Hsieh CS, Linehan DC

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 February 1182 (3):1746-55. Epub 1900 01 01.

The effect of mesh reinforcement of a stapled transection line on the rate of pancreatic occlusion failure after distal pancreatectomy: review of a single institution's experience.

Johnston FM, Cavataio A, Strasberg SM, Hamilton NA, Simon PO, Trinkaus K, Doyle MB, Mathews BD, Porembka MR, Linehan DC, Hawkins WG

HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2009 February 11 (1):25-31. Epub 1900 01 01.

Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer.

Moo-Young TA, Larson JW, Belt BA, Tan MC, Hawkins WG, Eberlein TJ, Goedegebuure PS, Linehan DC

Journal of immunotherapy.. 2009 January 32 (1):12-21. Epub 1900 01 01.

Invited Editorial Commentary on " A simple algorithm based on preoperative variables can indicated the extent of hepatecomty for hepatocellular carcinoma in cirrhoitc patients

Cescon, et al.

Arch Surg. 2009; 144(1).

'Sideways': results of repair of biliary injuries using a policy of side-to-side hepatico-jejunostomy

Winslow ER; Fialkowski EA; Linehan DC; Hawkins WG; Picus DD; Strasberg SM.

Annals of Surgery. 2009; 249(3): 426-34.

Laparoscopic gastric resection for gastrointestinal stromal tumors.

Sexton JA, Pierce RA, Halpin VJ, Eagon JC, Hawkins WG, Linehan DC, Brunt LM, Frisella MM, Matthews BD

Surgical endoscopy.. 2008 December 22 (12):2583-7. Epub 03/06/2008.

Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study.

Linehan DC, Tan MC, Strasberg SM, Drebin JA, Hawkins WG, Picus J, Myerson RJ, Malyapa RS, Hull M, Trinkaus K, Tan BR

Annals of surgery.. 2008 August 248 (2):145-51. Epub 1900 01 01.

A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables.

Tan MC, Castaldo ET, Gao F, Chari RS, Linehan DC, Wright JK, Hawkins WG, Siegel BA, Delbeke D, Pinson CW, Strasberg SM

Journal of the American College of Surgeons.. 2008 May 206 (5):857-68; discussion 868-9. Epub 03/17/2008.

Isolation of right main and right sectional portal pedicles for liver resection without hepatotomy or inflow occlusion.

Strasberg SM, Linehan DC, Hawkins WG

Journal of the American College of Surgeons.. 2008 February 206 (2):390-6. Epub 09/20/2007.

Establishing 'normal' values for liver function tests after reconstruction of biliary injuries

Fialkowski EA; Winslow ER; Scott MG; Hawkins WG; Linehan DC; Strasberg SM.

American College of Surgeons. 2008; 207(5): 707-9.

Unique site- and time-specific patterns of recurrence following resection of colorectal carcinoma hepatic metastases in patients staged by FDG-PET.

Finkelstein SE, Fernandez FG, Dehdashti F, Siegel BA, Hawkins WG, Linehan DC, Strasberg SM

Journal of hepato-biliary-pancreatic surgery.. 2008 15 (5):483-7. Epub 10/04/2008.

Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response.

Tan MC, Linehan DC, Hawkins WG, Siegel BA, Strasberg SM

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2007 September 11 (9):1112-9. Epub 07/11/2007.

Outcomes analysis of laparoscopic resection of pancreatic neoplasms.

Pierce RA, Spitler JA, Hawkins WG, Strasberg SM, Linehan DC, Halpin VJ, Eagon JC, Brunt LM, Frisella MM, Matthews BD

Surgical endoscopy.. 2007 April 21 (4):579-86. Epub 12/16/2006.

Proposal for definition and severity grading of pancreatic anastomosis failure and pancreatic occlusion failure.

Strasberg SM, Linehan DC, Clavien PA, Barkun JS

Surgery.. 2007 April 141 (4):420-6. Epub 03/09/2007.

Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins.

Strasberg SM, Linehan DC, Hawkins WG

Journal of the American College of Surgeons.. 2007 February 204 (2):244-9. Epub 01/04/2007.

Absorbable mesh reinforcement of a stapled pancreatic transection line reduces the leak rate with distal pancreatectomy.

Thaker RI, Matthews BD, Linehan DC, Strasberg SM, Eagon JC, Hawkins WG

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2007 January 11 (1):59-65. Epub 1900 01 01.

Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients.

Lin Y, Goedegebuure PS, Tan MC, Gross J, Malone JP, Feng S, Larson J, Phommaly C, Trinkaus K, Townsend RR, Linehan DC

Journal of proteome research.. 2006 September 5 (9):2169-76. Epub 1900 01 01.

Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing mice.

Viehl CT, Moore TT, Liyanage UK, Frey DM, Ehlers JP, Eberlein TJ, Goedegebuure PS, Linehan DC

Annals of surgical oncology.. 2006 September 13 (9):1252-8. Epub 09/03/2006.

Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma.

Liyanage UK, Goedegebuure PS, Moore TT, Viehl CT, Moo-Young TA, Larson JW, Frey DM, Ehlers JP, Eberlein TJ, Linehan DC

Journal of immunotherapy.. 2006 29 (4):416-24. Epub 1900 01 01.

A tat fusion protein-based tumor vaccine for breast cancer.

Viehl CT, Becker-Hapak M, Lewis JS, Tanaka Y, Liyanage UK, Linehan DC, Eberlein TJ, Goedegebuure PS

Annals of surgical oncology.. 2005 July 12 (7):517-25. Epub 05/10/2005.

Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases.

Fernandez FG, Ritter J, Goodwin JW, Linehan DC, Hawkins WG, Strasberg SM

Journal of the American College of Surgeons.. 2005 June 200 (6):845-53. Epub 1900 01 01.

A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma.

Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, Tan B, Thorstad WL, Myerson R

American journal of clinical oncology.. 2005 June 28 (3):234-41. Epub 1900 01 01.

Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma.

Hawkins WG, Busam KJ, Ben-Porat L, Panageas KS, Coit DG, Gyorki DE, Linehan DC, Brady MS

Annals of surgical oncology.. 2005 March 12 (3):207-13. Epub 03/03/2005.

CD25+ CD4+ regulatory T-cells in cancer.

Linehan DC, Goedegebuure PS

Immunologic research.. 2005 32 (1-3):155-68. Epub 1900 01 01.

Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET).

Fernandez FG, Drebin JA, Linehan DC, Dehdashti F, Siegel BA, Strasberg SM

Annals of surgery.. 2004 September 240 (3):438-47; discussion 447-50. Epub 1900 01 01.

Saline-linked surface radiofrequency ablation: factors affecting steam popping and depth of injury in the pig liver.

Topp SA, McClurken M, Lipson D, Upadhya GA, Ritter JH, Linehan D, Strasberg SM

Annals of surgery.. 2004 April 239 (4):518-27. Epub 1900 01 01.

Radiofrequency ablation of liver tumors.

Strasberg SM, Linehan D

Current problems in surgery.. 2003 August 40 (8):459-98. Epub 1900 01 01.

Radical antegrade modular pancreatosplenectomy.

Strasberg SM, Drebin JA, Linehan D

Surgery.. 2003 May 133 (5):521-7. Epub 1900 01 01.

Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cells.

Tanaka Y, Dowdy SF, Linehan DC, Eberlein TJ, Goedegebuure PS

The Journal of immunology : official journal of the American Association of Immunologists.. 2003 February 1170 (3):1291-8. Epub 1900 01 01.

Human dendritic cells induce tumor-specific apoptosis by soluble factors.

Joo HG, Fleming TP, Tanaka Y, Dunn TJ, Linehan DC, Goedegebuure PS, Eberlein TJ

International journal of cancer.. 2002 November 1102 (1):20-8. Epub 1900 01 01.

Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma.

Liyanage UK, Moore TT, Joo HG, Tanaka Y, Herrmann V, Doherty G, Drebin JA, Strasberg SM, Eberlein TJ, Goedegebuure PS, Linehan DC

The Journal of immunology : official journal of the American Association of Immunologists.. 2002 September 1169 (5):2756-61. Epub 1900 01 01.

Prospective trial of a blood supply-based technique of pancreaticojejunostomy: effect on anastomotic failure in the Whipple procedure.

Strasberg SM, Drebin JA, Mokadam NA, Green DW, Jones KL, Ehlers JP, Linehan D

Journal of the American College of Surgeons.. 2002 June 194 (6):746-58; discussion 759-60. Epub 1900 01 01.

Utility of staging laparoscopy in subsets of peripancreatic and biliary malignancies.

Vollmer CM, Drebin JA, Middleton WD, Teefey SA, Linehan DC, Soper NJ, Eagon CJ, Strasberg SM

Annals of surgery.. 2002 January 235 (1):1-7. Epub 1900 01 01.

Use of a bipolar vessel-sealing device for parenchymal transection during liver surgery.

Strasberg SM, Drebin JA, Linehan D

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2002 6 (4):569-74. Epub 1900 01 01.

Magnetic resonance imaging facilitates breast conservation for occult breast cancer.

Olson JA, Morris EA, Van Zee KJ, Linehan DC, Borgen PI

Annals of surgical oncology.. 2000 July 7 (6):411-5. Epub 1900 01 01.

Influence of biologic factors and anatomic site in completely resected liposarcoma.

Linehan DC, Lewis JJ, Leung D, Brennan MF

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2000 April 18 (8):1637-43. Epub 1900 01 01.

Chest wall resection for locally recurrent breast cancer: is it worthwhile?

Downey RJ, Rusch V, Hsu FI, Leon L, Venkatraman E, Linehan D, Bains M, van Zee K, Korst R, Ginsberg R

The Journal of thoracic and cardiovascular surgery.. 2000 March 119 (3):420-8. Epub 1900 01 01.

Mechanisms of radiocolloid localization in sentinel node biopsy.

Linehan DC, Eberlein TJ

Annals of surgical oncology.. 2000 March 7 (2):77. Epub 1900 01 01.

Survival of patients evaluated by FEG-PET before hepatic resection for metastatic colorectal carcinoma: a prospective database study

Strasberg SM, Dehdashti F, Siegal BA, Drebin JA and Linehan DC.

Annals of Surgery. 2000; 233(3): 293-299.

Sentinel lymph node biopsy in breast cancer: unfiltered radioisotope is superior to filtered.

Linehan DC, Hill AD, Tran KN, Yeung H, Yeh SD, Borgen PI, Cody HS

Journal of the American College of Surgeons.. 1999 April 188 (4):377-81. Epub 1900 01 01.

Immunotherapeutic approaches to sarcoma.

Linehan DC, Bowne WB, Lewis JJ

Seminars in surgical oncology.. 1999 17 (1):72-7. Epub 1900 01 01.

Intradermal radiocolloid and intraparenchymal blue dye injection optimize sentinel node identification in breast cancer patients.

Linehan DC, Hill AD, Akhurst T, Yeung H, Yeh SD, Tran KN, Borgen PI, Cody HS

Annals of surgical oncology.. 1999 6 (5):450-4. Epub 1900 01 01.

Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome.

Cady B, Jenkins RL, Steele GD, Lewis WD, Stone MD, McDermott WV, Jessup JM, Bothe A, Lalor P, Lovett EJ, Lavin P, Linehan DC

Annals of surgery.. 1998 April 227 (4):566-71. Epub 1900 01 01.

The HER2/neu-derived peptide p654-662 is a tumor-associated antigen in human pancreatic cancer recognized by cytotoxic T lymphocytes.

Peiper M, Goedegebuure PS, Linehan DC, Ganguly E, Douville CC, Eberlein TJ

European journal of immunology.. 1997 May 27 (5):1115-23. Epub 1900 01 01.

Simultaneous production of T helper-1-like cytokines and cytolytic activity by tumor-specific T cells in ovarian and breast cancer.

Goedegebuure PS, Douville CC, Doherty JM, Linehan DC, Lee KY, Ganguly EK, Eberlein TJ

Cellular immunology.. 1997 February 1175 (2):150-6. Epub 1900 01 01.

Vaccine therapy for cancer.

Linehan DC, Goedegebuure PS, Eberlein TJ

Annals of surgical oncology.. 1996 March 3 (2):219-28. Epub 1900 01 01.

Tumor-specific and HLA-A2-restricted cytolysis by tumor-associated lymphocytes in human metastatic breast cancer.

Linehan DC, Goedegebuure PS, Peoples GE, Rogers SO, Eberlein TJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1995 November 1155 (9):4486-91. Epub 1900 01 01.

Shared T cell epitopes in epithelial tumors.

Peoples GE, Smith RC, Linehan DC, Yoshino I, Goedegebuure PS, Eberlein TJ

Cellular immunology.. 1995 September 164 (2):279-86. Epub 1900 01 01.

Immunoregulatory effects of CD4+ T helper subsets in human melanoma.

Lee KY, Goedegebuure PS, Linehan DC, Eberlein TJ

Surgery.. 1995 April 117 (4):365-72. Epub 1900 01 01.

In vitro stimulation of ovarian tumour-associated lymphocytes with a peptide derived from HER2/neu induces cytotoxicity against autologous tumour.

Linehan DC, Peoples GE, Hess DT, Summerhayes IC, Parikh AS, Goedegebuure PS, Eberlein TJ

Surgical oncology.. 1995 February 4 (1):41-9. Epub 1900 01 01.

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

Peoples GE, Goedegebuure PS, Smith R, Linehan DC, Yoshino I, Eberlein TJ

Proceedings of the National Academy of Sciences of the United States of America.. 1995 January 1792 (2):432-6. Epub 1900 01 01.

T-cells isolated from breast cancer patients recognize a HER2/neu derived tumor-associated antigen shared by several epithelial-based tumors

Linehan DC; Goedegebuure PS; Peoples GE; Eberlein TJ.

Surgical Forum. 1995; 46: 496-498.

Lysis of pancreatic cancer cells by tumor-specific T-cells is associated with tumor cell expression of HER2/neu

Peiper M; Linehan DC; Ganguly E; Douville C; Goedegebuure PS; Eberlein TJ.

1995; 46: 140-142.

Ovarian and breast cancer express shared antigenic peptides recognized by tumor-specific cytotoxic T-lymphocytes

Peoples GE; Smith RC; Linehan DC; Goedegebuure PS; Eberlein TJ.

Surgical Forum. 1994; 45: 565-567.

Ovarian and breast tumor-associated lymphocytes stimulated with an antigenic peptide derived from HER2/neu show enhanced cytotoxicity against autologous tumor

Linehan DC; Peoples GE; Parikh AS; Goedegebuure PS; Eberlein TJ.

Surgical Forum. 1994; 45: 568-570.

Books

Surgery of the Liver, Biliary Tract and Pancreas (2007)

Authors: Linehan DC and Jarnagin WR

Publisher: Elsevier, Philadelphia 2007

Malignant Liver Tumors: Current and Emerging Therapies (2002)

Chapter: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy

Authors: Strasberg SM and Linehan DC

Publisher: Bartlett and Barnes, Chicago 2002

Surgical Treatment: Evidence-Based and Problem Oriented (2001)

Chapter: Soft Tissue Sarcoma

Authors: Linehan DC and Brennan MF

Publisher: W Zuckschwerdt Verlag, Munch 2001

Surgical Research (2001)

Chapter: Active Immunotherapy

Authors: Linehan DC; Amos K; Eberlein TJ

Publisher: Academic Press, San Diego, CA 2001

Ratings & Reviews

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.