Musculoskeletal Tissue Engineering
Tissue engineering or regenerative medicine approaches based on engineering cells and scaffolds into
spare-parts promise to shape the future of reconstructive surgery and organ transplantation. Our research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions, using in vivo and in vitro models of tissue repair and clinically translatable outcome measures to assess the efficacy of repair. To that end, a major theme in our laboratory is the development and evaluation of scaffolds that are derived from decellularized tissue grafts and modified as cell and drug delivery vehicles for applications in clinically relevant models of tendon, bone, and cartilage repair.
- TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair. J Cell Physiol. In press. (2014 Jun 24).
- Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone. 62, 79-89. (2014 May 01).