Musculoskeletal Tissue Engineering
Tissue engineering or regenerative medicine approaches based on engineering cells and scaffolds into
spare-parts promise to shape the future of reconstructive surgery and organ transplantation. Our research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions, using in vivo and in vitro models of tissue repair and clinically translatable outcome measures to assess the efficacy of repair. To that end, a major theme in our laboratory is the development and evaluation of scaffolds that are derived from decellularized tissue grafts and modified as cell and drug delivery vehicles for applications in clinically relevant models of tendon, bone, and cartilage repair.
- Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone. 73, 77-89. (2015 Apr 01).
- Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair. J Orthop Res. In press. (2015 Mar 11).