Musculoskeletal Tissue Engineering
Tissue engineering or regenerative medicine approaches based on engineering cells and scaffolds into
spare-parts promise to shape the future of reconstructive surgery and organ transplantation. Our research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions, using in vivo and in vitro models of tissue repair and clinically translatable outcome measures to assess the efficacy of repair. To that end, a major theme in our laboratory is the development and evaluation of scaffolds that are derived from decellularized tissue grafts and modified as cell and drug delivery vehicles for applications in clinically relevant models of tendon, bone, and cartilage repair.
- A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone. 72, 128-36. (2015 Mar 01).
- Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone. 72, 92-100. (2015 Mar 01).