Musculoskeletal Tissue Engineering
Tissue engineering or regenerative medicine approaches based on engineering cells and scaffolds into
spare-parts promise to shape the future of reconstructive surgery and organ transplantation. Our research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions, using in vivo and in vitro models of tissue repair and clinically translatable outcome measures to assess the efficacy of repair. To that end, a major theme in our laboratory is the development and evaluation of scaffolds that are derived from decellularized tissue grafts and modified as cell and drug delivery vehicles for applications in clinically relevant models of tendon, bone, and cartilage repair.
- Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone. 62, 79-89. (2014 May 01).
- 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials. 35, 4026-34. (2014 Apr 01).