Welcome to the Giacomelli Lab
Our research program focuses on the application of multiphoton and fluorescence imaging to surgical pathology and clinical medicine. We design custom multiphoton and fluorescence microscopes, algorithms, and electronics that enable surgical and clinical imaging of pathology in living human tissue with an emphasis on building instruments that can be directly used by clinicians and non-engineers.
Students interested in joining the Giacomelli Lab should contact Professor Giacomelli and visit our Working in the Lab page.
Michael Giacomelli, Ph.D.
Principal Investigator
Projects
View All Projects
Publications
View All Publications- Two-photon microscopy allows for rapid imaging and diagnosis of Mohs specimens.; JAAD case reports; Vol 67, pp. 63-67. 2025 Oct 30.
- High-throughput hyperspectral fluorescence imaging using a high-speed silicon photomultiplier array.; Biomedical optics express; Vol 16(10), pp. 3949-3957. 2025 Sep 05.
- High area and volumetric throughput parallel two-photon fluorescence microscopy using silicon photomultiplier arrays.; Photonics research; Vol 13(9), pp. 2704-2717. 2025 Aug 29.
- hyperPICASSO: adapting the mutual-information-based unmixing technique PICASSO to hyperspectral datasets.; Optics letters; Vol 50(13), pp. 4386-4389. 2025 Jul 01.
- Piston-based specimen holder for rapid surgical and biopsy specimen imaging.; Biomedical optics express; Vol 15(5), pp. 2898-2909. 2024 Apr 08.
Affiliations
News
Contact Us
Giacomelli Lab
?MC 5-8145
601 Elmwood Ave
Rochester, NY 14642