Infectious diseases have been principal threats to health throughout the history of man. The fight against deadly microbes relies largely on knowledge of the microbe's interactions with the body. Our Infectious Diseases Division specializes in viral infections such as Human Immunodeficiency Virus (HIV), Influenza, Human Papilloma Virus (HPV), and Dengue. We have expertise in the community surveillence of pathogens, vaccine research for HIV, vaccine research for influenza and the development of treatments for viral, fungal and bacterial pathogens.
Along with offering care for every variety of infectious disease, our New York State designated AIDS Center provides comprehensive, state-of-the-art care for persons with HIV infection.
The role of the Respiratory Pathogens Research Center is to provide the NIAID Division of Microbiology and Infectious Diseases (DMID) with the capability of conducting translational and clinical research focused on the development and optimization of control measures for viral and bacterial respiratory pathogens. The Center is co-directed by Dr. David Topham and Dr. Ann Falsey.
New York Influenza Center of Excellence
The New York Influenza Center of Excellence (NYICE) is collaborative, interdisciplinary approach involving investigators in the fields of immunology, virology, biochemistry, medicine, pediatrics, statistics and bioinformatics that will addresss directly the issues of cross-protective immunity and virus adaptation to the mammalian host. Our goal is to provide a truly transforming approach to influenza research. The center is directed by Dr. John J Treanor.
To provide leadership, services and infrastructure necessary to: establish multidisciplinary collaborations that achieve high-impact discoveries; support the early career development of diverse young HIV/AIDS investigators; and to establish a distinctive scientific identity, placing the University of Rochester at the forefront of HIV/AIDS research. The center is co-directed by Dr. Stephen Dewhurst and Dr. Michael Keefer.
Center for Community Health
The Center for Community Health was established by the University of Rochester Medical Center to develop and expand academic-community health partnerships dedicated to improving the health of our community. It represents a new model of institutional commitment to community health that focuses on prevention. Dr. Ghinwa Dumyati is director of the Communicable Diseases and Surveillance Program at the Center for Community Health which focuses on surveillance for emerging infections, healthcare associated infections and the prevention of healthcare associated infection in the Rochester area.
NEWS AND EVENTS
URMC Enrolling Patients to Test Live Pandemic Flu Vaccines
UR Named Center for AIDS Research by the National Institutes of Health
RECENT PUBLICATIONS AND PRESENTATIONS
Falsey AR, Becker KL, Swinburne AJ, Nylen ES, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Baran A, Walsh EE. Bacterial Complications of Respiratory Viral Illness: A Comprehensive Evaluation. J Infect Dis. 2013 May 9. PubMed PMID: 23661797.
Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW; Group for the Shingles Prevention Study. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. J Infect Dis. 2013 Apr 30. PubMed PMID: 23633406.
Wang J, Li D, Bambara RA, Yang H, Dykes C. L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness. J Gen Virol. 2013 Mar 27. PubMed PMID: 23535575.
Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K. The B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza vaccination. Clin Vaccine Immunol. 2013 Apr 10. PubMed PMID: 23576673.
Frey SE, Winokur PL, Salata RA, El-Kamary SS, Turley CB, Walter EB Jr, Hay CM, Newman FK, Hill HR, Zhang Y, Chaplin P, Tary-Lehmann M, Belshe RB. Safety and immunogenicity of IMVAMUNE(®) smallpox vaccine using different strategies for a post event scenario. Vaccine. 2013 May 9. PubMed PMID: 23664987.
Thompson ND, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Godine D, Maloney M, Kainer M, Ray S, Thompson D, Wilson L, Magill SS. "Evaluating the accuracy of sampling to estimate central line-days: simplification of the national healthcare safety network surveillance methods." Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. 2013 Mar 34(3):221-8.
PubMed PMID: 23388355
Duffy J, Dumyati G, Bulens S, Namburi S, Gellert A, Fridkin SK, Lessa FC. "Community-onset invasive methicillin-resistant Staphylococcus aureus infections following hospital discharge." American journal of infection control. 2013 Feb 5. PubMed PMID:
Zhang X, Tierney C, Albrecht M, Demeter LM, Morse G, DiFrancesco R, Dykes C, Jiang H, Haas DW. Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. Ther Drug Monit. 2013 35(2):209-16. PubMed PMID: 23503447.
Luque AE, van Keken A, Winters P, Keefer MC, Sanders M, Fiscella K. Barriers and Facilitators of Online Patient Portals to Personal Health Records Among Persons Living With HIV: Formative Research. JMIR Res Protoc. 2013 2(1):e8. PubMed PMID: 23612564.
Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR. Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza. PLoS One. 2013 8(3):e57275. PubMed PMID: 23526940.
Luque AE, Corales R, Fowler RJ, Dimarco J, van Keken A, Winters P, Keefer MC, Fiscella K. Bridging the Digital Divide in HIV Care: A Pilot Study of an iPod Personal Health Record. J Int Assoc Provid AIDS Care. 2013 12(2):117-21. PubMed PMID: 22965693.
Walsh EE, Swinburne AJ, Becker KL, Nylen ES, Snider RH, Baran A, Peterson DR, Falsey AR. Can serum procalcitonin levels help interpret indeterminate chest radiographs in patients hospitalized with acute respiratory illness? J Hosp Med. 2013 8(2):61-7. PubMed PMID: 23086568.
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine. J Infect Dis. 2013 207(2):297-305. PubMed PMID: 23148285.
Jones MC, Kobie JJ, Delouise LA. Characterization of cell seeding and specific capture of B cells in microbubble well arrays. Biomed Microdevices. 2013 15(3):453-63. PubMed PMID: 23358874.
Walsh EE, Peterson DR, Kalkanoglu AE, Lee FE, Falsey AR. Viral shedding and immune responses to respiratory syncytial virus infection in older adults. J Infect Dis. 2013 207(9):1424-32. PubMed PMID: 23382572.
Elizaga ML, Vasan S, Marovich MA, Sato AH, Lawrence DN, Chaitman BR, Frey SE, Keefer MC; MVA Cardiac Safety Working Group. Prospective surveillance for cardiac adverse events in healthy adults receiving modified vaccinia Ankara vaccines: a systematic review. PLoS One. 2013 8(1):e54407. PubMed PMID: 23349878.
Fowler VG, Allen KB, Moreira ED, Moustafa M, Isgro F, Boucher HW, Corey GR, Carmeli Y, Betts R, Hartzel JS, Chan IS, McNeely TB, Kartsonis NA, Guris D, Onorato MT, Smugar SS, DiNubile MJ, Sobanjo-ter Meulen A. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial. JAMA. 2013 309(13):1368-78. PubMed PMID: 23549582.