Department of Pediatrics - Infectious Diseases Research

Investigators

Francis Gigliotti, M.D., Chief

Research Interests:

  • Pathogenesis of disease caused by Pneumocystis carinii
  • Infections in the immunocompromised host
  • Pediatric AIDS clinical trials

Publications:

  • Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J.  Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation:  Role of CD4+ T cells.  Am J Physiol Lung Cell Mol Physiol  2006;290(6):L1087-96.
  • Wells J, Haidaris CG, Wright TW, Gigliotti F.  Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.  Infect Immun 2006;74(1):390-3.
  • Bhagwat SP, Gigliotti F, Xu H, Wright TW.  Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease.  Am J Physiol Lung Cell Mol Physiol 2006;291:L1256-66.
  • Gigliotti F, Crow EL, Bhagwat SP, Wright TW.  Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia.  Infect Immun 2006;74:6310-16.

Samir Bhagwat, Ph.D.

Research Interests:

  • Lung injury during Pneumocystis carinii pneumonia

Mary T. Caserta, M.D.

Research Interests:

  • Pathogenesis of HHV6 and HHV7 infection
  • Transplacental transmission of HHV6
  • Immune response to HHV6

Publications:

  • Caserta MT, Mock DJ, Dewhurst S. Human Herpesvirus 6.
    Clin Infect Dis 2001;33:829-833.
  • Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S. Congenital infections with human herpesviruses 6 and 7. J Pediatr 2004;145:472-7.
  • Caserta MT, McDermott MP, Dewhurst S, Schnabel K, Carnahan J, Gilbert L, Lathan G, Lofthus GK, Hall CB. Human Herpesvirus 6 (HHV6) DNA persistence and reactivation in normal children. J Pediatr 2004;145:478-84.

Cynthia Christy, M.D.

Research Interests:

  • Influenza vaccine and children with asthma
  • Medical student education

Publications:

  • Christy C, Aligne CA, Auinger P, Pulcino T, Weitzman M. Lack of effect of influenza vaccine for prevention of asthma exacerbations.
    Arch Dis Child 2004;89:734-35.
  • Garfunkel LC, Kaczorowski J, Christy C (editors). The Pediatric Clinical Advisor. Mosby-Year Book, Inc., St. Louis, MO (2001).

Damian J. Krysan, M.D., Ph.D.

Research Interests:

  • Yeast Aspartyl Proteases in Cell Wall Integrity: Investigating the role of a family of aspartyl proteases in yeast cell wall biosynthesis using a variety of biochemical, genetic and cell biological approaches
  • Development of High Throughput Assay for Cell Wall-Targeted Antifungal Drugs: Developing assays to identify small molecules that disrupt cell wall biosynthesis by detecting cell lysis and activation of cell wall integrity stress response pathways

Publications:

  • Krysan DJ, Gilsdorf JR. Clinical research abstracts for pediatricians: Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children. J Pediatr 2004;144:406.
  • Krysan DJ. Best Clinical Evidence Section: Effectiveness over time of varicella vaccination. J Pediatr 2002;145:416.

Geoffrey Weinberg, M.D.

Research Interests:

  • Pediatric AIDS clinical trials
  • Vaccine-preventable disease epidemiology and laboratory diagnostics

Publications:

  • Weinberg GA, Erdman DD, Edwards KM, Hall CB, Walker FJ, Griffin MR, Schwartz B, and the New Vaccine Surveillance Network Study Group. Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children.
    J Infect Dis 2004;189:706-10.
  • Griffin MR, Walker FJ, Iwane MK, Weinberg GA, Staat MA, Erdman DD, and the NVSN Study Group. Epidemiology of respiratory infections in young children: Insights from the New Vaccine Surveillance Network (NVSN).
    Pediatr Infect Dis J 2004;23:S188-S92.
  • Weinberg GA, Burchett SL. Pediatric human immunodeficiency virus (HIV) infection. In: Mandell GL, Bennett JE, Dolin R (eds). Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases, 6th Edition. Philadelphia: Elsevier, 2005, pp. 1638-54.

Melanie Wellington, M.D.

Research Interets:

  • Host defense against infection with Candida
  • Fungal infections in children
  • Infections in the immunocompromised host

Publications:

  • Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun 2003;71(12):7228-31.
  • Bliss JM, Wellington M, Gigliotti F. Antifungal therapy for neonatal candidiasis. Sem Perinatol 2003;27(5):365-84.
     

Terry W. Wright, Ph.D.

Research Interests:

  • Pneumocystis carinii biology
  • Pathogenesis of lung injury during Pneumocystis carinii pneumonia

Publications:

  • Wells J, Haidaris CG, Wright TW, Gigliotti F.  Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.  Infect Immun 2006;74(4):2446-8.
  • Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J.  Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation:  Role of CD4+ T cells.  Am J Physiol Lung Cell Mol Physiol 2006;290(6):L1087-96.
  • Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O’Reilly MA.  P21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol 2006;168(6):1838-47.
  • Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco M, Finkelstein JN, O’Reilly MA. Type II epithelial cells are a critical target for hyperoxia mediated impairment of postnatal lung development. Am Physiol Lung Cell Mol Physiol 2006; in press; [Epub ahead of print].