Department of Pediatrics - Nephrology Research

Nephrology Research

Because we are constantly working to improve the quality of life of our patients, research is a central part of the activities within the Division of Pediatric Nephrology.

Laboratory research is broad-based within the field and includes:

  • Physiological, cell biological, and molecular investigations into the understanding of how the kidney senses and responds to acid-base disorders.
  • Investigations into how carbonic anhydrase, hensin, galectin - 3 and cyclophilins influence the kidney's response to acid-base disorders.
  • The role of extracellular matrix proteins regulating acid-base transport was developed at the University of Rochester Medical Center.
  • Investigation into the mechanism of cyst formation and enlargement in models of autosomal recessive polycystic kidney disease.

Clinical research efforts include:

  • Recruitment site and Central Biochemistry Laboratory for the NIH Funded Chronic Kidney Disease in Children Study ( CKID) - 53 sites within the United States and Canada participate in the study involving 600 children. The goal is to monitor the progression of kidney disease and its growth, cardiovascular and neurocognitive effects on children.
  • Mechanisms and pathogenesis of pediatric hypertension
  • Investigation of kidney tubular disorders
  • Mechanisms of pediatric nephrolithiasis (kidney stones)
  • Use of iohexol to measure glomerular filtration rate in kidney patients
  • Successful development applications of the Schwartz Formula, a formula used internationally in estimations of glomerular filtration rate