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Ann Falsey

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
AddressRochester General Hospital
1425 Portland Avenue
Infectious Diseases Unit
Rochester NY 14621
 
 Selected Publications
  • Mehta J, Walsh EE, Mahadevia PJ, Falsey AR. Risk factors for respiratory syncytial virus illness among patients with chronic obstructive pulmonary disease. COPD. 2013 Jun; 10(3):293-9.
    View in: PubMed
  • McElhaney JE, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, Ruiz-Palacios GM, van Essen GA, Caplanusi A, Claeys C, Durand C, Duval X, El Idrissi M, Falsey AR, Feldman G, Frey SE, Galtier F, Hwang SJ, Innis BL, Kovac M, Kremsner P, McNeil S, Nowakowski A, Richardus JH, Trofa A, Oostvogels L. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. Lancet Infect Dis. 2013 Jun; 13(6):485-96.
    View in: PubMed
  • Gorse GJ, Falsey AR, Fling JA, Poling TL, Strout CB, Tsang PH. Intradermally-administered influenza virus vaccine is safe and immunogenic in healthy adults 18-64 years of age. Vaccine. 2013 May 1; 31(19):2358-65.
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  • Walsh EE, Peterson DR, Kalkanoglu AE, Lee FE, Falsey AR. Viral shedding and immune responses to respiratory syncytial virus infection in older adults. J Infect Dis. 2013 May; 207(9):1424-32.
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  • Walsh EE, Swinburne AJ, Becker KL, Nylen ES, Snider RH, Baran A, Peterson DR, Falsey AR. Can serum procalcitonin levels help interpret indeterminate chest radiographs in patients hospitalized with acute respiratory illness? J Hosp Med. 2013 Feb; 8(2):61-7.
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  • Gandhi A, Walsh EE, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Baran A, Falsey AR. Factors associated with symptomatic rhinovirus infection in patients with COPD. J Clin Virol. 2012 Dec; 55(4):343-7.
    View in: PubMed
  • Falsey AR. Current management of parainfluenza pneumonitis in immunocompromised patients: a review. Infect Drug Resist. 2012; 5:121-7.
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  • Falsey AR, Formica MA, Walsh EE. Simple method for combining sputum and nasal samples for virus detection by reverse transcriptase PCR. J Clin Microbiol. 2012 Aug; 50(8):2835.
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  • Walsh EE, Falsey AR. Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets. 2012 Apr 1; 12(2):98-102.
    View in: PubMed
  • Falsey AR, Becker KL, Swinburne AJ, Nylen ES, Snider RH, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Walsh EE. Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note. Int J Chron Obstruct Pulmon Dis. 2012; 7:127-35.
    View in: PubMed
  • High KP, Case D, Hurd D, Powell B, Lesser G, Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G, Rousey S, Shaw EG. A Randomized, Controlled Trial of Panax quinquefolius Extract (CVT-E002) to Reduce Respiratory Infection in Patients With Chronic Lymphocytic Leukemia. J Support Oncol. 2012 Sep-Oct; 10(5):195-201.
    View in: PubMed
  • Falsey AR, Formica MA, Walsh EE. Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness. J Clin Microbiol. 2012 Jan; 50(1):21-4.
    View in: PubMed
  • Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, Falsey AR, Mathur SK, Ramsdell JW, Rogers L, Stempel DA, Lima JJ, Fish JE, Wilson SR, Boyd C, Patel KV, Irvin CG, Yawn BP, Halm EA, Wasserman SI, Sands MF, Ershler WB, Ledford DK. Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol. 2011 Sep; 128(3 Suppl):S4-24.
    View in: PubMed
  • Hara H, Hara H, Hironaka T, Inoue M, Iida A, Shu T, Hasegawa M, Nagai Y, Falsey AR, Kamali A, Anzala O, Sanders EJ, Karita E, Mwananyanda L, Vasan S, Lombardo A, Parks CL, Sayeed E, Krebs M, Cormier E, Ackland J, Price MA, Excler JL. Prevalence of specific neutralizing antibodies against Sendai virus in populations from different geographic areas: implications for AIDS vaccine development using Sendai virus vectors. Hum Vaccin. 2011 Jun; 7(6):639-45.
    View in: PubMed
  • Lee FE, Walsh EE, Falsey AR. The effect of steroid use in hospitalized adults with respiratory syncytial virus-related illness. Chest. 2011 Nov; 140(5):1155-61.
    View in: PubMed
  • Lee FE, Halliley JL, Walsh EE, Moscatiello AP, Kmush BL, Falsey AR, Randall TD, Kaminiski DA, Miller RK, Sanz I. Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. J Immunol. 2011 May 1; 186(9):5514-21.
    View in: PubMed
  • Lee FE, Falsey AR, Halliley JL, Sanz I, Walsh EE. Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults. J Infect Dis. 2010 Dec 1; 202(11):1659-66.
    View in: PubMed
  • Falsey AR. New emerging technologies and the intradermal route: the novel way to immunize against influenza. Vaccine. 2010 Sep 7; 28 Suppl 4:D24-32.
    View in: PubMed
  • Shahid Z, Kleppinger A, Gentleman B, Falsey AR, McElhaney JE. Clinical and immunologic predictors of influenza illness among vaccinated older adults. Vaccine. 2010 Aug 31; 28(38):6145-51.
    View in: PubMed
  • Murata Y, Lightfoote PM, Biear JN, Falsey AR, Walsh EE. Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein. Vaccine. 2010 Aug 31; 28(38):6242-6.
    View in: PubMed
  • Halliley JL, Kyu S, Kobie JJ, Walsh EE, Falsey AR, Randall TD, Treanor J, Feng C, Sanz I, Lee FE. Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization. Vaccine. 2010 Apr 30; 28(20):3582-7.
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  • Talbot HK, Falsey AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis. 2010 Mar 1; 50(5):747-51.
    View in: PubMed
  • Murata Y, Lightfoote PM, Falsey AR, Walsh EE. Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein. Clin Vaccine Immunol. 2010 Apr; 17(4):695-7.
    View in: PubMed
  • Falsey AR, Hennessey PA, Formica MA, Criddle MM, Biear JM, Walsh EE. Humoral immunity to human metapneumovirus infection in adults. Vaccine. 2010 Feb 10; 28(6):1477-80.
    View in: PubMed
  • Duncan CB, Walsh EE, Peterson DR, Lee FE, Falsey AR. Risk factors for respiratory failure associated with respiratory syncytial virus infection in adults. J Infect Dis. 2009 Oct 15; 200(8):1242-6.
    View in: PubMed
  • Falsey AR, Formica MA, Walsh EE. Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirus. J Clin Virol. 2009 Dec; 46(4):314-7.
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  • Falsey AR, Treanor JJ, Tornieporth N, Capellan J, Gorse GJ. Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J Infect Dis. 2009 Jul 15; 200(2):172-80.
    View in: PubMed
  • Falsey AR. Half-dose influenza vaccine: stretching the supply or wasting it? Arch Intern Med. 2008 Dec 8; 168(22):2402-3.
    View in: PubMed
  • Walsh EE, Peterson DR, Falsey AR. Human metapneumovirus infections in adults: another piece of the puzzle. Arch Intern Med. 2008 Dec 8; 168(22):2489-96.
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  • Falsey AR, Walsh EE, Capellan J, Gravenstein S, Zambon M, Yau E, Gorse GJ, Edelman R, Hayden FG, McElhaney JE, Neuzil KM, Nichol KL, Simões EA, Wright PF, Sales VM. Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (rsv) vaccines--nonadjuvanted vaccine or vaccine adjuvanted with alum--given concomitantly with influenza vaccine to high-risk elderly individuals. J Infect Dis. 2008 Nov 1; 198(9):1317-26.
    View in: PubMed
  • Falsey AR. Human metapneumovirus infection in adults. Pediatr Infect Dis J. 2008 Oct; 27(10 Suppl):S80-3.
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  • Camargo CA, Ginde AA, Clark S, Cartwright CP, Falsey AR, Niewoehner DE. Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease. Intern Emerg Med. 2008 Dec; 3(4):355-9.
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  • Ljubin-Sternak S, Santak M, Cepin-Bogovic J, Bace A, Vojnovic G, Mlinaric-Galinovic G, Forcic D, Drazenovic V, Falsey AR. Detection of genetic lineages of human metapneumovirus in Croatia during the winter season 2005/2006. J Med Virol. 2008 Jul; 80(7):1282-7.
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  • Falsey AR, Dallal GE, Formica MA, Andolina GG, Hamer DH, Leka LL, Meydani SN. Long-term care facilities: a cornucopia of viral pathogens. J Am Geriatr Soc. 2008 Jul; 56(7):1281-5.
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  • Stevens WW, Falsey AR, Braciale TJ. RSV 2007: recent advances in respiratory syncytial virus research. Viral Immunol. 2008 Jun; 21(2):133-40.
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  • Falsey AR. Community-acquired viral pneumonia. Clin Geriatr Med. 2007 Aug; 23(3):535-52, vi.
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  • Li Q, Falsey RR, Gaitonde S, Sotello V, Kislin K, Martinez JD. Genetic analysis of p53 nuclear importation. Oncogene. 2007 Dec 13; 26(57):7885-93.
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  • Lee FE, Walsh EE, Falsey AR, Lumb ME, Okam NV, Liu N, Divekar AA, Hall CB, Mosmann TR. Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection. J Infect Dis. 2007 Jun 15; 195(12):1779-88.
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  • Falsey AR. Respiratory syncytial virus infection in adults. Semin Respir Crit Care Med. 2007 Apr; 28(2):171-81.
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  • Murata Y, Walsh EE, Falsey AR. Pulmonary complications of interpandemic influenza A in hospitalized adults. J Infect Dis. 2007 Apr 1; 195(7):1029-37.
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  • Walsh EE, Peterson DR, Falsey AR. Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly and high-risk adults possible? J Infect Dis. 2007 Apr 1; 195(7):1046-51.
    View in: PubMed
  • Falsey AR, Murata Y, Walsh EE. Impact of rapid diagnosis on management of adults hospitalized with influenza. Arch Intern Med. 2007 Feb 26; 167(4):354-60.
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  • Murata Y, Falsey AR. Respiratory syncytial virus infection in adults. Antivir Ther. 2007; 12(4 Pt B):659-70.
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  • Ljubin Sternak S, Vilibic Cavlek T, Falsey AR, Walsh EE, Mlinaric Galinovic G. Serosurvey of human metapneumovirus infection in Croatia. Croat Med J. 2006 Dec; 47(6):878-81.
    View in: PubMed
  • Falsey AR, Singh HK, Walsh EE. Serum antibody decay in adults following natural respiratory syncytial virus infection. J Med Virol. 2006 Nov; 78(11):1493-7.
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  • Falsey AR, Walsh EE. Viral pneumonia in older adults. Clin Infect Dis. 2006 Feb 15; 42(4):518-24.
    View in: PubMed
  • Falsey AR, Criddle MC, Walsh EE. Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness. J Clin Virol. 2006 Jan; 35(1):46-50.
    View in: PubMed
  • Falsey AR, Formica MA, Hennessey PA, Criddle MM, Sullender WM, Walsh EE. Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 Mar 15; 173(6):639-43.
    View in: PubMed
  • Lee FE, Walsh EE, Falsey AR, Liu N, Liu D, Divekar A, Snyder-Cappione JE, Mosmann TR. The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects. Mech Ageing Dev. 2005 Nov; 126(11):1223-9.
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  • Falsey AR. Respiratory syncytial virus infection in elderly and high-risk adults. Exp Lung Res. 2005 Sep; 31 Suppl 1:77.
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  • Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005 Apr 28; 352(17):1749-59.
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  • Falsey AR, Walsh EE. Respiratory syncytial virus infection in elderly adults. Drugs Aging. 2005; 22(7):577-87.
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  • Schmidt AC, Johnson TR, Openshaw PJ, Braciale TJ, Falsey AR, Anderson LJ, Wertz GW, Groothuis JR, Prince GA, Melero JA, Graham BS. Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003. Virus Res. 2004 Nov; 106(1):1-13.
    View in: PubMed
  • Lee FE, Walsh EE, Falsey AR, Betts RF, Treanor JJ. Experimental infection of humans with A2 respiratory syncytial virus. Antiviral Res. 2004 Sep; 63(3):191-6.
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  • Walsh EE, Falsey AR. Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. J Infect Dis. 2004 Jul 15; 190(2):373-8.
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  • Walsh EE, Falsey AR. Age related differences in humoral immune response to respiratory syncytial virus infection in adults. J Med Virol. 2004 Jun; 73(2):295-9.
    View in: PubMed
  • Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly persons. J Infect Dis. 2004 Jan 15; 189(2):233-8.
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  • Casiano-Colón AE, Hulbert BB, Mayer TK, Walsh EE, Falsey AR. Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults. J Clin Virol. 2003 Oct; 28(2):169-74.
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  • Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of hsp90 inhibitors. Curr Cancer Drug Targets. 2003 Oct; 3(5):349-58.
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  • Falsey AR, Formica MA, Treanor JJ, Walsh EE. Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding. J Clin Microbiol. 2003 Sep; 41(9):4160-5.
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  • Falsey AR, Walsh EE. Novel coronavirus and severe acute respiratory syndrome. Lancet. 2003 Apr 19; 361(9366):1312-3.
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  • Kaba NK, Francis CW, Hall WJ, Falsey AR, Smith BH. Protein S declines during winter respiratory infections. J Thromb Haemost. 2003 Apr; 1(4):729-34.
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  • Falsey AR, Erdman D, Anderson LJ, Walsh EE. Human metapneumovirus infections in young and elderly adults. J Infect Dis. 2003 Mar 1; 187(5):785-90.
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  • Walsh EE, Cox C, Falsey AR. Clinical features of influenza A virus infection in older hospitalized persons. J Am Geriatr Soc. 2002 Sep; 50(9):1498-503.
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  • Merchant SS, Falsey AR. Staphylococcus aureus cholecystitis: a report of three cases with review of the literature. Yale J Biol Med. 2002 Sep-Dec; 75(5-6):285-91.
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  • Falsey AR, Walsh EE, Hayden FG. Rhinovirus and coronavirus infection-associated hospitalizations among older adults. J Infect Dis. 2002 May 1; 185(9):1338-41.
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  • Falsey AR, Formica MA, Walsh EE. Diagnosis of respiratory syncytial virus infection: comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness. J Clin Microbiol. 2002 Mar; 40(3):817-20.
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  • Looney RJ, Falsey AR, Walsh E, Campbell D. Effect of aging on cytokine production in response to respiratory syncytial virus infection. J Infect Dis. 2002 Mar 1; 185(5):682-5.
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  • Dumyati G, Falsey AR. Antivirals for influenza: what is their role in the older patient? Drugs Aging. 2002; 19(10):777-86.
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  • Walsh EE, Falsey AR, Swinburne IA, Formica MA. Reverse transcription polymerase chain reaction (RT-PCR) for diagnosis of respiratory syncytial virus infection in adults: use of a single-tube "hanging droplet" nested PCR. J Med Virol. 2001 Mar; 63(3):259-63.
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  • Falsey AR, Walsh EE, Francis CW, Looney RJ, Kolassa JE, Hall WJ, Abraham GN. Response of C-reactive protein and serum amyloid A to influenza A infection in older adults. J Infect Dis. 2001 Apr 1; 183(7):995-9.
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  • Horan JT, Francis CW, Falsey AR, Kolassa J, Smith BH, Hall WJ. Prothrombotic changes in hemostatic parameters and C-reactive protein in the elderly with winter acute respiratory tract infections. Thromb Haemost. 2001 Feb; 85(2):245-9.
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  • Looney RJ, Hasan MS, Coffin D, Campbell D, Falsey AR, Kolassa J, Agosti JM, Abraham GN, Evans TG. Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant. J Clin Immunol. 2001 Jan; 21(1):30-6.
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  • Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev. 2000 Jul; 13(3):371-84.
    View in: PubMed
  • Gonzalez IM, Karron RA, Eichelberger M, Walsh EE, Delagarza VW, Bennett R, Chanock RM, Murphy BR, Clements-Mann ML, Falsey AR. Evaluation of the live attenuated cpts 248/404 RSV vaccine in combination with a subunit RSV vaccine (PFP-2) in healthy young and older adults. Vaccine. 2000 Mar 6; 18(17):1763-72.
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  • Treanor J, Falsey A. Respiratory viral infections in the elderly. Antiviral Res. 1999 Dec 15; 44(2):79-102.
    View in: PubMed
  • Falsey AR, Walsh EE, Looney RJ, Kolassa JE, Formica MA, Criddle MC, Hall WJ. Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adults. J Med Virol. 1999 Oct; 59(2):221-6.
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  • Walsh EE, Falsey AR, Hennessey PA. Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med. 1999 Sep; 160(3):791-5.
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  • Walsh EE, Falsey AR. A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgA. J Infect Dis. 1999 May; 179(5):1268-73.
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  • Falsey AR, Criddle MM, Kolassa JE, McCann RM, Brower CA, Hall WJ. Evaluation of a handwashing intervention to reduce respiratory illness rates in senior day-care centers. Infect Control Hosp Epidemiol. 1999 Mar; 20(3):200-2.
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  • Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol. 1999 Feb; 90(2):213-9.
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  • Falsey AR. Respiratory syncytial virus infection in older persons. Vaccine. 1998 Nov; 16(18):1775-8.
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  • Walsh EE, Falsey AR, Sullender WM. Monoclonal antibody neutralization escape mutants of respiratory syncytial virus with unique alterations in the attachment (G) protein. J Gen Virol. 1998 Mar; 79 ( Pt 3):479-87.
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  • Falsey AR, Walsh EE. Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults. J Infect Dis. 1998 Feb; 177(2):463-6.
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  • Falsey AR, Walsh EE. Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in the institutionalized elderly. Vaccine. 1997 Jul; 15(10):1130-2.
    View in: PubMed
  • Falsey AR, McCann RM, Hall WJ, Criddle MM, Formica MA, Wycoff D, Kolassa JE. The "common cold" in frail older persons: impact of rhinovirus and coronavirus in a senior daycare center. J Am Geriatr Soc. 1997 Jun; 45(6):706-11.
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  • Mlinaric-Galinovic G, Falsey AR, Walsh EE. Respiratory syncytial virus infection in the elderly. Eur J Clin Microbiol Infect Dis. 1996 Oct; 15(10):777-81.
    View in: PubMed
  • Falsey AR, Walsh EE. Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in ambulatory adults over age 60. Vaccine. 1996 Sep; 14(13):1214-8.
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  • Falsey AR, McCann RM, Hall WJ, Criddle MM. Evaluation of four methods for the diagnosis of respiratory syncytial virus infection in older adults. J Am Geriatr Soc. 1996 Jan; 44(1):71-3.
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  • Falsey AR, Cunningham CK, Barker WH, Kouides RW, Yuen JB, Menegus M, Weiner LB, Bonville CA, Betts RF. Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J Infect Dis. 1995 Aug; 172(2):389-94.
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  • Falsey AR, McCann RM, Hall WJ, Tanner MA, Criddle MM, Formica MA, Irvine CS, Kolassa JE, Barker WH, Treanor JJ. Acute respiratory tract infection in daycare centers for older persons. J Am Geriatr Soc. 1995 Jan; 43(1):30-6.
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  • Falsey AR, Walsh EE. Transmission of Chlamydia pneumoniae. J Infect Dis. 1993 Aug; 168(2):493-6.
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  • Falsey AR, Treanor JJ, Betts RF, Walsh EE. Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings. J Am Geriatr Soc. 1992 Feb; 40(2):115-9.
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  • Falsey AR, Walsh EE. Humoral immunity to respiratory syncytial virus infection in the elderly. J Med Virol. 1992 Jan; 36(1):39-43.
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  • Falsey AR. Noninfluenza respiratory virus infection in long-term care facilities. Infect Control Hosp Epidemiol. 1991 Oct; 12(10):602-8.
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  • Falsey AR, Walsh EE, Betts RF. Serologic evidence of respiratory syncytial virus infection in nursing home patients. J Infect Dis. 1990 Aug; 162(2):568-9.
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  • Falsey AR, Goldsticker RD, Ahern MJ. Fatal subcutaneous aspergillosis following necrotizing fasciitis: a case report. Yale J Biol Med. 1990 Jan-Feb; 63(1):9-13.
    View in: PubMed

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