Research

Järvinen-Seppo Laboratory

The Center for Food Allergy conducts research through the Järvinen-Seppo Laboratory, which studies the immunologic factors present in human milk and how those factors may modify developing immune systems for infants and their oral tolerance to foods. For more information on our research program and our team members, please visit the Järvinen-Seppo Lab site.

Recent Publications

• 1. Donovan SM
  2. Aghaeepour N
  3. Andres A
  4. Azad MB
  5. Becker M
  6. Carlson SE
  7. Järvinen KM
  8. Lin W
  9. Lönnerdal B
  10. Slupsky CM
  11. Steiber AL
  12. Raiten DJ
  Evidence for human milk as a biological system and recommendations for study design-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 4.; The American journal of clinical nutrition; Vol 117 Suppl 1, pp. S61-S86. 2023 Apr.
• 1. Smilowitz JT
  2. Allen LH
  3. Dallas DC
  4. McManaman J
  5. Raiten DJ
  6. Rozga M
  7. Sela DA
  8. Seppo A
  9. Williams JE
  10. Young BE
  11. McGuire MK
  Ecologies, synergies, and biological systems shaping human milk composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 2.; The American journal of clinical nutrition; Vol 117 Suppl 1, pp. S28-S42. 2023 Apr.
• 1. Ackley D
  2. Wang H
  3. D'Angio CT
  4. Meyers J
  5. Young BE
  Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review.; Journal of perinatology : official journal of the California Perinatal Association. 2023 Mar 29.
• 1. Seppo AE
  2. Jackson CM
  3. Järvinen KM
  The role of IgA in food allergy remains elusive - timing is everything?; The Journal of allergy and clinical immunology. 2023 Mar 09.
• 1. Cheung KY
  2. Petrou L
  3. Helfer B
  4. Porubayeva E
  5. Dolgikh E
  6. Ali S
  7. Ali I
  8. Archibald-Durham L
  9. Brockway MM
  10. Bugaeva P
  11. Chooniedass R
  12. Comberiati P
  13. Cortés-Macías E
  14. D'Elios S
  15. Feketea G
  16. Hsu P
  17. Kana MA
  18. Kriulina T
  19. Kunii Y
  20. Madaki C
  21. Omer R
  22. Peroni D
  23. Prokofiev J
  24. Simpson MR
  25. Shimojo N
  26. Siziba LP
  27. Genuneit J
  28. Thakor S
  29. Waris M
  30. Yuan Q
  31. Zaman S
  32. Young BE
  33. Bugos B
  34. Greenhawt M
  35. Levin ME
  36. Zheng J
  37. Boyle RJ
  38. Munblit D
  Health and nutrition claims for infant formula: international cross sectional survey.; BMJ (Clinical research ed.); Vol 380, pp. e071075. 2023 Feb 15.
• 1. Pier J
  2. Bingemann T
  3. Badwal J
  4. Rosloff D
  5. Pasha M
  6. Wang H
  7. Lomas JM
  8. Järvinen KM
  Food protein-induced enterocolitis syndrome: Healthcare utilization and referral patterns among a pediatric cohort.; Frontiers in allergy; Vol 4, pp. 1102410. 2023 Feb 10.
• 1. Jackson CM
  2. Kaplan AN
  3. Järvinen KM
  Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes.; Current allergy and asthma reports. 2023 Jan 07.
• 1. Strzalkowski AJ
  2. Järvinen KM
  3. Schmidt B
  4. Young BE
  Protein and carbohydrate content of infant formula purchased in the United States.; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022 Sep 21.
• 1. Davis EC
  2. Castagna VP
  3. Sela DA
  4. Hillard MA
  5. Lindberg S
  6. Mantis NJ
  7. Seppo AE
  8. Järvinen KM
  Gut microbiome and breast-feeding: Implications for early immune development.; The Journal of allergy and clinical immunology; Vol 150(3), pp. 523-534. 2022 Sep.
• 1. Järvinen KM
  2. Davis EC
  3. Bevec E
  4. Jackson CM
  5. Pizzarello C
  6. Catlin E
  7. Klein M
  8. Sunkara A
  9. Diaz N
  10. Miller J
  11. Martina CA
  12. Thakar J
  13. Seppo AE
  14. Looney RJ
  Biomarkers of Development of Immunity and Allergic Diseases in Farming and Non-farming Lifestyle Infants: Design, Methods and 1 Year Outcomes in the "Zooming in to Old Order Mennonites" Birth Cohort Study.; Frontiers in pediatrics; Vol 10, pp. 916184. 2022 Jul 06.
• 1. Pesonen M
  2. Kallio MJT
  3. Ranki A
  4. Siimes MA
  5. Järvinen KM
  Early-onset atopic dermatitis and food hypersensitivity increase the risk of atopic march.; Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022 Jun 22.
• 1. Wang J
  2. Young BE
  3. Li D
  4. Seppo A
  5. Zhou Q
  6. Wiltse A
  7. Nowak-Wegrzyn A
  8. Murphy K
  9. Widrick K
  10. Diaz N
  11. Cruz-Vasquez J
  12. M Järvinen K
  13. Zand MS
  Broad Cross-Reactive IgA and IgG against Human Coronaviruses in Milk Induced by COVID-19 Vaccination and Infection.; Vaccines; Vol 10(6). 2022 Jun 20.
• 1. Seppo AE
  2. Rajani PS
  3. Wong A
  4. Varrone JJ
  5. Fridy ST
  6. Kuitunen M
  7. Kukkonen K
  8. Savilahti E
  9. Järvinen KM
  The role of TGF-β and APRIL in human milk IgA production and development of allergic disease in early childhood.; Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology; Vol 33(6). 2022 Jun.
• 1. Davis EC
  2. Jackson CM
  3. Ting T
  4. Harizaj A
  5. Järvinen KM
  Predictors and biomarkers of food allergy and sensitization in early childhood.; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2022 Apr 28.
• 1. Wang J
  2. Young BE
  3. Li D
  4. Seppo AE
  5. Zhou Q
  6. Wiltse A
  7. Nowak-Wegrzyn A
  8. Murphy K
  9. Widrick K
  10. Diaz N
  11. Cruz-Vasquez J
  12. Järvinen KM
  13. Zand MS
  Broad Cross-reactive IgA and IgG Against Human Coronaviruses in Milk Induced by COVID-19 Vaccination and Infection.; medRxiv : the preprint server for health sciences. 2022 Mar 14.
• 1. Young BE
  2. Järvinen KM
  3. Seppo A
  Thinking More About Inhibition of Breast Milk on the Infectivity of SARS-CoV-2-Reply.; JAMA pediatrics. 2022 Feb 28.
• 1. Gamirova A
  2. Berbenyuk A
  3. Levina D
  4. Peshko D
  5. Simpson MR
  6. Azad MB
  7. Järvinen KM
  8. Brough HA
  9. Genuneit J
  10. Greenhawt M
  11. Verhasselt V
  12. Peroni D
  13. Perkin MR
  14. Warner JO
  15. Palmer DJ
  16. Boyle RJ
  17. Munblit D
  Food proteins in human breast milk and probability of IgE-mediated allergic reaction in children during breastfeeding: a systematic review.; The journal of allergy and clinical immunology. In practice. 2022 Feb 02.
• 1. Young BE
  2. Kyere-Davies G
  3. Farriester JW
  4. Varshney R
  5. MacLean PS
  6. Krebs NF
  7. Rudolph MC
  Infant Red Blood Cell Arachidonic to Docosahexaenoic Acid Ratio Inversely Associates with Fat-Free Mass Independent of Breastfeeding Exclusivity.; Nutrients; Vol 14(20). 2022 Jan 11.
• 1. Beck LA
  2. Pesonen M
  3. Thakar J
  4. Georas SN
  5. Järvinen KM
  IgE Sensitization Drives the Atopic March.; American journal of respiratory and critical care medicine. 2022 Jan 08.
• 1. Holm M
  2. Saraswat M
  3. Joenväärä S
  4. Seppo A
  5. Looney RJ
  6. Tohmola T
  7. Renkonen J
  8. Renkonen R
  9. Järvinen KM
  Quantitative glycoproteomics of human milk and association with atopic disease.; PloS one; Vol 17(5). 2022.
• 1. Young BE
  2. Seppo AE
  3. Diaz N
  4. Rosen-Carole C
  5. Nowak-Wegrzyn A
  6. Cruz Vasquez JM
  7. Ferri-Huerta R
  8. Nguyen-Contant P
  9. Fitzgerald T
  10. Sangster MY
  11. Topham DJ
  12. Järvinen KM
  Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination.; JAMA pediatrics. 2021 Nov 10.
• 1. Callahan EA
  2. Chatila T
  3. Deckelbaum RJ
  4. Field CJ
  5. Greer FR
  6. Hernell O
  7. Järvinen KM
  8. Kleinman RE
  9. Milner J
  10. Neu J
  11. Smolen KK
  12. Wallingford JC
  Assessing the safety of bioactive ingredients in infant formula that affect the immune system: Recommendations from an expert panel.; The American journal of clinical nutrition. 2021 Oct 11.
• 1. Jackson CM
  2. Mahmood MM
  3. Järvinen KM
  Farming lifestyle and human milk: modulation of the infant microbiome and protection against allergy.; Acta paediatrica (Oslo, Norway : 1992). 2021 Oct 09.
• 1. Rodel RL
  2. Farabi SS
  3. Hirsch NM
  4. Rolloff KP
  5. McNair B
  6. Hernandez TL
  7. Krebs NF
  8. Barbour LA
  9. Young BE
  Human milk imparts higher insulin concentration in infants born to women with type 2 diabetes mellitus.; The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2021 Aug 31.
• 1. Seppo AE
  2. Bu K
  3. Jumabaeva M
  4. Thakar J
  5. Choudhury R
  6. Yonemitsu C
  7. Bode L
  8. Martina CA
  9. Allen M
  10. Tamburini S
  11. Piras E
  12. Wallach DS
  13. Looney RJ
  14. Clemente JC
  15. Järvinen KM
  Infant Gut Microbiome Is Enriched with Bifidobacteria longumssp. infantisin Old Order Mennoniteswith Traditional Farming Lifestyle.; Allergy. 2021 Apr 27.
• 1. Azad MB
  2. Nickel NC
  3. Bode L
  4. Brockway M
  5. Brown A
  6. Chambers C
  7. Goldhammer C
  8. Hinde K
  9. McGuire M
  10. Munblit D
  11. Patel AL
  12. Pérez-Escamilla R
  13. Rasmussen KM
  14. Shenker N
  15. Young BE
  16. Zuccolo L
  Breastfeeding and the origins of health: Interdisciplinary perspectives and priorities.; Maternal & child nutrition; Vol 17(2). 2021 Apr.
• 1. Nowak S
  2. Wang H
  3. Schmidt B
  4. Jarvinen KM
  Vitamin D and iron status in food allergic children.; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 Mar 08.
• 1. Burris AD
  2. Lomas JM
  3. Järvinen KM
  Is It Time to Offer Peanut Oral Immunotherapy to Toddlers?; The journal of allergy and clinical immunology. In practice; Vol 9(3). 2021 Mar.
• 1. Schinkel ER
  2. Nelson ER
  3. Young BE
  4. Bernstein RM
  5. Taylor SN
  6. Brown LD
  7. Hay WW
  8. Brown KJ
  9. Prenni J
  Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants.; Journal of perinatology : official journal of the California Perinatal Association; Vol 41(3). 2021 Mar.
• 1. Pace RM
  2. Williams JE
  3. Järvinen KM
  4. Belfort MB
  5. Pace CDW
  6. Lackey KA
  7. Gogel AC
  8. Nguyen-Contant P
  9. Kanagaiah P
  10. Fitzgerald T
  11. Ferri R
  12. Young B
  13. Rosen-Carole C
  14. Diaz N
  15. Meehan CL
  16. Caffé B
  17. Sangster MY
  18. Topham D
  19. McGuire MA
  20. Seppo A
  21. McGuire MK
  Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19.; mBio; Vol 12(1). 2021 Feb 09.
• 1. Pier J
  2. Liu EG
  3. Eisenbarth S
  4. Järvinen KM
  The Role of Immunoglobulin A in Oral Tolerance and Food Allergy.; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 Feb 03.
• 1. Seppo AE
  2. Choudhury R
  3. Pizzarello C
  4. Palli R
  5. Fridy S
  6. Rajani PS
  7. Stern J
  8. Martina C
  9. Yonemitsu C
  10. Bode L
  11. Bu K
  12. Tamburini S
  13. Piras E
  14. Wallach DS
  15. Allen M
  16. Looney RJ
  17. Clemente JC
  18. Thakar J
  19. Järvinen KM
  Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.; Frontiers in immunology; Vol 12. 2021.
• 1. Pace RM
  2. Williams JE
  3. Järvinen KM
  4. Meehan CL
  5. Martin MA
  6. Ley SH
  7. Barbosa-Leiker C
  8. Andres A
  9. Yeruva L
  10. Belfort MB
  11. Caffé B
  12. Navarrete AD
  13. Lackey KA
  14. Pace CDW
  15. Gogel AC
  16. Fehrenkamp BD
  17. Klein M
  18. Young BE
  19. Rosen-Carole C
  20. Diaz N
  21. Gaw SL
  22. Flaherman V
  23. McGuire MA
  24. McGuire MK
  25. Seppo AE
  Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies.; Frontiers in immunology; Vol 12. 2021.
• 1. Young BE
  2. Westcott J
  3. Kemp J
  4. Allen L
  5. Hampel D
  6. Garcés AL
  7. Figueroa L
  8. Goudar SS
  9. Dhaded SM
  10. Somannavar M
  11. Saleem S
  12. Ali SA
  13. Hambidge KM
  14. Krebs NF
  B-Vitamins and Choline in Human Milk Are Not Impacted by a Preconception Lipid-Based Nutrient Supplement, but Differ Among Three Low-to-Middle Income Settings-Findings From the Women First Trial.; Frontiers in nutrition; Vol 8. 2021.
• 1. Burris AD
  2. Pizzarello C
  3. Järvinen KM
  Immunologic components in human milk and allergic diseases with focus on food allergy.; Seminars in perinatology. 2020 Dec 31.