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What is osteosarcoma in children?
Osteosarcoma is cancer of the bone. The cancer (malignant) cells make immature bone
cells (osteoid). Osteosarcoma is very rare, but it is the most common type of bone
cancer in children and teens. It is most common in teens and young adults.
The cancer most often grows in the ends of long bones, especially the bottom of the
thigh bone (femur) and the top of the larger shin bone (tibia). The top of the upper
arm bone (humerus) is another common place it grows.
The types of osteosarcoma include:
- High-grade. This is fast-growing cancer. Most osteosarcoma in children is high-grade. There are
several sub-types of high-grade osteosarcoma.
- Intermediate-grade. This type is uncommon. It is between high- and low-grade.
- Low-grade. This is slow-growing cancer. There are two sub-types of low-grade.
What causes osteosarcoma in a child?The exact cause is not known. The cancer may be caused by changes in the DNA of the
cells. In most cases, these changes are not passed on from parents to children. They
happen by chance.
Which children are at risk for osteosarcoma?
A child with one of certain rare genetic cancer syndromes may be at higher risk of
osteosarcoma. Having radiation or chemotherapy treatment for other cancers also increases
Other risk factors for osteosarcoma include:
- Age between 10 and 30 years
- Tall height
- Male sex
- African-American race
- Certain bone diseases
What are the symptoms of osteosarcoma in a child?
Symptoms can occur a bit differently in each child. They can include:
- Pain at the site of the tumor
- Swelling at the site of the tumor
- Lump (mass) in the area
- Increased pain with activity or at night
- A bone that breaks for no known reason
The symptoms of osteosarcoma can be like other health conditions. Make sure your child
sees a healthcare provider for a diagnosis.
How is osteosarcoma diagnosed in a child?
Your child's healthcare provider will ask about your child's health history and symptoms.
He or she will examine your child. Your child may be referred to a specialist. This
may be a bone specialist (orthopedic surgeon) or a bone cancer specialist (orthopedic
oncologist). Your child may have tests such as:
- X-ray. An X-ray uses a small amount of radiation to take pictures of bones and other body
- Blood tests. Some test results may be abnormal with osteosarcoma. For example, liver tests and
the erythrocyte sedimentation rate (ESR) may be higher than normal.
- CT scan. This test uses a series of X-rays and a computer to make detailed images of the body.
- MRI. This test uses large magnets, radio waves, and a computer to make detailed images
of the inside of the body.
- Bone scan. A small amount of radioactive dye is injected into a vein. The whole body is scanned.
The dye shows up in areas of bone where there may be cancer.
- Positron emission tomography (PET) scan. For this test, a radioactive sugar is injected into the bloodstream. Cancer cells
use more sugar than normal cells, so the sugar will collect in cancer cells. A special
camera is used to see where the radioactive sugar is in the body. A PET scan can sometimes
spot cancer cells in different areas of the body, even when they can’t be seen by
other tests. This test is often used in combination with a CT scan. This is called
a PET/CT scan.
- Biopsy of the tumor. A sample of the tumor is taken and checked under a microscope for cancer cells. A
biopsy is needed to diagnose osteosarcoma. The biopsy may be done with a needle or
with surgery. It’s very important that a biopsy be done by a doctor with experience
and knowledge about bone tumors.
After a diagnosis of osteosarcoma, other tests will be done. These help your child's
healthcare providers learn more about the cancer. They will show how much and how
far the cancer has spread (metastasized) in your child's body. A stage grouping is
The most commonly used system uses stage groupings with a value of 1 to 3. They are
written as Roman numerals I, II, and III. Some staging systems add a stage 4 (IV).
The higher the number, the more advanced the cancer is. Letters and numbers can be
used after the Roman numeral to give more details.
Staging for osteosarcoma also takes into account the grade of the cancer. This is
a measure of how much the cancer cells look like normal cells. A 1 or 2 is used. In
grade 1 tumors, the cancer cells look a lot like normal cells and tend to grow and
spread slower than grade 2. This may also be called a low-grade tumor. Grade 2 may
be called high grade, and the cells look very different from normal cells.
The stage of a cancer is one of the most important things to know when deciding how
to treat the cancer. Be sure to ask your child's healthcare provider to explain the
stage of your child's cancer to you in a way you can understand.
How is osteosarcoma treated in a child?
Treatment will depend on the stage and other factors. The cancer can be treated with
any of the below:
- Surgery. Surgery may be done to try to save the arm or leg. This is known as limb-salvage
or limb-sparing surgery. Or surgery may be done to remove an arm or leg (amputation).
Surgery may be done to remove tumors in other parts of the body.
- Chemotherapy. These are medicines that kill cancer cells. They are usually given before surgery.
They may also be given after surgery. Your child may have a port or catheter inserted
in order to receive the medicines into a vein (IV). Chemotherapy is given in cycles
with periods of rest.
- Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill
cancer cells or stop them from growing. It is not often used to treat osteosarcoma.
It may be used when a tumor can’t be fully removed with surgery. Or it may be used
to slow the growth of a tumor and control symptoms. Radioactive medicines may also
be given into a vein (IV).
- Clinical trials. Ask your child's healthcare provider if there are any treatments being tested that
may work well for your child.
- Supportive care. Growth factor may be given to help the bone marrow make blood cells. Other medicines
may be given for side effects of treatment. Pain medicines may also be given.
With any cancer, how well a child is expected to recover (prognosis) varies. Keep
- Getting medical treatment right away is important for the best prognosis. Cancer that
has spread is harder to treat.
- Ongoing follow-up care during and after treatment is needed.
- New treatments are being tested to improve outcome and to lessen side effects.
What are the possible complications of osteosarcoma in a child?
A child may have complications from the osteosarcoma or from treatment, such as:
- Infection or bleeding from surgery
- Loose or broken grafts or rods from limb-salvage surgery
- Hair loss, mouth sores, nausea, vomiting, diarrhea, increased infections, easy bruising
and bleeding, and feeling tired from chemotherapy
- Skin irritation, hair loss, nausea, diarrhea, poor bone growth, organ damage, and
new cancers from radiation
- Emotional and physical challenges from the tumor, surgery, or other treatments
- Heart and lung problems
- Problems with growth and development
- Learning problems
- Changes in sexual development
- Problems with the ability to have children (fertility) in the future
- Return of the cancer
- Growth of other cancers
How can I help my child live with osteosarcoma?
A child with osteosarcoma needs ongoing care. Your child will be seen by oncologists
and other healthcare providers to treat any late effects of treatment and to watch
for signs or symptoms of the tumor returning. Your child will be checked with imaging
tests and other tests. And your child may see other healthcare providers for problems
from the tumor or from treatment. Your child may need therapy to help with movement
and muscle strength. This may be done by physical and occupational therapists.
You can help your child manage his or her treatment in many ways. For example:
- Your child may have trouble eating. A dietitian may be able to help.
- Your child may be very tired. He or she will need to balance rest and activity. Encourage
your child to get some exercise. This is good for overall health. And it may help
to lessen tiredness.
- Get emotional support for your child. Find a counselor or child support group can
- Make sure your child attends all follow-up appointments.
When should I call my child’s healthcare provider?
Call the healthcare provider if your child has:
- Symptoms that get worse
- New symptoms
- Side effects from treatment
Key points about osteosarcoma in children
- Osteosarcoma is cancer of the bone. It’s rare, but it is the most common type of bone
cancer children and teens.
- Symptoms can include bone pain, swelling, or a lump (mass).
- The cancer may show up on an X-ray or on other imaging tests. It is diagnosed with
- The biopsy and surgery should be done by an orthopedic surgeon with experience treating
- Treatment is usually chemotherapy and surgery. Surgery may be limb-sparing or amputation.
- Ongoing follow-up care during and after treatment is needed.
Tips to help you get the most from a visit to your child’s healthcare provider:
- Know the reason for the visit and what you want to happen.
- Before your visit, write down questions you want answered.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you for your child.
- Know why a new medicine or treatment is prescribed and how it will help your child.
Also know what the side effects are.
- Ask if your child’s condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if your child does not take the medicine or have the test or procedure.
- If your child has a follow-up appointment, write down the date, time, and purpose
for that visit.
- Know how you can contact your child’s provider after office hours. This is important
if your child becomes ill and you have questions or need advice.
Online Medical Reviewers:
- Levy, Adam S, MD
- Stump-Sutliff, Kim, RN, MSN, AOCNS