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Open Positions

Postdoctoral Research Associate

A NIH funded postdoctoral position is available in the Stem Cell and Disease Modeling Laboratory at University of Rochester to study the role of extracellular matrix (ECM) alterations in macular degeneration. The specific focus of this project would include matrix metalloproteinase activity and regulation, ECM turnover and its impact on the function of retinal pigment epithelium and retinal pigment epithelium-vascular interaction. Ultimately the goal is to identify the molecular basis of drusen formation and choroidal neovascularization in patient-derived “human cell models” of inherited and age-related maculopathies. The overall objective of our laboratory is to understand the molecular mechanism(s) of specific retinal and neurodegenerative diseases with the goal of developing pharmacological therapies. Furthermore, the research projects in the laboratory have an an integrated focus on retinal physiology, neurodegenerative diseases, stem cells and pharmacology. The tissue/cells utilized to interrogate the molecular mechanism(s) of retinal and neurodegenerative diseases, including inherited and age-related macular degeneration, include patient-derived human induced pluripotent stem cells (hiPSCs), gene-edited (CRISPR) hiPSCs, primary eye tissue and relevant animal models. 

Well-qualified candidates will have the following qualifications/ experience: A Ph.D. in biological sciences. Prior experience in retinal cell biology and cell culture is preferred; especially experience working with hiPSCs and retinal cells. Experience with and knowledge of statistical and image analysis software would be advantageous.

Please submit your application including a cover letter, CV, and names of three professional references to ruchira_singh@urmc.rochester.edu.

Staff Scientist

Under the general guidance of the principal investigator, the staff scientist will be responsible for independently overseeing and carrying out specific research projects in a Stem Cell and disease modeling lab at the University of Rochester Flaum Eye Institute. The current projects in the laboratory are aimed at using human model system of retinal degenerative diseases for investigating disease mechanisms and identifying drug treatments. This position will have an initial appointment of 1 year that can be extended on a yearly basis depending on performance and availability of grant funding.

The staff scientist will lead multiple research projects in the laboratory and will be responsible for designing and performing experiments, analyzing data, helping with manuscript and grant preparation, overseeing and training other lab personnel. The scientific research will be focused on utilizing human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) to model and study retinal degenerative diseases. The suitable candidate should demonstrate the ability to carry out specific research projects independently under the guidance of the principal investigator (PI).

Well-qualified candidates will have the following qualifications/ experience: A Ph.D. in biological sciences and prior postdoctoral experience is required. Prior experience in retinal cell biology and cell culture is preferred; especially experience culturing and working with human stem cells and retinal cells. Experience with and knowledge of statistical and image analysis software would be advantageous.

Interested candidates should contact the PI at  ruchira_singh@urmc.rochester.edu.

Laboratory Technician

Laboratory Technician will be responsible for conducting research under the supervision of lab manager and principal investigator in a Stem Cell and disease modeling lab at the University of Rochester Flaum Eye Institute. Techniques include but are not limited to cell culture, quantitative real-time PCR, immunohistochemistry, western blotting, confocal microscopy. The research personnel will also be responsible for ensuring maintenance of laboratory supplies and equipment as well as proper disposal of waste material. The scientific research will be focused on utilizing human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) to model and study retinal degenerative diseases. The suitable candidate should demonstrate the ability to perform experiments and carry out cell culture work independently under the general guidance of senior laboratory personnel.

Bachelor’s degree in biological sciences and independent research experience. Prior experience in retinal cell biology and cell culture is preferred; especially experience culturing and working with human stem cells and retinal cells.   Required computer skills include familiarity with MS Office. Experience with and knowledge of other statistical and image analysis software would be advantageous. Weekend work as deemed necessary for taking care of cells may be required.

Interested candidates should contact the PI at  ruchira_singh@urmc.rochester.edu.

Graduate/Undergraduate Student

We are always looking for motivated students with a passion of science who truly believe they can make a difference!!!

Interested students should contact the PI at  ruchira_singh@urmc.rochester.edu