Overview

Research Support

Core Facilities

The Core Facilities provide services to all researchers at the University of Rochester School of Medicine and Dentistry. An Executive Oversight Committee provides the Senior Associate Dean of Basic Research, Stephen Dewhurst, Ph.D. with recommendations for overall core facility strategic planning and management.
Contact: Sally Quataert, Ph.D., URSMD Core Facilities Director, 273-2454, Sally_Quataert@urmc.rochester.edu

Biomolecular Interaction Core Facility

The Biomolecular Interaction core facility seeks to give access to custom affinity reagents to researchers in the University. We utilize phage display to generate recombinant antibodies to user provided target molecules and produce the single-chain Fv proteins for the user. We also can perform affinity measurements using surface plasmon resonance or provide access to trained users to this equipment.
Contact: Mark Sullivan, Ph.D., 273-1629, Mark_Sullivan@urmc.rochester.edu

Biosafety Level 3 (BSL-3) Core

The Biosafety level three facility (BSL-3) is available for the use of any researcher at the university whose work requires manipulation of biological agentswhich may cause serious or potentially lethal disease as a result of exposure by the inhalation route.
Contact: Marty Pavelka, Ph.D., 275-4670, Martin_Pavelka@urmc.rochester.edu.

Electron Microscope Research Core

The principal mission of this Electron Microscope Research Core (EM Core) is to provide University of Rochester researchers support in high magnification image analysis of cells and tissue in the fields of Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and combined Scanning/Transmission EM (STEM).
Contact: Karen Bentley, M.S, 275-1954, Karen_Bentley@urmc.rochester.edu.

Flow Cytometry and Immunologic Analysis

Flow cytometry and immunologic assessment resources within the medical center are available in several venues. Flow cytometry resources are currently in the process of being restructured and integrated into a single new flow cytometry core structure. The overall mission of the core is to provide researchers with access to and training to operate state-of-the art flow cytometry, as well as increasing the outreach to casual users. Additionally, the core will continue to serve as an expert resource to push the limits of current technology to support cutting edge research.
Contact: Tim Bushnell, Ph.D., 273-1361, Tim_Bushnell@urmc.rochester.edu
Peter Keng, Ph.D., 275-6332, Peter_Keng@urmc.rochester.edu.
Sally Quataert, Ph.D., 273-2454, Sally_Quataert@urmc.rochester.edu

Functional Genomics Center

This core facility consolidates the Microarray Core, & the Nucleic Acid Core Facilites into one entity. The center provides DNA sequencing; DNA and RNA extraction, purification, and measurement; microarray services, quantitative RT-PCR, genotyping, DNA fragment analysis; SNP analysis; assistance with interpretation of results.
Contact: Stephen L. Welle, Ph.D., 273-3117, Stephen_Welle@urmc.rochester.edu.

Gene Targeting and Transgenic Core

At this time, this core provides expertise and assistance in the production of transgenic mouse models by either DNA microinjection or gene targeting in embryonic stem (ES) cells.
Contact: Lin Gan, Ph.D., 273-1510, Lin_Gan@urmc.rochester.edu.

Human Immunology Center Laboratory

The Human Immunology Center (HIC) and its core laboratory were established to acquire, refine and develop expertise in cutting-edge techniques and to support applications in Human Immunology research. The HIC serves to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology. The Center's core lab provides assistance and expertise in immunological method development, standardization and validation through individual and group training programs.

Molecular Imaging Facility

The Molecular Imaging Facility provides researchers at the University of Rochester with access to state of the art instruments capable of detecting and quantifying the levels and positions of radio- and fluorescently labeled molecules in a variety of formats including gels, blots and microtiter plates.
Contact: Scott Butler, Ph.D., 275-7921, btlr@mail.rochester.edu

Pathology/Morphology Imaging Facility

This core facility provides a Leica Confocal Microscope, an Olympus Flourescent Microscope, and an Arcturus PixCell Laser Capture Microscope for use by University of Rochester faculty. All users are provided the ability and expertise to characterize biologic specimens using sophisticated fluorescent and/or brightfield microscopy.
Contact: Linda Callahan, PhD, 275-1317, Linda_Callahan@urmc.rochester.edu; for assistance with experimental design and data interpretation.
Contact: David Pasternack, M.S, 273-4097, David_Pasternack@urmc.rochester.edu for an appointment to learn the equipment. Schedule sign-up on the web at: http://www2.envmed.rochester.edu/binsh/ureserve.pl

Proteomics Center

The University of Rochester Proteomics Center provides protein characterization support, predominantly in the form of proteomic technology. The analytical strengths of the core are mass spectrometry and separation sciences. In a classical proteomic application, a complex sample matrix, such as serum, is separated into individual protein fractions, the identities of which are then determined with mass spectrometry. The core processes a myriad of sample types, from complex clinical matrices to simple purified proteins, for identification of unknowns or verification of identity.
Contact: Alan Friedman Ph.D., 276-0769, Alan_Friedman@urmc.rochester.edu.

RCBI (Rochester Center for Brain Imaging)

The Rochester Center for Brain Imaging (RCBI) provides researchers at the University of Rochester, as well as neighboring institutions, with access to a state-of-the-art 3T magnet for research using magnetic resonance imaging (MRI).
Contact: Richard N. Aslin, 275-8687, aslin@cvs.rochester.edu

Vivarium

The Vivarium is a centralized resource facility with staff and programs that support the research and educational uses of laboratory animals.
Contact: Jeff Wyatt, DVM., 275-2651, Jeff_Wyatt@urmc.rochester.edu

Xenogen IVIS In Vivo Imaging Core

The mission of the in vivo bioluminescence imaging core is to allow the detection of bioluminescent tracer molecules in living small animals.
Contact: Nick Crispe, M.D., Ph.D., 273-5647, Nick_Crispe@urmc.rochester.edu

Cold Storage Core (CSC)

The CSC provides a discreet area where investigators can keep freezers for long term storage of research materials. The entire facility is alarmed and power protected.
Contact: Richard Reichman, 275-5871, Richard_Reichman@urmc.rochester.edu

Business Opportunities

Facilitating the transfer of URMC science and technology from the laboratory to the realm of medical advancement.