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McGraw Lab

Overview

The primary focus of the McGraw lab is understanding the mechanisms of fibrotic lung diseases. One of the lung diseases studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal narrowing and obliteration of the small airways, or bronchioles. The laboratory uses chemicals known to cause bronchiolitis obliterans for modeling fibrotic lung disease. Our goal is to bring new therapies to patients suffering from this devastating disease.

bronchiolitis obliterans

Matthew D. McGraw, M.D.

Matthew D. McGraw, M.D.
Principal Investigator

In Vitro and In Vivo Inhalation Exposure Systems

In collaboration with the URMC Environmental Health Sciences Center’s Inhalation Exposure Facility, the McGraw lab has developed a variety of in vitro and in vivo vapor exposure systems. These exposure systems are used to model acute and chronic lung and airway diseases following inhalation exposures to toxic chemicals.

in vivo vapor exposure systems

Development of novel in vivo exposure systems with continuous monitoring and closed loop communication

in vitro vapor exposure systems

In vitro inhalation exposures systems for exposing human tissue to chemicals

Lung function Testing and Real-Time Monitoring in Small Rodents

In collaboration with the O’Reilly/Dylag lab, the McGraw lab utilizes a variety of novel technologies for physiologic monitoring of respiratory function and mechanics after inhalation exposures.

Real-time monitoring of animal vital signs (heart rate, oxygen saturations) using STARR Life Science software and sensors

Real-time monitoring of animal vital signs (heart rate, oxygen saturations) using STARR Life Science software and sensors

Measurement of respiratory mechanics using the SQIREQ Flexivent ventilator and affiliated software

Measurement of respiratory mechanics using the SQIREQ Flexivent® ventilator and affiliated software

Lung function testing in chemically-exposed rodents. Pressure-volume loops, as seen on a ventilator in the ICU

Lung function testing in chemically-exposed rodents. Pressure-volume loops, as seen on a ventilator in the ICU

Lung Regeneration Modeling

The McGraw lab has adapted 3D ‘organoid’ cultures for studying epithelial biology and regeneration after inhalation injuries.

Lung Regeneration 3D Culture
Airway colonies, or 'bronchospheres,' grown from a single cell In 3D culture

Airway colonies, or ‘bronchospheres’, grown from a single cell In 3D culture

Immunofluorescent image of airway grown from a single Keratin 5+ cell

Immunofluorescent image of airway grown from a single Keratin 5+ cell

Recent Publications

View All Publications

Lab Members

Principal Investigator

Matthew D. McGraw, M.D.

Matthew_Mcgraw@URMC.Rochester.edu

 

Lab Technician

So-Young Kim, M.S.

Soyoung_Kim@URMC.Rochester.edu

Funding Sources

  • Golisano’s Children’s Hospital & URMC’s David H. Smith Fund

UR Medicine's Golisano Children's Hospital logo

  • NIH CounterAct Program

Counter ACT logo

Contact Us

McGraw Lab

Matthew D. McGraw, M.D.
Assistant Professor, Department of Pediatrics, Division of Pulmonology
University of Rochester, Golisano Children's Hospital
601 Elmwood Avenue, Box 667
Rochester, NY 14642

 

Matthew_Mcgraw@URMC.Rochester.edu
Phone: (585) 275-2464
Fax: (585) 275-8706