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Mark J. Utell, M.D.

Mark J. Utell, M.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Professor - Department of Environmental Medicine (SMD) - Joint

Credentials

Education

MD | Tufts University Sch Medicine. Medicine. 1972

BA | Dartmouth College. Psychology. 1968

Publications

Journal Articles

Source specific fine particles and rates of asthma and COPD healthcare encounters pre- and post-implementation of the Tier 3 vehicle emissions control regulations.

Lin S, Xue Y, Thandra S, Qi Q, Thurston SW, Croft DP, Utell MJ, Hopke PK, Rich DQ

Journal of hazardous materials.. 2024 December 1484 :136737. Epub 12/01/2024.

Comparison of the rate of healthcare encounters for influenza from source-specific PM before and after tier 3 vehicle standards in New York state.

Croft DP, Utell MJ, Hopke PK, Liu H, Lin S, Thurston SW, Thandra S, Chen Y, Islam MR, Thevenet-Morrison K, Johnston CJ, Zhao T, Yount C, Rich DQ

Journal of exposure science & environmental epidemiology.. 2024 August 10 Epub 08/10/2024.

Tuberculosis screening for patients on biologic Medications: A Single-Center experience and Society guideline Review, Monroe County, New York, 2018-2021.

Maeda T, Connolly M, Thevenet-Morrison K, Levy P, Utell M, Munsiff S, Croft D

Journal of clinical tuberculosis and other mycobacterial diseases.. 2024 August 36 :100460. Epub 06/22/2024.

Can Long-term Residential Air Cleaning Reduce Cardiovascular Morbidity in Patients with Chronic Obstructive Pulmonary Disease?

Croft DP, Utell MJ, Rich DQ

American journal of respiratory and critical care medicine.. 2023 March 15207 (6):651-653. Epub 1900 01 01.

Triggering of ST-elevation myocardial infarction by ultrafine particles in New York: Changes following Tier 3 vehicle introduction.

Yount CS, Utell MJ, Hopke PK, Thurston SW, Lin S, Ling FS, Chen Y, Chalupa D, Deng X, Rich DQ

Environmental research.. 2023 January 1216 (Pt 1):114445. Epub 09/29/2022.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

Croft D, Block R, Cameron SJ, Evans K, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Rich DQ

Air quality, atmosphere, & health.. 2018 11 (7):791-799. Epub 06/03/2018.

Air pollution and health: emerging information on susceptible populations.

O'Neill MS, Breton CV, Devlin RB, Utell MJ

Air quality, atmosphere, & health.. 2012 June 15 (2):189-201. Epub 1900 01 01.

Vascular effects of ultrafine particles in persons with type 2 diabetes.

Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW

Environmental health perspectives.. 2010 December 118 (12):1692-8. Epub 09/07/2010.

ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.

Zareba W, Couderc JP, Oberdörster G, Chalupa D, Cox C, Huang LS, Peters A, Utell MJ, Frampton MW

Inhalation toxicology.. 2009 February 21 (3):223-33. Epub 1900 01 01.

Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects.

Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang LS, Utell MJ, Frampton MW

Environmental health perspectives.. 2008 March 116 (3):375-80. Epub 1900 01 01.

Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli.

Pietropaoli AP, Perillo IB, Perkins PT, Frasier LM, Speers DM, Frampton MW, Utell MJ, Hyde RW

Inhalation toxicology.. 2007 May 19 (6-7):533-41. Epub 1900 01 01.

Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats.

Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G

Inhalation toxicology.. 2007 January 19 (1):1-12. Epub 1900 01 01.

Changes in markers of epithelial permeability and inflammation in chronic smokers switching to a nonburning tobacco device (Eclipse).

Stewart JC, Hyde RW, Boscia J, Chow MY, O'Mara RE, Perillo I, Pietropaoli A, Smith CJ, Torres A, Utell MJ, Frampton MW

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2006 December 8 (6):773-83. Epub 1900 01 01.

Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans.

Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ

Environmental health perspectives.. 2006 January 114 (1):51-8. Epub 1900 01 01.

Implications for occupational exposure to particulate matter.

Utell MJ, Beckett WS

Clinics in occupational and environmental medicine. 2006 5 (4):883-93. Epub 1900 01 01.

Clinical activities in an academic hospital-based occupational medicine program.

Barron BA, Beckett WS, Utell MJ

Journal of occupational and environmental medicine. 2005 June 47 (6):587-93. Epub 1900 01 01.

Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study.

Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang LS, Cox C, Zareba W, Oberdörster G

American journal of respiratory and critical care medicine.. 2005 May 15171 (10):1129-35. Epub 02/25/2005.

Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma.

Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J

Research report. 2004 December (126):1-47; discussion 49-63. Epub 1900 01 01.

Ultrafine particle deposition in subjects with asthma.

Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW

Environmental health perspectives.. 2004 June 112 (8):879-82. Epub 1900 01 01.

On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats.

Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G

Inhalation toxicology.. 2004 16 Suppl 1 :41-53. Epub 1900 01 01.

Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles.

Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ

Inhalation toxicology.. 2004 16 Suppl 1 :59-72. Epub 1900 01 01.

Ultrafine particle deposition in humans during rest and exercise.

Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW

Inhalation toxicology.. 2003 May 15 (6):539-52. Epub 1900 01 01.

Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing.

Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE

Inhalation toxicology.. 2002 December 14 (12):1231-47. Epub 1900 01 01.

Nitrogen dioxide exposure: effects on airway and blood cells.

Frampton MW, Boscia J, Roberts NJ, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ

American journal of physiology. Lung cellular and molecular physiology.. 2002 January 282 (1):L155-65. Epub 1900 01 01.

Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.

Zareba G, Gelein R, Morrow PE, Utell MJ

Skin pharmacology and applied skin physiology. 2002 15 (3):184-94. Epub 1900 01 01.

Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans.

Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE, Utell MJ, Frampton MW

Journal of applied physiology.. 2001 November 91 (5):1931-40. Epub 1900 01 01.

Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans.

Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW

Inhalation toxicology.. 2001 June 13 (6):465-83. Epub 1900 01 01.

Neutrophils in lung inflammation: Which reactive oxygen species are being measured?

Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW

Inhalation toxicology.. 2001 June 13 (6):485-95. Epub 1900 01 01.

Toxicologic methods: controlled human exposures.

Utell MJ, Frampton MW

Environmental health perspectives.. 2000 August 108 Suppl 4 (Suppl 4):605-13. Epub 1900 01 01.

Acute health effects of ambient air pollution: the ultrafine particle hypothesis.

Utell MJ, Frampton MW

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.. 2000 13 (4):355-59. Epub 1900 01 01.

Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure.

Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ

Research report. 1999 November (90):1-15; discussion 17-8. Epub 1900 01 01.

Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans.

Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, Hyde RW

Journal of applied physiology.. 1999 October 87 (4):1532-42. Epub 1900 01 01.

Interferon-alpha therapy associated with the development of sarcoidosis.

Pietropaoli A, Modrak J, Utell M

Chest.. 1999 August 116 (2):569-72. Epub 1900 01 01.

Ozone exposure increases aldehydes in epithelial lining fluid in human lung.

Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ

American journal of respiratory and critical care medicine.. 1999 April 159 (4 Pt 1):1134-7. Epub 1900 01 01.

Rate of nitric oxide production by lower alveolar airways of human lungs.

Geigel EJ, Hyde RW, Perillo IB, Torres A, Perkins PT, Pietropaoli AP, Frasier LM, Frampton MW, Utell MJ

Journal of applied physiology.. 1999 January 86 (1):211-21. Epub 1900 01 01.

Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor.

Utell MJ, Gelein R, Yu CP, Kenaga C, Geigel E, Torres A, Chalupa D, Gibb FR, Speers DM, Mast RW, Morrow PE

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 August 44 (2):206-13. Epub 1900 01 01.

Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.

Looney RJ, Frampton MW, Byam J, Kenaga C, Speers DM, Cox C, Mast R, Klykken PC, Morrow PE, Utell MJ

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 August 44 (2):214-20. Epub 1900 01 01.

Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers.

Tong Z, Utell MJ, Morrow PE, Rusch GM, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1998 July 26 (7):711-3. Epub 1900 01 01.

Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone.

Torres A, Utell MJ, Morow PE, Voter KZ, Whitin JC, Cox C, Looney RJ, Speers DM, Tsai Y, Frampton MW

American journal of respiratory and critical care medicine.. 1997 September 156 (3 Pt 1):728-36. Epub 1900 01 01.

Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers.

Frampton MW, Morrow PE, Torres A, Voter KZ, Whitin JC, Cox C, Speers DM, Tsai Y, Utell MJ

Research report. 1997 June (78):39-72; discussion 81-99. Epub 1900 01 01.

Effects of ozone on normal and potentially sensitive human subjects. Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study.

Frampton MW, Balmes JR, Cox C, Krein PM, Speers DM, Tsai Y, Utell MJ

Research report. 1997 June (78):73-9; discussion 81-99. Epub 1900 01 01.

Determination of production of nitric oxide by lower airways of humans--theory.

Hyde RW, Geigel EJ, Olszowka AJ, Krasney JA, Forster RE, Utell MJ, Frampton MW

Journal of applied physiology.. 1997 April 82 (4):1290-6. Epub 1900 01 01.

Ozone responsiveness in smokers and nonsmokers.

Frampton MW, Morrow PE, Torres A, Cox C, Voter KZ, Utell MJ

American journal of respiratory and critical care medicine.. 1997 January 155 (1):116-21. Epub 1900 01 01.

Human performance during exposure to toluene.

Rahill AA, Weiss B, Morrow PE, Frampton MW, Cox C, Gibb R, Gelein R, Speers D, Utell MJ

Aviation, space, and environmental medicine.. 1996 July 67 (7):640-7. Epub 1900 01 01.

Production of reactive oxygen intermediates following exposure to ozone. Relative contribution of alveolar macrophages.

Torres A, Voter KZ, Utell MJ, Whitin JC, Morrow PE, Frampton MW

Chest.. 1996 March 109 (3 Suppl):8S. Epub 1900 01 01.

Environmentally induced asthma.

Utell MJ, Looney RJ

Toxicology letters.. 1995 December 82-83 :47-53. Epub 1900 01 01.

Composition of human airway mucins and effects after inhalation of acid aerosol.

Culp DJ, Latchney LR, Frampton MW, Jahnke MR, Morrow PE, Utell MJ

The American journal of physiology.. 1995 September 269 (3 Pt 1):L358-70. Epub 1900 01 01.

The acute respiratory distress syndrome: current trends in pathogenesis and management.

Levy PC, Utell MJ, Sickel JZ, Apostolakos MJ

Comprehensive therapy.. 1995 August 21 (8):438-44. Epub 1900 01 01.

Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects.

Frampton MW, Morrow PE, Cox C, Levy PC, Condemi JJ, Speers D, Gibb FR, Utell MJ

Environmental research.. 1995 April 69 (1):1-14. Epub 1900 01 01.

Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma.

Utell MJ, Frampton MW, Morrow PE, Cox C, Levy PC, Speers DM, Gibb FR

Research report. 1994 November (70):37-93, discussion 95-112. Epub 1900 01 01.

Public health risks from motor vehicle emissions.

Utell MJ, Warren J, Sawyer RF

Annual review of public health.. 1994 15 :157-78. Epub 1900 01 01.

Measurement of gene expression by multiplex competitive polymerase chain reaction.

Apostolakos MJ, Schuermann WH, Frampton MW, Utell MJ, Willey JC

Analytical biochemistry.. 1993 September 213 (2):277-84. Epub 1900 01 01.

Sulfuric acid aerosol exposure in humans assessed by bronchoalveolar lavage.

Frampton MW, Voter KZ, Morrow PE, Roberts NJ, Culp DJ, Cox C, Utell MJ

The American review of respiratory disease.. 1992 September 146 (3):626-32. Epub 1900 01 01.

Effect of pattern of aerosol inhalation on clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid from the lungs of normal humans.

Smith RJ, Hyde RW, Waldman DL, Freund GG, Weber DA, Utell MJ, Morrow PE

The American review of respiratory disease.. 1992 May 145 (5):1109-16. Epub 1900 01 01.

Assessment of acute effects in controlled human studies. Lessons from field studies.

Utell MJ, Samet JM

Annals of the New York Academy of Sciences.. 1992 April 30641 :37-45. Epub 1900 01 01.

Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide.

Morrow PE, Utell MJ, Bauer MA, Smeglin AM, Frampton MW, Cox C, Speers DM, Gibb FR

The American review of respiratory disease.. 1992 February 145 (2 Pt 1):291-300. Epub 1900 01 01.

Toxicological implications of extended space flights.

Weiss B, Utell M, Morrow P

Acta astronautica.. 1992 27 :239-42. Epub 1900 01 01.

Environmental factors and atmospheric pollutants.

Frampton MW, Samet JM, Utell MJ

Seminars in respiratory infections.. 1991 December 6 (4):185-93. Epub 1900 01 01.

Characterization of human alveolar macrophage Fc gamma receptor III: a transmembrane glycoprotein that is shed under in vitro culture conditions.

Levy PC, Utell MJ, Fleit HB, Roberts NJ, Ryan DH, Looney RJ

American journal of respiratory cell and molecular biology.. 1991 October 5 (4):307-14. Epub 1900 01 01.

Mechanisms of nitrogen dioxide toxicity in humans.

Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE

Research report. 1991 August (43):1-33. Epub 1900 01 01.

Theophylline in asthma and COPD: changing perspectives and controversies.

Poe RH, Utell MJ

Geriatrics.. 1991 April 46 (4):55-6, 61-5. Epub 1900 01 01.

Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans.

Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ

The American review of respiratory disease.. 1991 March 143 (3):522-7. Epub 1900 01 01.

Air pollution and asthma: clinical studies with sulfuric acid aerosols.

Utell MJ, Frampton MW, Morrow PE

Allergy proceedings : the official journal of regional and state

Human alveolar macrophage FcR-mediated cytotoxicity. Heteroantibody- versus conventional antibody-mediated target cell lysis.

Levy PC, Looney RJ, Shen L, Graziano RF, Fanger MW, Roberts NJ, Ryan DH, Utell MJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 May 15144 (10):3693-700. Epub 1900 01 01.

Environmentally mediated disorders of the respiratory tract.

Utell MJ, Samet JM

The Medical clinics of North America.. 1990 March 74 (2):291-306. Epub 1900 01 01.

[Why do we need controlled clinical studies?].

Utell MJ, Schürmann WH

Pneumologie.. 1990 February 44 Suppl 1 :399-402. Epub 1900 01 01.

Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.

Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ

American journal of respiratory cell and molecular biology.. 1989 December 1 (6):499-505. Epub 1900 01 01.

Diagnosis and management of pulmonary sarcoidosis.

Poe RH, Utell MJ

Comprehensive therapy.. 1989 December 15 (12):35-42. Epub 1900 01 01.

Lung weight in vivo measured with computed tomography and rebreathing of soluble gases.

Hyde RW, Wandtke JC, Fahey PJ, Utell MJ, Plewes DB, Goske M

Journal of applied physiology.. 1989 July 67 (1):166-73. Epub 1900 01 01.

Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro.

Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ

Environmental research.. 1989 April 48 (2):179-92. Epub 1900 01 01.

Responses of susceptible subpopulations to nitrogen dioxide.

Morrow PE, Utell MJ

Research report. 1989 February (23):1-45. Epub 1900 01 01.

Effects of in vitro exposure to nitrogen dioxide on human alveolar macrophage release of neutrophil chemotactic factor and interleukin-1.

Pinkston P, Smeglin A, Roberts NJ, Gibb FR, Morrow PE, Utell MJ

Environmental research.. 1988 October 47 (1):48-58. Epub 1900 01 01.