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George B. Segel, M.D.

George B. Segel, M.D.

Contact

Office (585) 275-3489
Fax (585) 270-0350
Administrative (585) 273--557

About Me

Anemia, Neutropenia, Thrombocytopenia and Other Hematologic Disorders including hemostasis and thrombosis. Consultation for hematologic disorders on Pediatrics and Internal Medicine.
Anemia, Neutropenia, Thrombocytopenia and Other Hematologic Disorders including hemostasis and thrombosis. Consultation for hematologic disorders on Pediatrics and Internal Medicine.

Faculty Appointments

Professor Emeritus - Department of Pediatrics, Hematology and Oncology (SMD)

Professor (Part-Time) - Department of Medicine, Hematology/Oncology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Academic leave - Laboratory of John W. Semple PhD., Toronto Platelet Immunobiology Group, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Canada 2011 - 2011

Academic Leave: University of Toronto, Hopsital for Sick Children - Thrombosis and Hemostasis Service, Toronto, Canada 2010 - 2010

Academic Leave: Laboratory of Fred Sherman, PhD, Department of Biochemistry, University of Rochester School of Medicine, Rochester, NY 1991 - 1992

Pediatric Hematology/Oncology Fellowship, Children's Hospital Medical Center, Harvard University Medical School, Boston, MA 1969 - 1971

Residency in Pediatrics, St. Christopher's Hospital for Children, Temple University, Philadelphia, PA 1965 - 1967

Rotating Internship, Abington Memorial Hospital, Abington, PA 1964 - 1965

Education

MD | Jefferson Medical College. Medicine. 1964

Awards

Teaching Award - Morning Report MVP Award. 2011

Outstanding Hospital Teaching Award from the University of Rochester Third year class. 2007 - 2008

Outstanding Hospital Teaching Award from the University of Rochester Fourth Year Class. 2005 - 2006

Appointed to the Board of Directors for New York State, Genetics Task Force. 1988 - 1992

Clara Barton Honor Award for Meritorious Volunteer Leadership, American Red Cross. 1988

Certificate of Appreciation - American Red Cross Board of Directors. 1982 - 1992

Buswell Distinguished Service Fellowship for Senior Faculty Support, University of Rochester. 1981 - 1982

Faculty Service Award, Department of Pediatrics, University of Rochester. 1981 - 1982

Recipient, Research Career Development Award U.S.P.H.S. #CA00019. 1975 - 1980

Research

Dr. Segel's research interests are:
1) Chronic leukemia
2) Control of cell maturation
3) Early gene activation in chronic leukemia B lymphocytes induced toward a plasma cell phenotype

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of lymphocytes that are arr...
Dr. Segel's research interests are:
1) Chronic leukemia
2) Control of cell maturation
3) Early gene activation in chronic leukemia B lymphocytes induced toward a plasma cell phenotype

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of lymphocytes that are arrested at an intermediate stage of B lymphocyte development. CLL B lymphocytes transform (mature) to a plasmacytic phenotype when treated in vitro with phorbol esters. We have used array hybridization technology to describe gene expression patterns for untreated and tetradecanoyl phorbol acetate (TPA)-treated CLL B-cells at 5, 10, and 20 minutes following initial TPA exposure. Three genes, Early Growth Response Factor 1 (EGR-1), dual specificity phosphatase 2, and CD69 (Early T-cell Activation Antigen), showed a 2.0-fold or greater increase in mRNA transcription at four or more of six time points in two studies. Upregulation of expression of these genes was confirmed by real-time polymerase chain reaction (RT-PCR) in the TPA-treated cells of four CLL patients.

A progressive increase in gene expression was observed during the 20 minute time course for all three genes. In addition, protein expression of EGR-1 and CD69 was increased as measured by immunofluorescence cell analysis. Several genes (PKC, n-myc, jun D, BCL-2) previously reported as overexpressed in CLL lymphocytes were overexpressed in these studies also, but were not altered by TPA treatment. Genes for proteins whose upregulation requires hours of TPA exposure (the 4F2hc component of the L-system amino acid transporter, prohibition, and hsp60) were assessed, and their later expression contrasted with the early expression of EGR-1, dual specificity phosphatase 2, and CD69. EGR-1 encodes a zinc-finger transcription factor that is induced by pokeweed mitogen and TPA and promotes B lymphocyte maturation.

The dual specificity phosphatase 2 encodes an enzyme that reverses mitogen activated protein (MAP) kinase cell activation by dephosphorylation. The CD69 protein is induced by TPA in thymocytes and is a type II transmembrane signaling molecule in hematopoietic cells. These findings suggest that the products of these three genes may be central to early steps in the TPA-induced evolution of CLL B-cells to a plasmacytic phenotype.

Publications

Journal Articles

Commentary: Should we still be focused on red cell hemoglobin F as the principal explanation for the salutary effect of hydroxyurea in sickle cell disease?

Segel GB, Simon W and Lichtman MA.

Pediatric Blood and Cancer. 2011; 57: 8-9.

Management of Idiopathic Thrombocytopenic Purpura in Children: Potential Role of Novel Agents.

Bredlau AL, Semple JW and Segel GB.

Pediatric Drugs. 2011; .

The paradox of the neutrophil's role in tissue injury: a review.

Segel GB, Halterman MW, Lichtman MA.

J Leukoc Biol. 2010; .

Controversies in the Diagnosis and Management of Childhood Acute Immune Thrombocytopenic Purpura.

Segel GB and Feig SA.

Pediatric Blood and Cancer. 2009; 53: 318-324.

Neutropenia in pediatric practice.

Segel GB, Halterman JS

Pediatrics in review. 2008 January 29 (1):12-23; quiz 24. Epub 1900 01 01.

Early allogeneic stem cell transplantation for chronic myelogeneous leukemia in the imatinib era: A preliminary assessment.

Simon W, Segel GB and Lichtman MA.

Blood Cells, Molecules and Diseases. 2006; 37: 116-124.

Early allogeneic stem cell transplantation for chronic myelogenous leukemia in the imatinib era: a preliminary assessment.

Simon W, Segel GB, Lichtman MA

Blood cells, molecules & diseases.. 2006 37 (2):116-24; discussion 125-7. Epub 08/10/2006.

Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiae.

Kabir MA, Kaminska J, Segel GB, Bethlendy G, Lin P, Della Seta F, Blegen C, Swiderek KM, Zo?adek T, Arndt KT, Sherman F

Yeast.. 2005 February 22 (3):219-39. Epub 1900 01 01.

Uncommon Phenotypes of Acute Myelogeneous Leukemia: Basophilic, Mast Cell, Eosinophilic and Myeloid Dendritic Cell Subtypes: A review.

Lichtman MA and Segel GB.

Blood Cells, Molecules and Diseases. 2005; 35: 370-383.

Uncommon phenotypes of acute myelogenous leukemia: basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: a review.

Lichtman MA, Segel GB

Blood cells, molecules & diseases.. 2005 35 (3):370-83. Epub 10/03/2005.

Familial (inherited) leukemia, lymphoma, and myeloma: an overview.

Segel GB, Lichtman MA

Blood cells, molecules & diseases.. 2004 32 (1):246-61. Epub 1900 01 01.

Early gene activation in chronic leukemic B lymphocytes induced toward a plasma cell phenotype.

Segel GB, Woodlock TJ, Xu J, Li L, Felgar RE, Ryan DH, Lichtman MA, Wang N

Blood cells, molecules & diseases.. 2003 30 (3):277-87. Epub 1900 01 01.

Managing anemia in a pediatric office practice: Part 2.

Segel GB, Hirsh MG, Feig SA

Pediatrics in review. 2002 April 23 (4):111-22. Epub 1900 01 01.

Managing anemia in pediatric office practice: Part 1.

Segel GB, Hirsh MG, Feig SA

Pediatrics in review. 2002 March 23 (3):75-84. Epub 1900 01 01.

Prohibitin expression is increased in phorbol ester-treated chronic leukemic B-lymphocytes.

Woodlock TJ, Bethlendy G, Segel GB

Blood cells, molecules & diseases.. 2001 27 (1):27-34. Epub 1900 01 01.

Anticoagulant proteins in childhood venous and arterial thrombosis: a review.

Segel GB, Francis CA

Blood cells, molecules & diseases.. 2000 October 26 (5):540-60. Epub 1900 01 01.

Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues.

Schwartz GJ, Kittelberger AM, Segel GB

Experimental nephrology.. 2000 8 (3):152-60. Epub 1900 01 01.

Developmental biology of erythropoiesis.

Palis J, Segel GB

Blood reviews.. 1998 June 12 (2):106-14. Epub 1900 01 01.

Analysis of mutationally altered forms of the Cct6 subunit of the chaperonin from Saccharomyces cerevisiae.

Lin P, Cardillo TS, Richard LM, Segel GB, Sherman F

Genetics.. 1997 December 147 (4):1609-33. Epub 1900 01 01.

Abnormal erythrocyte endothelial adherence in hereditary stomatocytosis.

Smith BD, Segel GB

Blood.. 1997 May 189 (9):3451-6. Epub 1900 01 01.

Association of HSP60-like proteins with the L-system amino acid transporter.

Woodlock TJ, Chen X, Young DA, Bethlendy G, Lichtman MA, Segel GB

Archives of biochemistry and biophysics.. 1997 February 1338 (1):50-6. Epub 1900 01 01.

Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.

Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F

The Journal of biological chemistry.. 1994 July 15269 (28):18616-22. Epub 1900 01 01.

Phorbol ester-induced membrane proteins in chronic leukemic B-lymphocytes. Candidate proteins for the L-system amino acid transporter.

Woodlock TJ, Young DA, Boal TR, Lichtman MA, Segel GB

The Journal of biological chemistry.. 1993 July 25268 (21):16020-7. Epub 1900 01 01.

Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA.

Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F

Proceedings of the National Academy of Sciences of the United States of America.. 1992 July 189 (13):6060-4. Epub 1900 01 01.

Decreased L system amino acid transport and decreased gamma-glutamyl transpeptidase are independent processes in human chronic lymphocytic leukemia B-lymphocytes.

Woodlock TJ, Brown R, Mani M, Pompeo L, Hoffman H, Segel GB, Silber R

Journal of cellular physiology.. 1990 November 145 (2):217-21. Epub 1900 01 01.

Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated human neutrophils: superoxide production without a rise in intracellular free calcium.

Liang SL, Woodlock TJ, Whitin JC, Lichtman MA, Segel GB

Journal of cellular physiology.. 1990 November 145 (2):295-302. Epub 1900 01 01.

Activation of the Na+/H+ exchanger by phorbol ester and osmotic shock is dependent on the degree of neutrophilic maturation.

Costa-Casnellie MR, Cragoe EJ, Segel GB, Lichtman MA

Journal of cellular physiology.. 1989 November 141 (2):294-300. Epub 1900 01 01.

Photoinhibition of 2-amino-2-carboxybicyclo[2,2,1]heptane transport by O-diazoacetyl-L-serine. An initial step in identifying the L-system amino acid transporter.

Segel GB, Woodlock TJ, Murant FG, Lichtman MA

The Journal of biological chemistry.. 1989 October 5264 (28):16399-402. Epub 1900 01 01.

Diacylglycerol and calcium induce rapid enhancement of A-system amino acid transport by independent mechanisms in human T-lymphocytes.

Woodlock TJ, Segel GB, Lichtman MA

Journal of cellular physiology.. 1989 October 141 (1):33-9. Epub 1900 01 01.

Upper and lower time limits in the decision to recommend marrow transplantation for patients with chronic myelogenous leukaemia.

Simon W, Segel GB, Lichtman MA

British journal of haematology.. 1988 September 70 (1):31-6. Epub 1900 01 01.

Anemia.

Segel GB

Pediatrics in review. 1988 September 10 (3):77-88. Epub 1900 01 01.

The Na+/H+ exchanger in immature and mature granulocytic HL-60 cells. Property changes induced by intracellular acidification and cell maturation.

Costa-Casnellie MR, Segel GB, Lichtman MA

The Journal of biological chemistry.. 1988 August 25263 (24):11851-5. Epub 1900 01 01.

Trans-stimulation of L-system amino acid transport in normal and chronic leukemic human lymphocytes: phorbol ester restores function in CLL.

Segel GB, Woodlock TJ, Lichtman MA

Journal of cellular physiology.. 1988 March 134 (3):503-8. Epub 1900 01 01.

Phorbol ester restores L-system amino acid transport of B lymphocytes in chronic lymphocytic leukemia.

Woodlock TJ, Segel GB, Lichtman MA

The Journal of clinical investigation.. 1988 January 81 (1):32-8. Epub 1900 01 01.

Characterization of the Na+/H+ exchanger during maturation of HL-60 cells induced by dimethyl sulfoxide.

Costa-Casnellie MR, Segel GB, Cragoe EJ, Lichtman MA

The Journal of biological chemistry.. 1987 July 5262 (19):9093-7. Epub 1900 01 01.

Signal transduction in human monocytes: relationship between superoxide production and the level of kinase C in the membrane.

Costa-Casnellie MR, Segel GB, Lichtman MA

Journal of cellular physiology.. 1986 December 129 (3):336-42. Epub 1900 01 01.

Variables influencing the timing of marrow transplantation in patients with chronic myelogenous leukemia.

Segel GB, Simon W, Lichtman MA

Blood.. 1986 November 68 (5):1055-64. Epub 1900 01 01.

Relationship of superoxide production to cytoplasmic free calcium in human monocytes.

Scully SP, Segel GB, Lichtman MA

The Journal of clinical investigation.. 1986 April 77 (4):1349-56. Epub 1900 01 01.

Concanavalin A and phorbol ester cause opposite subcellular redistribution of protein kinase C.

Costa-Casnellie MR, Segel GB, Lichtman MA

Biochemical and biophysical research communications.. 1985 December 31133 (3):1139-44. Epub 1900 01 01.

Y+- and L-system amino acid transport in normal and chronic lymphocytic leukemia lymphocytes: photoinhibition by fluoronitrophenylazide.

Segel GB, Tometsko AM, Lichtman MA

Archives of biochemistry and biophysics.. 1985 November 1242 (2):347-54. Epub 1900 01 01.

Ecto-nucleotide triphosphatase activity of human lymphocytes: studies of normal and CLL lymphocytes.

Segel GB, Ryan DH, Lichtman MA

Journal of cellular physiology.. 1985 September 124 (3):424-32. Epub 1900 01 01.

The requirements for ionized calcium and magnesium in lymphocyte proliferation.

Abboud CN, Scully SP, Lichtman AH, Brennan JK, Segel GB

Journal of cellular physiology.. 1985 January 122 (1):64-72. Epub 1900 01 01.

Calcium exchange and ionized cytoplasmic calcium in resting and activated human monocytes.

Scully SP, Segel GB, Lichtman MA

The Journal of clinical investigation.. 1984 August 74 (2):589-99. Epub 1900 01 01.

Multicomponent analysis of amino acid transport in human lymphocytes. Diminished L-system transport in chronic leukemic B lymphocytes.

Segel GB, Simon W, Lichtman MA

The Journal of clinical investigation.. 1984 July 74 (1):17-24. Epub 1900 01 01.

A multicomponent analysis of amino acid transport systems in human lymphocytes. 1. Kinetic parameters of the A and L systems and pathways of uptake of naturally occurring amino acids in blood lymphocytes.

Segel GB, Simon W, Lichtman MA

Journal of cellular physiology.. 1983 September 116 (3):372-8. Epub 1900 01 01.

The role of calcium in lymphocyte proliferation. (An interpretive review).

Lichtman AH, Segel GB, Lichtman MA

Blood.. 1983 March 61 (3):413-22. Epub 1900 01 01.

Plasma membrane vesicles prepared from unadhered monocytes: characterization of calcium transport and the calcium ATPase.

Scully SP, Segel GB, Lichtman MA

Cell calcium.. 1982 December 3 (6):515-30. Epub 1900 01 01.

Decreased L-system for amino acid transport in chronic lymphocytic leukemic lymphocytes.

Segel GB, Lichtman MA

The Journal of biological chemistry.. 1982 August 25257 (16):9255-7. Epub 1900 01 01.

Effects of trifluoperazine and mitogenic lectins on calcium ATPase activity and calcium transport by human lymphocyte plasma membrane vesicles.

Lichtman AH, Segel GB, Lichtman MA

Journal of cellular physiology.. 1982 May 111 (2):213-7. Epub 1900 01 01.

The activation of lymphocyte plasma membrane (Na,K)-ATPase by EGTA is explained better by zinc than calcium chelation.

Segel GB, Simon W, Lichtman AH, Lichtman MA

The Journal of biological chemistry.. 1981 July 10256 (13):6629-32. Epub 1900 01 01.

Calcium transport and calcium-ATPase activity in human lymphocyte plasma membrane vesicles.

Lichtman AH, Segel GB, Lichtman MA

The Journal of biological chemistry.. 1981 June 25256 (12):6148-54. Epub 1900 01 01.

The effect of calcium chelation on lymphocyte monovalent cation permeability, transport and concentration.

Quastel MR, Segel GB, Lichtman MA

Journal of cellular physiology.. 1981 May 107 (2):165-70. Epub 1900 01 01.

The measurement of lymphocyte volume: importance of reference particle deformability and counting solution tonicity.

Segel GB, Cokelet GR, Lichtman MA

Blood.. 1981 May 57 (5):894-9. Epub 1900 01 01.

Amino acid transport in human lymphocytes: distinctions in the enhanced uptake with PHA treatment or amino acid deprivation.

Segel GB, Lichtman MA

Journal of cellular physiology.. 1981 February 106 (2):303-8. Epub 1900 01 01.

Human lymphocyte plasma membrane Ca transport and Ca ATPase: Effects of calmodulin, phenothiazines and lectins.

Lichtman, A.H.; Segel, G.B.; Lichtman, M.A.

Mechanisms of Lymphocyte Activation. 1981; : 234.

Membrane alterations in lymphocyte proliferation.

Segel GB

The American journal of pediatric hematology/oncology. 1981 3 (4):433-8. Epub 1900 01 01.

The apparent discrepancy of ouabain inhibition of cation transport and of lymphocyte proliferation is explained by time-dependency of ouabain binding.

Segel GB, Lichtman MA

Journal of cellular physiology.. 1980 July 104 (1):21-6. Epub 1900 01 01.

Glucocorticoid suppression of human lymphocyte DNA synthesis: influence of phytohemagglutinin concentration.

Segel GB, Lukacher A, Gordon BR, Lichtman MA

The Journal of laboratory and clinical medicine.. 1980 April 95 (4):624-32. Epub 1900 01 01.

Total and exchangeable calcium in lymphocytes: Effects of PHA and A23187.

Lichtman, A.H.; Segel, G.B.; Lichtman, M.A.

J Supramolec Struct. 1980; 14: 65-75.

Total and exchangeable calcium in lymphocytes: effects of PHA and A23187.

Lichtman AH, Segel GB, Lichtman MA

Journal of supramolecular structure.. 1980 14 (1):65-75. Epub 1900 01 01.

An ultrasensitive method for the measurement of human leukocyte calcium: lymphocytes.

Lichtman AH, Segel GB, Lichtman MA

Clinica chimica acta; international journal of clinical chemistry.. 1979 October 197 (2-3):107-21. Epub 1900 01 01.

Regulation of sodium and potassium transport in phytohemagglutinin-stimulated human blood lymphocytes.

Segel GB, Simon W, Lichtman MA

The Journal of clinical investigation.. 1979 September 64 (3):834-41. Epub 1900 01 01.

Sodium-potassium adenosine triphosphatase activity of human lymphocyte membrane vesicles: kinetic parameters, substrate specificity, and effects of phytohemagglutinin.

Segel GB, Kovach G, Lichtman MA

Journal of cellular physiology.. 1979 July 100 (1):109-17. Epub 1900 01 01.

A model for the control of potassium transport in PHA stimulated human blood lymphocytes.

Segel, G.B.; Simon, W.;Lichtman, M.A.

Cell Biology and Immunology of Leukocyte Function. 1979; : 63.

Lymphocyte sodium concentration regulates monovalent cation transport after PHA stimulation.

Segel, G.B., and Lichtman, M.A.

The Molecular Basis of Immune Cell Function,. 1979; : 399.

Increased ouabain-sensitive glycolysis of lymphocytes treated with phytohemagglutinin: relationship to potassium transport.

Segel GB, Androphy EJ, Lichtman MA

Journal of cellular physiology.. 1978 December 97 (3 Pt 2 Suppl 1):407-12. Epub 1900 01 01.

The effect of method on the measurement of K+ concentration in PHA-treated human blood lymphocytes.

Segel GB, Lichtman MA

Experimental cell research.. 1978 March 1112 (1):95-102. Epub 1900 01 01.

Effect of molecular modification on the inhibition of lymphocyte blastogenesis by cardiac glycosides.

Gordon BR, Segel GB, Brennan JK, Lichtman MA

Blood.. 1978 March 51 (3):497-505. Epub 1900 01 01.

Decreased membrane potassium permeability and transport in human chronic leukemic and tonsillar lymphocytes.

Segel GB, Lichtman MA

Journal of cellular physiology.. 1977 November 93 (2):277-84. Epub 1900 01 01.

Segel, G.B.; Lichtman, M.A.

Transmembrane K+ turnover by phytohemagglutinin

The effects of splenectomy and glucocorticoids on survival and hepatic uptake of damaged red cells in the mouse.

Ganick DJ, Segel GB, Chamberlain J, Hirsch L, Klemperer MR

American journal of hematology.. 1977 2 (4):365-73. Epub 1900 01 01.

Potasssium transport in human blood lymphocytes treated with phytohemagglutinin.

Segel GB, Lichtman MA

The Journal of clinical investigation.. 1976 December 58 (6):1358-69. Epub 1900 01 01.

Human lymphocyte potassium content during the initiation of phytohemagglutinin-induced mitogenesis.

Segel GB, Lichtman MA, Hollander MM, Gordon BR, Klemperer MR

Journal of cellular physiology.. 1976 May 88 (1):43-8. Epub 1900 01 01.

Exodus of 42K+ and 86Rb+ from rat thymic and human blood lymphocytes exposed to phytohemagglutinin.

Segel GB, Gordon BR, Lichtman MA, Hollander MM, Klemperer MR

Journal of cellular physiology.. 1976 March 87 (3):337-43. Epub 1900 01 01.

Attempted treatment of a child with metastatic neuroblastoma employing syngeneic marrow transplantation.

Klemperer MR, Ganick D, Shigeoka A, Lee H, Segel G

Transplantation.. 1976 February 21 (2):161-4. Epub 1900 01 01.

Plateletpheresis residues: a source of large quantities of human blood lymphocytes.

Segel GB, Lichtman MA, Gordon BR, MacPherson JL, Nusbacher J

Transfusion.. 1976 16 (5):455-9. Epub 1900 01 01.

Cation transport and its altered regulations in human stomatocytic erythrocytes.

Dutcher PO, Segel GB, Feig SA, Miller DR, Klemperer MR

Pediatric research.. 1975 December 9 (12):924-7. Epub 1900 01 01.

Contrasting splenic mechanisms in the blood clearance of red blood cells and colloidal particles.

Klausner MA, Hirsch LJ, Leblond PF, Chamberlain JK, Klemperer MR, Segel GB

Blood.. 1975 December 46 (6):965-76. Epub 1900 01 01.

A rapid phytohemagglutinin induced alteration in lymphocyte potassium permeability.

Segel GB, Hollander MM, Gordon BR, Klemperer MR, Lichtman MA

Journal of cellular physiology.. 1975 October 86 (2 PT 2 SUPPL 1):327-35. Epub 1900 01 01.

Energy metabolism in human erythrocytes: the role of phosphoglycerate kinase in cation transport.

Segel GB, Feig SA, Glader BE, Muller A, Dutcher P, Nathan DG

Blood.. 1975 August 46 (2):271-8. Epub 1900 01 01.

Erythrocyte transport function in cystic fibrosis.

Feig SA, Segel GB, Kern KA, Osher AB, Schwartz RH

Pediatric research.. 1974 May 8 (5):594-7. Epub 1900 01 01.

Abnormal cation fluxes in human erythrocytes: Relation to ATP.

Segel, G.B.; Feig, S.A.; Mentzer, W.C.; Jensen, M.C.; Nathan, D.G.;Shohet, S.B.

Erythrocytes Thrombocytes Leukocytes, Recent Advances in Membrane and Metabolic Research. 1973; : 118.

Survival prediction based on morphology of lymphoblasts.

Bennett JM, Klemperer MR, Segel GB

Recent results in cancer research. Fortschritte der Krebsforschung.

The interaction of 1-fluoro-2,4-dinitrobenzene with amino-phospholipids in membranes of intact erythrocytes, modified erythrocytes, and erythrocytes ghosts.

Gordesky SE, Marinetti GV, Segel GB

The Journal of membrane biology.. 1973 14 (3):229-42. Epub 1900 01 01.

Effects of urea and cyanate on sickling in vitro.

Segel GB, Feig SA, Mentzer WC, McCaffrey RP, Wells R, Bunn HF, Shohet SB, Nathan DG

The New England journal of medicine.. 1972 July 13287 (2):59-64. Epub 1900 01 01.

Differences in the reactivity of phospholipids with FDNB in normal RBC, sickle cells and RBC ghosts.

Gordesky SE, Marinetti GV, Segel GB

Biochemical and biophysical research communications.. 1972 June 947 (5):1004-9. Epub 1900 01 01.

Energy metabolism in human erythrocytes. II. Effects of glucose depletion.

Feig SA, Segel GB, Shohet SB, Nathan DG

The Journal of clinical investigation.. 1972 June 51 (6):1547-54. Epub 1900 01 01.

Fluorometric analysis of glycolytic intermediates and pyridine nucleotides in peripheral blood cells.

Segel GB, Feig SA, Baehner RL, Nathan DG

The Journal of laboratory and clinical medicine.. 1971 December 78 (6):969-76. Epub 1900 01 01.

Pathophysiology of common hemolytic syndromes.

Nathan DG, Segel GB

Postgraduate medicine.. 1971 October 50 (4):179-85. Epub 1900 01 01.

Buffy-coat observations and red-cell antibodies in acquired hemolytic anemia.

Gelfand EW, Abramson N, Segel GB, Nathan DG

The New England journal of medicine.. 1971 June 3284 (22):1250-2. Epub 1900 01 01.

Books

Chronic Complex Diseases of Childhood (2011)

Chapter: A Practical Guide for Clinicians

Authors: Segel GB, Feig SA and Morimoto K.

Publisher: Brown Walker Press, Boca Raton, FLA 2011

Textbook of Pediatric Care, 2nd Edition (2011)

Chapter: Lymphadenopathy

Authors: Segel GB and Hall C.

Publisher: American Academy of Pediatrics, Elk Grove, Ill 2011

Hematology (2010)

Chapter: Aplastic Anemia

Authors: Segel GB and Lichtman MA

Publisher: McGraw Hill Co, New York 2010

Hematology (2010)

Chapter: Hematology of the Newborn

Authors: Palis J and Segel GB

Publisher: McGraw Hill Co., New York 2010

Nelson Textbook of Pediatrics, 19th edition. (2010)

Chapter: Hemolytic Anemias (introduction): Hereditary Spherocytosis; Hereditary Elliptocytosis; Hereditary Stomatocytosis: Other Membrane Defects:

Authors: Segel GB

Publisher: WB Saunders Co. 2010

Mosby's Pediaric Clinical Advisor, Instant Diagnosis and Treatment. (2008)

Chapter: Iron Deficiency Anemia, Megaloblastic Anemias, Folic Acid Deficiency, Vitamin B12 Deficiency, Hereditary Spherocytosis

Authors: Halterman J and Segel GB

Publisher: Harcourt Health Sciences, Inc. 2008

Primary Pediatric Care, 5th ed (2008)

Chapter: Lymphadenopathy

Authors: Segel GB and Hall C.

Publisher: American Academy of Pediatrics, Elk Grove, Ill 2008

Nelson Textbook of Pediatrics (2007)

Chapter: Hemolytic Anemias (Intro), Hereditary Spherocytosis, Hereditary Elliptocytosis, Membrane Defects, Enzymatic Defects, Hemolytic Anemias Resulting from Extracellular Factors

Authors: Segel GB

Publisher: WB Saunders Company, Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Iron Deficiency Anemia

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Megaloblastic Anemias

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Folic Acid Deficiency

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Vitamin B12 Deficiency

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Hereditary Spherocytosis

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Transient Erythroblastopenia of Childhood

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2007)

Chapter: Erythroid Aplastic Crisis and Other Disease of Erythroid Failure

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2007

William's Hematology (2006)

Chapter: Hematology of the Newborn

Authors: Segel GB, Palis J

Publisher: McGraw Hill Co., New York, NY 2006

William's Hematology (2006)

Chapter: Aplastic Anemia

Authors: Segel GB, Lichtman MA

Publisher: McGraw Hill Co., New York, NY 2006

Nelson Textbook of Pediatrics (2003)

Chapter: Hemolytic Anemias (Intro), Hered.Spherocytosis, Hered.Elliptocytosis, Hered.Stomatocytosis, Membrane Defects, Enzymatic Defects, Hemolytic Anemias from Extracellular Factors, Other Factors

Authors: Segel GB

Publisher: WB Saunders Company, Philadelphia, PA 2003

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Iron Deficiency Anemia

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Megaloblastic Anemias

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Folic Acid Deficiency

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Vitamin B12 Deficiency

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Hereditary Spherocytosis

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Transient Erythroblastopenia of Childhood

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

Mosby's Pediatric Clinical Advisor, Instant Diagnosis and Treatment (2002)

Chapter: Erythroid Aplastic Crisis and Other Disease of Erythroid Failure

Authors: Halterman J, Segel GB

Publisher: Harcourt Health Sciences, Inc., Philadelphia, PA 2002

William's Hematology (2001)

Chapter: Hematology of the Newborn

Authors: Segel GB, Palis J

Publisher: McGraw Hill Co., New York, NY 2001

Primary Pediatric Care (2001)

Chapter: Lymphadenopathy

Authors: Segel GB, Hall C

Publisher: C.V. Mosby Company, St. Louis, MO 2001

Nelson Textbook of Pediatrics (1999)

Chapter: Hemolytic Anemias (Intro), Hered.Spherocytosis, Hered. Elliptocytosis, Hered. Stomatocytosis, Membrane Defects, Enzymatic Defects, Extracellular Factors, Other Extracellular Factors

Authors: Segel GB

Publisher: WB Saunders Company, Philadelphia, PA 1999

Primary Pediatric Care (1996)

Chapter: Lymphadenopathy

Authors: Segel GB, Hall CB

Publisher: C.V. Mosby Company, St. Louis, MO 1996

Nelson Textbook of Pediatrics (1996)

Chapter: Hemolytic Anemias (Intro), Hered. Spherocytosis, Hered. Spherocytosis, Hered. Elliptocytosis, Hered. Stomatocytosis, Membrane Defects, Enzymatic Defects, Extracellular Factors, Other Factors

Authors: Segel GB

Publisher: WB Saunders Company, Philadelphia, PA 1996

Hematology (1995)

Chapter: Hematology of the Newborn

Authors: Segel GB

Publisher: McGraw Hill Co., New York, NY 1995

Anemia Conn's Current Therapy (1994)

Chapter: Nonimmune Hemolytic

Authors: Asselin B, Segel GB

Publisher: Philadelphia, PA, W.B. Saunders Co. 1994

Mammalian Amino Acid Transport: Mechanisms and Control (1992)

Chapter: Amino Acid Transport in Lymphocytes

Authors: Segel GB

Publisher: Plenum Company 1992

Hematology Basic Principles and Practice (1991)

Chapter: Monocyte Development and Function

Authors: Segel GB, Cohen HJ

Publisher: Churchill Livingstone, NY 1991

Primary Pediatric Care (1991)

Chapter: Lymphadenopathy

Authors: Segel GB, Hall CB

Publisher: CV Mosby Company, St. Louis, MO 1991

Hematology (1990)

Chapter: Hematology of the newborn

Authors: Segel GB, Oski FA

Publisher: McGraw Hill Publishing Co., New York, NY 1990

Clinical Oncology for Medical Students & Physicians (1983)

Chapter: The Leukemias

Authors: Lichtman MA., Segel GB

Publisher: American Cancer Society 1983

Hematology for Practitioners (1978)

Chapter: Pancytopenia

Authors: Lichtman MA, Segel GB

Publisher: Little, Brown & Co., Boston, MA 1978