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John L. O'Donoghue, D.V.M., Ph.D.

Contact

Office (585) 275-4203

About Me

Faculty Appointments

Adjunct Associate Professor - Department of Environmental Medicine (SMD)

Credentials

Education

PhD | Univ of Pennsylvania. Pathology. 1975

DVM | Univ of Pennsylvania. Veterinary Medicine. 1970

Awards

African Society for Toxicological Sciences, Recognition Award (2005) 2005

International Imaging Industry, Achievement Award (2004) 2004

US Environmental Protection Agency, Stratospheric Ozone Protection Award,
Kodak Corporate Sponsor (2003) 2003

US Environmental Protection Agency, WasteWise Hall of Fame Award,
Kodak Corporate Sponsor (2003) 2003

R&D 100 Award, Kodak Enzygraphic Web, Kodak Corporate Sponsor (1991) 1991

Phi Zeta Award, University of Pennsylvania (1970). 1970

Sigma Xi Award, University of Pennsylvania (1970). 1970

John C. Hall Trophy, University of Massachusetts (1966) 1966

Publications

Journal Articles

Lack of Induction of Micronuclei in Human Peripheral Blood

Patrick, E., Juberg, D., O'Donoghue, J.L., and Maibach, H.I.

Depigmentation with t-butyl Hydroquinone Using Black

O'Donoghue, J.L., Barber, E.D., Hill, T., Aebi, J., and Fiorica, L.

Hydroquinone: Genotoxicity and Prevention of Genotoxicity

The effect of repeated methyl isobutyl ketone vapor exposure

Lack of Nephrotoxicity and Renal Cell Proliferation

Evaluation of Subchronic Neurotoxicity of

Workshop Overview: EPAs Neurotoxicity Risk Assessment

The Synergistic Effect of Feed Restriction and

Animal behavior methods in neurotoxicity assessment:

Clinical neurologic indices of toxicity in animals

O'Donoghue, J.L.

Environ. Hlth. Perspec. 1996; 104: 323-330.

Embedding Media for Electron Microscopy

O'Donoghue, J.L.

Microtomy Report. 1995; 3: 1-3.

Pifer, J.W., Hearne, F.T., Swanson, F.A., and O'Donoghue, J.L.

Mortality Study of Employees Engaged in the Manufacture

Measurement of nuclear DNA modification by 32P-postlabeling in the kidneys of male and female Fischer 344 rats after multiple gavage doses of hydroquinone.

English JC, Hill T, O'Donoghue JL, Reddy MV

Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1994 October 23 (3):391-6. Epub 1900 01 01.

Measurement of cell proliferation in the kidneys of Fischer 344 and Sprague-Dawley rats after gavage administration of hydroquinone.

English JC, Perry LG, Vlaovic M, Moyer C, O'Donoghue JL

Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1994 October 23 (3):397-406. Epub 1900 01 01.

O'Donoghue, J.L.

Screening for Neurotoxicity Using a Neurologically

Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone.

O'Donoghue JL, Haworth SR, Curren RD, Kirby PE, Lawlor T, Moran EJ, Phillips RD, Putnam DL, Rogers-Back AM, Slesinski RS

Mutation research.. 1988 October 206 (2):149-61. Epub 1900 01 01.

A 14-week vapor inhalation toxicity study of methyl isobutyl ketone.

Phillips RD, Moran EJ, Dodd DE, Fowler EH, Kary CD, O'Donoghue J

Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1987 October 9 (3):380-8. Epub 1900 01 01.

Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.

O'Donoghue JL

Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1986 April 6 (3):551-8. Epub 1900 01 01.

Further studies on ketone neurotoxicity and interactions.

O'Donoghue JL, Krasavage WJ, DiVincenzo GD, Katz GV

Toxicology and applied pharmacology.. 1984 February 72 (2):201-9. Epub 1900 01 01.

Krasavage, W.J. and O'Donoghue, J.L.

Lack of Lung Damage in Mice Following Administration

Possible role of metabolism in 5-nonanone neurotoxicity.

DiVincenzo GD, Ziegler DA, O'Donoghue JL, Krasavage WJ

Neurotoxicology.. 1982 July 3 (1):55-63. Epub 1900 01 01.

Commercial-grade methyl heptyl ketone (5-methyl-2-octanone) neurotoxicity: contribution of 5-nonanone.

O'Donoghue JL, Krasavage WJ, DiVincenzo GD, Ziegler DA

Toxicology and applied pharmacology.. 1982 February 62 (2):307-16. Epub 1900 01 01.

The relative neurotoxicity of methyl-n-butyl ketone, n-hexane and their metabolites.

Krasavage WJ, O'Donoghue JL, DiVincenzo GD, Terhaar CJ

Toxicology and applied pharmacology.. 1980 March 1552 (3):433-41. Epub 1900 01 01.

Comparative neurotoxicity and metabolism of ethyl n-butyl ketone and methyl n-butyl ketone in rats.

Katz GV, O'Donoghue JL, DiVincenzo GD, Terhaar CJ

Toxicology and applied pharmacology.. 1980 January 52 (1):153-8. Epub 1900 01 01.

Reed C.R.; and O'Donoghue, J.L.

A New Guinea Pig Mutant with Abnormal Hair Production

Studies on the Respiratory Uptake, Excretion and the

Toxic Neuropathy An Overview

O'Donoghue, J.L.; Nasr, A.N.M; and Raleigh, R.L.

J. Occ. Medicine. 1977; 19: 379-382.

Contrasting projections from the posterior and ventrobasal thalamic nuclear complexes to the anterior ectosylvian gyrus of the cat.

Morrison AR, Hand PJ, O'Donoghue J

Brain research.. 1970 June 3021 (1):115-21. Epub 1900 01 01.

Hirsch M., Emmons V., Roser K., English J., and Rennie I.,.

Effects or iron and micronutrients metal on algal

Books

Neurobiology of Disease (2006)

Chapter: Organic Chemicals

Authors: O'Donoghue, J.L.

Publisher: Elsevier, New York 2006

Pattys Toxicology, Fith Edition (2001)

Chapter: Ketones of Four or Five Carbons

Authors: Morgott, D. A., Topping, D.C., and O'Donoghue, J.L.

Publisher: John Wiley and Sons, Inc., New York 2001

Patty's Toxicology, Fifth Edition (2001)

Chapter: Ketones of Six to Thirteen Carbons

Authors: Topping, D.C., Morgott, D.A., and O'Donoghue, J.L.

Publisher: John Wiley and Sons, Inc, New York 2001

Patty's Toxicology, Fifth Edition (2001)

Chapter: Phenol and Phenolics

Authors: Gingell, R., O'Donoghue, J., Staab, R.J., Daly, I.W., Bernard, B.K., Ranpuria, A., Wilkinson, E.J., Woltering, D., Johns, P.A., Hammond, L.E., and Leng, M.

Publisher: John Wiley and Sons, Inc., New York 2001

Experimental and Clinical Neurotoxicology (2000)

Chapter: Assistant Editor and Contributor to 12 chemical sections

Authors: O'Donoghue, J.L.

Publisher: Williams and Wilkins Company, Baltimore 2000

Neurobehavioral Toxicity: Analysis and Interpretation (1994)

Chapter: Defining What is Neurotoxic

Authors: O'Donoghue, J.L.

Publisher: Raven Press, New York 1994

Patty's Industrial Hygiene and Toxicology (1994)

Chapter: Keytones

Authors: Topping, D.C., David, R., and O'Donoghue, J.L.

Publisher: John Wiley and Sons, New York 1994

A Guide to General Toxicology, 2nd Edition (1989)

Chapter: Neurotoxicology.

Authors: O'Donoghue, J.L.

Publisher: Kager, Basel 1989

Guides for Toxicology Pathology STP/ARP/AFIP (1987)

Chapter: Non-Proliferative Lesions of the Nervous System in Rats

Authors: McMartin, D.N., O'Donoghue, J.L., Morissey, R., and Fix, A.S.

Publisher: STP/ARP/AFIP, Washington, DC 1987

Neurotoxicity of Industrial and Commercial Chemicals, (1985)

Chapter: Ed

Authors: O'Donoghue, J.L.

Publisher: CRC Press, Boca Raton, Florida 1985

A Guide to General Toxicology (1983)

Chapter: Neurotoxicity

Authors: O'Donoghue, J.L.

Publisher: S Kager, Basel 1983

Patty's Industrial Hygiene and Toxicology (1982)

Chapter: Ketones

Authors: Krasavage, W.J., O'Donoghue, J.L. and DiVincenzo, G.D.

Publisher: Wiley Interscience, New York 1982

Proceedings of the Third International Workshop on Nude Mice (1982)

Chapter: The Hairless Athymic Guinea Pig.

Authors: Reed, C.R. and O'Donoghue, J.L.

Publisher: Gustav Fischer, Inc., New York 1982

The Scientific Basis of Toxicity Assessment (1980)

Chapter: The Role of Metabolism in Hexacarbon Neuropathy

Authors: DiVincenzo, G.D., Krasavage, W.J. and O'Donoghue, J.L.

Publisher: Biomedical Press, Elsevier North Holland 1980

Experimental and Clinical Neurotoxicology (1979)

Chapter: Identification and Characterization of MnBK Neurotoxicity in Laboratory Animals

Authors: O'Donoghue, J.L. and Krasavage, W.J.

Publisher: Williams and Wilkins Company, Baltimore, Maryland 1979