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Bruce M. Fenton, Ph.D.

Bruce M. Fenton, Ph.D.

Contact

Office (585) 275-7911

About Me

Faculty Appointments

Professor Emeritus - Department of Radiation Oncology (SMD)

Credentials

Education

PhD | Univ of Cal San Diego. Bioengineering. 1980

MS | Montana State University. Chemical Engineering. 1975

BS | Montana State University. Chemical Engineering. 1972

Awards

Casarett Research Award. 2010

1980 Lamport Award: Top Presentation at Microcirculatory Soc. Meeting, Los Angeles, CA

1992 Invited Presentation, NIH workshop: "Oxygen in human tumors: Correlations Between Methods of Measurement and Response to Therapy", National Cancer Institute

1992 Invited Presentation, Symposium on "Geographical Physiology of Tumors", Radiation Research Meeting, Salt Lake City, UT

1996 Distinguished Visitor Series, "Tumor Biology", University of Tennessee Biomedical Engineering Department, Memphis, TN

1998 Invited Presentation, "Microregional Measurement of Tumor Oxygenation and Vascular Structure", Bristol-Myers/Squibb Pharmaceutical Corp., Princeton, NJ

1998 Invited Presentation, Symposium on "Cancer Cells and the Microvasculature", Biomedical Engineering Society Annual Meeting, Cleveland, OH

1999 Radiation Research Society Travel Award to attend 11th International Congress of Radiation Research Meeting in Dublin, Ireland

2001 Invited Presentation, First Radiation Therapy Oncology Group Workshop for Translational Research, "Effect of Angiogenesis Factor Expression on Tumor Vascular Distribution and Function", Tampa, FL

2001 Casarett Translational Research Award, Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY

2002 Invited Presentation, Banbury Center Meeting: A critical review of endostatin and its biology, "Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas", Cold Spring Harbor Laboratory, NY

2003 Invited Presentation, Regional Cancer Center Consortium for the Biological Therapy of Cancer, "VEGF Receptor-2-Blocking Antibody Potentiates the Antitumor Effects of Fractionated Radiotherapy", Roswell Park Cancer Center, Buffalo, NY.

Publications

Journal Articles

The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature.

Fenton BM, Paoni SF

Cancer research.. 2007 October 1567 (20):9921-8. Epub 1900 01 01.

Enhanced antitumor effect of combined triptolide and ionizing radiation.

Wang W, Yang S, Su Y, Xiao Z, Wang C, Li X, Lin L, Fenton BM, Paoni SF, Ding I, Keng P, Okunieff P, Zhang L

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2007 August 1513 (16):4891-9. Epub 1900 01 01.

Intratumoral VEGF and FGF1 administration alters tumor growth, vascular density, oxygenation, and expression of MCP-1 and interleukins.

Okunieff P, Sun J, Fenton B, Liu W, Ding I

Advances in experimental medicine and biology.. 2007 599 :109-16. Epub 1900 01 01.

In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model.

Winey BA, Misic V, Liao L, Parker K, Fenton BM, Yu Y

Medical physics.. 2006 June 33 (6):1623-33. Epub 1900 01 01.

Cone beam computed tomography angiogenesis imaging: Preliminary studies

Conover,D.L.; Ning,R.; Paoni,S.; Wilson,I.; Lu,X.; Zhang,Y.; Fenton,B.;.

Proc.of SPIE. 2006; 6143: 61433G1-6.

In vivo optical spectroscopy of acoustically induced blood stasis

Winey,B.A.; Misic,V.; Fenton,B.; Paoni,S.; Liao,L.; Okunieff,P.; Liu,H..; Parker,K.J.; Yu,Y;.

Proceedings of the 2005 IEEE. 2005; .

Varied response of spontaneous tumors to antiangiogenic agents.

Fenton BM, Paoni SF, Grimwood B, Ding I

Advances in experimental medicine and biology.. 2005 566 :59-65. Epub 1900 01 01.

Past, present, and future of oxygen in cancer research.

Okunieff P, Fenton B, Chen Y

Advances in experimental medicine and biology.. 2005 566 :213-22. Epub 1900 01 01.

Tumor Detection in vivo with Optical Spectroscopy.

Misic V, Winey B, Liu H, Liao L, Okunieff P, Parker K, Fenton B, Yu Y

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society.. 2005 2005 :4708-11. Epub 1900 01 01.

Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors.

Fenton BM, Paoni SF, Ding I

Cancer research.. 2004 August 1564 (16):5712-9. Epub 1900 01 01.

Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors.

Fenton BM, Paoni SF, Ding I

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2004 August 72 (2):221-30. Epub 1900 01 01.

Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model.

Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN

Radiation research.. 2004 May 161 (5):560-7. Epub 1900 01 01.

Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours.

Fenton BM, Paoni SF, Liu W, Cheng SY, Hu B, Ding I

British journal of cancer.. 2004 January 2690 (2):430-5. Epub 1900 01 01.

Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas.

Fenton BM, Paoni SF, Grimwood BG, Ding I

International journal of radiation oncology, biology, physics.. 2003 November 1557 (4):1038-46. Epub 1900 01 01.

Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo.

Guo P, Fang Q, Tao HQ, Schafer CA, Fenton BM, Ding I, Hu B, Cheng SY

Cancer research.. 2003 August 163 (15):4684-91. Epub 1900 01 01.

Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth.

Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I

American journal of clinical oncology.. 2003 August 26 (4):S103-9. Epub 1900 01 01.

Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts.

Gerber SA, Moran JP, Frelinger JG, Frelinger JA, Fenton BM, Lord EM

British journal of cancer.. 2003 May 688 (9):1453-61. Epub 1900 01 01.

Evaluation of microregional variations in tumor hypoxia following the administration of endostatin.

Fenton BM, Paoni SF, Beauchamp BK, Tran B, Liang L, Grimwood B, Ding I

Advances in experimental medicine and biology.. 2003 510 :19-24. Epub 1900 01 01.

Oxygenation and vascular perfusion in spontaneous and transplanted tumor models.

Fenton BM, Paoni SF

Advances in experimental medicine and biology.. 2003 530 :165-76. Epub 1900 01 01.

Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density.

Okunieff P, Fenton BM, Zhang L, Kern FG, Wu T, Greg JR, Ding I

Advances in experimental medicine and biology.. 2003 530 :593-601. Epub 1900 01 01.

FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice.

Ding I, Liu W, Sun J, Paoni SF, Hernady E, Fenton BM, Okunieff P

Advances in experimental medicine and biology.. 2003 530 :603-9. Epub 1900 01 01.

A new intrinsic hypoxia marker in esophageal cancer.

Ding I, Okunieff P, Salnikow K, Liu W, Fenton B

Advances in experimental medicine and biology.. 2003 540 :227-33. Epub 1900 01 01.

Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis.

Fenton BM, Paoni SF, Beauchamp BK, Ding I

British journal of cancer.. 2002 June 586 (11):1831-6. Epub 1900 01 01.

Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas.

Ding I, Liu W, Sun J, Fenton B, Okunieff P

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.. 2002 May 132 (1):17-25. Epub 1900 01 01.

Characterization of the effects of antiangiogenic agents on tumor pathophysiology.

Fenton BM, Beauchamp BK, Paoni SF, Okunieff P, Ding I

American journal of clinical oncology.. 2001 October 24 (5):453-7. Epub 1900 01 01.

Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma.

Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I

American journal of clinical oncology.. 2001 October 24 (5):491-5. Epub 1900 01 01.

Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.

Fenton BM, Lord EM, Paoni SF

International journal of cancer.. 2001 September 193 (5):693-8. Epub 1900 01 01.

Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models.

Fenton BM

International journal of radiation oncology, biology, physics.. 2001 March 149 (3):799-808. Epub 1900 01 01.

Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival.

Fenton BM, Lord EM, Paoni SF

Radiation research.. 2001 February 155 (2):360-8. Epub 1900 01 01.

Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas.

Ding I, Sun JZ, Fenton B, Liu WM, Kimsely P, Okunieff P, Min W

Cancer research.. 2001 January 1561 (2):526-31. Epub 1900 01 01.

An evaluation of near infrared spectroscopy and cryospectrophotometry estimates of haemoglobin oxygen saturation in a rodent mammary tumour model

Conover,D.L.; Fenton,B.M.; Foster,T.H.; Hull,E.L.;.

Phys Med Biol. 2001; 45(9): 2685-2700.

Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation.

Fenton BM, Lord EM, Paoni SF

Radiation research.. 2000 January 153 (1):75-83. Epub 1900 01 01.

Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements.

Fenton BM, Paoni SF, Lee J, Koch CJ, Lord EM

British journal of cancer.. 1999 February 79 (3-4):464-71. Epub 1900 01 01.

Alteration of tumor response to radiation by interleukin-2 gene transfer

Lee,J.; Moran,J.P.; Fenton,B.M.; Koch,C.J.; Frelinger,J.G.; Keng,P.C.; Lord,E.M.;.

Br.J.Cancer. 1999; 82(4): 937-944.

Characterization of the dose perturbation by stents as a function of X-ray beam energy.

Schell MC, Rosenzweig DP, Weaver KA, Fenton BM, Rubin P

Cardiovascular radiation medicine. 1999 1 (2):154-9. Epub 1900 01 01.

Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment.

Lee J, Fenton BM, Koch CJ, Frelinger JG, Lord EM

Cancer research.. 1998 April 158 (7):1478-85. Epub 1900 01 01.

Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia.

Fenton BM, Paoni SF, Koch CJ, Lord EM

Advances in experimental medicine and biology.. 1998 454 :619-28. Epub 1900 01 01.

Effects of carbogen plus fractionated irradiation on KHT tumor oxygenation.

Fenton BM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 1997 August 44 (2):183-90. Epub 1900 01 01.

Effects of ionizing radiation on the adhesive interaction of human tumor and endothelial cells in vitro.

Kiani MF, Fenton BM, Sporn LA, Siemann DW

Clinical & experimental metastasis.. 1997 January 15 (1):12-8. Epub 1900 01 01.

Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor?

Fenton BM, Kiani MF, Siemann DW

International journal of radiation oncology, biology, physics.. 1995 September 3033 (2):365-73. Epub 1900 01 01.

The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumours.

Fenton BM

British journal of cancer.. 1995 May 71 (5):945-9. Epub 1900 01 01.

Inherent cellular differences may explain the dissimilar survival of RIF-1 and KHT tumour cells under aerobic and hypoxic conditions.

Kiani MF, Fenton BM

International journal of radiation biology.. 1995 April 67 (4):449-52. Epub 1900 01 01.

Quantification of micro-regional heterogeneities in tumor oxygenation using intravascular HbO2 saturations.

Fenton BM, Raubertas RF, Boyce DJ

Radiation research.. 1995 January 141 (1):49-56. Epub 1900 01 01.

Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation?

Fenton BM, Siemann DW

Acta oncologica.. 1995 34 (3):307-11. Epub 1900 01 01.

Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration.

Fenton BM, Boyce DJ

International journal of radiation oncology, biology, physics.. 1994 June 1529 (3):459-62. Epub 1900 01 01.

Investigations of perfusion-limited hypoxia and oxygenation in the KHT sarcoma.

Fenton BM, Siemann DW

Advances in experimental medicine and biology.. 1994 361 :627-34. Epub 1900 01 01.

Vascular morphometry of KHT and RIF-1 murine sarcomas.

Fenton BM, Way BA

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 1993 July 28 (1):57-62. Epub 1900 01 01.

Effect of flunarizine on micro-regional distributions of intravascular HbO2 saturations in RIF-1 and KHT sarcomas.

Fenton BM, Sutherland RM

International journal of radiation oncology, biology, physics.. 1992 22 (3):447-50. Epub 1900 01 01.

Time-dependent effects of anesthetic agents on 31P NMR high-energy phosphates in KHT and RIF-1 fibrosarcomas.

Fenton BM, Raubertas RF, Sutherland RM

NMR in biomedicine.. 1991 June 4 (3):137-41. Epub 1900 01 01.

Effects of anaesthetic agent on [31P]NMR high-energy phosphates and regional distributions of intravascular oxyhaemoglobin saturations.

Fenton BM, Sutherland RM

International journal of radiation biology.. 1991 60 (1-2):115-9. Epub 1900 01 01.

Determination of microvascular oxyhemoglobin saturations using cryospectrophotometry.

Fenton BM, Gayeski TE

The American journal of physiology.. 1990 December 259 (6 Pt 2):H1912-20. Epub 1900 01 01.

Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry.

Mueller-Klieser W, Schaefer C, Walenta S, Rofstad EK, Fenton BM, Sutherland RM

Cancer research.. 1990 March 1550 (6):1681-5. Epub 1900 01 01.

31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia.

Rofstad EK, DeMuth P, Fenton BM, Ceckler TL, Sutherland RM

International journal of radiation oncology, biology, physics.. 1989 April 16 (4):919-23. Epub 1900 01 01.

Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth.

Fenton BM, Rofstad EK, Degner FL, Sutherland RM

Journal of the National Cancer Institute.. 1988 December 2180 (20):1612-9. Epub 1900 01 01.

31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia.

Rofstad EK, DeMuth P, Fenton BM, Sutherland RM

Cancer research.. 1988 October 148 (19):5440-6. Epub 1900 01 01.

Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells.

Rofstad EK, Fenton BM, Sutherland RM

British journal of cancer.. 1988 May 57 (5):494-502. Epub 1900 01 01.

Analysis of the effects of measured white blood cell entrance times on hemodynamics in a computer model of a microvascular bed.

Fenton BM, Wilson DW, Cokelet GR

Pflu?gers Archiv : European journal of physiology.. 1985 April 403 (4):396-401. Epub 1900 01 01.

Nonuniform red cell distribution in 20 to 100 micrometers bifurcations.

Fenton BM, Carr RT, Cokelet GR

Microvascular research.. 1985 January 29 (1):103-26. Epub 1900 01 01.

Influence of wall surface on the flow of blood through endothelial-lined glass tubes

Fenton,B.M.; Cokelet,G.R.; LaCelle,P.L.;.

Int.J.Microcirc.(Clin.and Expt.). 1982; 1: 157-162.

Morphometry of diabetic conjunctival blood vessels.

Worthen DM, Fenton BM, Rosen P, Zweifach B

Ophthalmology.. 1981 July 88 (7):655-7. Epub 1900 01 01.

Microcirculatory model relating geometrical variation to changes in pressure and flow rate

Fenton,B.M.; Zweifach,B.W.;.

Annals Biomed.Eng. 1981; 9: 303-321.

Morphometric analysis of the microcirculation

Zweifach,B.W.; Schmid-Schonbein,G.; Fenton,B.;.

Biblthca.Anat. 1981; 20: 1-4.

Quantitative morphometry of conjunctival microcirculation in diabetes mellitus.

Fenton BM, Zweifach BW, Worthen DM

Microvascular research.. 1979 September 18 (2):153-66. Epub 1900 01 01.