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Karen L. Bentley, M.S.

Karen L. Bentley, M.S.

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About Me

Ms.(de Mesy) Bentley has over 35 years of experience in Ultrastructural Pathology and is considered an expert in both diagnostic and research electron microscopy. She previously served as the Associate Director of the Diagnostic Electron Microscope (EM) Laboratory with P. Anthony di Sant'Agnese, M....
Ms.(de Mesy) Bentley has over 35 years of experience in Ultrastructural Pathology and is considered an expert in both diagnostic and research electron microscopy. She previously served as the Associate Director of the Diagnostic Electron Microscope (EM) Laboratory with P. Anthony di Sant'Agnese, M.D., a surgical pathologist, who was the Laboratory Director. Together they developed a month long resident Diagnostic EM rotation which focused on interpretation of tumors, infectious and storage diseases. They also organized 100 Diagnostic EM teaching sets for Pathology residents and other URMC departmental resident trainees. She has also been innovative in the development of EM specialized technical approaches to interrogate both EM based clinical and research projects.

At present, she serves as the Director of the Medical Center's Electron Microscopy Resource (EMR) and supports URMC researchers in projects requiring Transmission Electron Microscopy and Scanning Electron Microscopy in the Center for Advanced Research Technologies (CART). In 2020 the EMR acquired a Thermo Fisher Talos 120C Cryo Electron Microscope for structural biology researchers who request imaging of macromolecular structures.

Faculty Appointments

Senior Associate - Department of Pathology and Laboratory Medicine (SMD)

Senior Associate - Center for Musculoskeletal Research - Joint

Credentials

Education

MS | Univ Rochester Sch Med/Dent. Anatomy. 1984

BS | University of Rochester. Biology. 1982

Awards

Best Poster Teaser Platform Presentation. 2017 - 2017

Current Concepts in Ultrastructural Pathology. 1988

M.S. Anatomy/Pathology. 1984

B.S. Cum laude. 1982

Research

Ms. (de Mesy) Bentley is currently, the Director of the Electron Microscopy Resource (EMR) in the Center for Advanced Research Technologies (CART) and has over 35 years of teaching and Electron Microscopy based diagnostic experience in Ultrastructural Pathology, and Immunoelectron Microscopy labelin...
Ms. (de Mesy) Bentley is currently, the Director of the Electron Microscopy Resource (EMR) in the Center for Advanced Research Technologies (CART) and has over 35 years of teaching and Electron Microscopy based diagnostic experience in Ultrastructural Pathology, and Immunoelectron Microscopy labeling using gold-tagged secondary antibodies. Additonal expertise also includes Dental Research, Infectious Agents, Biofilm Formation, Nanoparticle Characterization, Morphometric Analysis and X-ray Dispersive Spectroscopy using both Transmission and Scanning Electron Microscopes.

Ms. Bentley published in 2021 in the Journal of Orthopaedic Research the first 3-dimensional volume reconstruction (cover of journal) of 264 consecutive 60 nm epoxy sections of Stapylococcus aureus invading the Osteocyte-Lacuno Canalicular Network (OLCN). This 3D volume rendering analyzed S. aureus occupation in the OLCN, in that, 70% of the OLCN were invaded by S. aureus, while the remaining 30% non-infected canaliculi appeared to be resistant to infection. This observation has led to the hypothesis that viable osteocytes of the OLCN can respond and resist infection, opening future research directions to explain the paradox of adjacent uninfected canaliculi and life long deep bone infection in patients with chronic osteomyelitis. This work was done in collaboration with Dr. Edward Schwarz, director of the Center for Musculoskeletal Research and Dr. Jonathan Leckenby, an expert in volume reconstruction.

Previously, in 2014, Ms. Bentley initiated the first transmission electron microscopy (TEM) studies on Staphylococcus aureus infected mouse bone (using a bacteria coated stainless steel wire implant) 14 days post- infection. Ms. Bentley's high magnification TEM study revealed for the first time that Staphylococcus aureus deforms from rounded 1.0 micron diameter bacteria into rod-shaped bacteria to colonize the 0.8 to 0.2 micron diameter sized osteocyte-canaliculi of bone. This finding was published in the Journal of Bone and Mineral Research in May, 2017 and prior to this publication an electron micrograph from her study was also chosen for a book cover, Osteoimmunology, 2nd Ed. In 2018, Ms Bentley published the a patient case study demonstrating the first evidence of S. aureus deformation and invasion of the osteocytic-canalicular system in human bone which confirmed the clinical importance of her finding. These studies were performed in collaboration with Dr. Edward Schwarz, the Director of the Center for Musculoskeletal Research in the Department of Orthopaedics at URMC.

Ms Bentley has also authored and co-authored over 100 research publications resulting from her years of collaborative TEM and SEM imaging support to researchers here at the University. URMC Researchers who require high magnification imaging support can request a consultation and an estimate of cost prior to starting a research project. This facility provides full wet-lab services for tissue/cells processing, embedding, sectioning and utilizes a Hitachi 7650 TEM/STEM electron microscope with an attached 11 megapixel Gatan digital camera system. The facility has recently acquired a Cryo-Electron Microscope and all the instruments are located in the basement of the Medical School building. A Zeiss Auriga scanning electron microscope housed in Wilmot Hall on the River Campus is used by the Electron Microscopy Resource laboratory when performing SEM studies.

Publications

Journal Articles

Cutaneous Superficial Basal Cell Carcinoma is a Basal Cell Carcinoma In Situ: Electron Microscopy of a Case Series of Basal Cell Carcinomas.

Kaur H, de Mesy Bentley KL, Rahman SM, Cohen PR, Smoller BR

Dermatology and therapy.. 2024 May 9 Epub 05/09/2024.

Coordinated metabolic responses to cyclophilin D deletion in the developing heart.

Beutner G, Burris JR, Collins MP, Kulkarni CA, Nadtochiy SM, de Mesy Bentley KL, Cohen ED, Brookes PS, Porter GA

iScience.. 2024 March 1527 (3):109157. Epub 02/09/2024.

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.

Schwarz EM, Archer NK, Atkins GJ, Bentley KLM, Botros M, Cassat JE, Chisari E, Coraça-Huber DC, Daiss JL, Gill SR, Goodman SB, Harro J, Hernandez CJ, Ivashkiv LB, Kates SL, Marques CNH, Masters EA, Muthukrishnan G, Owen JR, Raafat D, Saito M, Veis DJ, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 December 16 Epub 12/16/2023.

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.

Lee H, Lee TJ, Galloway CA, Zhi W, Xiao W, de Mesy Bentley KL, Sharma A, Teng Y, Sesaki H, Yoon Y

Nature communications.. 2023 October 2314 (1):6721. Epub 10/23/2023.

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis.

Ren Y, Weeks J, Xue T, Rainbolt J, de Mesy Bentley KL, Shu Y, Liu Y, Masters E, Cherian P, McKenna CE, Neighbors J, Ebetino FH, Schwarz EM, Sun S, Xie C

Bone research.. 2023 October 1811 (1):51. Epub 10/18/2023.

Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma.

Shah T, Leurgans SE, Mehta RI, Yang J, Galloway CA, de Mesy Bentley KL, Schneider JA, Mehta RI

The Journal of experimental medicine.. 2023 February 6220 (2)Epub 12/05/2022.

The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?

Kenney HM, Peng Y, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM

Current rheumatology reviews.. 2023 January 27 Epub 01/27/2023.

Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice.

Peng Y, Kenney HM, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM

Frontiers in immunology.. 2023 14 :1275871. Epub 12/14/2023.

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.

Morita Y, Saito M, Rangel-Moreno J, Franchini AM, Owen JR, Martinez JC, Daiss JL, de Mesy Bentley KL, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2022 August 2610 (1):56. Epub 08/26/2022.

Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.

Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI

Nature communications.. 2022 July 613 (1):3897. Epub 07/06/2022.

Skeletal infections: microbial pathogenesis, immunity and clinical management.

Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF, Schwarz EM, Muthukrishnan G

Nature reviews. Microbiology.. 2022 February 15 Epub 02/15/2022.

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi.

Ren Y, Xue T, Rainbolt J, Bentley KLM, Galloway CA, Liu Y, Cherian P, Neighbors J, Hofstee MI, Ebetino FH, Moriarty TF, Sun S, Schwarz EM, Xie C

Frontiers in cellular and infection microbiology.. 2022 12 :910970. Epub 06/24/2022.

Bone infection: a clinical priority for clinicians, scientists and educators.

Moriarty TF, Muthukrishnan G, Daiss JL, Xie C, Nishitani K, Morita Y, Awad H, de Mesy Bentley KL, Masters E, Bui T, Yan M, Owen J, Mooney B, Gill S, Puetzler J, Wenke JC, Morgenstern M, Metsemakers WJ, Noll C, Joeris A, Richards RG, Schwarz EM, Kates SL

European cells & materials.. 2021 October 1841 :312-333. Epub 10/18/2021.

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid.

Adjei-Sowah E, Peng Y, Weeks J, Jonason JH, de Mesy Bentley KL, Masters E, Morita Y, Muthukrishnan G, Cherian P, Hu XE, McKenna CE, Ebetino FH, Sun S, Schwarz EM, Xie C

Antibiotics.. 2021 June 1710 (6)Epub 06/17/2021.

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Osteomyelitis.

Muthukrishnan G, Wallimann A, Rangel-Moreno J, Bentley KLM, Hildebrand M, Mys K, Kenney HM, Sumrall ET, Daiss JL, Zeiter S, Richards RG, Schwarz EM, Moriarty TF

Frontiers in immunology.. 2021 12 :651515. Epub 03/18/2021.

Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis.

Masters EA, Muthukrishnan G, Ho L, Gill AL, de Mesy Bentley KL, Galloway CA, McGrath JL, Awad HA, Gill SR, Schwarz EM

Frontiers in microbiology.. 2021 12 :723498. Epub 08/16/2021.

Emerging Electron Microscopy and 3D Methodologies to Interrogate Staphylococcus aureus Osteomyelitis in Murine Models.

de Mesy Bentley KL, Galloway CA, Muthukrishnan G, Echternacht SR, Masters EA, Zeiter S, Schwarz EM, Leckenby JI

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 December 30 Epub 12/30/2020.

Distinct Vasculotropic vs. Osteotropic Features of S. agalactiae vs. S. aureus Implant-Associated Bone Infection in Mice.

Masters EA, Hao SP, Mark Kenney H, Morita Y, Galloway CA, de Mesy Bentley KL, Ricciardi BF, Boyce BF, Schwarz EM, Oh I

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 December 18 Epub 12/18/2020.

Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.

Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy DR, McGrath JL, Awad HA, Gill SR, Schwarz EM

PLoS pathogens.. 2020 October 2216 (10):e1008988. Epub 10/22/2020.

IsdB antibody-mediated sepsis following S. aureus surgical site infection.

Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM

JCI insight.. 2020 October 25 (19)Epub 10/02/2020.

Biofilm producing Staphylococcus epidermidis (RP62A strain) inhibits osseous integration without osteolysis and histopathology in a murine septic implant model.

Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 November 6 Epub 11/06/2019.

A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis.

Trombetta RP, de Mesy Bentley KL, Schwarz EM, Kate SL, Awad HA

European cells & materials.. 2019 June 2737 :431-443. Epub 06/27/2019.

An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis.

Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL

Nanomedicine : nanotechnology, biology, and medicine.. 2019 June 24 :102039. Epub 06/24/2019.

Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles.

Chen W, Anokhina V, Dieudonne G, Abramowitz MK, Kashyap R, Yan C, Wu TT, de Mesy Bentley KL, Miller BL, Bushinsky DA

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.. 2019 June 134 (6):992-1000. Epub 1900 01 01.

Intrasinusoidal Spread of Hepatic Epithelioid Hemangioendothelioma: Implications for the Diagnosis in Minimal Samples.

Agostini-Vulaj D, Pehlivanoglu B, Weiss SW, Krasinskas A, Feely MM, Hornick JL, Cates JMM, Bentley KLM, Adsay NV, Gonzalez RS

The American journal of surgical pathology.. 2019 April 43 (4):573-579. Epub 1900 01 01.

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.

Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA

Pharmaceutics.. 2019 February 2211 (2)Epub 02/22/2019.

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".

Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2019 7 :20. Epub 07/15/2019.

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.

Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM

Circulation.. 2018 October 23138 (17):1864-1878. Epub 1900 01 01.

Vancomycin-Loaded Polymethylmethacrylate Spacers Fail to Eradicate Periprosthetic Joint Infection in a Clinically Representative Mouse Model.

Carli AV, Bhimani S, Yang X, de Mesy Bentley KL, Ross FP, Bostrom MPG

The Journal of bone and joint surgery. American volume.. 2018 June 6100 (11):e76. Epub 1900 01 01.

Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report.

de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I

JBJS case connector.. 2018 8 (1):e8. Epub 1900 01 01.

Surface topography of silicon nitride affects antimicrobial and osseointegrative properties of tibial implants in a murine model.

Ishikawa M, de Mesy Bentley KL, McEntire BJ, Bal BS, Schwarz EM, Xie C

Journal of biomedical materials research. Part A.. 2017 December 105 (12):3413-3421. Epub 09/26/2017.

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca /NFATc1 Axis.

Chiu YH, Schwarz E, Li D, Xu Y, Sheu TR, Li J, Bentley KL, Feng C, Wang B, Wang JC, Albertorio-Saez L, Wood R, Kim M, Wang W, Ritchlin CT

Journal of cellular physiology.. 2017 September 232 (9):2538-2549. Epub 04/12/2017.

Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury.

Geary MB, Li H, Zingman A, Ketz J, Zuscik M, De Mesy Bentley KL, Noble M, Elfar JC

Muscle & nerve.. 2017 July 56 (1):143-151. Epub 02/06/2017.

The complex genetics of hypoplastic left heart syndrome.

Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Woodrow Benson D, Aronow BJ, Lo CW

Nature genetics.. 2017 July 49 (7):1152-1159. Epub 05/22/2017.

Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.

Barnett RC, Lin X, Barravecchia M, Norman RA, de Mesy Bentley KL, Fazal F, Young JL, Dean DA

Experimental biology and medicine. 2017 July 242 (13):1345-1354. Epub 06/05/2017.

Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress.

Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM

Arthritis & rheumatology.. 2017 June 69 (6):1187-1193. Epub 04/04/2017.

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis.

de Mesy Bentley KL, Trombetta R, Nishitani K, Bello-Irizarry SN, Ninomiya M, Zhang L, Chung HL, McGrath JL, Daiss JL, Awad HA, Kates SL, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May 32 (5):985-990. Epub 01/26/2017.

The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles.

Shi M, de Mesy Bentley KL, Palui G, Mattoussi H, Elder A, Yang H

Nanoscale.. 2017 April 69 (14):4739-4750. Epub 1900 01 01.

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.

Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 April 56 (4):453-464. Epub 1900 01 01.

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM

Proceedings of the National Academy of Sciences of the United States of America.. 2017 March 28114 (13):E2739-E2747. Epub 03/14/2017.

Quantification of Peri-Implant Bacterial Load and in Vivo Biofilm Formation in an Innovative, Clinically Representative Mouse Model of Periprosthetic Joint Infection.

Carli AV, Bhimani S, Yang X, Shirley MB, de Mesy Bentley KL, Ross FP, Bostrom MP

The Journal of bone and joint surgery. American volume.. 2017 March 1599 (6):e25. Epub 1900 01 01.

Short to Midterm Follow-Up of the Tritanium Primary Acetabular Component: A Cause for Concern.

Carli AV, Warth LC, de Mesy Bentley KL, Nestor BJ

The Journal of arthroplasty.. 2017 February 32 (2):463-469. Epub 08/08/2016.

Effect of Nanoparticle Surface Coating on Cell Toxicity and Mitochondria Uptake.

Zheng H, Mortensen LJ, Ravichandran S, Bentley K, DeLouise LA

Journal of biomedical nanotechnology.. 2017 February 13 (2):155-66. Epub 1900 01 01.

Katzman, PJ; de Mesy Bentley, KL; Gelein, R.

Parenchymal Calcifications in Third Trimester Placentas Contain Little or No Detectable Lead As Determined by Atomic

Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality.

Patel N, Hoffman CM, Goldman BI, Bentley K, Burack WR, Evans AG

Acta haematologica.. 2017 138 (2):85-90. Epub 08/17/2017.

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.

Shum LC, White NS, Mills BN, de Mesy Bentley KL, Eliseev RA

Stem cells and development.. 2016 January 1525 (2):114-22. Epub 12/10/2015.

Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH, Eliseev RA

PloS one.. 2016 11 (5):e0155709. Epub 05/16/2016.

Development and characterization of antibody reagents for detecting nanoparticles.

Ravichandran S, Sullivan MA, Callahan LM, Bentley KL, DeLouise LA

Nanoscale.. 2015 December 217 (47):20042-54. Epub 11/16/2015.

Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors.

Nishitani K, Sutipornpalangkul W, de Mesy Bentley KL, Varrone JJ, Bello-Irizarry SN, Ito H, Matsuda S, Kates SL, Daiss JL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 September 33 (9):1311-9. Epub 05/18/2015.

Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.

Trembley MA, Velasquez LS, de Mesy Bentley KL, Small EM

Development.. 2015 January 1142 (1):21-30. Epub 1900 01 01.

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.

Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K

Nature communications.. 2014 November 55 :5244. Epub 11/05/2014.

Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters.

Varrone JJ, de Mesy Bentley KL, Bello-Irizarry SN, Nishitani K, Mack S, Hunter JG, Kates SL, Daiss JL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 October 32 (10):1389-96. Epub 07/03/2014.

Quantification of quantum dot murine skin penetration with UVR barrier impairment.

Mortensen LJ, Jatana S, Gelein R, Debenedetto A, de Mesy Bentley KL, Beck L, Elder A, Delouise L

Nanotoxicology.. 2013 December 7 (8):1386-98. Epub 04/17/2013.

Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect.

Giang AH, Raymond T, Brookes P, Demesy-Bentley K, Schwarz E, O'Keefe R, Eliseev R

The Journal of biological chemistry.. 2013 November 15288 (46):33303-11. Epub 10/07/2013.

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes.

Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD

Neurobiology of aging.. 2013 June 34 (6):1680-6. Epub 01/05/2013.

Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis.

Bouta EM, Ju Y, Rahimi H, de Mesy-Bentley KL, Wood RW, Xing L, Schwarz EM

PloS one.. 2013 8 (9):e73766. Epub 09/09/2013.

Clinically aggressive primary solid pseudopapillary tumor of the ovary in a 45-year-old woman.

Syriac S, Kesterson J, Izevbaye I, de Mesy Bentley KL, Lele S, Mhawech-Fauceglia P

Annals of diagnostic pathology.. 2012 December 16 (6):498-503. Epub 07/20/2011.

Aldolase mRNA expression in endometrial cancer and the role of clotrimazole in endometrial cancer cell viability and morphology.

Mhawech-Fauceglia P, Wang D, Kesterson J, Beck A, de Mesy Bentley KL, Shroff S, Syriac S, Frederick P, Liu S, Odunsi K

Histopathology.. 2011 November 59 (5):1015-8. Epub 09/21/2011.

The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation.

Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA

Developmental cell.. 2011 September 1321 (3):469-78. Epub 1900 01 01.

An 11-?m-thick glycocalyx?: it's all in the technique!

de Mesy Bentley KL

Arteriosclerosis, thrombosis, and vascular biology.. 2011 August 31 (8):1712-3. Epub 1900 01 01.

Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication.

Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA

The Journal of biological chemistry.. 2011 June 24286 (25):22331-8. Epub 05/02/2011.

Bioenergetics, mitochondria, and cardiac myocyte differentiation.

Porter GA, Hom J, Hoffman D, Quintanilla R, de Mesy Bentley K, Sheu SS

Progress in pediatric cardiology.. 2011 May 31 (2):75-81. Epub 1900 01 01.

A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study.

Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY

Nanotoxicology.. 2010 March 4 (1):42-51. Epub 1900 01 01.

Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response.

Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE

Nanotoxicology.. 2009 January 13 (4):307-318. Epub 1900 01 01.

The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae.

Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ

Molecular biology of the cell.. 2009 January 20 (1):164-75. Epub 10/29/2008.

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

Norman JP, Perry SW, Reynolds HM, Kiebala M, De Mesy Bentley KL, Trejo M, Volsky DJ, Maggirwar SB, Dewhurst S, Masliah E, Gelbard HA

PloS one.. 2008 3 (11):e3731. Epub 11/14/2008.

The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage.

Lu JF, Barron-Casella E, Deering R, Heinzer AK, Moser AB, deMesy Bentley KL, Wand GS, C McGuinness M, Pei Z, Watkins PA, Pujol A, Smith KD, Powers JM

Laboratory investigation; a journal of technical methods and pathology.. 2007 March 87 (3):261-72. Epub 01/29/2007.

The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.

Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, de Mesy-Bentley KK, Waugh R, Palis J

Blood.. 2007 February 15109 (4):1433-41. Epub 10/24/2006.

Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes.

Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'Agnese PA, deMesy-Bentley KL, Tzeng CR, Chang C

Endocrinology.. 2006 December 147 (12):5624-33. Epub 09/14/2006.

Ultrastructure of zebrafish dorsal aortic cells.

Miano JM, Georger MA, Rich A, De Mesy Bentley KL

Zebrafish.. 2006 3 (4):455-63. Epub 1900 01 01.

Restricted inactivation of serum response factor to the cardiovascular system.

Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP

Proceedings of the National Academy of Sciences of the United States of America.. 2004 December 7101 (49):17132-7. Epub 11/29/2004.

The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors.

Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC

Journal of cell science.. 2002 March 1115 (Pt 5):1027-39. Epub 1900 01 01.

The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress.

O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC

American journal of respiratory cell and molecular biology.. 2001 June 24 (6):703-10. Epub 1900 01 01.

Isolation and propagation of human papillomavirus type 16 in human xenografts implanted in the severe combined immunodeficiency mouse.

Bonnez W, DaRin C, Borkhuis C, de Mesy Jensen K, Reichman RC, Rose RC

Journal of virology.. 1998 June 72 (6):5256-61. Epub 1900 01 01.

Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy.

Ryan CK, Miller JH, Seydel AS, de Mesy Jensen K, Sax HC

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 1997 1 (5):467-73. Epub 1900 01 01.

Propagation of human papillomavirus type 11 in human xenografts using the severe combined immunodeficiency (SCID) mouse and comparison to the nude mouse model.

Bonnez W, Rose RC, Da Rin C, Borkhuis C, de Mesy Jensen KL, Reichman RC

Virology.. 1993 November 197 (1):455-8. Epub 1900 01 01.

Chlamydia trachomatis in routine cervical smears. A microscopic and ultrastructural analysis.

Henry MR, de Mesy Jensen KL, Skoglund CD, Armstrong DW

Acta cytologica.. 1993 37 (3):343-52. Epub 1900 01 01.

Large block embedding and "pop-off" technique for immunoelectron microscopy.

de Mesy Jensen KL, di Sant'Agnese PA

Ultrastructural pathology.. 1992 16 (1-2):51-9. Epub 1900 01 01.

Myelinoid bodies in endocrine-paracrine (neuroendocrine, APUD) cells of the prostatourethral region.

di Sant'Agnese PA, de Mesy Jensen KL

Journal of submicroscopic cytology and pathology. 1989 July 21 (3):557-64. Epub 1900 01 01.

Calcitonin, katacalcin, and calcitonin gene-related peptide in the human prostate. An immunocytochemical and immunoelectron microscopic study.

di Sant'Agnese PA, de Mesy Jensen KL, Ackroyd RK

Archives of pathology & laboratory medicine.. 1989 July 113 (7):790-6. Epub 1900 01 01.

Age-related changes in the neuroendocrine (endocrine-paracrine) cell population and the serotonin content of the guinea pig prostate.

Di Sant'Agnese PA, Davis NS, Chen M, de Mesy Jensen KL

Laboratory investigation; a journal of technical methods and pathology.. 1987 December 57 (6):729-36. Epub 1900 01 01.

Neuroendocrine differentiation in prostatic carcinoma.

di Sant'Agnese PA, de Mesy Jensen KL

Human pathology.. 1987 August 18 (8):849-56. Epub 1900 01 01.

Endocrine-paracrine (APUD) cells of the human female urethra and paraurethral ducts.

di Sant'Agnese PA, de Mesy Jensen KL

The Journal of urology.. 1987 June 137 (6):1250-4. Epub 1900 01 01.

Neuroendocrine Differentiation in Prostatic Carcinoma.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L:.

Human Pathology. 1987; 18:849.

Neuroendocrine Differentiation in Prostatic Carcinoma.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L:.

Human Pathology. 1987; 18:849.

Pop-off" technique for FNA smears for diagnostic electron microscopy.

de Mesy Jensen, K.L.:.

Tech. Sample CY-1, American Society of Clinical Pathologists. 1987; .

Endocrine-paracrine (neuroendocrine, APUD) cells of the human prostate and urethra and neuroendocrine differentiation in prostatic carcinoma.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

Journal of Urology. 1987; 137:361A.

Human prostatic endocrine-paracrine (APUD) cells. Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains.

di Sant'Agnese PA, de Mesy Jensen KL, Churukian CJ, Agarwal MM

Archives of pathology & laboratory medicine.. 1985 July 109 (7):607-12. Epub 1900 01 01.

Plastic embedded semi-thin sections of fine needle aspiration biopies with dibasic staining.

di Sant'Agnese, P.A.,;de Mesy Jensen, K.L.; Bonfiglio, T.A.; King, D.E.; Patten, Jr., S.F.:.

Acta Cytologica. 1985; 29:477.

Human prostatic endocrine-paracrine (APUD) cells - distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains.

di Sant'Agnese, P.A.; de Mesy Jensen, K.L.,;Churukian, C.J.; Agarwal, M.M.:.

Archives of Pathology and Laboratory Medicine. 1985; 109:607.

Plastic-embedded semi-thin sections of fine needle aspiration biopsies with dibasic staining. Diagnostic and didactic applications.

di Sant'Agnese PA, de Mesy Jensen KL, Bonfiglio TA, King DE, Patten SF

Acta cytologica.. 1985 29 (3):477-83. Epub 1900 01 01.

Endocrine-paracrine cells of the prostate and prostatic urethra: an ultrastructural study.

di Sant'Agnese PA, De Mesy Jensen KL

Human pathology.. 1984 November 15 (11):1034-41. Epub 1900 01 01.

Somatostatin and/or somatostatin-like immunoreactive endocrine-paracrine cells in the human prostate gland.

di Sant'Agnese PA, de Mesy Jensen KL

Archives of pathology & laboratory medicine.. 1984 September 108 (9):693-6. Epub 1900 01 01.

Dibasic staining of large epoxy tissue sections and applications to surgical pathology.

di Sant' Agnese PA, De Mesy Jensen KL

American journal of clinical pathology.. 1984 January 81 (1):25-9. Epub 1900 01 01.

Dibasic staining of large epoxy tissue sections and applications to surgical pathology.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

The American Journal of Clinical Pathology. 1984; .

Somatostatin and/or somatostatin-like immunoreactive endocrine -paracrine cells in the human prostate gland.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

Archives of Pathology and Laboratory Medicine. 1984; 108:093.

Diagnostic electron microscopy on reembedded ("popped off") areas of large spurr epoxy sections.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

Ultrastructural Pathology. 1984; .

Endocrine-paracrine cells of the prostate and prostatic urethra - An ultrastructural study.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

Human Pathology. 1984; 15:1034.

Diagnostic electron microscopy on reembedded ("popped off") areas of large Spurr epoxy sections.

di Sant'Agnese PA, De Mesy-Jensen KL

Ultrastructural pathology.. 1984 6 (2-3):247-53. Epub 1900 01 01.

Histiomonocytic malignancy. A spectrum of disease in an 11-month-old infant.

Di Sant'Agnese PA, Ettinger LJ, Ryan CK, Jensen KL, Anderson VM, Biro FM, Emmens RW

Cancer.. 1983 October 1552 (8):1417-22. Epub 1900 01 01.

Thick (myosin) filaments in a glomus tumor.

di Sant'Agnese PA, De Mesy Jensen KL

American journal of clinical pathology.. 1983 January 79 (1):130-4. Epub 1900 01 01.

Thick (myosin) filaments in a glomus tumor.

di Sant'Agnese, P.A. and de Mesy Jensen, K.L.:.

The American Journal of Clinical Pathology. 1983; 79:130.

A technique for electron microscopy on needle aspirate specimens.

de Mesy Jensen, K.L. and di Sant'Agnese, P.A.:.

The Cytopathologic Interpretation of Transthoracic Fine Needle Biopsies. Masson Monographs in Diagnostic Cytopathology. 1983; Vol. 4.

Placental toxicity of cadmium in the rat: An ultrastructural study.

di Sant'Agnese, P.A.; Levin, A.A.;(deMesy) Jensen, K.L. and Miller, R.K.:.

Placenta. 1983; 4:149.

Histiomonocytic malignancy: A spectrum of disease in an 11 month old infant.

di Sant'Agnese, P.A.; Ettinger, L.J.; Ryan, C.K., de Mesy Jensen, K.L.; Wood, B.P.; Biro, F.M. and Emmens, R.W.:.

Cancer. 1983; 52:1417.

Placental toxicity of cadmium in the rat: an ultrastructural study.

Di Sant'Agnese PA, Jensen KD, Levin A, Miller RK

Placenta.. 1983 4 (2):149-63. Epub 1900 01 01.

Lung ultrastructure in non-cardiogenic pulmonary edema induced by air embolization in dogs

Moosavi, H.; Utell, M.J.; Hyde, R.W.; Fahey, P.J.; Peterson, B.T.; de Mesy Jensen, K.L.; and Donnelly, J.L.:.

Laboratory Investigation. 1981; 45:456.

Books

Osteoimmunology: Interactions of the Immune and Skeletal Systems (2016)

Chapter: The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis.

Authors: Kohei Nishitani, Sheila N. Bello-Irizarry, Karen L. de Mesy Bentley, John L. Daiss, Edward M. Schwarz:

Publisher: Elsevier, London 2016

Principles of Orthopedic Infection Management (2016)

Chapter: Implant-Associated Biofilm

Authors: Kohei Nishitani, Karen de Mesy Bentley, John L. Daiss

Publisher: George Thieme Verlag, Stuttgart, Germany 2016

Ultrastructure of the Male Urogenital Glands: Prostate, Seminal Vesicles, etc (1994)

Chapter: Prostatic and urethral endocrine-paracrine cells in health and disease. An ultrastructural review.

Authors: Karen L. de Mesy Jensen (now Bentley) and P. Anthony di Sant'Agnese

Publisher: Kluwer Academic Publishers, Dordrecht 1994