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Constantine G. Haidaris, Ph.D.

Constantine G. Haidaris, Ph.D.

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About Me

Faculty Appointments

Professor Emeritus - Department of Microbiology and Immunology (SMD)

Credentials

Education

PhD | Univ Cincinnati Coll Medicine. Microbiology. 1982

MS | Miami University. Microbiology. 1976

BA | Wittenberg University. Biology. 1974

Research

Research Description:

Research in my lab focuses on infections in the immunocompromised host. We examine mechanisms of pathogenesis, host-microbe interactions and approaches to therapy. Much of our recent work centers on a novel approach to treat of infections termed photodynamic therapy, i...
Research Description:

Research in my lab focuses on infections in the immunocompromised host. We examine mechanisms of pathogenesis, host-microbe interactions and approaches to therapy. Much of our recent work centers on a novel approach to treat of infections termed photodynamic therapy, in which a chemical agent termed a photosensitizer is activated by light to convert molecular oxygen to reactive oxygen species that are toxic for the target cell. In collaboration with colleagues in the Departments of Physics and Imaging Sciences, we are exploring mechanisms to increase the sensitivity of pathogens to antimicrobial photodynamic therapy and developing methods to treat experimental infections using this technology.

Patents

Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof

Issue date: October 19, 2010

Patent #: 7,815,918

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright

Optimized Antigens of Pneumocystis and Use Thereof

Issue date: December 06, 2016

Patent #: 9,512,189

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright

Publications

Journal Articles

A Role for Bradykinin Signaling in Chronic Vulvar Pain.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Haidaris CG, Phipps RP

The journal of pain.. 2016 November 17 (11):1183-1197. Epub 08/18/2016.

Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection.

Barlow ML, Cummings RJ, Pentland AP, Love TM, Haidaris CG, Ryan JL, Lord EM, Gerber SA

Radiation research.. 2016 November 186 (5):436-446. Epub 10/06/2016.

Identification of novel mechanisms involved in generating localized vulvodynia pain.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Haidaris CG, Stodgell CJ, Phipps RP

American journal of obstetrics and gynecology.. 2015 July 213 (1):38.e1-38.e12. Epub 02/12/2015.

Site-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia-afflicted and pain-free women.

Foster DC, Falsetta ML, Woeller CF, Pollock SJ, Song K, Bonham A, Haidaris CG, Stodgell CJ, Messing SP, Iadarola M, Phipps RP

Pain.. 2015 March 156 (3):386-396. Epub 1900 01 01.

Effective photodynamic therapy against microbial populations in human deep tissue abscess aspirates.

Haidaris CG, Foster TH, Waldman DL, Mathes EJ, McNamara J, Curran T

Lasers in surgery and medicine.. 2013 October 45 (8):509-16. Epub 08/29/2013.

Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy.

Snell SB, Foster TH, Haidaris CG

Photochemistry and photobiology.. 2012 88 (3):596-603. Epub 12/20/2011.

Effective photosensitization and selectivity in vivo of Candida Albicans by meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate.

Mitra S, Haidaris CG, Snell SB, Giesselman BR, Hupcher SM, Foster TH

Lasers in surgery and medicine.. 2011 April 43 (4):324-32. Epub 1900 01 01.

Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida.

Chabrier-Roselló Y, Giesselman BR, De Jesús-Andino FJ, Foster TH, Mitra S, Haidaris CG

Journal of photochemistry and photobiology. B, Biology.. 2010 June 199 (3):117-25. Epub 03/21/2010.

Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa.

Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH

Infection and immunity.. 2009 October 77 (10):4446-54. Epub 08/03/2009.

Compensatory periplasmic nitrate reductase activity supports anaerobic growth of Pseudomonas aeruginosa PAO1 in the absence of membrane nitrate reductase.

Van Alst NE, Sherrill LA, Iglewski BH, Haidaris CG

Canadian journal of microbiology.. 2009 October 55 (10):1133-44. Epub 1900 01 01.

Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment.

Chabrier-Roselló Y, Foster TH, Mitra S, Haidaris CG

Photochemistry and photobiology.. 2008 84 (5):1141-8. Epub 01/29/2008.

Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition.

Wellington M, Dolan K, Haidaris CG

FEMS immunology and medical microbiology.. 2007 October 51 (1):70-83. Epub 07/04/2007.

Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa.

Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG

Infection and immunity.. 2007 August 75 (8):3780-90. Epub 05/25/2007.

Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis.

Foster DC, Piekarz KH, Murant TI, LaPoint R, Haidaris CG, Phipps RP

American journal of obstetrics and gynecology.. 2007 April 196 (4):346.e1-8. Epub 1900 01 01.

Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 April 74 (4):2446-8. Epub 1900 01 01.

Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 January 74 (1):390-3. Epub 1900 01 01.

Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity.

Chabrier-Roselló Y, Foster TH, Pérez-Nazario N, Mitra S, Haidaris CG

Antimicrobial agents and chemotherapy.. 2005 October 49 (10):4288-95. Epub 1900 01 01.

Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa.

Filiatrault MJ, Wagner VE, Bushnell D, Haidaris CG, Iglewski BH, Passador L

Infection and immunity.. 2005 June 73 (6):3764-72. Epub 1900 01 01.

Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.

Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F

Antimicrobial agents and chemotherapy.. 2005 April 49 (4):1326-30. Epub 1900 01 01.

Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens.

Burns R, Luzina I, Nasir A, Haidaris CG, Barth RK, Gaspari AA

The Journal of allergy and clinical immunology.. 2005 February 115 (2):383-90. Epub 1900 01 01.

Susceptibility of Candida species to photodynamic effects of photofrin.

Bliss JM, Bigelow CE, Foster TH, Haidaris CG

Antimicrobial agents and chemotherapy.. 2004 June 48 (6):2000-6. Epub 1900 01 01.

Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA.

Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG

Infection and immunity.. 2004 March 72 (3):1548-56. Epub 1900 01 01.

Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment.

Wellington M, Bliss JM, Haidaris CG

Infection and immunity.. 2003 December 71 (12):7228-31. Epub 1900 01 01.

Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae.

Bliss JM, Sullivan MA, Malone J, Haidaris CG

Journal of clinical microbiology.. 2003 March 41 (3):1152-60. Epub 1900 01 01.

Uptake and antifungal activity of oligonucleotides in Candida albicans.

Disney MD, Haidaris CG, Turner DH

Proceedings of the National Academy of Sciences of the United States of America.. 2003 February 18100 (4):1530-4. Epub 01/27/2003.

Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques.

Board KF, Patil S, Lebedeva I, Capuano S, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA

The Journal of infectious diseases.. 2003 February 15187 (4):576-88. Epub 02/07/2003.

Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques.

Croix DA, Board K, Capuano S, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA

AIDS research and human retroviruses.. 2002 March 2018 (5):391-401. Epub 1900 01 01.

Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia.

Gigliotti F, Haidaris CG, Wright TW, Harmsen AG

Infection and immunity.. 2002 March 70 (3):1069-74. Epub 1900 01 01.

Recombinant human antibody single chain variable fragments reactive with Candida albicans surface antigens.

Haidaris CG, Malone J, Sherrill LA, Bliss JM, Gaspari AA, Insel RA, Sullivan MA

Journal of immunological methods.. 2001 November 1257 (1-2):185-202. Epub 1900 01 01.

Recognition elements for 5' exon substrate binding to the Candida albicans group I intron.

Disney MD, Haidaris CG, Turner DH

Biochemistry.. 2001 May 2940 (21):6507-19. Epub 1900 01 01.

Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells.

Odrljin TM, Haidaris CG, Lerner NB, Simpson-Haidaris PJ

American journal of respiratory cell and molecular biology.. 2001 January 24 (1):12-21. Epub 1900 01 01.

Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes.

Wakem P, Burns RP, Ramirez F, Zlotnick D, Ferbel B, Haidaris CG, Gaspari AA

The Journal of investigative dermatology.. 2000 June 114 (6):1085-92. Epub 1900 01 01.

Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii.

Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG

Gene.. 2000 January 25242 (1-2):141-50. Epub 1900 01 01.

Antigenic characterization of Pneumocystis carinii.

Gigliotti F, Haidaris CG

Seminars in respiratory infections.. 1998 December 13 (4):313-22. Epub 1900 01 01.

The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence.

Guadiz G, Haidaris CG, Maine GN, Simpson-Haidaris PJ

The Journal of biological chemistry.. 1998 October 2273 (40):26202-9. Epub 1900 01 01.

CD86 (B7-2), but not CD80 (B7-1), expression in the epidermis of transgenic mice enhances the immunogenicity of primary cutaneous Candida albicans infections.

Gaspari AA, Burns R, Nasir A, Ramirez D, Barth RK, Haidaris CG

Infection and immunity.. 1998 September 66 (9):4440-9. Epub 1900 01 01.

Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice.

Gigliotti F, Garvy BA, Haidaris CG, Harmsen AG

The Journal of infectious diseases.. 1998 July 178 (1):235-42. Epub 1900 01 01.

Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A.

Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ

DNA research : an international journal for rapid publication of

Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells.

Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ

Molecular biotechnology.. 1998 April 9 (2):91-7. Epub 1900 01 01.

Selected animal models: vaginal candidosis, Pneumocystis pneumonia, dermatophytosis and trichosporosis.

Sobel JD, Hasegawa A, Debernardis F, Adriani D, Pellegrini G, Cassone A, Fidel PL, Haidaris CG, Gigliotti F, Harmsen AG, Fujita S, Yamamoto K, Makimura K, Shibuya K, Uchida K, Yamaguchi H

Medical mycology.. 1998 36 Suppl 1 :129-36. Epub 1900 01 01.

A Pneumocystis carinii group I intron ribozyme that does not require 2' OH groups on its 5' exon mimic for binding to the catalytic core.

Testa SM, Haidaris CG, Gigliotti F, Turner DH

Biochemistry.. 1997 December 936 (49):15303-14. Epub 1900 01 01.

Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA.

Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ

Gene.. 1995 December 29167 (1-2):185-9. Epub 1900 01 01.

Interaction of outer envelope proteins of Chlamydia psittaci GPIC with the HeLa cell surface.

Ting LM, Hsia RC, Haidaris CG, Bavoil PM

Infection and immunity.. 1995 September 63 (9):3600-8. Epub 1900 01 01.

Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii.

Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ

DNA research : an international journal for rapid publication of

Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species.

Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG

Infection and immunity.. 1994 May 62 (5):1513-9. Epub 1900 01 01.

Identification and characterization of a Candida albicans-binding proteoglycan secreted from rat submandibular salivary glands.

Hoffman MP, Haidaris CG

Infection and immunity.. 1994 March 62 (3):828-36. Epub 1900 01 01.

Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization.

Thertulien R, Simpson-Haidaris PJ, Haidaris CG

The Journal of eukaryotic microbiology.. 1994 41 (4):402-7. Epub 1900 01 01.

Pneumocystis carinii is not universally transmissible between mammalian species.

Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ

Infection and immunity.. 1993 July 61 (7):2886-90. Epub 1900 01 01.

Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction.

Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR

The Journal of infectious diseases.. 1993 July 168 (1):191-4. Epub 1900 01 01.

Analysis of Candida albicans adhesion to salivary mucin.

Hoffman MP, Haidaris CG

Infection and immunity.. 1993 May 61 (5):1940-9. Epub 1900 01 01.

In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene.

Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG

Molecular microbiology.. 1993 March 7 (5):647-56. Epub 1900 01 01.

Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii.

Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG

The Journal of infectious diseases.. 1992 November 166 (5):1113-23. Epub 1900 01 01.

The influence of morphological variation on Candida albicans adhesion to denture acrylic in vitro.

Vasilas A, Molina L, Hoffman M, Haidaris CG

Archives of oral biology.. 1992 August 37 (8):613-22. Epub 1900 01 01.

Evidence that the entire length of a kinetoplast DNA minicircle is transcribed in Trypanosoma cruzi.

Thertulien R, Harth G, Haidaris CG

Molecular microbiology.. 1991 January 5 (1):207-15. Epub 1900 01 01.

Molecular cloning and characterization of ferret Pneumocystis carinii gp120.

Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ

The Journal of protozoology. 1991 38 (6):5S-6S. Epub 1900 01 01.

Oral and esophageal Candida albicans infection in hyposalivatory rats.

Meitner SW, Bowen WH, Haidaris CG

Infection and immunity.. 1990 July 58 (7):2228-36. Epub 1900 01 01.

Purification and characterization of stage-specific glycoproteins from Trypanosoma cruzi.

Harth G, Haidaris CG, So M

Molecular and biochemical parasitology.. 1989 March 133 (2):143-50. Epub 1900 01 01.

Neuraminidase from Trypanosoma cruzi: analysis of enhanced expression of the enzyme in infectious forms.

Harth G, Haidaris CG, So M

Proceedings of the National Academy of Sciences of the United States of America.. 1987 December 84 (23):8320-4. Epub 1900 01 01.

Monoclonal antibody characterization of the 195-kilodalton major surface glycoprotein of Plasmodium falciparum malaria schizonts and merozoites: identification of additional processed products and a serotype-restricted repetitive epitope.

Lyon JA, Haynes JD, Diggs CL, Chulay JD, Haidaris CG, Pratt-Rossiter J

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 February 1138 (3):895-901. Epub 1900 01 01.

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

Fields PI, Swanson RV, Haidaris CG, Heffron F

Proceedings of the National Academy of Sciences of the United States of America.. 1986 July 83 (14):5189-93. Epub 1900 01 01.

Serum containing tumor necrosis factor is cytotoxic for the human malaria parasite Plasmodium falciparum.

Haidaris CG, Haynes JD, Meltzer MS, Allison AC

Infection and immunity.. 1983 October 42 (1):385-93. Epub 1900 01 01.

Efficacy of combined immunostimulation and chemotherapy in experimental visceral Leishmaniasis.

Haidaris CG, Bonventre PF

The American journal of tropical medicine and hygiene.. 1983 March 32 (2):286-95. Epub 1900 01 01.

A role for oxygen-dependent mechanisms in killing of Leishmania donovani tissue forms by activated macrophages.

Haidaris CG, Bonventre PF

The Journal of immunology : official journal of the American Association of Immunologists.. 1982 August 129 (2):850-5. Epub 1900 01 01.

Killing of Leishmania donovani. Amastigotes by murine macrophages.

Bonventre PF, Haidaris CG

Advances in experimental medicine and biology.. 1982 141 :189-98. Epub 1900 01 01.

Elimination of Leishmania donovani amastigotes by activated macrophages.

Haidaris CG, Bonventre PF

Infection and immunity.. 1981 September 33 (3):918-26. Epub 1900 01 01.