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James Palis, M.D.

James Palis, M.D.

Contact

Research Lab

About Me

Certified Specialties

Pediatrics - American Board of Pediatrics

Faculty Appointments

Professor - Department of Pediatrics, Hematology and Oncology (SMD)

Northumberland Trust Professorship in Pediatrics - Department of Pediatrics (SMD)

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Pediatric Hematology/Oncology Fellowship, University of Rochester School of Medicine and Dentistry, Rochester, NY 1984 - 1988

Residency in Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 1981 - 1984

Education

MD | University of Rochester School of Medicine and Dentistry. Medicine. 1981

BA | University of Rochester. Biology and Hellenic Studies. 1975

Awards

Donald Metcalf Award. 2022

Dean's Lecture. 2022

Ruth Lawrence Award for Research Excellence. 2021

Davey Memorial Award for Outstanding Contributions to Cancer Research. 2015 - 2015

George Washington Goler Associate Professor of Pediatrics. 2005

George Washington Goler Professor of Pediatrics. 2005

University of Rochester Postdoctoral Academic Mentoring Award. 1999

Second Choremion Research Award, Athens, Greece. 1982

Research

Dr. Palis' research interests are:
1) Ontogeny of the mammalian hematopoietic system,
2) Differentiation of the erythroid lineage,
3) Erythroid precursor self-renewal, and
4) Response of the hematopoietic system to ionizing radiation

Hematopoietic stem cells responsible for the p...
Dr. Palis' research interests are:
1) Ontogeny of the mammalian hematopoietic system,
2) Differentiation of the erythroid lineage,
3) Erythroid precursor self-renewal, and
4) Response of the hematopoietic system to ionizing radiation

Hematopoietic stem cells responsible for the production of blood cells throughout life arise during embryogenesis. However, the mechanisms that initiate blood cell development are largely unknown. The long-term aim of Dr. Palis' laboratory is to elucidate the cellular and molecular events underlying the initiation of hematopoiesis in the mammalian embryo. The first hematopoietic cells to emerge during mammalian embryogenesis are "primitive" red cells that are necessary for survival of the fetus. Their recent studies indicate that the primitive erythroid lineage in mice as "mammalian", rather than "non-mammalian" in character. Primitive erythropoiesis will thus serve as an important model of mammalian erythroid differentiation. Hematopoiesis originates in the yolk sac of embryos and transitions to the liver of the fetus. Two waves of hematopoietic progenitors have been identified in the yolk sac prior to colonization of the liver and the lineage composition and relationships of these primitive and definitive progenitor waves are under active investigation. Their studies indicate that the onset of hematopoiesis within the yolk sac of mammals is much more complex than previously thought.

The hematopoietic system of the adult is exquisitely sensitive to xenotoxic insults. The Palis laboratory is investigating the response of the erythroid and megakaryocyte lineages to ionizing radiation. These studies will provide for the rational use of cytokines and other agents to mitigate the deleterious effects of external radiation.

An understanding of the ontogeny of mammalian hematopoiesis and its response to damage will ultimately produce insights into the regulation and expansion of hematopoietic stem cells. These insights will also lead to a better understanding of genetic disorders, bone marrow failure syndromes and leukemias, ultimately leading to improvements in bone marrow transplantation for the curative treatment of numerous congenital anemias, genetic diseases, and several forms of childhood and adult cancers.

Patents

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: July 28, 2020

Patent #: ZL2014800280231

Country: China, People's Republic of

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: April 29, 2020

Patent #: 2997135

Country: Europe

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: May 15, 2020

Patent #: 6704848

Country: Japan

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: April 16, 2019

Patent #: 10,260,043

Country: United States

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: April 29, 2020

Patent #: FR2997135

Country: France

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: April 29, 2020

Patent #: 60 2014 064 603.4

Country: Germany

Inventors: Samantha England, Ah Ram Kim, James S Palis

Human Extensively Self-Renewing Erythroblasts (ESRE)

Issue date: April 29, 2020

Patent #: GB2997135

Country: United Kingdom

Inventors: Samantha England, Ah Ram Kim, James S Palis

Publications

Journal Articles

Developmental regulation of primitive erythropoiesis.

Rossmann MP, Palis J

Current opinion in hematology.. 2024 February 12 Epub 02/12/2024.

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation.

McGrath KE, Koniski AD, Murphy K, Getman M, An HH, Schulz VP, Kim AR, Zhang B, Schofield TL, Papoin J, Blanc L, Kingsley PD, Westhoff CM, Gallagher PG, Chou ST, Steiner LA, Palis J

bioRxiv : the preprint server for biology.. 2024 February 6 Epub 02/06/2024.

Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways.

Papoin J, Yan H, Leduc M, Le Gall M, Narla A, Palis J, Steiner LA, Gallagher PG, Hillyer CD, Gautier EF, Mohandas N, Blanc L

American journal of hematology.. 2023 November 6 Epub 11/06/2023.

HEXIM1 is an Essential Transcription Regulator During Human Erythropoiesis.

Lv X, Murphy K, Murphy Z, Getman MR, Rahman NF, Nakamura Y, Blanc L, Gallagher PG, Palis J, Mohandas N, Steiner LA

Blood.. 2023 September 22 Epub 09/22/2023.

Yolk sac cell atlas reveals multiorgan functions during human early development.

Goh I, Botting RA, Rose A, Webb S, Engelbert J, Gitton Y, Stephenson E, Quiroga Londoño M, Mather M, Mende N, Imaz-Rosshandler I, Yang L, Horsfall D, Basurto-Lozada D, Chipampe NJ, Rook V, Lee JTH, Ton ML, Keitley D, Mazin P, Vijayabaskar MS, Hannah R, Gambardella L, Green K, Ballereau S, Inoue M, Tuck E, Lorenzi V, Kwakwa K, Alsinet C, Olabi B, Miah M, Admane C, Popescu DM, Acres M, Dixon D, Ness T, Coulthard R, Lisgo S, Henderson DJ, Dann E, Suo C, Kinston SJ, Park JE, Polanski K, Marioni J, van Dongen S, Meyer KB, de Bruijn M, Palis J, Behjati S, Laurenti E, Wilson NK, Vento-Tormo R, Chédotal A, Bayraktar O, Roberts I, Jardine L, Göttgens B, Teichmann SA, Haniffa M

Science.. 2023 August 18381 (6659):eadd7564. Epub 08/18/2023.

Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.

Maurya P, Ture SK, Li C, Scheible KM, McGrath KE, Palis J, Morrell CN

Arteriosclerosis, thrombosis, and vascular biology.. 2023 March 23 Epub 03/23/2023.

Mammalian life depends on two distinct pathways of DNA damage tolerance.

Buoninfante OA, Pilzecker B, Spanjaard A, de Groot D, Prekovic S, Song JY, Lieftink C, Ayidah M, Pritchard CEJ, Vivié J, Mcgrath KE, Huijbers IJ, Philipsen S, von Lindern M, Zwart W, Beijersbergen RL, Palis J, van den Berk PCM, Jacobs H

Proceedings of the National Academy of Sciences of the United States of America.. 2023 January 24120 (4):e2216055120. Epub 01/20/2023.

Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice.

Bourne JH, Campos J, Hopkin SJ, Whitworth K, Palis J, Senis YA, Rayes J, Iqbal AJ, Brill A

Frontiers in immunology.. 2023 14 :1226196. Epub 08/09/2023.

Modeling human yolk sac hematopoiesis with pluripotent stem cells.

Atkins MH, Scarfò R, McGrath KE, Yang D, Palis J, Ditadi A, Keller GM

The Journal of experimental medicine.. 2022 March 7219 (3)Epub 12/20/2021.

Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation.

Nemkov T, Kingsley PD, Dzieciatkowska M, Malik J, McGrath K, Hansen KC, D'Alessandro A, Palis J

Blood advances.. 2022 February 9 Epub 02/09/2022.

Mds1, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells.

Zhang Y, McGrath KE, Ayoub E, Kingsley PD, Yu H, Fegan K, McGlynn KA, Rudzinskas S, Palis J, Perkins AS

Cell reports.. 2021 August 1736 (7):109562. Epub 1900 01 01.

Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis.

Jeffery NN, Davidson C, Peslak SA, Kingsley PD, Nakamura Y, Palis J, Bulger M

Epigenetics & chromatin.. 2021 July 3014 (1):37. Epub 07/30/2021.

Long-acting PGE2 and Lisinopril Mitigate H-ARS.

Saunders J, Niswander LM, McGrath KE, Koniski A, Catherman SC, Ture SK, Medhora M, Kingsley PD, Calvi LM, Williams JP, Morrell CN, Palis J

Radiation research.. 2021 June 21 Epub 06/21/2021.

Development of Mechanical Stability in Late-Stage Embryonic Erythroid Cells: Insights From Fluorescence Imaged Micro-Deformation Studies.

Delgadillo LF, Huang YS, Leon S, Palis J, Waugh RE

Frontiers in physiology.. 2021 12 :761936. Epub 01/10/2022.

A human cell atlas of fetal gene expression.

Cao J, O'Day DR, Pliner HA, Kingsley PD, Deng M, Daza RM, Zager MA, Aldinger KA, Blecher-Gonen R, Zhang F, Spielmann M, Palis J, Doherty D, Steemers FJ, Glass IA, Trapnell C, Shendure J

Science.. 2020 November 13370 (6518)Epub 1900 01 01.

Endothelial Cells Transition to Blood Cells but Probably Not Back Again.

Palis J, Yoder MC

Circulation research.. 2020 October 23127 (10):1233-1235. Epub 10/22/2020.

Lung megakaryocytes are immune modulatory cells.

Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C

The Journal of clinical investigation.. 2020 October 20 Epub 10/20/2020.

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.

Dege C, Fegan KH, Creamer JP, Berrien-Elliott MM, Luff SA, Kim D, Wagner JA, Kingsley PD, McGrath KE, Fehniger TA, Palis J, Sturgeon CM

Developmental cell.. 2020 April 2053 (2):229-239.e7. Epub 03/19/2020.

Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.

Calvi LM, Frisch BJ, Kingsley PD, Koniski AD, Love TM, Williams JP, Palis J

International journal of radiation biology.. 2019 July 30 :1-15. Epub 07/30/2019.

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

Frisch BJ, Hoffman CM, Latchney SE, LaMere MW, Myers J, Ashton J, Li AJ, Saunders J, Palis J, Perkins AS, McCabe A, Smith JN, McGrath KE, Rivera-Escalera F, McDavid A, Liesveld JL, Korshunov VA, Elliott MR, MacNamara KC, Becker MW, Calvi LM

JCI insight.. 2019 April 185 Epub 04/18/2019.

Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.

Kizilyer A, Singh MV, Singh VB, Suwunnakorn S, Palis J, Maggirwar SB

Scientific reports.. 2019 February 269 (1):2781. Epub 02/26/2019.

Platelet-derived ?2M regulates monocyte inflammatory responses.

Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN

JCI insight.. 2019 January 31 Epub 01/31/2019.

regulates age-dependent differences in murine platelet function.

Stolla MC, Catherman SC, Kingsley PD, Rowe RG, Koniski AD, Fegan K, Vit L, McGrath KE, Daley GQ, Palis J

Blood advances.. 2019 January 83 (1):72-82. Epub 1900 01 01.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH

The Journal of biological chemistry.. 2018 December 21293 (51):19797-19811. Epub 10/26/2018.

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.

Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS

Nature communications.. 2018 October 129 (1):4239. Epub 10/12/2018.

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E, Frontera V, McGrath KE, Harman J, Carrelha J, Nerlov C, Palis J, Jacobsen SEW, de Bruijn MF

EMBO reports.. 2018 October 19 (10)Epub 08/30/2018.

Functional Analysis of Erythroid Progenitors by Colony-Forming Assays.

Palis J, Koniski A

Methods in molecular biology.. 2018 1698 :117-132. Epub 1900 01 01.

The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.

Peraki I, Palis J, Mavrothalassitis G

Molecular and cellular biology.. 2017 October 137 (19)Epub 09/12/2017.

Microfluidic assay of the deformability of primitive erythroblasts.

Zhou S, Huang YS, Kingsley PD, Cyr KH, Palis J, Wan J

Biomicrofluidics. 2017 September 11 (5):054112. Epub 10/23/2017.

Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.

Huang YS, Delgadillo LF, Cyr KH, Kingsley PD, An X, McGrath KE, Mohandas N, Conboy JG, Waugh RE, Wan J, Palis J

Scientific reports.. 2017 July 127 (1):5164. Epub 07/12/2017.

Delineating stages of erythropoiesis using imaging flow cytometry.

McGrath KE, Catherman SC, Palis J

Methods : a companion to Methods in enzymology.. 2017 January 1112 :68-74. Epub 08/28/2016.

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR

Experimental hematology.. 2016 October 44 (10):947-63. Epub 07/01/2016.

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.

Gnanapragasam MN, McGrath KE, Catherman S, Xue L, Palis J, Bieker JJ

Blood.. 2016 September 22128 (12):1631-41. Epub 08/01/2016.

Behaving better: stem cells singled out.

Palis J

Blood.. 2016 September 1128 (9):1157-8. Epub 1900 01 01.

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.

Frame JM, Fegan KH, Conway SJ, McGrath KE, Palis J

Stem cells.. 2016 February 34 (2):431-44. Epub 10/23/2015.

Imaging Flow Cytometric Analysis of Primary Bone Marrow Megakaryocytes.

Niswander LM, Palis J, McGrath KE

Methods in molecular biology.. 2016 1389 :265-77. Epub 1900 01 01.

Interaction of the Macrophage and Primitive Erythroid Lineages in the Mammalian Embryo.

Palis J

Frontiers in immunology.. 2016 7 :669. Epub 01/09/2017.

Early hematopoiesis and macrophage development.

McGrath KE, Frame JM, Palis J

Seminars in immunology.. 2015 December 27 (6):379-87. Epub 03/25/2016.

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.

Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, Bigarella CL, Rimmelé P, Zhang X, Gnanapragasam MN, Bieker JJ, Papatsenko D, Ma'ayan A, Bresnick E, Fowler V, Palis J, Ghaffari S

PLoS genetics.. 2015 October 11 (10):e1005526. Epub 10/09/2015.

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.

Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmüller U, Palis J, Zheng Y, Kalfa TA

Blood.. 2015 September 17126 (12):1473-82. Epub 07/30/2015.

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo.

McGrath KE, Frame JM, Fegan KH, Bowen JR, Conway SJ, Catherman SC, Kingsley PD, Koniski AD, Palis J

Cell reports.. 2015 June 3011 (12):1892-904. Epub 06/18/2015.

Bmi-1 Regulates Extensive Erythroid Self-Renewal.

Kim AR, Olsen JL, England SJ, Huang YS, Fegan KH, Delgadillo LF, McGrath KE, Kingsley PD, Waugh RE, Palis J

Stem cell reports.. 2015 June 94 (6):995-1003. Epub 05/28/2015.

Stochastic modeling of stress erythropoiesis using a two-type age-dependent branching process with immigration.

Hyrien O, Peslak SA, Yanev NM, Palis J

Journal of mathematical biology.. 2015 June 70 (7):1485-521. Epub 07/03/2014.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH

Science signaling.. 2015 April 148 (372):ra34. Epub 04/14/2015.

Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages.

Bulger M, Palis J

Trends in immunology.. 2015 February 36 (2):61-2. Epub 01/07/2015.

Interleukin-12 preserves the cutaneous physical and immunological barrier after radiation exposure.

Gerber SA, Cummings RJ, Judge JL, Barlow ML, Nanduri J, Johnson DE, Palis J, Pentland AP, Lord EM, Ryan JL

Radiation research.. 2015 January 183 (1):72-81. Epub 01/07/2015.

Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.

Dertinger SD, Avlasevich SL, Torous DK, Bemis JC, Phonethepswath S, Labash C, Carlson K, Mereness J, Cottom J, Palis J, Macgregor JT

Toxicological sciences : an official journal of the Society of Toxicology.. 2014 August 1140 (2):307-14. Epub 05/05/2014.

Emergence of the neutrophil lineage in the mammalian embryo.

McGrath KE, Fegan K, Catherman S, Palis J

Experimental hematology.. 2014 August 42 (8 Suppl):S13. Epub 1900 01 01.

Emergence of primitive and definitive waves of erythroid progenitors and of self-renewing erythroblast potential in human embryonic stem cells (ESCs).

Kim AR, Steinberg-Shemer O, Weiss MJ, Palis J

Experimental hematology.. 2014 August 42 (8 Suppl):S43. Epub 1900 01 01.

SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.

Niswander LM, Fegan KH, Kingsley PD, McGrath KE, Palis J

Blood.. 2014 July 10124 (2):277-86. Epub 04/15/2014.

Extensively self-renewing erythroblasts derived from transgenic ?-yac mice is a novel model system for studying globin switching and erythroid maturation.

Getman M, England SJ, Malik J, Peterson K, Palis J, Steiner LA

Experimental hematology.. 2014 July 42 (7):536-46.e8. Epub 04/02/2014.

Of mice and men….

Palis J

Blood.. 2014 May 29123 (22):3367-8. Epub 1900 01 01.

Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry.

Niswander LM, McGrath KE, Kennedy JC, Palis J

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2014 April 85 (4):302-12. Epub 01/16/2014.

Primitive and definitive erythropoiesis in mammals.

Palis J

Frontiers in physiology.. 2014 5 :3. Epub 01/28/2014.

Preface to issue on embryonic and fetal hematopoiesis.

Palis J

Blood cells, molecules & diseases.. 2013 December 51 (4):205. Epub 1900 01 01.

Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.

Frame JM, McGrath KE, Palis J

Blood cells, molecules & diseases.. 2013 December 51 (4):220-5. Epub 10/02/2013.

Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts.

Malik J, Kim AR, Tyre KA, Cherukuri AR, Palis J

Haematologica.. 2013 November 98 (11):1778-87. Epub 07/26/2013.

Development of membrane mechanical function during terminal stages of primitive erythropoiesis in mice.

Waugh RE, Huang YS, Arif BJ, Bauserman R, Palis J

Experimental hematology.. 2013 April 41 (4):398-408.e2. Epub 11/30/2012.

Ontogeny of erythroid gene expression.

Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, Stoeckert CJ, Palis J

Blood.. 2013 February 7121 (6):e5-e13. Epub 12/12/2012.

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.

Peslak SA, Wenger J, Bemis JC, Kingsley PD, Koniski AD, McGrath KE, Palis J

Blood.. 2012 September 20120 (12):2501-11. Epub 08/13/2012.

Losing a "nucleus" to gain a cytoplasm.

Palis J

Blood.. 2012 June 21119 (25):5948-9. Epub 1900 01 01.

A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo.

McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J

Blood.. 2011 April 28117 (17):4600-8. Epub 03/04/2011.

Sublethal radiation injury uncovers a functional transition during erythroid maturation.

Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J

Experimental hematology.. 2011 April 39 (4):434-45. Epub 02/01/2011.

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.

England SJ, McGrath KE, Frame JM, Palis J

Blood.. 2011 March 3117 (9):2708-17. Epub 12/02/2010.

Blood in a dish: In vitro synthesis of red blood cells.

Migliaccio AR, Palis J

Drug discovery today. Disease mechanisms. 2011 8 (1-2):e3-e8. Epub 1900 01 01.

Interaction of retinoic acid and scl controls primitive blood development.

de Jong JL, Davidson AJ, Wang Y, Palis J, Opara P, Pugach E, Daley GQ, Zon LI

Blood.. 2010 July 15116 (2):201-9. Epub 04/21/2010.

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, Macgregor JT

Toxicological sciences : an official journal of the Society of Toxicology.. 2010 June 115 (2):401-11. Epub 03/04/2010.

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Phonethepswath S, Franklin D, Torous DK, Bryce SM, Bemis JC, Raja S, Avlasevich S, Weller P, Hyrien O, Palis J, Macgregor JT, Dertinger SD

Toxicological sciences : an official journal of the Society of Toxicology.. 2010 March 114 (1):59-70. Epub 12/04/2009.

Primitive erythropoiesis in the mammalian embryo.

Palis J, Malik J, McGrath KE, Kingsley PD

The International journal of developmental biology.. 2010 54 (6-7):1011-8. Epub 1900 01 01.

Transient glutathione depletion determines terminal differentiation in HL-60 cells.

Krance SM, Keng PC, Palis J, Ballatori N

Oxidative medicine and cellular longevity.. 2010 3 (1):53-60. Epub 1900 01 01.

Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK

Cell metabolism.. 2009 August 10 (2):119-30. Epub 1900 01 01.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.

Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y

Mutation research.. 2009 April 30675 (1-2):77-80. Epub 02/11/2009.

15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.

O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP

Blood.. 2008 November 15112 (10):4051-60. Epub 08/28/2008.

Multispectral imaging of hematopoietic cells: where flow meets morphology.

McGrath KE, Bushnell TP, Palis J

Journal of immunological methods.. 2008 July 31336 (2):91-7. Epub 05/15/2008.

Ontogeny of erythropoiesis.

Palis J

Current opinion in hematology.. 2008 May 15 (3):155-61. Epub 1900 01 01.

All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.

Lux CT, Yoshimoto M, McGrath K, Conway SJ, Palis J, Yoder MC

Blood.. 2008 April 1111 (7):3435-8. Epub 10/11/2007.

Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb.

Tober J, McGrath KE, Palis J

Blood.. 2008 March 1111 (5):2636-9. Epub 01/03/2008.

Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.

McGrath KE, Kingsley PD, Koniski AD, Porter RL, Bushnell TP, Palis J

Blood.. 2008 February 15111 (4):2409-17. Epub 11/21/2007.

A heme export protein is required for red blood cell differentiation and iron homeostasis.

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL

Science.. 2008 February 8319 (5864):825-8. Epub 1900 01 01.

Ontogeny of erythropoiesis in the mammalian embryo.

McGrath K, Palis J

Current topics in developmental biology.. 2008 82 :1-22. Epub 1900 01 01.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.

Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y

Mutation research.. 2007 December 1634 (1-2):119-25. Epub 07/05/2007.

The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.

Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, de Mesy-Bentley KK, Waugh R, Palis J

Blood.. 2007 February 15109 (4):1433-41. Epub 10/24/2006.

"Maturational" globin switching in primary primitive erythroid cells.

Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J

Blood.. 2006 February 15107 (4):1665-72. Epub 11/01/2005.

Sox6 directly silences epsilon globin expression in definitive erythropoiesis.

Yi Z, Cohen-Barak O, Hagiwara N, Kingsley PD, Fuchs DA, Erickson DT, Epner EM, Palis J, Brilliant MH

PLoS genetics.. 2006 February 2 (2):e14. Epub 02/03/2006.

Hematopoiesis in the yolk sac: more than meets the eye.

McGrath KE, Palis J

Experimental hematology.. 2005 September 33 (9):1021-8. Epub 1900 01 01.

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, Weber GJ, Dooley K, Davidson AJ, Schmid B, Schmidt B, Paw BH, Shaw GC, Kingsley P, Palis J, Schubert H, Chen O, Kaplan J, Zon LI,

Nature.. 2005 August 18436 (7053):1035-39. Epub 1900 01 01.

Analysis of hematopoietic progenitors in the mouse embryo.

Palis J, Koniski A

Methods in molecular medicine.. 2005 105 :289-302. Epub 1900 01 01.

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.

Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G

Nature.. 2004 December 2432 (7017):625-30. Epub 1900 01 01.

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.

Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI

PLoS biology.. 2004 August 2 (8):E237. Epub 08/17/2004.

Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis.

Kingsley PD, Malik J, Fantauzzo KA, Palis J

Blood.. 2004 July 1104 (1):19-25. Epub 03/18/2004.

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.

Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI

Nature.. 2003 September 18425 (6955):300-6. Epub 1900 01 01.

Circulation is established in a stepwise pattern in the mammalian embryo.

McGrath KE, Koniski AD, Malik J, Palis J

Blood.. 2003 March 1101 (5):1669-76. Epub 10/24/2002.

Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper.

Ji RP, Phoon CK, Aristizábal O, McGrath KE, Palis J, Turnbull DH

Circulation research.. 2003 February 792 (2):133-5. Epub 1900 01 01.

Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression.

Chung YS, Zhang WJ, Arentson E, Kingsley PD, Palis J, Choi K

Development.. 2002 December 129 (23):5511-20. Epub 1900 01 01.

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

Lacaud G, Gore L, Kennedy M, Kouskoff V, Kingsley P, Hogan C, Carlsson L, Speck N, Palis J, Keller G

Blood.. 2002 July 15100 (2):458-66. Epub 1900 01 01.

Angiocentric T-cell lymphoma of the temporal bone.

Lewis WB, Patel U, Roberts JK, Palis J, Teot L

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2002 January 126 (1):85-6. Epub 1900 01 01.

Yolk-sac hematopoiesis: the first blood cells of mouse and man.

Palis J, Yoder MC

Experimental hematology.. 2001 August 29 (8):927-36. Epub 1900 01 01.

Serglycin proteoglycan synthesis in the murine uterine decidua and early embryo.

Keith Ho HC, McGrath KE, Brodbeck KC, Palis J, Schick BP

Biology of reproduction.. 2001 June 64 (6):1667-76. Epub 1900 01 01.

Regulation of hemangioblast development.

Lacaud G, Robertson S, Palis J, Kennedy M, Keller G

Annals of the New York Academy of Sciences.. 2001 June 938 :96-107; discussion 108. Epub 1900 01 01.

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis.

Palis J, Chan RJ, Koniski A, Patel R, Starr M, Yoder MC

Proceedings of the National Academy of Sciences of the United States of America.. 2001 April 1098 (8):4528-33. Epub 1900 01 01.

Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development.

Kingsley PD, McGrath KE, Maltby KM, Koniski AD, Ramchandran R, Palis J

Development, growth & differentiation.. 2001 April 43 (2):133-43. Epub 1900 01 01.

The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells.

Borrello MA, Palis J, Phipps RP

International reviews of immunology.. 2001 February 20 (1):137-55. Epub 1900 01 01.

"Liver function tests" are not always tests of liver function.

Korones DN, Brown MR, Palis J

American journal of hematology.. 2001 January 66 (1):46-8. Epub 1900 01 01.

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.

Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI

Nature.. 2000 February 17403 (6771):776-81. Epub 1900 01 01.

Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells.

Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM

Current topics in microbiology and immunology.. 2000 252 :293-300. Epub 1900 01 01.

Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.

Palis J, Robertson S, Kennedy M, Wall C, Keller G

Development.. 1999 November 126 (22):5073-84. Epub 1900 01 01.

Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals.

Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Palis J, Phipps RP

European journal of immunology.. 1999 November 29 (11):3793-803. Epub 1900 01 01.

Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.

McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J

Developmental biology.. 1999 September 15213 (2):442-56. Epub 1900 01 01.

A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation.

Liu LQ, Ilaria R, Kingsley PD, Iwama A, van Etten RA, Palis J, Zhang DE

Molecular and cellular biology.. 1999 April 19 (4):3029-38. Epub 1900 01 01.

Characterization of human endotoxin lipopolysaccharide receptor CD14 expression in transgenic mice.

Hetherington CJ, Kingsley PD, Crocicchio F, Zhang P, Rabin MS, Palis J, Zhang DE

The Journal of immunology : official journal of the American Association of Immunologists.. 1999 January 1162 (1):503-9. Epub 1900 01 01.

Developmental biology of erythropoiesis.

Palis J, Segel GB

Blood reviews.. 1998 June 12 (2):106-14. Epub 1900 01 01.

Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin.

Kingsley PD, Whitin JC, Cohen HJ, Palis J

Molecular reproduction and development.. 1998 April 49 (4):343-55. Epub 1900 01 01.

Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.

McGrath KE, Palis J

Molecular reproduction and development.. 1997 October 48 (2):145-53. Epub 1900 01 01.

Erythropoietin-receptor expression and function during the initiation of murine yolk sac erythropoiesis.

McGann JK, Silver L, Liesveld J, Palis J

Experimental hematology.. 1997 October 25 (11):1149-57. Epub 1900 01 01.

Initiation of murine embryonic erythropoiesis: a spatial analysis.

Silver L, Palis J

Blood.. 1997 February 1589 (4):1154-64. Epub 1900 01 01.

Developmental regulation and primary structure of murine CNBP, a zinc finger-containing protein whose general structure is present in evolutionarily diverse eukaryotes

Kingsley PD; Zinkin AS; Silver LS; Pendola FL; Palis J.

Development, Growth, and Differentiation. 1996; 38: 697-706.

Differential gene expression during early murine yolk sac development.

Palis J, Kingsley PD

Molecular reproduction and development.. 1995 September 42 (1):19-27. Epub 1900 01 01.

Initiation of hematopoiesis and vasculogenesis in murine yolk sac explants.

Palis J, McGrath KE, Kingsley PD

Blood.. 1995 July 186 (1):156-63. Epub 1900 01 01.

GRP2 proteins contain both CCHC zinc fingers and a cold shock domain.

Kingsley PD, Palis J

The Plant cell.. 1994 November 6 (11):1522-3. Epub 1900 01 01.

Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm.

Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ

Cancer.. 1993 May 1571 (10):2977-82. Epub 1900 01 01.

MacConkey-II lactose agar for screening recombinant plasmids.

Pendola F, Palis J

Trends in genetics : TIG.. 1993 January 9 (1):4. Epub 1900 01 01.

Early mRNAs, spatially restricted along the animal-vegetal axis of sea urchin embryos, include one encoding a protein related to tolloid and BMP-1.

Reynolds SD, Angerer LM, Palis J, Nasir A, Angerer RC

Development.. 1992 March 114 (3):769-86. Epub 1900 01 01.

Sickle cell syndromes: Recognition and management of six crises

Rodewald LE; Slovis CM; Palis J.

Emergency Medicine Reports. 1990; 11: 43-52.

Separation of spontaneously differentiating and cell cycle-specific populations of HL-60 cells.

Palis J, King B, Keng P

Leukemia research.. 1988 12 (4):339-44. Epub 1900 01 01.

The Hippocratic concept of hysteria: A translation of the original texts

Palis J.; Rossopoulos E.; Triarhou LC.

Integrative Psychiatry. 1985; 3: 226-228.

Abnormal glucose tolerance in children with acute leukemia. Effect of induction chemotherapy including L-asparaginase.

Dacou-Voutetakis C, Palis J, Haidas S, Zannos-Mariolea L, Georgiopoulou P, Matsaniotis N

The American journal of pediatric hematology/oncology. 1983 5 (2):139-46. Epub 1900 01 01.

A reliable procedure for multiple globin synthetic determinations in isolated human reticulocytes by microzone electrophoresis

Constantsas N; Palis J.

Hellenic Biochemical Biophysical Newsletter. 1979; : 5-7.

Books

William's Hematology (2021)

Chapter: Hematology of the Newborn

Authors: Palis J, Segel GB

Publisher: McGraw-Hill, New York 2021

Imaging Flow Cytometry-Methods and Protocols, Methods in Molecular Biology (2016)

Chapter: Imaging flow cytometric analysis of primary bone marrow megakaryocytes

Authors: Niswander LM, Palis J, McGrath KE

Publisher: Springer, New York 2016

William's Hematology (2016)

Chapter: Hematology of the Newborn

Authors: Palis J, Segel GB

Publisher: McGraw-Hill, New York 2016

Atlas of the Cellular and Molecular Development of Human Hematopoiesis (2016)

Chapter: Primitive and definitive erythropoiesis

Authors: Palis, J

Publisher: Springer Verlag, Heidelberg 2016

William's Hematology (2010)

Chapter: Hematology of the Newborn

Authors: Palis J, Segel G

Publisher: McGraw-Hill, New York, NY 2010

Molecular Basis of Hematopoiesis (2009)

Chapter: Molecular Biology of Erythropoiesis

Authors: Palis J

Publisher: Springer, New York, NY 2009

Red Cell Development (2008)

Chapter: Ontogeny of erythropoiesis in the mammalian embryo

Authors: McGrath KE, Palis J

Publisher: Elsevier Press 2008

The Pediatric Clinical Advisor (2007)

Chapter: Thalassemia

Authors: Palis J

Publisher: Mosby, Inc., St. Louis, MO 2007

The Pediatric Clinical Advisor (2007)

Chapter: Transfusion reactions

Authors: Palis J

Publisher: Mosby, Inc., St. Louis, MO 2007

Hematopoietic Stem Cell Development (2006)

Chapter: Yolk sac development in mice

Authors: Palis, J

Publisher: Landes Bioscience, Georgetown, TX 2006

William's Hematology (2006)

Chapter: Hematology of the Newborn

Authors: Segel GB, Palis J

Publisher: McGraw-Hill, New York, NY 2006

Developmental Regulation of Hematopoiesis: Methods and Practical Approaches (2004)

Chapter: Analysis of hematopoietic progenitors in the mouse embryo

Authors: Palis J, Koniski A

Publisher: The Humana Press, Totowa, NJ 2004

The Pediatric Clinical Advisor (2002)

Chapter: Thalassemia

Authors: Palis J

Publisher: Mosby, Inc., St. Louis, MO 2002

The Pediatric Clinical Advisor (2002)

Chapter: Transfusion reactions

Authors: Palis J

Publisher: Mosby, Inc., St. Louis, MO 2002

Developmental Biology of Hematopoiesis (2001)

Chapter: Ventral (yolk sac) hematopoiesis in the mouse

Authors: Yoder M, Palis J

Publisher: Oxford University Press, New York, NY 2001

William's Hematology (2001)

Chapter: Hematology of the Newborn

Authors: Segel GB, Palis J

Publisher: McGraw-Hill, New York, NY 2001

Primary Pediatric Care (2001)

Chapter: Iron deficiency anemia

Authors: Palis J

Publisher: Mosby Yearbook, St. Louis, MO 2001

Primary Pediatric Care (1996)

Chapter: Iron deficiency anemia

Authors: Palis J

Publisher: Mosby Yearbook, St. Louis, MO 1996

Primary Pediatric Care (1992)

Chapter: Iron deficiency anemia

Authors: Palis J

Publisher: Mosby Yearbook, St. Louis, MO 1992