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Francis Gigliotti, M.D.

Francis Gigliotti, M.D.

Pediatrics, Pediatric Infectious Diseases

Contact

Appointment (585) 275-5944
Office (585) 275-5944
Fax (585) 273-1104

About Me

Certified Specialties

Pediatrics - American Board of Pediatrics

Faculty Appointments

Professor - Department of Pediatrics, Infectious Diseases (SMD)

Credentials

Post-doctoral Training & Residency

Pediatric Infectious Diseases and Immunology Fellowship, University of Rochester School of Medicine and Dentistry, Rochester, NY 1980 - 1983

Residency in Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 1977 - 1980

Education

MD | University of Virginia School of Medicine. Medicine. 1977

AB | West Virginia University. Biology. 1974

Awards

Best Doctor's in America. 2008

American's Top Pediatricians. 2007

Lindsey Distinguished Professorship for Pediatric Research. 2007

Ruth A. Lawrence Faculty Service Award for Research. 2006

Elected to American Society for Clinical Investigation. 1995

Lowell Glasgow Dean's Teaching Scholar. 1992 - 1995

House Staff Teaching Award. 1989

Research

Dr. Gigliotti's research interests are:

1) Pneumocystis carinii pneumonia
2) Infections in the immunocompromised host
3) Inflammatory lung injury
4) Opportunistic infections.

Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromi...
Dr. Gigliotti's research interests are:

1) Pneumocystis carinii pneumonia
2) Infections in the immunocompromised host
3) Inflammatory lung injury
4) Opportunistic infections.

Pneumocystis carinii is a life-threatening cause of pneumonitis among patients who are immunocompromised because of malignancies, AIDS, or congenital immunodeficiency disorders. P. carinii pneumonia also occurs in children who are immunocompromised on the basis of malnutrition; thus the global significance of P. carinii pneumonia is potentially great. However, because this organism is difficult to work with and because it cannot be cultivated outside an animal host, almost nothing is known about its biology.

The focus of Dr. Gigliotti's laboratory is elucidating the immunopathogenesis of P. carinii pneumonia. A major area of investigation relates to studying active and passive immunity to P. carinii. This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia.

The second major area of emphasis is the study of lung injury resulting from immune-mediated inflammation in response to infection with P. carinii. Together with Dr. Terry Wright, we are trying to develop means to manipulate this inflammatory process so as to decrease the morbidity and mortality associated with P. carinii pneumonia. It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia.

Patents

Human Monoclonal Antibodies Against Bacterial Toxins

Issue date: August 25, 1987

Patent #: 4,689,299

Country: United States

Inventors: Francis Gigliotti, Richard A Insel

Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof

Issue date: October 19, 2010

Patent #: 7,815,918

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright

Optimized Antigens of Pneumocystis and Use Thereof

Issue date: December 06, 2016

Patent #: 9,512,189

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright

Publications

Journal Articles

Combination immunotherapy with passive antibody and sulfasalazine accelerates fungal clearance and promotes the resolution of associated immunopathogenesis.

Hoy Z, Wright TW, Elliott M, Malone J, Bhagwat S, Wang J, Gigliotti F

Infection and immunity.. 2019 October 14 Epub 10/14/2019.

Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii.

Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F

Infection and immunity.. 2017 April 85 (4)Epub 03/23/2017.

Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles.

Chemello G, Piccinetti C, Randazzo B, Carnevali O, Maradonna F, Magro M, Bonaiuto E, Vianello F, Radaelli G, Fifi AP, Gigliotti F, Olivotto I

Zebrafish.. 2016 December 13 (6):495-503. Epub 08/10/2016.

Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome.

Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T

Infection and immunity.. 2015 December 83 (12):4594-603. Epub 09/14/2015.

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.

Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R

Oncotarget.. 2015 November 106 (35):37511-25. Epub 1900 01 01.

Epidemiology of Bacteremia in Previously Healthy Febrile Infants: A Follow-up Study.

Mischler M, Ryan MS, Leyenaar JK, Markowsky A, Seppa M, Wood K, Ren J, Asche C, Gigliotti F, Biondi E

Hospital pediatrics.. 2015 June 5 (6):293-300. Epub 1900 01 01.

SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.

D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.. 2015 35 (5):2006-18. Epub 03/27/2015.

Pneumocystis.

Gigliotti F, Limper AH, Wright T

Cold Spring Harbor perspectives in medicine.. 2014 November 34 (12):a019828. Epub 11/03/2014.

Simultaneous testing of erythrocyte sedimentation rate and C-reactive protein: increased expenditure without demonstrable benefit.

Kainth MK, Gigliotti F

The Journal of pediatrics.. 2014 September 165 (3):625-7. Epub 06/21/2014.

In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold.

Ortuso F, Amato R, Artese A, D'antona L, Costa G, Talarico C, Gigliotti F, Bianco C, Trapasso F, Schenone S, Musumeci F, Botta L, Perrotti N, Alcaro S

Journal of chemical information and modeling.. 2014 July 2854 (7):1828-32. Epub 06/13/2014.

MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.

Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 January 1192 (1):282-92. Epub 11/29/2013.

Epidemiology of bacteremia in febrile infants in the United States.

Biondi E, Evans R, Mischler M, Bendel-Stenzel M, Horstmann S, Lee V, Aldag J, Gigliotti F

Pediatrics.. 2013 December 132 (6):990-6. Epub 11/11/2013.

Executive summary: 2013 update of the guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children.

Siberry GK, Abzug MJ, Nachman S,

The Pediatric infectious disease journal.. 2013 December 32 (12):1303-7. Epub 1900 01 01.

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.

Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 November 1191 (9):4720-30. Epub 09/27/2013.

Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics.

Siberry GK, Abzug MJ, Nachman S, Brady MT, Dominguez KL, Handelsman E, Mofenson LM, Nesheim S,

The Pediatric infectious disease journal.. 2013 November 32 Suppl 2 :i-KK4. Epub 1900 01 01.

A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children.

Williams L, Malhotra Y, Murante B, Laverty S, Cook S, Topa D, Hardy D, Wang H, Gigliotti F

The Journal of pediatrics.. 2013 April 162 (4):857-61. Epub 10/23/2012.

Fever and bacteremia.

Biondi E, Murzycki J, Ralston S, Gigliotti F

Pediatrics in review. 2013 March 34 (3):134-6. Epub 1900 01 01.

The alveolar epithelial cell chemokine response to pneumocystis requires adaptor molecule MyD88 and interleukin-1 receptor but not toll-like receptor 2 or 4.

Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW

Infection and immunity.. 2012 November 80 (11):3912-20. Epub 08/27/2012.

Pneumocystis: where does it live?

Gigliotti F, Wright TW

PLoS pathogens.. 2012 8 (11):e1003025. Epub 11/29/2012.

Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia.

Wang J, Wright TW, Gigliotti F

Interdisciplinary perspectives on infectious diseases. 2011 2011 :918038. Epub 08/29/2011.

Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia.

Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW

PLoS pathogens.. 2010 August 196 (8):e1001058. Epub 08/19/2010.

Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia.

Bhagwat SP, Wright TW, Gigliotti F

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 January 1184 (1):497-502. Epub 11/30/2009.

Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia.

Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 July 15181 (2):1409-19. Epub 1900 01 01.

Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism.

Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW

American journal of physiology. Lung cellular and molecular physiology.. 2007 June 292 (6):L1495-505. Epub 02/16/2007.

Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease.

Bhagwat SP, Gigliotti F, Xu H, Wright TW

American journal of physiology. Lung cellular and molecular physiology.. 2006 December 291 (6):L1256-66. Epub 08/04/2006.

Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia.

Gigliotti F, Crow EL, Bhagwat SP, Wright TW

Infection and immunity.. 2006 November 74 (11):6310-6. Epub 08/28/2006.

Viridans group streptococcal infections among children with cancer and the importance of emerging antibiotic resistance.

Bruckner L, Gigliotti F

Seminars in pediatric infectious diseases. 2006 July 17 (3):153-60. Epub 1900 01 01.

Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells.

Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J

American journal of physiology. Lung cellular and molecular physiology.. 2006 June 290 (6):L1087-96. Epub 01/06/2006.

Pneumocystis carinii nomenclature: response to Cushion and Stringer.

Gigliotti F

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2006 April 1542 (8):1208-9. Epub 1900 01 01.

Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 April 74 (4):2446-8. Epub 1900 01 01.

Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 January 74 (1):390-3. Epub 1900 01 01.

Pneumocystis carinii: has the name really been changed?

Gigliotti F

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2005 December 1541 (12):1752-5. Epub 11/04/2005.

Immunopathogenesis of Pneumocystis carinii pneumonia.

Gigliotti F, Wright TW

Expert reviews in molecular medicine. 2005 November 147 (26):1-16. Epub 11/14/2005.

Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro.

Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1124-31. Epub 1900 01 01.

Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW

Infection and immunity.. 2005 May 73 (5):2766-77. Epub 1900 01 01.

Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.

Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F

Antimicrobial agents and chemotherapy.. 2005 April 49 (4):1326-30. Epub 1900 01 01.

Passive immunization of neonatal mice against Pneumocystis carinii f. sp. muris enhances control of infection without stimulating inflammation.

Empey KM, Hollifield M, Schuer K, Gigliotti F, Garvy BA

Infection and immunity.. 2004 November 72 (11):6211-20. Epub 1900 01 01.

Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice.

Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG

Infection and immunity.. 2004 October 72 (10):5722-32. Epub 1900 01 01.

Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA.

Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG

Infection and immunity.. 2004 March 72 (3):1548-56. Epub 1900 01 01.

Vancomycin usage in central venous catheters in a neonatal intensive care unit.

Elhassan NO, Stevens TP, Gigliotti F, Hardy DJ, Cole CA, Sinkin RA

The Pediatric infectious disease journal.. 2004 March 23 (3):201-6. Epub 1900 01 01.

TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia.

Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 February 15172 (4):2511-21. Epub 1900 01 01.

Antifungal pharmacotherapy for neonatal candidiasis.

Bliss JM, Wellington M, Gigliotti F

Seminars in perinatology.. 2003 October 27 (5):365-74. Epub 1900 01 01.

Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice.

Gigliotti F, Harmsen AG, Wright TW

Infection and immunity.. 2003 July 71 (7):3852-6. Epub 1900 01 01.

Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response.

An CL, Gigliotti F, Harmsen AG

Infection and immunity.. 2003 April 71 (4):2065-70. Epub 1900 01 01.

Immune reconstitution syndrome after successful treatment of Pneumocystis carinii pneumonia in a man with human immunodeficiency virus type 1 infection.

Koval CE, Gigliotti F, Nevins D, Demeter LM

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2002 August 1535 (4):491-3. Epub 07/24/2002.

Alpha-hemolytic streptococcal infections among immunocompromised hosts: increasing incidence, severity and antibiotic resistance.

Bruckner L, Gigliotti F

The Pediatric infectious disease journal.. 2002 April 21 (4):343-5. Epub 1900 01 01.

Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia.

Gigliotti F, Haidaris CG, Wright TW, Harmsen AG

Infection and immunity.. 2002 March 70 (3):1069-74. Epub 1900 01 01.

High incidence of penicillin resistance among alpha-hemolytic streptococci isolated from the blood of children with cancer.

Bruckner LB, Korones DN, Karnauchow T, Hardy DJ, Gigliotti F

The Journal of pediatrics.. 2002 January 140 (1):20-6. Epub 1900 01 01.

Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine.

McFarland EJ, Borkowsky W, Fenton T, Wara D, McNamara J, Samson P, Kang M, Mofenson L, Cunningham C, Duliege AM, Sinangil F, Spector SA, Jimenez E, Bryson Y, Burchett S, Frenkel LM, Yogev R, Gigliotti F, Luzuriaga K, Livingston RA,

The Journal of infectious diseases.. 2001 November 15184 (10):1331-5. Epub 10/10/2001.

Update on antifungal agents.

Wellington M, Gigliotti F

The Pediatric infectious disease journal.. 2001 October 20 (10):993-5. Epub 1900 01 01.

Short course directly observed therapy to monitor compliance with antiretroviral therapy in human immunodeficiency virus-infected children.

Gigliotti F, Murante BL, Weinberg GA

The Pediatric infectious disease journal.. 2001 July 20 (7):716-8. Epub 1900 01 01.

Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants.

Vargas SL, Hughes WT, Santolaya ME, Ulloa AV, Ponce CA, Cabrera CE, Cumsille F, Gigliotti F

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2001 March 1532 (6):855-61. Epub 03/09/2001.

Identification of Pneumocystis carinii in the lungs of infants dying of sudden infant death syndrome.

Morgan DJ, Vargas SL, Reyes-Mugica M, Walterspiel JN, Carver W, Gigliotti F

The Pediatric infectious disease journal.. 2001 March 20 (3):306-9. Epub 1900 01 01.

Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia.

Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F

Infection and immunity.. 2001 February 69 (2):758-64. Epub 1900 01 01.

Transmission of Pneumocystis carinii DNA from a patient with P. carinii pneumonia to immunocompetent contact health care workers.

Vargas SL, Ponce CA, Gigliotti F, Ulloa AV, Prieto S, Muñoz MP, Hughes WT

Journal of clinical microbiology.. 2000 April 38 (4):1536-8. Epub 1900 01 01.

Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii.

Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG

Gene.. 2000 January 25242 (1-2):141-50. Epub 1900 01 01.

Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia.

Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG

The Journal of clinical investigation.. 1999 November 104 (9):1307-17. Epub 1900 01 01.

Antigenic characterization of Pneumocystis carinii.

Gigliotti F, Haidaris CG

Seminars in respiratory infections.. 1998 December 13 (4):313-22. Epub 1900 01 01.

Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia.

Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F

Infection and immunity.. 1998 September 66 (9):4431-9. Epub 1900 01 01.

Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia.

Gigliotti F, Wiley JA, Harmsen AG

Infection and immunity.. 1998 July 66 (7):3179-82. Epub 1900 01 01.

Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice.

Gigliotti F, Garvy BA, Haidaris CG, Harmsen AG

The Journal of infectious diseases.. 1998 July 178 (1):235-42. Epub 1900 01 01.

Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A.

Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ

DNA research : an international journal for rapid publication of

Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells.

Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ

Molecular biotechnology.. 1998 April 9 (2):91-7. Epub 1900 01 01.

Selected animal models: vaginal candidosis, Pneumocystis pneumonia, dermatophytosis and trichosporosis.

Sobel JD, Hasegawa A, Debernardis F, Adriani D, Pellegrini G, Cassone A, Fidel PL, Haidaris CG, Gigliotti F, Harmsen AG, Fujita S, Yamamoto K, Makimura K, Shibuya K, Uchida K, Yamaguchi H

Medical mycology.. 1998 36 Suppl 1 :129-36. Epub 1900 01 01.

A Pneumocystis carinii group I intron ribozyme that does not require 2' OH groups on its 5' exon mimic for binding to the catalytic core.

Testa SM, Haidaris CG, Gigliotti F, Turner DH

Biochemistry.. 1997 December 936 (49):15303-14. Epub 1900 01 01.

Protection against Pneumocystis carinii pneumonia by antibodies generated from either T helper 1 or T helper 2 responses.

Garvy BA, Wiley JA, Gigliotti F, Harmsen AG

Infection and immunity.. 1997 December 65 (12):5052-6. Epub 1900 01 01.

Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization.

Gigliotti F, Harmsen AG

The Journal of infectious diseases.. 1997 November 176 (5):1322-6. Epub 1900 01 01.

Lack of relation of granulocyte antibodies (antineutrophil antibodies) to neutropenia in children with human immunodeficiency virus infection.

Weinberg GA, Gigliotti F, Stroncek DF, Eiber G, Kassmann B, Murante B, Korones DN

The Pediatric infectious disease journal.. 1997 September 16 (9):881-4. Epub 1900 01 01.

Neutralization of interferon-gamma exacerbates pneumocystis-driven interstitial pneumonitis after bone marrow transplantation in mice.

Garvy BA, Gigliotti F, Harmsen AG

The Journal of clinical investigation.. 1997 April 199 (7):1637-44. Epub 1900 01 01.

Antibody-mediated shift in the profile of glycoprotein A phenotypes observed in a mouse model of Pneumocystis carinii pneumonia.

Gigliotti F, Garvy BA, Harmsen AG

Infection and immunity.. 1996 June 64 (6):1892-9. Epub 1900 01 01.

Delayed type hypersensitivity testing in hospitalized children: a retrospective chart review.

Gingras TM, Powell KR, Ringrose K, Gigliotti F

The Pediatric infectious disease journal.. 1996 March 15 (3):267-9. Epub 1900 01 01.

Glycoprotein A is the immunodominant antigen of Pneumocystis carinii in mice following immunization.

Gigliotti F, McCool T

Parasitology research.. 1996 82 (1):90-1. Epub 1900 01 01.

Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA.

Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ

Gene.. 1995 December 29167 (1-2):185-9. Epub 1900 01 01.

Active immunity to Pneumocystis carinii reinfection in T-cell-depleted mice.

Harmsen AG, Chen W, Gigliotti F

Infection and immunity.. 1995 July 63 (7):2391-5. Epub 1900 01 01.

Acute conjunctivitis.

Gigliotti F

Pediatrics in review. 1995 June 16 (6):203-7; quiz 208. Epub 1900 01 01.

Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii.

Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ

DNA research : an international journal for rapid publication of

Management of the child with conjunctivitis.

Gigliotti F

The Pediatric infectious disease journal.. 1994 December 13 (12):1161-2. Epub 1900 01 01.

Response of immunocompromised children with solid tumors to a conjugate vaccine for Haemophilus influenzae type b.

Shenep JL, Feldman S, Gigliotti F, Roberson PK, Marina N, Foreschle JE, Fullen GH, Lott L, Brodkey TO

The Journal of pediatrics.. 1994 October 125 (4):581-4. Epub 1900 01 01.

Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species.

Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG

Infection and immunity.. 1994 May 62 (5):1513-9. Epub 1900 01 01.

Latency is not an inevitable outcome of infection with Pneumocystis carinii.

Chen W, Gigliotti F, Harmsen AG

Infection and immunity.. 1993 December 61 (12):5406-9. Epub 1900 01 01.

Pneumocystis carinii is not universally transmissible between mammalian species.

Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ

Infection and immunity.. 1993 July 61 (7):2886-90. Epub 1900 01 01.

Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction.

Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR

The Journal of infectious diseases.. 1993 July 168 (1):191-4. Epub 1900 01 01.

Acute conjunctivitis of childhood.

Gigliotti F

Pediatric annals.. 1993 June 22 (6):353-6. Epub 1900 01 01.

In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene.

Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG

Molecular microbiology.. 1993 March 7 (5):647-56. Epub 1900 01 01.

Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response.

Chen W, Havell EA, Gigliotti F, Harmsen AG

Infection and immunity.. 1993 January 61 (1):97-102. Epub 1900 01 01.

Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii.

Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG

The Journal of infectious diseases.. 1992 November 166 (5):1113-23. Epub 1900 01 01.

Host species-specific antigenic variation of a mannosylated surface glycoprotein of Pneumocystis carinii.

Gigliotti F

The Journal of infectious diseases.. 1992 February 165 (2):329-36. Epub 1900 01 01.

Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120) after immunization and natural infection.

Fisher DJ, Gigliotti F, Zauderer M, Harmsen AG

Infection and immunity.. 1991 October 59 (10):3372-6. Epub 1900 01 01.

Serologic follow-up of children with sickle cell disease immunized with a Haemophilus influenzae type b conjugate vaccine during early infancy.

Gigliotti F, Feldman S, Wang WC, Day SW, Brunson G

The Journal of pediatrics.. 1991 June 118 (6):917-9. Epub 1900 01 01.

Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120).

Fisher DJ, Gigliotti F, Zauderer M, Harmsen AG

The Journal of protozoology. 1991 38 (6):22S-23S. Epub 1900 01 01.

Antigenic variation of a major surface glycoprotein of Pneumocystis carinii.

Gigliotti F

The Journal of protozoology. 1991 38 (6):4S-5S. Epub 1900 01 01.

Molecular cloning and characterization of ferret Pneumocystis carinii gp120.

Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ

The Journal of protozoology. 1991 38 (6):5S-6S. Epub 1900 01 01.

Risk of Haemophilus influenzae type b disease in children with cancer and response of immunocompromised leukemic children to a conjugate vaccine.

Feldman S, Gigliotti F, Shenep JL, Roberson PK, Lott L

The Journal of infectious diseases.. 1990 May 161 (5):926-31. Epub 1900 01 01.

Immunization of young infants with sickle cell disease with a Haemophilus influenzae type b saccharide-diphtheria CRM197 protein conjugate vaccine.

Gigliotti F, Feldman S, Wang WC, Day SW, Brunson G

The Journal of pediatrics.. 1989 June 114 (6):1006-10. Epub 1900 01 01.

Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer.

Shenep JL, Hughes WT, Roberson PK, Blankenship KR, Baker DK, Meyer WH, Gigliotti F, Sixbey JW, Santana VM, Feldman S

The New England journal of medicine.. 1988 October 20319 (16):1053-8. Epub 1900 01 01.

Immunolabeling of lipopolysaccharide liberated from antibiotic-treated Escherichia coli.

Flynn PM, Shenep JL, Gigliotti F, Davis DS, Hildner WK

Infection and immunity.. 1988 October 56 (10):2760-2. Epub 1900 01 01.

Purification and initial characterization of a ferret Pneumocystis carinii surface antigen.

Gigliotti F, Ballou LR, Hughes WT, Mosley BD

The Journal of infectious diseases.. 1988 October 158 (4):848-54. Epub 1900 01 01.

Immunodeficiency associated with recurrent infections and an isolated in vivo inability to respond to bacterial polysaccharides: follow-up immunization with pneumococcal polysaccharides.

Gigliotti F

The Pediatric infectious disease journal.. 1988 August 7 (8):604. Epub 1900 01 01.

Atypical mycobacterial infections of Hickman catheter exit sites.

Flynn PM, Van Hooser B, Gigliotti F

The Pediatric infectious disease journal.. 1988 July 7 (7):510-3. Epub 1900 01 01.

Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models.

Gigliotti F, Hughes WT

The Journal of clinical investigation.. 1988 June 81 (6):1666-8. Epub 1900 01 01.

Immunodeficiency associated with recurrent infections and an isolated in vivo inability to respond to bacterial polysaccharides.

Gigliotti F, Herrod HG, Kalwinsky DK, Insel RA

The Pediatric infectious disease journal.. 1988 June 7 (6):417-20. Epub 1900 01 01.

Cryptosporidiosis in ferrets.

Rehg JE, Gigliotti F, Stokes DC

Laboratory animal science.. 1988 April 38 (2):155-8. Epub 1900 01 01.

Nomenclature for Pneumocystis carinii.

Hughes WT, Gigliotti F

The Journal of infectious diseases.. 1988 March 157 (3):432-3. Epub 1900 01 01.

Measles and rubella antibody status in previously vaccinated children with cancer.

Feldman S, Gigliotti F, Bockhold C, Naegele R

Medical and pediatric oncology.. 1988 16 (5):308-11. Epub 1900 01 01.

Pneumocystis carinii in the temporal bone as a primary manifestation of the acquired immunodeficiency syndrome.

Breda SD, Hammerschlag PE, Gigliotti F, Schinella R

The Annals of otology, rhinology, and laryngology.. 1988 97 (4 Pt 1):427-31. Epub 1900 01 01.

Induction of prostaglandin synthesis as the mechanism responsible for the chills and fever produced by infusing amphotericin B.

Gigliotti F, Shenep JL, Lott L, Thornton D

The Journal of infectious diseases.. 1987 November 156 (5):784-9. Epub 1900 01 01.

IgG penetration into the cerebrospinal fluid in a rabbit model of meningitis.

Gigliotti F, Lee D, Insel RA, Scheld WM

The Journal of infectious diseases.. 1987 August 156 (2):394-8. Epub 1900 01 01.

Experimental Pneumocystis carinii pneumonia in the ferret.

Stokes DC, Gigliotti F, Rehg JE, Snellgrove RL, Hughes WT

British journal of experimental pathology.. 1987 April 68 (2):267-76. Epub 1900 01 01.

Reactivity of antibodies to core glycolipid with gram-negative bacteria.

Shenep JL, Gigliotti F, Davis DS, Hildner WK

Reviews of infectious diseases.. 1987 9 Suppl 5 :S639-43. Epub 1900 01 01.

Development of murine monoclonal antibodies to Pneumocystis carinii.

Gigliotti F, Stokes DC, Cheatham AB, Davis DS, Hughes WT

The Journal of infectious diseases.. 1986 August 154 (2):315-22. Epub 1900 01 01.

Failure of monoclonal antibodies to core glycolipid to bind intact smooth strains of Escherichia coli.

Gigliotti F, Shenep JL

The Journal of infectious diseases.. 1985 June 151 (6):1005-11. Epub 1900 01 01.

Prevention of infectious complications in acute lymphoblastic leukemia.

Hughes WT, Feldman S, Gigliotti F, Shenep J, Sixbey J

Seminars in oncology.. 1985 June 12 (2):180-91. Epub 1900 01 01.

Efficacy of topical antibiotic therapy in acute conjunctivitis in children.

Gigliotti F, Hendley JO, Morgan J, Michaels R, Dickens M, Lohr J

The Journal of pediatrics.. 1984 April 104 (4):623-6. Epub 1900 01 01.

Reproducible production of protective human monoclonal antibodies by fusion of peripheral blood lymphocytes with a mouse myeloma cell line.

Gigliotti F, Smith L, Insel RA

The Journal of infectious diseases.. 1984 January 149 (1):43-7. Epub 1900 01 01.

Central nervous system toxoplasmosis mimicking a brain abscess in a compromised pediatric patient.

Connor E, Menegus M, Cecalupo A, Gigliotti F

Pediatric infectious disease. 1984 3 (6):552-5. Epub 1900 01 01.

Monoclonal antibodies. Clinical relevance to pediatrics.

Insel RA, Gigliotti F

American journal of diseases of children. 1983 January 137 (1):69-76. Epub 1900 01 01.

Protective human hybridoma antibody to tetanus toxin.

Gigliotti F, Insel RA

The Journal of clinical investigation.. 1982 December 70 (6):1306-9. Epub 1900 01 01.

Protection from infection with Haemophilus influenzae type b by monoclonal antibody to the capsule.

Gigliotti F, Insel RA

The Journal of infectious diseases.. 1982 August 146 (2):249-54. Epub 1900 01 01.

Etiology of acute conjunctivitis in children.

Gigliotti F, Williams WT, Hayden FG, Hendley JO, Benjamin J, Dickens M, Gleason C, Perriello VA, Wood J

The Journal of pediatrics.. 1981 April 98 (4):531-6. Epub 1900 01 01.

Books

Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant (2015)

Chapter: Pneumocystis and Other Less Common

Authors: Gigliotti F, Wright TW, Krysan

Publisher: Elsevier Saunders, Philadelphia 2015

Feigin and Cherry's Textbook of Pediatric Infectious Diseases (2015)

Chapter: Pneumocystis pneumonia

Authors: Gigliotti F

Publisher: Elsevier Saunders, Philadelphia 2015

Principles and Practice of Pediatric Infectious Diseases (2015)

Chapter: Pneumocystis Jirovecii

Authors: Gigliotti, F

Publisher: Saunders, Philadelphia 2015

Nelson Textbook of Pediatrics (2015)

Chapter: Pneumocystis

Authors: Gigliotti F

Publisher: Saunders, Philadelphia 2015

Principles and Practice of Pediatric Infectious Diseases (2011)

Chapter: Pneumocystis carinii

Authors: Gigliotti F, Wright T

Publisher: Churchill Livingstone 2011

Diagnosis and Treatment of Human MYcoses (2008)

Chapter: Pneumocystis carinii

Authors: Gigliotti F, Wright TW

Publisher: Humana Press 2008

Nelson Textbook of Pediatrics, 18th edition, Philadelphia (2007)

Chapter: Pneumocystis carinii.

Authors: Gigliotti F, Wright TW

Publisher: Elsevier, 2007 2007

Nelson Textbook of Pediatrics (2006)

Chapter: Pneumocystis carinii

Authors: Gigliotti F, Wright TW

Publisher: Elsevier, Philadelphia, PA 2006

Principles and Practice of Pediatric Infectious Diseases (2006)

Chapter: Pneumocystis carinii

Authors: Gigliotti F, Wright TW

Publisher: Churchville Livingstone 2006

Pneumocystis carinii Pneumonia (2005)

Chapter: Mechanisms of lung damage

Authors: Wright TW, Harmsen AG, Gigliotti F

Publisher: Marcel Dekker, Inc., New York, NY 2005

Pneumocystis carinii Pneumonia (2005)

Chapter: Antibodies and other non-T cell defenses

Authors: Gigliotti F, Haidaris CG, Harmsen AG, Wright TW

Publisher: Marcel Dekker, Inc., New York, NY 2005

Fungal Immunology from an Organ Perspective (2004)

Chapter: Antibody-mediated immunity to pneumocystis in the lungs

Authors: Garvy BA, Gigliotti F

Publisher: Kluwer, Norwell, MA 2004

Principles and Practice of Pediatric Infectious Diseases (2002)

Chapter: Pneumocystis carinii

Authors: Gigliotti F, Wright TW

Publisher: Churchill Livingstone, Philadelphia, PA 2002

Review of Pediatrics (2000)

Chapter: Pneumonia in a 4-year-old boy with leukemia in remission

Authors: Gigliotti F

Publisher: W. B. Saunders Co., Philadelphia, PA 2000

Gellis & Kagan's Current Pediatric Therapy (1999)

Chapter: Pneumocystis carinii pneumonia

Authors: Gigliotti F, Weinberg GA

Publisher: W. B. Saunders Co., Philadelphia, PA 1999

Hand Book of Pediatric Psychology (1995)

Chapter: Neuropsychological aspects of pediatric infectious diseases

Authors: Palumbo DR, Davidson PW, Peloquin LJ, Gigliotti F

Publisher: Guilford Press, New York, NY 1995

Pneumocystis carinii Pneumonia (1994)

Chapter: Antigenic characteristics (of P. carinii).

Authors: Gigliotti F

Publisher: Marcel Dekker, Inc., New York, NY 1994

Comprehensive Pediatrics (1990)

Chapter: H. influenzae

Authors: Gigliotti F

Publisher: The C.V. Mosby Co., St. Louis, MO 1990

Bedside Pediatrics (1983)

Chapter: Rapid diagnosis of infectious disease

Authors: Gigliotti F, Insel RA

Publisher: Little, Brown and Co., Boston, MA 1983

Annual Reports in Medicinal Chemistry (1983)

Chapter: Immunotherapy of infectious diseases

Authors: Ades EW, Schmidtke JR, Insel RA, Gigliotti F

Publisher: Elsevier Science and Technology Books, Burlington, VT 1983