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Chawnshang Chang, Ph.D.

Chawnshang Chang, Ph.D.

About Me

Dr. Chang is an internationally-recognized expert in the role of androgen receptor in prostate cancer and other organs and diseases. Androgens (steroid hormones) control the development and function of male reproductive tissues, and also influence other organs and tissues, such as skin, skeletal mus...
Dr. Chang is an internationally-recognized expert in the role of androgen receptor in prostate cancer and other organs and diseases. Androgens (steroid hormones) control the development and function of male reproductive tissues, and also influence other organs and tissues, such as skin, skeletal muscle, bone marrow, hair follicles, and brain. Androgen regulates gene expression through the androgen receptor.

In 1988, Dr. Chang became the first scientist to clone the complete human and rat androgen receptors. (Science, 1988; PNAS, 1988). He then applied recombinant techniques to overexpress a large quantity of androgen receptor (AR) and used it to produce the first monoclonal antibody to the androgen receptor (Endo., 1989). The successful cloning of the androgen receptor and the generation of the first androgen receptor monoclonal antibody were groundbreaking. Dr. Chang has continued his research in this field; has had more than 200 papers published on the roles of AR, TR2 and TR4; and has served as a mentor to numerous graduate students, postdoctoral fellows, and junior faculty.

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Education

PhD | University of Chicago. Biochemistry & Molecular Biology. 1985

BS | National Taiwan University. Agriculture Chemistry. 1978

Awards

The Milheim Award for Excellence in Cancer Research from Milheim Foundation 2003

Dr. Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN 2002

Who's Who in America 2001

Dr. S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong. 2001

President Award for Outstanding Andrology Research, The highest honor from The Chinese Andrology Association for the studies of Androgens and Androgen Receptor. 2001

President Award for Outstanding Andrology Research, The highest honor from The Taiwanese Andrology Association for the studies of Androgens and Androgen Receptor. 2000

President Award for Outstanding Urology Research, The highest honor from The Urology Association of Taiwan for the Contribution in Androgen Receptor and Prostate Cancer. 1999

Davey Memorial Award for Outstanding Cancer Research, University of Rochester. 1999

Scholar of the Year, The highest honor from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex hormones and Osteoporosis. 1998

George Hoyt Whipple Lecture, University of Rochester, Rochester, NY 1998

Jiepimg Wu Award, for Outstanding Achievement in Urology (The highest honor for Chinese-Urology Researcher). Beijing, China. 1998

Award with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese ever awarded such honor) 1996

Blowity-Ridgeway Award in Andrology from Blowity-Ridgeway Foundation 1995 - 1997

Tokyo Society of Medical Science and University of Tokyo Lecturer 1992

American Cancer Society Junior Professorship in Cancer Research 1991 - 1994

CapCure Award (6 times) for Excellence in Prostate Cancer Research 1991 - 1997

Outstanding Young Investigator Award from Cancer Research Foundation 1990

Andrew Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation 1989

The Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society 1988

Research

Patents

Androgen Receptor Coactivators

Issue date: March 02, 2004

Patent #: 6,699,714

Country: United States

Inventors: Chawnshang Chang

Androgen Receptor Coactivators

Issue date: July 08, 2004

Patent #: 771,564

Country: Australia

Inventors: Chawnshang Chang

Androgen Receptor Coactivators

Issue date: May 30, 2006

Patent #: 7,052,908

Country: United States

Inventors: Chawnshang Chang

Curcumin Analogues and Uses Thereof

Issue date: September 14, 2004

Patent #: 6,790,979

Country: United States

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Creation of Female Mice without Androgen Receptor and Creation

Issue date: December 14, 2006

Patent #: 531,223

Country: New Zealand

Inventors: Chawnshang Chang, Shu-Yuan Yeh

Androgen Receptor Coactivators

Issue date: March 27, 2008

Patent #: 2004203835

Country: Australia

Inventors: Chawnshang Chang

Novel Curcumin Analogs and Uses Thereof

Issue date: October 12, 2012

Patent #: 5108198

Country: Japan

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: October 13, 2010

Patent #: ZL03808650.6

Country: China, People's Republic of

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: July 17, 2012

Patent #: 2,482,002

Country: Canada

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 10, 2007

Patent #: NZ 535773

Country: New Zealand

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: October 31, 2006

Patent #: 106864

Country: Singapore

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: 1494993

Country: Europe

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 08, 2013

Patent #: 309419

Country: Mexico

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 30, 2008

Patent #: 131444

Country: Singapore

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Li Lin, Hironori Ohtsu, Charles Shih, Ching-Yuan Su, Hui-Kang Wang

Curcumin Analogues and Uses Thereof

Issue date: April 08, 2008

Patent #: 7,355,081

Country: United States

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: March 07, 2011

Patent #: HK1078846

Country: Hong Kong

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Li Lin, Hironori Ohtsu, Charles Shih, Ching-Yuan Su, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: December 22, 2011

Patent #: 2008243284

Country: Australia

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: July 05, 2012

Patent #: 2009215207

Country: Australia

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 04, 2010

Patent #: 7,709,535

Country: United States

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Li Lin, Hironori Ohtsu, Charles Shih, Ching-Yuan Su, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: December 22, 2010

Patent #: 1025226

Country: Korea, Republic of

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: June 12, 2012

Patent #: 8,198,323

Country: United States

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Li Lin, Hironori Ohtsu, Charles Shih, Ching-Yuan Su, Hui-Kang Wang

Methods and Compositions Related to TR4 Ligand

Issue date: September 03, 2013

Patent #: 8,524,455

Country: United States

Inventors: Chawnshang Chang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: BE1494993

Country: Belgium

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: IE1494993

Country: Ireland

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: IT1494993

Country: Italy

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: ES1494993

Country: Spain

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: SE1494993

Country: Sweden

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: CH1494993

Country: Switzerland/Liechtenstein

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: September 24, 2010

Patent #: KP984512

Country: Korea, Republic of

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: FR1494993

Country: France

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: DE1494993

Country: Germany

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: NL1494993

Country: Netherlands

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: GB1494993

Country: United Kingdom

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Novel Curcumin Analogues and Uses Thereof

Issue date: May 05, 2010

Patent #: DK03718072.6

Country: Denmark

Inventors: Chawnshang Chang, Junko Ishida, Hideji Itokawa, Kuo-Hsiung Lee, Hironori Ohtsu, Charles Shih, Hui-Kang Wang

Methods for Treating Prostate Cancer

Issue date: October 11, 2016

Patent #: 9,463,242

Country: United States

Inventors: Chawnshang Chang

Publications

Journal Articles

Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status.

Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C

Oncotarget.. 2015 October 136 (31):31203-15. Epub 1900 01 01.

Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals.

Ou Z, Wang Y, Liu L, Li L, Yeh S, Qi L, Chang C

Oncotarget.. 2015 September 226 (28):26065-78. Epub 1900 01 01.

Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-?1/Smad/MMP9 signals.

Xie H, Li L, Zhu G, Dang Q, Ma Z, He D, Chang L, Song W, Chang HC, Krolewski JJ, Nastiuk KL, Yeh S, Chang C

Oncotarget.. 2015 May 206 (14):12326-39. Epub 1900 01 01.

Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice.

Wang RS, Chang HY, Kao SH, Kao CH, Wu YC, Yeh S, Tzeng CR, Chang C

International journal of molecular sciences.. 2015 April 3016 (5):9831-49. Epub 04/30/2015.

TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression.

Park SS, Kim SJ, Choi H, Chang C, Kim E

FEBS letters.. 2014 November 3588 (21):3947-53. Epub 09/19/2014.

Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails.

Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ, Chang C

Oncogene.. 2010 June 2429 (25):3593-604. Epub 05/03/2010.

Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth.

Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE, Chang C

The Prostate.. 2010 February 170 (2):190-9. Epub 1900 01 01.

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression.

Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ, Chang C

The Journal of clinical investigation.. 2009 December 119 (12):3739-51. Epub 11/09/2009.

Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling.

Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C

Endocrine.. 2009 October 36 (2):211-7. Epub 07/18/2009.

TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.

Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe JI, Berk B, Ho FM, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2009 August 11106 (32):13353-8. Epub 07/28/2009.

NF-kappaB regulates androgen receptor expression and prostate cancer growth.

Zhang L, Altuwaijri S, Deng F, Chen L, Lal P, Bhanot UK, Korets R, Wenske S, Lilja HG, Chang C, Scher HI, Gerald WL

The American journal of pathology.. 2009 August 175 (2):489-99. Epub 07/23/2009.

Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer.

Kang HY, Huang HY, Hsieh CY, Li CF, Shyr CR, Tsai MY, Chang C, Chuang YC, Huang KE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 July 24 (7):1180-93. Epub 1900 01 01.

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor.

Chuang KH, Altuwaijri S, Li G, Lai JJ, Chu CY, Lai KP, Lin HY, Hsu JW, Keng P, Wu MC, Chang C

The Journal of experimental medicine.. 2009 May 11206 (5):1181-99. Epub 05/04/2009.

Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells.

Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE, Chang C

Endocrinology.. 2009 May 150 (5):2454-62. Epub 01/08/2009.

Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells.

Altuwaijri S, Chuang KH, Lai KP, Lai JJ, Lin HY, Young FM, Bottaro A, Tsai MY, Zeng WP, Chang HC, Yeh S, Chang C

Molecular endocrinology.. 2009 April 23 (4):444-53. Epub 01/22/2009.

Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice.

Wang RS, Yeh S, Tzeng CR, Chang C

Endocrine reviews.. 2009 April 30 (2):119-32. Epub 01/27/2009.

Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice.

Chen M, Hsu I, Wolfe A, Radovick S, Huang K, Yu S, Chang C, Messing EM, Yeh S

Endocrinology.. 2009 January 150 (1):251-9. Epub 08/28/2008.

Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology.

Chen M, Wolfe A, Wang X, Chang C, Yeh S, Radovick S

Molecular and cellular biochemistry.. 2009 January 321 (1-2):145-53. Epub 10/25/2008.

The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer.

Yu SQ, Lai KP, Xia SJ, Chang HC, Chang C, Yeh S

Asian journal of andrology.. 2009 January 11 (1):39-48. Epub 12/22/2008.

Altered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor.

Kang HY, Shyr CR, Huang CK, Tsai MY, Orimo H, Lin PC, Chang C, Huang KE

Molecular and cellular biology.. 2008 December 28 (24):7354-67. Epub 10/06/2008.

Tissue prostate-specific antigen facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation.

Niu Y, Yeh S, Miyamoto H, Li G, Altuwaijri S, Yuan J, Han R, Ma T, Kuo HC, Chang C

Cancer research.. 2008 September 168 (17):7110-9. Epub 1900 01 01.

Actin associated proteins function as androgen receptor coregulators: an implication of androgen receptor's roles in skeletal muscle.

Ting HJ, Chang C

The Journal of steroid biochemistry and molecular biology.. 2008 September 111 (3-5):157-63. Epub 06/11/2008.

Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma.

Ma WL, Ma CL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S, Chang C

Gastroenterology.. 2008 September 135 (3):947-55, 955.e1-5. Epub 05/22/2008.

Targeting the stromal androgen receptor in primary prostate tumors at earlier stages.

Niu Y, Altuwaijri S, Yeh S, Lai KP, Yu S, Chuang KH, Huang SP, Lardy H, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2008 August 26105 (34):12188-93. Epub 08/22/2008.

Androgen receptor is a tumor suppressor and proliferator in prostate cancer.

Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2008 August 26105 (34):12182-7. Epub 08/22/2008.

A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.

Cai Y, Lee YF, Li G, Liu S, Bao BY, Huang J, Hsu CL, Chang C

International journal of cancer.. 2008 July 1123 (1):195-201. Epub 1900 01 01.

Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a.

Li G, Lee YF, Liu S, Cai Y, Xie S, Liu NC, Bao BY, Chen Z, Chang C

Endocrinology.. 2008 July 149 (7):3490-9. Epub 04/03/2008.

Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor.

Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C

Hepatology : official journal of the American Association for the Study of Liver Diseases.. 2008 June 47 (6):1924-35. Epub 1900 01 01.

Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue.

Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C

Endocrinology.. 2008 May 149 (5):2361-8. Epub 02/14/2008.

Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4.

Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC, Chang C

Molecular endocrinology.. 2008 April 22 (4):858-67. Epub 01/03/2008.

The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development.

Chen YT, Collins LL, Chang SS, Chang C

The cerebellum.. 2008 7 (1):9-17. Epub 1900 01 01.

Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.

Zhao X, Zheng B, Huang Y, Yang D, Katzman S, Chang C, Fowell D, Zeng WP

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 December 15179 (12):8297-304. Epub 1900 01 01.

Association of tri-nucleotide (CAG and GGC) repeat polymorphism of androgen receptor gene in Taiwanese women with refractory or remission rheumatoid arthritis.

Yu SF, Cheng TT, Hsu YH, Lai HM, Chen YC, Chiu CK, Lin KM, Chang C, Chen CJ, Kang HY

Clinical rheumatology.. 2007 December 26 (12):2051. Epub 04/13/2007.

Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis.

Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C

Diabetes.. 2007 December 56 (12):2901-9. Epub 09/07/2007.

Temporal and spatial changes of histone 3 K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation.

Hamalainen-Laanaya HK, Kobie JJ, Chang C, Zeng WP

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 November 15179 (10):6410-5. Epub 1900 01 01.

TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression.

Kim E, Ma WL, Lin DL, Inui S, Chen YL, Chang C

Biochemical and biophysical research communications.. 2007 September 21361 (2):323-8. Epub 07/10/2007.

Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor.

Chen YT, Collins LL, Uno H, Chou SM, Meshul CK, Chang SS, Chang C

Brain research.. 2007 September 71168 :72-82. Epub 07/17/2007.

Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells.

Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S, Chang C

Endocrine.. 2007 August 32 (1):96-106. Epub 10/23/2007.

Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.

Wu CT, Altuwaijri S, Ricke WA, Huang SP, Yeh S, Zhang C, Niu Y, Tsai MY, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2007 July 31104 (31):12679-84. Epub 07/25/2007.

Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein.

Zheng Y, Chen WL, Ma WL, Chang C, Ou JH

Virology.. 2007 July 5363 (2):454-61. Epub 02/28/2007.

Promotion of bladder cancer development and progression by androgen receptor signals.

Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, Yeh S, Messing EM, Chang C

Journal of the National Cancer Institute.. 2007 April 499 (7):558-68. Epub 1900 01 01.

Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain.

Zhang Y, Chen YT, Xie S, Wang L, Lee YF, Chang SS, Chang C

Molecular endocrinology.. 2007 April 21 (4):908-20. Epub 01/16/2007.

Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54.

Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'Agnese PA, Tsai MY, Chang C

Endocrinology.. 2007 March 148 (3):1340-9. Epub 11/16/2006.

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.

Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C

Nature medicine.. 2007 March 13 (3):348-53. Epub 03/04/2007.

Expression of human AR cDNA driven by its own promoter results in mild promotion, but not suppression, of growth in human prostate cancer PC-3 cells.

Altuwaijri S, Wu CC, Niu YJ, Mizokami A, Chang HC, Chang C

Asian journal of andrology.. 2007 March 9 (2):181-8. Epub 1900 01 01.

Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.

Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant'Agnese PA, Chang C

Molecular endocrinology.. 2007 February 21 (2):343-58. Epub 11/02/2006.

Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells.

Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tzeng CR, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2006 December 12103 (50):18975-80. Epub 12/01/2006.

Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes.

Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'Agnese PA, deMesy-Bentley KL, Tzeng CR, Chang C

Endocrinology.. 2006 December 147 (12):5624-33. Epub 09/14/2006.

Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells.

Zhang C, Yeh S, Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis-Handagama C, Hu L, Lardy H, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2006 November 21103 (47):17718-23. Epub 11/09/2006.

C19-steroids as androgen receptor modulators: design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists.

Marwah P, Marwah A, Lardy HA, Miyamoto H, Chang C

Bioorganic & medicinal chemistry.. 2006 September 114 (17):5933-47. Epub 06/08/2006.

Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis.

Mu X, Yang L, Chang C

Biochemical and biophysical research communications.. 2006 March 10341 (2):464-9. Epub 01/11/2006.

Abnormal Cerebellar Cytoarchitecture with Impaired Cerebellar Inhibitory Circuit in Adult Mice Lacking Testicular Orphan Nuclear Receptor 4

Chen, CY.; Collins, L.; Uno, H.; Chou, SM.; Meshul, CK.; Chang, SS.; and Chang, C.

MCB. 2006; .

Premature aging like syndromes and impaired genomic stability maintenance in mice lacking TR4 orphan nuclear receptor

Lee, YL.; Liu, NC.; Liu, S.; Wang, RS.; Ho, HC.; Yan, SJ.; Li, G.; Chen, LM.; Lin, WJ.; Puzas, E.; and Chang, C.

Nature. 2006; .

Hypoglycemia and impaired hepatic glucose production in mice lacking TR4 orphan nuclear receptor.

Liu, NC.; Lin, WJ.; Lee, YF.; Kim, E.; Collins, L.; Lin, HY.; Sparks, JD.; Hanson, RW.; Chen, LM.; and Chang, C.

Cell Metabolism. 2006; .

Curcumin derivative ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor aggregation and restoration of VEGF164 expression

Yang , Z.; Chang, YJ.; Yu, IC.; Miyamoto, H.; Wu, CC.; Yeh, S.; Merry, DE.; Sobue, G.; Chen, LM,; and Chang, C.

Nature Medicine. 2006; .

Identification of steroid derivatives that function as potent antiandrogens.

Miyamoto H, Marwah P, Marwah A, Yang Z, Chung CY, Altuwaijri S, Chang C, Lardy H

International journal of cancer.. 2005 December 10117 (5):866-72. Epub 1900 01 01.

Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells.

Yang L, Xie S, Jamaluddin MS, Altuwaijri S, Ni J, Kim E, Chen YT, Hu YC, Wang L, Chuang KH, Wu CT, Chang C

The Journal of biological chemistry.. 2005 September 30280 (39):33558-65. Epub 08/01/2005.

Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: potential therapeutic approaches for prostate cancer.

Miyamoto H, Altuwaijri S, Cai Y, Messing EM, Chang C

Molecular carcinogenesis.. 2005 September 44 (1):1-10. Epub 1900 01 01.

Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor.

Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD, Chang C

Diabetes.. 2005 June 54 (6):1717-25. Epub 1900 01 01.

Androgen receptor corepressors: an overview.

Wang L, Hsu CL, Chang C

The Prostate.. 2005 May 163 (2):117-30. Epub 1900 01 01.

9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor.

Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YJ, Chang C

Molecular endocrinology.. 2005 May 19 (5):1200-12. Epub 01/13/2005.

Does androgen deprivation improve treatment outcomes in patients with low-risk and intermediate-risk prostate cancer?

Miyamoto H, Messing EM, Chang C

Nature clinical practice. Oncology.. 2005 May 2 (5):236-7. Epub 1900 01 01.

Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4.

Chen YT, Collins LL, Uno H, Chang C

Molecular and cellular biology.. 2005 April 25 (7):2722-32. Epub 1900 01 01.

Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region.

Kim E, Yang Z, Liu NC, Chang C

Biochemical and biophysical research communications.. 2005 March 4328 (1):85-90. Epub 1900 01 01.

Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth.

Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW, Chang C

Molecular endocrinology.. 2005 February 19 (2):350-61. Epub 10/28/2004.

Can we prevent prostate cancer? Rationale and current status of prostate cancer chemoprevention.

Fujimoto N, Chang C, Nomura M, Matsumoto T

Urologia internationalis.. 2005 74 (4):289-97. Epub 1900 01 01.

Androgen deprivation therapy for prostate cancer: current status and future prospects.

Miyamoto H, Messing EM, Chang C

The Prostate.. 2004 December 161 (4):332-53. Epub 1900 01 01.

Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor.

Lee YF, Bao BY, Chang C

Biochemical and biophysical research communications.. 2004 October 22323 (3):876-83. Epub 1900 01 01.

Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4.

Collins LL, Lee YF, Heinlein CA, Liu NC, Chen YT, Shyr CR, Meshul CK, Uno H, Platt KA, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2004 October 19101 (42):15058-63. Epub 10/11/2004.

Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types.

Altuwaijri S, Lee DK, Chuang KH, Ting HJ, Yang Z, Xu Q, Tsai MY, Yeh S, Hanchett LA, Chang HC, Chang C

Endocrine.. 2004 October 25 (1):27-32. Epub 1900 01 01.

Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.

Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C

The Journal of biological chemistry.. 2004 August 6279 (32):33438-46. Epub 05/27/2004.

Subfertility and defective folliculogenesis in female mice lacking androgen receptor.

Hu YC, Wang PH, Yeh S, Wang RS, Xie C, Xu Q, Zhou X, Chao HT, Tsai MY, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2004 August 3101 (31):11209-14. Epub 07/26/2004.

Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells.

Wang L, Lin HK, Hu YC, Xie S, Yang L, Chang C

The Journal of biological chemistry.. 2004 July 30279 (31):32444-52. Epub 06/03/2004.

Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts.

Kang HY, Cho CL, Huang KL, Wang JC, Hu YC, Lin HK, Chang C, Huang KE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 July 19 (7):1181-90. Epub 03/08/2004.

Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis.

Mu X, Lee YF, Liu NC, Chen YT, Kim E, Shyr CR, Chang C

Molecular and cellular biology.. 2004 July 24 (13):5887-99. Epub 1900 01 01.

Actin monomer enhances supervillin-modulated androgen receptor transactivation.

Ting HJ, Hu YC, Chang C

Biochemical and biophysical research communications.. 2004 June 25319 (2):393-6. Epub 1900 01 01.

Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells.

Xie S, Lin HK, Ni J, Yang L, Wang L, di Sant'Agnese PA, Chang C

The Prostate.. 2004 June 1560 (1):61-7. Epub 1900 01 01.

Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.

Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H, Yeh S

Proceedings of the National Academy of Sciences of the United States of America.. 2004 May 4101 (18):6876-81. Epub 04/23/2004.

Androgen receptor coregulators in prostate cancer: mechanisms and clinical implications.

Rahman M, Miyamoto H, Chang C

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2004 April 110 (7):2208-19. Epub 1900 01 01.

Androgen receptor in prostate cancer.

Heinlein CA, Chang C

Endocrine reviews.. 2004 April 25 (2):276-308. Epub 1900 01 01.

Molecular characterization of the commonly used human androgen receptor expression vector, pSG5-AR.

Litvinov IV, Chang C, Isaacs JT

The Prostate.. 2004 March 158 (4):319-24. Epub 1900 01 01.

Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.

Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C

Molecular and cellular biology.. 2004 March 24 (5):2202-13. Epub 1900 01 01.

ARA67/PAT1 functions as a repressor to suppress androgen receptor transactivation.

Zhang Y, Yang Y, Yeh S, Chang C

Molecular and cellular biology.. 2004 February 24 (3):1044-57. Epub 1900 01 01.

Androgen suppresses PML protein expression in prostate cancer CWR22R cells.

Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH, Chang C

Biochemical and biophysical research communications.. 2004 January 30314 (1):69-75. Epub 1900 01 01.

Molecular basis for the antiandrogen withdrawal syndrome.

Miyamoto H, Rahman MM, Chang C

Journal of cellular biochemistry.. 2004 January 191 (1):3-12. Epub 1900 01 01.

Androgens and ovarian cancers.

Wang PH, Chang C

European journal of gynaecological oncology.. 2004 25 (2):157-63. Epub 1900 01 01.

Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers.

Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY, Chang C

The Journal of biological chemistry.. 2003 December 19278 (51):50902-7. Epub 10/10/2003.

Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor.

Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH, Chang C

The Journal of experimental medicine.. 2003 December 15198 (12):1899-908. Epub 1900 01 01.

Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth.

Fu M, Rao M, Wang C, Sakamaki T, Wang J, Di Vizio D, Zhang X, Albanese C, Balk S, Chang C, Fan S, Rosen E, Palvimo JJ, Jänne OA, Muratoglu S, Avantaggiati ML, Pestell RG

Molecular and cellular biology.. 2003 December 23 (23):8563-75. Epub 1900 01 01.

Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster.

Kim E, Xie S, Yeh SD, Lee YF, Collins LL, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH, Chang C

The Journal of biological chemistry.. 2003 November 21278 (47):46919-26. Epub 09/03/2003.

Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.

Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH

Bioorganic & medicinal chemistry.. 2003 November 1711 (23):5083-90. Epub 1900 01 01.

Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.

Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C

Cancer research.. 2003 November 163 (21):7106-12. Epub 1900 01 01.

TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells.

Mu X, Chang C

The Journal of biological chemistry.. 2003 October 31278 (44):42840-5. Epub 08/28/2003.

TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3.

Mu X, Chang C

The Prostate.. 2003 October 157 (2):129-33. Epub 1900 01 01.

Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication.

Lee DK, Chang C

The Journal of clinical endocrinology and metabolism.. 2003 September 88 (9):4043-54. Epub 1900 01 01.

Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.

Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Miyamoto H, Shin M, Aozasa K, Okuyama A, Chang C

Cancer research.. 2003 August 1563 (16):4888-94. Epub 1900 01 01.

Recent advances in androgen receptor action.

Lee HJ, Chang C

Cellular and molecular life sciences : CMLS.. 2003 August 60 (8):1613-22. Epub 1900 01 01.

The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs.

Hsu CL, Chen YL, Yeh S, Ting HJ, Hu YC, Lin H, Wang X, Chang C

The Journal of biological chemistry.. 2003 June 27278 (26):23691-8. Epub 04/24/2003.

Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells.

Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C

Biochemical and biophysical research communications.. 2003 June 6305 (3):462-9. Epub 1900 01 01.

Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice.

Cai Y, Dai T, Ao Y, Konishi T, Chuang KH, Lue Y, Chang C, Wan YJ

Endocrinology.. 2003 June 144 (6):2311-8. Epub 1900 01 01.

Mechanisms and clinical relevance of androgens and androgen receptor actions.

Kang HY, Tsai MY, Chang C, Huang KE

Chang Gung medical journal. 2003 June 26 (6):388-402. Epub 1900 01 01.

Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells.

Rahman MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S, Chang C

The Journal of biological chemistry.. 2003 May 30278 (22):19619-26. Epub 03/20/2003.

APPL suppresses androgen receptor transactivation via potentiating Akt activity.

Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C

The Journal of biological chemistry.. 2003 May 9278 (19):16820-7. Epub 03/05/2003.

Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells.

Rahman MM, Miyamoto H, Lardy H, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2003 April 29100 (9):5124-9. Epub 04/16/2003.

3 beta-acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity.

Miyamoto H, Marwah P, Marwah A, Lardy H, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2003 April 15100 (8):4440-4. Epub 04/02/2003.

Evidence on the presence of secretin cells in the gastric antral and oxyntic mucosa.

Chey WY, Chang CH, Pan HJ, Chang C, Kim BM, Park IS, Chang TM

Regulatory peptides.. 2003 March 28111 (1-3):183-90. Epub 1900 01 01.

Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.

Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C

The Journal of biological chemistry.. 2003 March 14278 (11):9353-60. Epub 01/08/2003.

Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation.

Yang Y, Wang X, Dong T, Kim E, Lin WJ, Chang C

The Journal of biological chemistry.. 2003 February 28278 (9):7709-17. Epub 12/16/2002.

Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment.

Thin TH, Wang L, Kim E, Collins LL, Basavappa R, Chang C

The Journal of biological chemistry.. 2003 February 28278 (9):7699-708. Epub 12/23/2002.

The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor.

Lee DK, Li M, Chang C

Biochemical and biophysical research communications.. 2003 February 28302 (1):162-9. Epub 1900 01 01.

Molecular communication between androgen receptor and general transcription machinery.

Lee DK, Chang C

The Journal of steroid biochemistry and molecular biology.. 2003 January 84 (1):41-9. Epub 1900 01 01.

The androgen receptor in spermatogenesis.

Collins LL, Lee HJ, Chen YT, Chang M, Hsu HY, Yeh S, Chang C

Cytogenetic and genome research.. 2003 103 (3-4):299-301. Epub 1900 01 01.

Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4.

Kang HY, Huang KE, Chang SY, Ma WL, Lin WJ, Chang C

The Journal of biological chemistry.. 2002 November 15277 (46):43749-56. Epub 09/10/2002.

Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH

Journal of medicinal chemistry.. 2002 November 745 (23):5037-42. Epub 1900 01 01.

Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, Chang C

Cancer research.. 2002 November 162 (21):6039-44. Epub 1900 01 01.

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.

Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC

Proceedings of the National Academy of Sciences of the United States of America.. 2002 October 1599 (21):13498-503. Epub 10/07/2002.

The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.

Heinlein CA, Chang C

Molecular endocrinology.. 2002 October 16 (10):2181-7. Epub 1900 01 01.

Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.

Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C

The Journal of biological chemistry.. 2002 September 27277 (39):36499-508. Epub 06/14/2002.

Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells.

Lin HK, Altuwaijri S, Lin WJ, Kan PY, Collins LL, Chang C

The Journal of biological chemistry.. 2002 September 27277 (39):36570-6. Epub 07/15/2002.

Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.

Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C

The Journal of biological chemistry.. 2002 September 13277 (37):33571-9. Epub 07/01/2002.

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.

Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C

The EMBO journal.. 2002 August 121 (15):4037-48. Epub 1900 01 01.

Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily.

Lee YF, Lee HJ, Chang C

The Journal of steroid biochemistry and molecular biology.. 2002 August 81 (4-5):291-308. Epub 1900 01 01.

Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2.

Shyr CR, Collins LL, Mu XM, Platt KA, Chang C

Molecular and cellular biology.. 2002 July 22 (13):4661-6. Epub 1900 01 01.

Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.

Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C

The Journal of biological chemistry.. 2002 May 3277 (18):15426-31. Epub 02/20/2002.

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function.

Fu M, Wang C, Wang J, Zhang X, Sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua SA, Jaffray E, Hay RT, Palvimo JJ, Jänne OA, Pestell RG

Molecular and cellular biology.. 2002 May 22 (10):3373-88. Epub 1900 01 01.

Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells.

Shyr CR, Hu YC, Kim E, Chang C

The Journal of biological chemistry.. 2002 April 26277 (17):14622-8. Epub 02/13/2002.

Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study.

Hsing AW, Chokkalingam AP, Gao YT, Wu G, Wang X, Deng J, Cheng J, Sesterhenn IA, Mostofi FK, Chiang T, Chen YL, Stanczyk FZ, Chang C

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2002 April 11 (4):337-41. Epub 1900 01 01.

Androgen receptor (AR) coregulators: an overview.

Heinlein CA, Chang C

Endocrine reviews.. 2002 April 23 (2):175-200. Epub 1900 01 01.

A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth.

Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C

The Journal of biological chemistry.. 2002 February 15277 (7):4609-17. Epub 10/22/2001.

Supervillin associates with androgen receptor and modulates its transcriptional activity.

Ting HJ, Yeh S, Nishimura K, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2002 January 2299 (2):661-6. Epub 01/15/2002.

Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity.

Schinner S, Dellas C, Schroder M, Heinlein CA, Chang C, Fischer J, Knepel W

The Journal of biological chemistry.. 2002 January 18277 (3):1941-8. Epub 11/13/2001.

"The use of a flow cytometry analysis in the study of different expression of androgen receptor in human prostate cancer LNCaP and PC-3 cells."

Shih, C.; Chang, E.; Zhang, Y.; Lai, C.; Su, C.; Chen, Y.; Chang, H.; Chiang, T.; and Chang, C.

New Taipei Journal of Medicine. 2002; 4: 151-158.

"Phosphorylation-dependent ubiquitination and degradation of AR by Akt requires Mdm2 E3 ligase."

Lin, HK.; Wang, L.; Hu, YC.; Altuwaijri, S.; and Chang, C.

EMBO 21, 1-12. 2002; 21: 1-12.

Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells.

Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C

The Journal of biological chemistry.. 2001 November 2276 (44):40417-23. Epub 08/16/2001.

Potential anti-androgenic activity of roxithromycin in skin.

Inui S, Nakajima T, Fukuzato Y, Fujimoto N, Chang C, Yoshikawa K, Itami S

Journal of dermatological science.. 2001 October 27 (2):147-51. Epub 1900 01 01.

TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif.

Lee HJ, Lee YF, Chang C

Biochemical and biophysical research communications.. 2001 August 3285 (5):1361-8. Epub 1900 01 01.

Gender difference in cytoprotection induced by estrogen on female and male bovine aortic endothelial cells.

Si ML, Al-Sharafi B, Lai CC, Khardori R, Chang C, Su CY

Endocrine.. 2001 August 15 (3):255-62. Epub 1900 01 01.

Feedback regulation between orphan nuclear receptor TR2 and human papilloma virus type 16.

Collins LL, Lin DL, Mu XM, Chang C

The Journal of biological chemistry.. 2001 July 20276 (29):27316-21. Epub 05/17/2001.

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin HK, Yeh S, Kang HY, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2001 June 1998 (13):7200-5. Epub 06/12/2001.

Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation.

Lee DK, Duan HO, Chang C

The Journal of biological chemistry.. 2001 March 30276 (13):9978-84. Epub 12/21/2000.

From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells.

Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2001 March 1398 (6):3018-23. Epub 03/06/2001.

Localization of androgen receptor expression in human bone marrow.

Mantalaris A, Panoskaltsis N, Sakai Y, Bourne P, Chang C, Messing EM, Wu JH

The Journal of pathology.. 2001 March 193 (3):361-6. Epub 1900 01 01.

Role of chaperones in nuclear translocation and transactivation of steroid receptors.

Heinlein CA, Chang C

Endocrine.. 2001 March 14 (2):143-9. Epub 1900 01 01.

Identification and characterization of androgen receptor associated coregulators in prostate cancer cells.

Sampson ER, Yeh SY, Chang HC, Tsai MY, Wang X, Ting HJ, Chang C

Journal of biological regulators and homeostatic agents.. 2001 15 (2):123-9. Epub 1900 01 01.

Quercetin cumulatively enhances copper induction of metallothionein in intestinal cells.

Kuo SM, Huang CT, Blum P, Chang C

Biological trace element research.. 2001 84 (1-3):1-10. Epub 1900 01 01.

Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer.

Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, Chang HC, Altuwaijri S, Huang KE, Chang C

Journal of the Formosan Medical Association = Taiwan yi zhi.. 2000 December 99 (12):885-94. Epub 1900 01 01.

Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.

Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2000 October 1097 (21):11256-61. Epub 1900 01 01.

Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China.

Hsing AW, Gao YT, Wu G, Wang X, Deng J, Chen YL, Sesterhenn IA, Mostofi FK, Benichou J, Chang C

Cancer research.. 2000 September 1560 (18):5111-6. Epub 1900 01 01.

The p53/retinoblastoma-mediated repression of testicular orphan receptor-2 in the rhesus monkey with cryptorchidism.

Mu X, Liu Y, Collins LL, Kim E, Chang C

The Journal of biological chemistry.. 2000 August 4275 (31):23877-83. Epub 1900 01 01.

Methylation of the androgen receptor minimal promoter silences transcription in human prostate cancer.

Kinoshita H, Shi Y, Sandefur C, Meisner LF, Chang C, Choon A, Reznikoff CR, Bova GS, Friedl A, Jarrard DF

Cancer research.. 2000 July 160 (13):3623-30. Epub 1900 01 01.

Lack of androgen receptor transcriptional activity in human keratinocytes.

Inui S, Itami S, Pan HJ, Chang C

Journal of dermatological science.. 2000 June 23 (2):87-92. Epub 1900 01 01.

Expression of the orphan receptor TR4 during brain development of the rat.

van Schaick HS, Rosmalen JG, Lopes da Silva S, Chang C, Burbach JP

Brain research. Molecular brain research.. 2000 April 1477 (1):104-10. Epub 1900 01 01.

Differential regulation of testosterone vs. 5alpha-dihydrotestosterone by selective androgen response elements.

Hsiao PW, Thin TH, Lin DL, Chang C

Molecular and cellular biochemistry.. 2000 March 206 (1-2):169-75. Epub 1900 01 01.

Antiandrogens fail to block androstenedione-mediated mutated androgen receptor transactivation in human prostate cancer cells.

Miyamoto H, Chang C

International journal of urology : official journal of the Japanese Urological Association.. 2000 January 7 (1):32-4. Epub 1900 01 01.

Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.

Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1999 December 2196 (26):14724-9. Epub 1900 01 01.

Roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells.

Pan HJ, Uno H, Inui S, Fulmer NO, Chang C

Endocrine.. 1999 December 11 (3):321-7. Epub 1900 01 01.

Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids.

Kameoka S, Leavitt P, Chang C, Kuo SM

Cancer letters.. 1999 November 15146 (2):161-7. Epub 1900 01 01.

Monoclonal anti-androgen receptor antibodies: production, characterization and potential diagnostic applications.

Shih CC, Young WJ, Wang CH, Jin LP, Ji XD, Guan Q, Wang M, Chang C

Molecular and cellular biochemistry.. 1999 November 201 (1-2):131-40. Epub 1900 01 01.

Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells.

Yeh S, Kang HY, Miyamoto H, Nishimura K, Chang HC, Ting HJ, Rahman M, Lin HK, Fujimoto N, Hu YC, Mizokami A, Huang KE, Chang C

Endocrine.. 1999 October 11 (2):195-202. Epub 1900 01 01.

Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells.

Chang HC, Miyamoto H, Marwah P, Lardy H, Yeh S, Huang KE, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1999 September 2896 (20):11173-7. Epub 1900 01 01.

Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.

Hsiao PW, Chang C

The Journal of biological chemistry.. 1999 August 6274 (32):22373-9. Epub 1900 01 01.

The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.

Hsiao PW, Lin DL, Nakao R, Chang C

The Journal of biological chemistry.. 1999 July 16274 (29):20229-34. Epub 1900 01 01.

Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.

Heinlein CA, Ting HJ, Yeh S, Chang C

The Journal of biological chemistry.. 1999 June 4274 (23):16147-52. Epub 1900 01 01.

Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor.

Lee YF, Young WJ, Lin WJ, Shyr CR, Chang C

The Journal of biological chemistry.. 1999 June 4274 (23):16198-205. Epub 1900 01 01.

Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators.

Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK, Chang C

The Keio journal of medicine.. 1999 June 48 (2):87-92. Epub 1900 01 01.

Isolation of Ku70-binding proteins (KUBs).

Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA

Nucleic acids research.. 1999 May 1527 (10):2165-74. Epub 1900 01 01.

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.

Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1999 May 1196 (10):5458-63. Epub 1900 01 01.

Androgen effects on the solubility and conformational change of the androgen receptor in baculovirus expression system.

Wang C, Young WJ, Chang C

Molecular and cellular biochemistry.. 1999 May 195 (1-2):19-23. Epub 1900 01 01.

Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes.

Inui S, Lee YF, Haake AR, Goldsmith LA, Chang C

The Journal of investigative dermatology.. 1999 April 112 (4):426-31. Epub 1900 01 01.

Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor.

Lee HJ, Lee YF, Chang C

Molecular and cellular biochemistry.. 1999 April 194 (1-2):199-207. Epub 1900 01 01.

Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.

Kang HY, Yeh S, Fujimoto N, Chang C

The Journal of biological chemistry.. 1999 March 26274 (13):8570-6. Epub 1900 01 01.

Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.

Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C

The Journal of biological chemistry.. 1999 March 19274 (12):8316-21. Epub 1900 01 01.

Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells.

Jarrard DF, Kinoshita H, Shi Y, Sandefur C, Hoff D, Meisner LF, Chang C, Herman JG, Isaacs WB, Nassif N

Cancer research.. 1998 December 158 (23):5310-4. Epub 1900 01 01.

Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells.

Miyamoto H, Yeh S, Lardy H, Messing E, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1998 September 1595 (19):11083-8. Epub 1900 01 01.

A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway.

Young WJ, Lee YF, Smith SM, Chang C

The Journal of biological chemistry.. 1998 August 14273 (33):20877-85. Epub 1900 01 01.

Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: transactivation of the TR3/nur77 gene by Tax protein.

Chen X, Zachar V, Chang C, Ebbesen P, Liu X

Journal of virology.. 1998 August 72 (8):6902-6. Epub 1900 01 01.

Induction of an intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR3 orphan receptor.

Mu XM, Young WJ, Liu YX, Uemura H, Chang C

Endocrine.. 1998 August 9 (1):27-32. Epub 1900 01 01.

Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques.

Pan HJ, Wilding G, Uno H, Inui S, Goldsmith L, Messing E, Chang C

Endocrine.. 1998 August 9 (1):39-43. Epub 1900 01 01.

Ontogeny and autoregulation of androgen receptor mRNA expression in the nervous system.

Young WJ, Chang C

Endocrine.. 1998 August 9 (1):79-88. Epub 1900 01 01.

Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells.

Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, Chang C

Biochemical and biophysical research communications.. 1998 July 20248 (2):361-7. Epub 1900 01 01.

Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.

Miyamoto H, Yeh S, Wilding G, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1998 June 2395 (13):7379-84. Epub 1900 01 01.

Androgen receptors in ovarian tumors: correlation with oestrogen and progesterone receptors in an immunohistochemical and semiquantitative image analysis study.

Cardillo MR, Petrangeli E, Aliotta N, Salvatori L, Ravenna L, Chang C, Castagna G

Journal of experimental & clinical cancer research : CR.. 1998 June 17 (2):231-7. Epub 1900 01 01.

Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily.

Lee YF, Young WJ, Burbach JP, Chang C

The Journal of biological chemistry.. 1998 May 29273 (22):13437-43. Epub 1900 01 01.

From estrogen to androgen receptor: a new pathway for sex hormones in prostate.

Yeh S, Miyamoto H, Shima H, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1998 May 1295 (10):5527-32. Epub 1900 01 01.

Antisense TR3 orphan receptor can increase prostate cancer cell viability with etoposide treatment.

Uemura H, Chang C

Endocrinology.. 1998 May 139 (5):2329-34. Epub 1900 01 01.

Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines.

Lin MF, Meng TC, Rao PS, Chang C, Schonthal AH, Lin FF

The Journal of biological chemistry.. 1998 March 6273 (10):5939-47. Epub 1900 01 01.

Constitutive and inducible hsp70s are involved in oxidative resistance evoked by heat shock or ethanol.

Su CY, Chong KY, Owen OE, Dillmann WH, Chang C, Lai CC

Journal of molecular and cellular cardiology.. 1998 March 30 (3):587-98. Epub 1900 01 01.

Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection.

Chong KY, Lai CC, Lille S, Chang C, Su CY

Journal of molecular and cellular cardiology.. 1998 March 30 (3):599-608. Epub 1900 01 01.

Immunohistochemical quantification and determination of Cathepsin D in prostatic neoplasia: correlation with steroid.

Cardillo, MR.; Petrangeli, E.; Ravenna, L.; Salvatori, L.; Chang, C.; DiSilverio, F.

Applied Immunohistochemistry 6(3), 133-139. 1998; 6(3): 133-139.

Mechanism of the interaction between orphan receptor TR3 and cis-acting element in CNTFR? gene.

Mu, XM.; Liu, YX.; and Chang, C.

Chinese J. Biochemistry and Molecular Biology . 1998; 14: 484-492.

Heterogeneity of androgen receptor content in advanced prostate cancer.

Magi-Galluzzi C, Xu X, Hlatky L, Hahnfeldt P, Kaplan I, Hsiao P, Chang C, Loda M

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 1997 August 10 (8):839-45. Epub 1900 01 01.

Identification of the human aldolase A gene as the first induced target for the TR2 orphan receptor, a member of the steroid hormone receptor superfamily.

Chang C, Lee HJ, Lee YF

Biochemical and biophysical research communications.. 1997 June 9235 (1):205-11. Epub 1900 01 01.

Transcriptional up-regulation of the human androgen receptor by androgen in bone cells.

Wiren KM, Zhang X, Chang C, Keenan E, Orwoll ES

Endocrinology.. 1997 June 138 (6):2291-300. Epub 1900 01 01.

Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone.

Lin TM, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1997 May 1394 (10):4988-93. Epub 1900 01 01.

Identification of direct repeat 4 as a positive regulatory element for the human TR4 orphan receptor. A modulator for the thyroid hormone target genes.

Lee YF, Pan HJ, Burbach JP, Morkin E, Chang C

The Journal of biological chemistry.. 1997 May 2272 (18):12215-20. Epub 1900 01 01.

Hydroxyflutamide may not always be a pure antiandrogen.

Yeh S, Miyamoto H, Chang C

Lancet.. 1997 March 22349 (9055):852-3. Epub 1900 01 01.

Androgen receptor and androgen receptor cofactors in prostate.

Miyamoto, H.; Yeh, S.; Kinoshita, H.; Fujimoto, N.; Nishimura, K.; Inui, S.; Mizokami, A.; Uemura, H.; and Chang, C.

Proc. Jap. Nat. Conf. Andrology, 1-4. 1997; : 1-4.

Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter.

Keller ET, Chang C, Ershler WB

The Journal of biological chemistry.. 1996 October 18271 (42):26267-75. Epub 1900 01 01.

The first detection of complete androgen insensitivity with no mutation in the coding sequence of the androgen receptor gene.

Lee HJ, Mowszowicz I, Chang C

Frontiers in bioscience : a journal and virtual library.. 1996 July 11 :a34-8. Epub 07/01/1996.

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

Yeh S, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 1996 May 2893 (11):5517-21. Epub 1900 01 01.

Suppression of the human erythropoietin gene expression by the TR2 orphan receptor, a member of the steroid receptor superfamily.

Lee HJ, Young WJ, Shih CY, Chang C

The Journal of biological chemistry.. 1996 April 26271 (17):10405-12. Epub 1900 01 01.

Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system.

Lin TM, Young WJ, Chang C

The Journal of biological chemistry.. 1995 December 15270 (50):30121-8. Epub 1900 01 01.

Suppression of gene expression on the simian virus 40 major late promoter by human TR4 orphan receptor. A member of the steroid receptor superfamily.

Lee HJ, Lee Y, Burbach JP, Chang C

The Journal of biological chemistry.. 1995 December 15270 (50):30129-33. Epub 1900 01 01.

Expression of nuclear hormone receptors in the rat supraoptic nucleus.

Lopes da Silva S, Van Horssen AM, Chang C, Burbach JP

Endocrinology.. 1995 May 136 (5):2276-83. Epub 1900 01 01.

The expression of prostatic acid phosphatase is transcriptionally regulated in human prostate carcinoma cells.

Garcia-Arenas R, Lin FF, Lin D, Jin LP, Shih CC, Chang C, Lin MF

Molecular and cellular endocrinology.. 1995 April 28111 (1):29-37. Epub 1900 01 01.

Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily.

Ideta R, Yeh S, Lee Y, Adachi K, Takeda H, Su C, Saltzman A, Chang C

Endocrine.. 1995 April 3 (4):277-83. Epub 1900 01 01.

Identification of a new enhancer in the promoter region of human TR3 orphan receptor gene. A member of steroid receptor superfamily.

Uemura H, Mizokami A, Chang C

The Journal of biological chemistry.. 1995 March 10270 (10):5427-33. Epub 1900 01 01.

Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter.

Lee HJ, Chang C

The Journal of biological chemistry.. 1995 March 10270 (10):5434-40. Epub 1900 01 01.

Differential regulation of glutathione S-transferase -Yb1 mRNA levels in rat prostate, liver, and brain by androgen.

Yuan, Z.; Zhang, Y.; Chang, C.; and Zhang, YL.

Cell Research. 1995; 55: 235-242.

Androgen receptor: an overview.

Chang C, Saltzman A, Yeh S, Young W, Keller E, Lee HJ, Wang C, Mizokami A

Critical reviews in eukaryotic gene expression.. 1995 5 (2):97-125. Epub 1900 01 01.

An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells.

Lustig RH, Hua P, Smith LS, Wang C, Chang C

Molecular and cellular neurosciences.. 1994 December 5 (6):587-96. Epub 1900 01 01.

Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats.

Pugh TD, Chang C, Uemura H, Weindruch R

Cancer research.. 1994 November 1554 (22):5766-70. Epub 1900 01 01.

Induction of translation by the 5'-untranslated region of human androgen receptor mRNA.

Mizokami A, Chang C

The Journal of biological chemistry.. 1994 October 14269 (41):25655-9. Epub 1900 01 01.

Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.

Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP

Proceedings of the National Academy of Sciences of the United States of America.. 1994 June 2191 (13):6040-4. Epub 1900 01 01.

Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells.

Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M, Akedo Y, Nakamura T, Ouchi Y, Chang C, Orimo H

Calcified tissue international.. 1994 April 54 (4):325-6. Epub 1900 01 01.

Quantitation of androgen receptor mRNA by competitive reverse transcription-polymerase chain reaction.

Young, W-J.; Roecker, EB.; Weindruch, R.; and Chang, C.

Endocrine. 1994; 2: 321-329.

Ultrastructural localization of androgen receptors in levator ani muscle in the rat.

Joubert , Y,; Tobin, C,; Lebart, MC,; and Chang, C.

Proc. Intl. Conf. Elec. Microscopy. 1994; 13: 325-326.

Identification of an androgen-induced C3-P4 DNA binding protein in the cytosol of rat ventral prostate.

Zhang YL, Wang C, Wilding G, Chang C

Biochemical and biophysical research communications.. 1993 September 15195 (2):710-6. Epub 1900 01 01.

The use of a DNA-binding domain replacement method for the detection of a potential TR3 orphan receptor response element in the mouse mammary tumor virus long terminal repeat.

Lee HJ, Kokontis J, Wang KC, Chang C

Biochemical and biophysical research communications.. 1993 July 15194 (1):97-103. Epub 1900 01 01.

Immunolocalization of androgen receptor in the small, preovulatory, and postovulatory follicles of laying hens.

Yoshimura Y, Chang C, Okamoto T, Tamura T

General and comparative endocrinology.. 1993 July 91 (1):81-9. Epub 1900 01 01.

A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance.

Mowszowicz I, Lee HJ, Chen HT, Mestayer C, Portois MC, Cabrol S, Mauvais-Jarvis P, Chang C

Molecular endocrinology.. 1993 July 7 (7):861-9. Epub 1900 01 01.

Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.

Rennie PS, Bruchovsky N, Leco KJ, Sheppard PC, McQueen SA, Cheng H, Snoek R, Hamel A, Bock ME, MacDonald BS

Molecular endocrinology.. 1993 January 7 (1):23-36. Epub 1900 01 01.

Complete androgen insensitivity due to a single base substitution in exon 8 of the steroid-binding domain of the androgen receptor.

Mowszowicz, I.; Lee, H-J.; Portois, M-C.; Kuttenn, F.; and Chang, C.

Endocrine. 1993; 1: 203-209.

Genomic structure, chromosomal localization and expression of an inducible TR3 orphan receptor: A member of the steroid receptor superfamily.

Chang, C.; Saltzman, AG.; Lee, H.; Uemura, H.; Su, C.; Chodak, GW.; Nakamoto, T.; LeBeau, M.; Espinosa, R.; Davis, E.; Lemons, R.; Sivak, L.; and Shih, C.

Endocrine. 1993; 1: 541-549.

Immunolocalization of androgen receptor in the cloacal gland of male Japanese quail (Coturnis coturnix japonica).

Kaku, A,.; Chang, C.; Tamura, T.; Okamoto, T.; and Yoshimura, Y.

Japanese Poultry Science. 1993; : 413-418.

An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.

Jiang SY, Wolf DM, Yingling JM, Chang C, Jordan VC

Molecular and cellular endocrinology.. 1992 December 90 (1):77-86. Epub 1900 01 01.

Immunohistochemical and in situ hybridization studies of androgen receptor expression in a transplantable androgen-independent prostatic carcinoma line (AIT) of Noble rats.

Leav I, Kwan PW, Merk FB, Chang C, Ho SM

Laboratory investigation; a journal of technical methods and pathology.. 1992 December 67 (6):788-95. Epub 1900 01 01.

Characterization of human androgen receptor overexpressed in the baculovirus system.

Chang C, Wang C, DeLuca HF, Ross TK, Shih CC

Proceedings of the National Academy of Sciences of the United States of America.. 1992 July 189 (13):5946-50. Epub 1900 01 01.

Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes.

Prior L, Bordet S, Trifiro MA, Mhatre A, Kaufman M, Pinsky L, Wrogeman K, Belsham DD, Pereira F, Greenberg C

American journal of human genetics.. 1992 July 51 (1):143-55. Epub 1900 01 01.

Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase.

Gipp JJ, Chang C, Mulcahy RT

Biochemical and biophysical research communications.. 1992 May 29185 (1):29-35. Epub 1900 01 01.

Nuclear localization of androgen receptor in heterogeneous samples of normal, hyperplastic and neoplastic human prostate.

Chodak GW, Kranc DM, Puy LA, Takeda H, Johnson K, Chang C

The Journal of urology.. 1992 March 147 (3 Pt 2):798-803. Epub 1900 01 01.

Basic fibroblast growth factor in human prostate cancer cells.

Nakamoto T, Chang CS, Li AK, Chodak GW

Cancer research.. 1992 February 152 (3):571-7. Epub 1900 01 01.

Regulation of androgen receptor mRNA in rat Sertoli and peritubular cells.

Sanborn BM, Caston LA, Chang C, Liao S, Speller R, Porter LD, Ku CY

Biology of reproduction.. 1991 October 45 (4):634-41. Epub 1900 01 01.

Autoregulation of androgen receptor expression in rodent prostate: immunohistochemical and in situ hybridization analysis.

Takeda H, Nakamoto T, Kokontis J, Chodak GW, Chang C

Biochemical and biophysical research communications.. 1991 May 31177 (1):488-96. Epub 1900 01 01.

The 56/58 kDa androgen-binding protein in male genital skin fibroblasts with a deleted androgen receptor gene.

Trifiro M, Gottlieb B, Pinsky L, Kaufman M, Prior L, Belsham DD, Wrogemann K, Brown CJ, Willard HF, Trapman J

Molecular and cellular endocrinology.. 1991 January 75 (1):37-47. Epub 1900 01 01.

[Expression of androgen receptor gene in normal subjects and patients with complete androgen insensitivity].

Mestayer C, Gabou L, Portois MC, Boucekkine C, Chang C, Mowszowicz I

Annales d'endocrinologie.. 1991 52 (6):431-4. Epub 1900 01 01.

Transcriptional activation by TR3 receptor, a member of the steroid receptor superfamily.

Kokontis J, Liao S, Chang C

Receptor. 1991 1 (4):261-70. Epub 1900 01 01.

Localization and regulation of estrogen, progestin and androgen receptors in the seminal vesicle of the rhesus monkey.

West NB, Chang CS, Liao SS, Brenner RM

The Journal of steroid biochemistry and molecular biology.. 1990 September 37 (1):11-21. Epub 1900 01 01.

Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor.

Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C

The Journal of endocrinology.. 1990 July 126 (1):17-25. Epub 1900 01 01.

An exonic point mutation of the androgen receptor gene in a family with complete androgen insensitivity.

Sai TJ, Seino S, Chang CS, Trifiro M, Pinsky L, Mhatre A, Kaufman M, Lambert B, Trapman J, Brinkmann AO

American journal of human genetics.. 1990 June 46 (6):1095-100. Epub 1900 01 01.

DNA linkage analysis and studies of the androgen receptor gene in a large kindred with complete androgen insensitivity.

Imperato-McGinley J, Ip NY, Gautier T, Neuweiler J, Gruenspan H, Liao S, Chang C, Balazs I

American journal of medical genetics.. 1990 May 36 (1):104-8. Epub 1900 01 01.

Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study.

Simerly RB, Chang C, Muramatsu M, Swanson LW

The Journal of comparative neurology.. 1990 April 1294 (1):76-95. Epub 1900 01 01.

Androgen receptor staining in heterogeneous samples of normal, hyperplastic, and neoplastic human prostate

Kranc DM; Chodak GW; and Chang C.

Surgical Forum. 1990; 41: 687-689.

Immunohistochemical study of androgen receptor in benign hyperplastic and cancerous human prostates.

Masai M, Sumiya H, Akimoto S, Yatani R, Chang CS, Liao SS, Shimazaki J

The Prostate.. 1990 17 (4):293-300. Epub 1900 01 01.

Molecular cloning and structural analysis of complementary DNA of human and rat androgen receptors.

Chang C, Kokontis J, Swift S, Liao ST

Progress in clinical and biological research.. 1990 322 :53-63. Epub 1900 01 01.

Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains.

Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y

Biochemical and biophysical research communications.. 1989 December 15165 (2):735-41. Epub 1900 01 01.

Induction of the TRPM-2 gene in cells undergoing programmed death.

Buttyan R, Olsson CA, Pintar J, Chang C, Bandyk M, Ng PY, Sawczuk IS

Molecular and cellular biology.. 1989 August 9 (8):3473-81. Epub 1900 01 01.

Fusion proteins containing androgen receptor sequences and their use in the production of poly- and monoclonal anti-androgen receptor antibodies.

Chang CS, Whelan CT, Popovich TC, Kokontis J, Liao ST

Endocrinology.. 1989 August 125 (2):1097-9. Epub 1900 01 01.

Prostate androgen receptor: immunohistological localization and mRNA characterization.

Chang C, Chodak G, Sarac E, Takeda H, Liao S

Journal of steroid biochemistry.. 1989 34 (1-6):311-3. Epub 1900 01 01.

Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.

Chang C, Kokontis J, Liao SS, Chang Y

Journal of steroid biochemistry.. 1989 34 (1-6):391-5. Epub 1900 01 01.

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

Chang CS, Kokontis J, Liao ST

Proceedings of the National Academy of Sciences of the United States of America.. 1988 October 85 (19):7211-5. Epub 1900 01 01.

Identification of a new member of the steroid receptor super-family by cloning and sequence analysis.

Chang C, Kokontis J

Biochemical and biophysical research communications.. 1988 September 15155 (2):971-7. Epub 1900 01 01.

Correction of the cDNA-derived protein sequence of prostatic spermine binding protein: pivotal role of tandem mass spectrometry in sequence analysis.

Anderegg RJ, Carr SA, Huang IY, Hiipakka RA, Chang CS, Liao ST

Biochemistry.. 1988 June 1427 (12):4214-21. Epub 1900 01 01.

Molecular cloning of human and rat complementary DNA encoding androgen receptors.

Chang CS, Kokontis J, Liao ST

Science.. 1988 April 15240 (4850):324-6. Epub 1900 01 01.

Gene expression and structure analysis of cDNA's for androgen-sensitive proteins and different forms of steroid-receptors.

Chang, C.; and Liao, S.

Progress in Cancer Research and Therapy. 1988; 35: 43-48.

Cloning and sequence analysis of the rat ventral prostate glucocorticoid receptor cDNA.

Chang CS, Kokontis J, Chang CT, Liao SS

Nucleic acids research.. 1987 November 2515 (22):9603. Epub 1900 01 01.

Identification of glutathione S-transferase Yb1 mRNA as the androgen-repressed mRNA by cDNA cloning and sequence analysis.

Chang CS, Saltzman AG, Sorensen NS, Hiipakka RA, Liao SS

The Journal of biological chemistry.. 1987 September 5262 (25):11901-3. Epub 1900 01 01.

Prostatic spermine-binding protein. Cloning and nucleotide sequence of cDNA, amino acid sequence, and androgenic control of mRNA level.

Chang CS, Saltzman AG, Hiipakka RA, Huang IY, Liao SS

The Journal of biological chemistry.. 1987 February 25262 (6):2826-31. Epub 1900 01 01.

Androgen repression of the production of a 29-kilodalton protein and its mRNA in the rat ventral prostate.

Saltzman AG, Hiipakka RA, Chang C, Liao S

The Journal of biological chemistry.. 1987 January 5262 (1):432-7. Epub 1900 01 01.

Topographic recognition of cyclic hydrocarbons and related compounds by receptors for androgens, estrogens, and glucocorticoids.

Chang CS, Liao SS

Journal of steroid biochemistry.. 1987 27 (1-3):123-31. Epub 1900 01 01.

The use of a hydroxylapatite-filter steroid receptor assay method in the study of the modulation of androgen receptor interaction.

Liao S, Witte D, Schilling K, Chang C

Journal of steroid biochemistry.. 1984 January 20 (1):11-7. Epub 1900 01 01.

Books

Prostate Cancer: Basic Mechanisms and Therapeutic Approaches (2005)

Authors: Chang, et al

Publisher: World Scientific 2005

Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. (2005)

Chapter: "Study of androgen receptor roles in prostate cancer using mice lacking functional prostate androgen receptor"

Authors: Wu C, Yeh S, Xu Q, Yang Z, Chang P, Yu Y, and Chang C

Publisher: World Scientific. USA. 2005

Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. (2005)

Chapter: "Hormonal therapy for prostate cancer: clinical and experimental evidence."

Authors: Miyamoto, H.; and Chang, C

Publisher: World Scientific. USA. 2005

Molecular mechanisms of action of steroid receptors (2003)

Chapter: "Androgen receptor."

Authors: Lee HJ, Sampson ER, Hsu CL, Chen YT and Chang C

Publisher: Research Signpost, India. 2003

Androgens and Androgen Receptor: Mechanisms, Functions, and Clinical Application (2002)

Authors: Chang, et al

Publisher: Kluwer Academic Publishers 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors.

Authors: Heinlein C, Sampson E and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: Structural and Functional Analysis of the Androgen Receptor.

Authors: Heinlein C and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: Nongenomic Androgen Action.

Authors: Heinlein C and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application (2002)

Chapter: Androgens in Dermatology: Hair Loss, Acne, and Other Diseases.

Authors: Itami S. Inui S, Uno H, Pan H, Chang E, Takayasu S, Ye F, Imamura K, Seki T, Ideta R, Aoki H, Adachi K, Price V, Kurata S, Collins L, Heinlein C and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: "Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity."

Authors: Heinlein C and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: "The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications."

Authors: Hsing A, Culig Z, Wang X, Uemura H and Chang C

Publisher: Kluwer, USA. 2002

Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (2002)

Chapter: "Androgens in Spermatogenesis and Contraception."

Authors: Collins L and Chang C

Publisher: Kluwer, USA. 2002

Steroid hormones and cell cycle regulation. (2002)

Chapter: "Interaction of cell cycle regulatory proteins with the androgen receptor."

Authors: Sampson E, Yeh S. Miyamoto H, Lee DK, Tsi, MY, Wang X, Hsu CL, and Chang C

Publisher: Kluwer, USA. 2002

Yeast Hybrid Technologies (2000)

Chapter: "Yeast two-hybrid screening of associated proteins and characterization of mutant androgen receptors."

Authors: Nishimura K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh S, and Chang C

Publisher: Eaton Publishing. 2000

Molecular Basis of Sex Hormone Receptor Function (1998)

Chapter: The Androgen Receptor Coregulator ARA70.

Authors: Miyamoto H, Yeh S, Huang S-B, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C, Uemura H, Kang H, and Chang C

Publisher: Springer, Berlin 1998

Pharmacology, Biology and Clinical Application of Androgens. (1996)

Chapter: "Androgen-responsive genes."

Authors: Chang C, Lin T-M, Hsiao P, Su C, Riebe J, and Lin D-L

Publisher: Wiley-Liss, Inc. 1996

Pharmacology in Exercise and Sports. (1996)

Chapter: "Induction of heat shock proteins by exercise.

Authors: Su C-Y, Chang C, and Lai C-C

Publisher: CRC Press,, London. 1996

The Physiology of Immunity (1996)

Chapter: "The role of androgens-androgen receptor in immune system activity."

Authors: Lin T, Lustig RH, and Chang C

Publisher: CRC Press,, Boca Raton FL. 1996

in The Steroid/Thyroid Hormone Receptor Family and Gene Regulation. (1989)

Chapter: Characterization of new members of steroid receptor superfamily." eds.) 183-195,

Authors: Chang C, Lau L, Liao S, and Kokontis J

Publisher: Congressdruck R. Bruckner, Berlin, Burkhauser Verlag Basel. 1989

The Steroid/Thyroid Hormone Receptor Family and Gene Regulation. (1989)

Chapter: Structure and intranuclear dynamics of androgen receptors.

Authors: Liao S, Chang C, Kokontis J, Popovich T, and Hiipakka RA

Publisher: Congressdruck R. Bruckner, Berlin, Burkhauser Verlag Basel. 1989

Hormonal Therapy of Prostatic Disease: Basic and Clinical Aspects (1987)

Chapter: Modulation of androgen receptor activity and the effect of androgens on gene expression for specific proteins.

Authors: Liao S, Chang C, Sorensen NS, Chang C-T, and Hiipakka RA

Publisher: Medicom Europe, The Netherlands. 1987

Regulation of Androgen Action, (1985)

Chapter: "Modulation of androgen receptor and androgen-dependent enhancement and repression of protein synthesis."

Authors: Liao S, Chang C, Witte D, Saltzman AG, and Hiipakka RA

Publisher: Congressdruck R. Bruckner, Berlin 1985

Interaction of Steroid Hormone Receptors with DNA (1985)

Chapter: "Cellular dynamics and control of androgen receptor activity."

Authors: Liao S, and Chang C

Publisher: Ellis Horwood Ltd. Publishers, , Chichester, England. 1985