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Carl J. Johnston, Ph.D.

Carl J. Johnston, Ph.D.

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About Me

Faculty Appointments

Research Associate Professor - Department of Pediatrics, Neonatology (SMD)

Credentials

Education

PhD | SUNY at Buffalo. Pharmacology and Toxicology. 2006

MS | University of Rochester. Toxicology. 1993

BA | Buffalo State College. Biology. 1987

Awards

SOT Meeting, Outstanding Presentation – Mixtures Specialty Section. 2012

Research

Dr. Carl Johnston's work seeks to understand how the postnatal lung copes with external stress. A critical biological factor that plays a role in childhood pulmonary susceptibility is that a significant portion of lung development takes place postnatally. One of the environmental factors relevant t...
Dr. Carl Johnston's work seeks to understand how the postnatal lung copes with external stress. A critical biological factor that plays a role in childhood pulmonary susceptibility is that a significant portion of lung development takes place postnatally. One of the environmental factors relevant to developmental lung disease is the recent increase in complexity and distribution, if not the levels, of airborne pollutants, including allergens and endotoxins, respirable particulate matter and irritant gases, exposure to which damages various cell types. Among the most important of these are the respiratory epithelium and critical immune effector cell populations. Furthermore; combined exposures to multiple pollutants may activate several unique signaling pathways which are age dependent and depending on the sequence of initiation may result in responses not predicted by evaluating exposures to an individual pollutant. His work depends heavily on mRNA analysis, microarray technology, immuno-histochemistry and in situ hybridization. This work is supported by participation in several NIH grants.

Publications

Journal Articles

Cranial irradiation disrupts homeostatic microglial dynamic behavior.

Strohm AO, Johnston C, Hernady E, Marples B, O'Banion MK, Majewska AK

Journal of neuroinflammation.. 2024 April 321 (1):82. Epub 04/03/2024.

IL-17A Neutralization Fails to Attenuate Airway Remodeling and Potentiates a Pro-Inflammatory Lung Microenvironment in Diacetyl-Exposed Rats.

House EL, Kim SY, Chalupa D, Hernady E, Groves AM, Johnston CJ, McGraw MD

American journal of physiology. Lung cellular and molecular physiology.. 2023 August 29 Epub 08/29/2023.

Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model.

Groves AM, Johnston CJ, Beutner G, Dahlstrom JE, Koina M, O'Reilly M, Marples B, Porter G, Brophy PD, Kent AL

Physiological reports.. 2023 August 11 (15):e15773. Epub 1900 01 01.

CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models.

Ye J, Gavras NW, Keeley DC, Hughson AL, Hannon G, Vrooman TG, Lesch ML, Johnston CJ, Lord EM, Belt BA, Linehan DC, Eyles J, Gerber SA

Journal for immunotherapy of cancer.. 2023 May 11 (5)Epub 1900 01 01.

Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures.

Day NJ, Wang J, Johnston CJ, Kim SY, Olson HM, House EL, Attah IK, Clair GC, Qian WJ, McGraw MD

American journal of physiology. Lung cellular and molecular physiology.. 2023 March 7 Epub 03/07/2023.

Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics.

Groves AM, Misra R, Clair G, Hernady E, Olson H, Orton D, Finkelstein J, Marples B, Johnston CJ

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2023 February 20 :109543. Epub 02/20/2023.

Neonatal hypoxic ischemic encephalopathy increases acute kidney injury urinary biomarkers in a rat model.

Groves AM, Johnston CJ, Beutner GG, Dahlstrom JE, Koina M, O'Reilly MA, Porter G, Brophy PD, Kent AL

Physiological reports.. 2022 December 10 (24):e15533. Epub 1900 01 01.

Prevention of radiation-induced bladder injury: A murine study using captopril.

Groves AM, Paris N, Hernady E, Johnston CJ, Aljitawi O, Lee YF, Kerns SL, Marples B

International journal of radiation oncology, biology, physics.. 2022 November 15 Epub 11/15/2022.

Short-term and bystander effects of radiation on murine submandibular glands.

Uchida H, Ingalls MH, Maruyama EO, Johnston CJ, Hernady E, Faustoferri RC, Ovitt CE

Disease models & mechanisms.. 2022 October 20 Epub 10/20/2022.

Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer.

Uccello TP, Lecsh ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA

International journal of radiation oncology, biology, physics.. 2022 October 3 Epub 10/03/2022.

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.

Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Journal for immunotherapy of cancer.. 2022 July 10 (7)Epub 1900 01 01.

Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress.

O'Connor TN, Kallenbach JG, Orciuoli HM, Paris ND, Bachman JF, Johnston CJ, Hernady E, Williams JP, Dirksen RT, Chakkalakal JV

Skeletal muscle. 2022 April 1212 (1):8. Epub 04/12/2022.

Muscle-specific functional deficits and lifelong fibrosis in response to paediatric radiotherapy and tumour elimination.

Kallenbach JG, Bachman JF, Paris ND, Blanc RS, O'Connor T, Furati E, Williams JP, Chakkalakal JV

Journal of cachexia, sarcopenia and muscle.. 2022 January 8 Epub 01/08/2022.

Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy.

Uccello TP, Kintzel SA, Mills BN, Murphy JD, Garrett-Larsen J, Battaglia NG, Rodriguez CJ, Drage MG, Ye J, Love TMT, Johnston CJ, Repasky EA, Qiu H, Linehan DC, Lord EM, Gerber SA

Advances in radiation oncology.. 2022 7 (2):100867. Epub 12/09/2021.

Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4CD25 T Cells in the Rat.

House EL, Kim SY, Johnston CJ, Groves AM, Hernady E, Misra RS, McGraw MD

Toxics.. 2021 December 209 (12)Epub 12/20/2021.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

In vivo imaging of the microglial landscape after whole brain radiation therapy.

Whitelaw BS, Tanny S, Johnston CJ, Majewska AK, O'Banion MK, Marples B

International journal of radiation oncology, biology, physics.. 2021 July 24 Epub 07/24/2021.

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD

Archives of toxicology.. 2021 May 24 Epub 05/24/2021.

Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number.

Bachman JF, Blanc RS, Paris ND, Kallenbach JG, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV

iScience.. 2020 November 2023 (11):101760. Epub 11/02/2020.

Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model.

Paris ND, Kallenbach JG, Bachman JF, Blanc RS, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV

Scientific reports.. 2020 November 1110 (1):19501. Epub 11/11/2020.

Protein thiol oxidation in the rat lung following e-cigarette exposure.

Wang J, Zhang T, Johnston CJ, Kim SY, Gaffrey MJ, Chalupa D, Feng G, Qian WJ, McGraw MD, Ansong C

Redox biology.. 2020 October 1037 :101758. Epub 10/10/2020.

Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.

Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Cancer immunology research.. 2019 November 12 Epub 11/12/2019.

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.

Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SA

Cell reports.. 2019 October 829 (2):406-421.e5. Epub 1900 01 01.

Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation.

Hanson KM, Hernady E, Reed CK, Johnston CJ, Groves AM, Finkelstein JN

Toxicological sciences : an official journal of the Society of Toxicology.. 2019 April 24 Epub 04/24/2019.

Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis.

Beach TA, Groves AM, Johnston CJ, Williams JP, Finkelstein JN

International journal of radiation biology.. 2018 December 94 (12):1104-1115. Epub 09/21/2018.

A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung.

Groves AM, Williams JP, Hernady E, Reed C, Fenton B, Love T, Finkelstein JN, Johnston CJ

Radiation research.. 2018 November 190 (5):513-525. Epub 08/17/2018.

Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis.

Groves AM, Johnston CJ, Williams JP, Finkelstein JN

Radiation research.. 2018 March 189 (3):300-311. Epub 01/13/2018.

Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes.

Beach TA, Johnston CJ, Groves AM, Williams JP, Finkelstein JN

Experimental lung research.. 2017 April 43 (3):134-149. Epub 05/23/2017.

Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation.

Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN

International journal of radiation biology.. 2016 December 92 (12):754-765. Epub 09/15/2016.

Whole-Lung Irradiation Results in Pulmonary Macrophage Alterations that are Subpopulation and Strain Specific.

Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN

Radiation research.. 2015 December 184 (6):639-49. Epub 12/03/2015.

Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP

Radiation research.. 2015 October 184 (4):352-66. Epub 09/23/2015.

Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A.

Misra RS, Johnston CJ, Groves A, DeDiego ML, St Martin J, Reed C, Hernady E, Miller JN, Love T, Finkelstein JN, Williams JP

Radiation research.. 2015 July 184 (1):3-13. Epub 06/26/2015.

Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation.

Allen JL, Liu X, Weston D, Prince L, Oberdörster G, Finkelstein JN, Johnston CJ, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2014 July 140 (1):160-78. Epub 04/01/2014.

MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.

Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 January 1192 (1):282-92. Epub 11/29/2013.

Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein.

Manning CM, Johnston CJ, Hernady E, Miller JN, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

Radiation research.. 2013 June 179 (6):617-29. Epub 04/26/2013.

Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.

Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

International journal of radiation oncology, biology, physics.. 2013 May 186 (1):128-35. Epub 11/27/2012.

Neonatal irradiation sensitizes mice to delayed pulmonary challenge.

Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP

Radiation research.. 2013 April 179 (4):475-84. Epub 03/15/2012.

Developmental exposure to concentrated ambient particles and preference for immediate reward in mice.

Allen JL, Conrad K, Oberdörster G, Sleezer B, Cory-Slechta DA

Environmental health perspectives.. 2013 January 121 (1):32-8. Epub 10/11/2012.

Effect of total body irradiation on late lung effects: hidden dangers.

Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP

International journal of radiation biology.. 2011 August 87 (8):902-13. Epub 05/17/2011.

Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?

Williams JP, Johnston CJ, Finkelstein JN

Current drug targets.. 2010 November 11 (11):1386-94. Epub 1900 01 01.

Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ

Experimental lung research.. 2010 August 36 (6):331-41. Epub 1900 01 01.

Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure.

Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP

Radiation research.. 2010 April 173 (4):522-35. Epub 1900 01 01.

The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice.

Saperstein S, Huyck H, Kimball E, Johnston C, Finkelstein J, Pryhuber G

Mediators of inflammation.. 2009 2009 :958658. Epub 11/04/2009.

Postnatal lung development: immediate-early gene responses post ozone and LPS exposure.

Johnston CJ, Holm BA, Gelein R, Finkelstein JN

Inhalation toxicology.. 2006 October 18 (11):875-83. Epub 1900 01 01.

p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.

Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA

The American journal of pathology.. 2006 June 168 (6):1838-47. Epub 1900 01 01.

Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW

Infection and immunity.. 2005 May 73 (5):2766-77. Epub 1900 01 01.

Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses.

Johnston CJ, Holm BA, Finkelstein JN

Experimental lung research.. 2005 May 31 (4):431-47. Epub 1900 01 01.

Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate.

Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G

Experimental lung research.. 2005 31 (6):527-46. Epub 1900 01 01.

Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model.

Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN

Radiation research.. 2004 May 161 (5):560-7. Epub 1900 01 01.

Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress.

Finkelstein JN, Johnston CJ

Pediatrics.. 2004 April 113 (4 Suppl):1092-6. Epub 1900 01 01.

Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage.

D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN

American journal of physiology. Lung cellular and molecular physiology.. 2004 January 286 (1):L30-6. Epub 08/08/2003.

Inflammatory cell recruitment following thoracic irradiation.

Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN

Experimental lung research.. 2004 30 (5):369-82. Epub 1900 01 01.

Differential proinflammatory cytokine responses of the lung to ozone and lipopolysaccharide exposure during postnatal development.

Carl J, Bruce H, Jacob F

Experimental lung research.. 2004 30 (7):599-614. Epub 1900 01 01.

Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.

Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT

Inflammation.. 2003 June 27 (3):137-45. Epub 1900 01 01.

Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses.

Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN

Experimental lung research.. 2002 September 28 (6):419-33. Epub 1900 01 01.

Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families.

Johnston CJ, Williams JP, Okunieff P, Finkelstein JN

Radiation research.. 2002 March 157 (3):256-65. Epub 1900 01 01.

Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures.

Johnston CJ, Oberdörster G, Finkelstein JN

Inhalation toxicology.. 2001 August 13 (8):689-702. Epub 1900 01 01.

Pulmonary effects induced by ultrafine PTFE particles.

Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G

Toxicology and applied pharmacology.. 2000 November 1168 (3):208-15. Epub 1900 01 01.

Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica.

Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2000 August 56 (2):405-13. Epub 1900 01 01.

Acute pulmonary effects of ultrafine particles in rats and mice.

Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC

Research report. 2000 August (96):5-74; disc. 75-86. Epub 1900 01 01.

Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice.

Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN

Inhalation toxicology.. 2000 March 12 (3):187-203. Epub 1900 01 01.

Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin.

Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN

Inhalation toxicology.. 2000 March 12 (3):205-24. Epub 1900 01 01.

Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice.

Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G

Inhalation toxicology.. 2000 March 12 (3):225-43. Epub 1900 01 01.

Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

Toxicology and applied pharmacology.. 1999 December 1161 (2):111-22. Epub 1900 01 01.

Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

Toxicology and applied pharmacology.. 1999 August 1158 (3):211-20. Epub 1900 01 01.

Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

Infection and immunity.. 1999 July 67 (7):3452-60. Epub 1900 01 01.

Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

The American journal of physiology.. 1999 June 276 (6):L979-88. Epub 1900 01 01.

Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin.

Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR

Experimental lung research.. 1999 25 (1):7-21. Epub 1900 01 01.

Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures.

Johnston CJ, Stripp BR, Reynolds SD, Avissar NE, Reed CK, Finkelstein JN

Experimental lung research.. 1999 25 (1):81-97. Epub 1900 01 01.

Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

The American journal of physiology.. 1998 December 275 (6):L1110-9. Epub 1900 01 01.

Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice.

Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 December 46 (2):300-7. Epub 1900 01 01.

Clara cell secretory protein deficiency increases oxidant stress response in conducting airways.

Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR

The American journal of physiology.. 1998 August 275 (2):L348-56. Epub 1900 01 01.

Interleukin-1 expression during hyperoxic lung injury in the mouse.

Piedboeuf B, Horowitz S, Johnston CJ, Gamache M, Bélanger S, Poubelle PE, Welty SE, Watkins RH

Free radical biology & medicine.. 1998 June 24 (9):1446-54. Epub 1900 01 01.

Pulmonary inflammatory responses and cytokine and antioxidant mRNA levels in the lungs of young and old C57Bl/6 mice after exposure to teflon fumes

Johnston CJ, Finkelstein JN,Gelein R, Oberdörster G.

Inhalation Toxicology. 1998; 10(10): 931-953.

Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury.

Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (2):189-202. Epub 1900 01 01.

Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation.

Johnston CJ, Wright TW, Rubin P, Finkelstein JN

Experimental lung research.. 1998 24 (3):321-37. Epub 1900 01 01.

Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia.

D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (5):685-702. Epub 1900 01 01.

Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1997 October 17 (4):491-500. Epub 1900 01 01.

Particulate-cell interactions and pulmonary cytokine expression.

Finkelstein JN, Johnston C, Barrett T, Oberdörster G

Environmental health perspectives.. 1997 September 105 Suppl 5 :1179-82. Epub 1900 01 01.

Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice.

Johnston CJ, Mango GW, Finkelstein JN, Stripp BR

American journal of respiratory cell and molecular biology.. 1997 August 17 (2):147-55. Epub 1900 01 01.

Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen.

O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN

The American journal of physiology.. 1997 January 272 (1 Pt 1):L60-7. Epub 1900 01 01.

Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia.

Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1997 23 (6):537-52. Epub 1900 01 01.

Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure.

Driscoll KE, Howard BW, Carter JM, Asquith T, Johnston C, Detilleux P, Kunkel SL, Isfort RJ

The American journal of pathology.. 1996 November 149 (5):1627-37. Epub 1900 01 01.

Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals.

Stripp BR, Lund J, Mango GW, Doyen KC, Johnston C, Hultenby K, Nord M, Whitsett JA

The American journal of physiology.. 1996 October 271 (4 Pt 1):L656-64. Epub 1900 01 01.

Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure.

Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G

Toxicology and applied pharmacology.. 1996 September 140 (1):154-63. Epub 1900 01 01.

Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy.

Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR

Experimental cell research.. 1996 July 10226 (1):197-207. Epub 1900 01 01.

Ultrafine particles as a potential environmental health hazard. Studies with model particles.

Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD

Chest.. 1996 March 109 (3 Suppl):68S-69S. Epub 1900 01 01.

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis.

Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN

International journal of radiation oncology, biology, physics.. 1995 August 3033 (1):99-109. Epub 1900 01 01.

Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis.

Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN

Radiation research.. 1995 May 142 (2):197-203. Epub 1900 01 01.

Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis.

Finkelstein JN, Johnston CJ, Baggs R, Rubin P

International journal of radiation oncology, biology, physics.. 1994 February 128 (3):621-31. Epub 1900 01 01.

Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure.

Piedboeuf B, Johnston CJ, Watkins RH, Hudak BB, Lazo JS, Cherian MG, Horowitz S

American journal of respiratory cell and molecular biology.. 1994 February 10 (2):123-32. Epub 1900 01 01.

Cell-specific alterations in expression of hyperoxia-induced mRNAs of lung.

Veness-Meehan KA, Cheng ER, Mercier CE, Blixt SL, Johnston CJ, Watkins RH, Horowitz S

American journal of respiratory cell and molecular biology.. 1991 December 5 (6):516-21. Epub 1900 01 01.

Changes in gene expression in hyperoxia-induced neonatal lung injury.

Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ

The American journal of physiology.. 1990 February 258 (2 Pt 1):L107-11. Epub 1900 01 01.

Carcinogenicity of benzo(a) pyrene in the rainbow trout as the result of ovo exposure by egg microinjection.

Black JJ, Maccubin AE, Johnston CJ.

Aquatic Toxicology. 1988; 13(4): 297-308.

Books

Relationships between respiratory disease and exposure to air pollution (1998)

Chapter: Ambient ultrafine particles: Inducers of acute injury?

Authors: Oberdörster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein J.

Publisher: ILSI Monographs, ILSI press, Washington, DC 1998

Skeletal growth and development (1998)

Chapter: Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation

Authors: Reynolds PR, Romano PR, Chi H, Wang J, Reynolds SD, Johnston C, Leboy PS, Tiller GE, Dasouk MJ, O'Keefe RJ, Puzas E, Rosier RN

Publisher: American Academy of Orthopaedic Surgeons, Rosemont, IL 1998