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Tim R. Mosmann, Ph.D.

Tim R. Mosmann, Ph.D.

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About Me

Dr. Tim R. Mosmann is Director of the Human Immunology Center (HIC), and also serves as the Director and Michael and Angela Pichichero Director's Endowed Chair of the David H. Smith Center for Vaccine Biology and Immunology.

Dr. Mosmann received B.S. degrees in both Chemistry and Physiology, ...
Dr. Tim R. Mosmann is Director of the Human Immunology Center (HIC), and also serves as the Director and Michael and Angela Pichichero Director's Endowed Chair of the David H. Smith Center for Vaccine Biology and Immunology.

Dr. Mosmann received B.S. degrees in both Chemistry and Physiology, and in Microbiology, from the University of Natal and Rhodes University in South Africa. He subsequently emigrated to Canada and obtained his Ph.D. in Microbiology at the University of British Columbia. Research fellowships at the University of Toronto and University of Glasgow were followed by his appointment as an assistant professor at the University of Alberta. He then spent 8 years in industry, as a research scientist at DNAX Research Institute in Palo Alto, California - prior to rejoining the University of Alberta as Chairman of the Department of Immunology. In 1998, he was recruited to the University of Rochester.

Dr. Mosmann has made many important contributions to the field of Immunology, and is perhaps best known for his discovery, with his colleague Dr. Robert Coffman, of the TH1 and TH2 subsets of T lymphocytes, which determine whether the host response to infection will be characterized by a predominantly humoral immune response (TH2) or a predominantly cellular immune response (TH1). This discovery was a crucial event in our understanding of how the host immune response is regulated, and has fundamental implications for vaccine design and disease pathogenesis. Dr. Mosmann is recognized by the Institute for Scientific Information as a highly cited scientist, and has won many honours and awards for his unique contributions to understanding of the immune system. Note that "highly cited" scientists comprise less than 0.5% of all publishing researchers in science.

Faculty Appointments

Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD)

Director - Center for Vaccine Biology and Immunology

Michael and Angela Pichichero Director in the David H. Smith Center for Vaccine Biology and Immunology - Center for Vaccine Biology and Immunology

Credentials

Post-doctoral Training & Residency

Glasgow University, Glasgow, Scotland; Immunology 1975 - 1977

Hospital for Sick Children, Toronto; Immunology 1973 - 1975

Education

PhD | University of British Columbia. Microbiology. 1973

B. Sc. | Rhodes University. Microbiology. 1969

BS | University of Natal. Chemistry, and Physiology. 1968

Awards

Novartis Prize for Basic Immunology. 2013

Pillars of Immunology, 1989 article, IL-10 discovery. 2012

Thomson Reuters Citation Laureate. 2011

Paul Ehrlich and Ludwig Darmstaedter Prize. 2008

Pillars of Immunology, 1986 paper, T cell subsets. 2005

ASTECH award for Outstanding Leadership in Alberta Science. 1997

International Research Scholar, Howard Hughes Medical Institute.. 1997 - 2001

William B. Coley Award, Cancer Research Institute (USA). 1997

NIH Fogarty Scholar-in-Residence, 12 months total. 1996 - 1999

Fellow of the Royal Society of Canada. 1995

Avery-Landsteiner Prize, German Society for Immunology. 1994

Bernhard Cinader Lectureship, Canadian Society for Immunology.. 1993

International Research Scholar, Howard Hughes Medical Institute.. 1991 - 1996

Centennial Fellow, MRC of Canada.. 1975 - 1977

Research

The Th1 and Th2 subsets of CD4+ T cells induce different types of effector functions that are useful in combating different pathogens. Th1 cells producing Interferon gamma induce cytotoxic, inflammatory responses that are most effective against intracellular parasites, whereas Th2 cells producing IL...
The Th1 and Th2 subsets of CD4+ T cells induce different types of effector functions that are useful in combating different pathogens. Th1 cells producing Interferon gamma induce cytotoxic, inflammatory responses that are most effective against intracellular parasites, whereas Th2 cells producing IL4 and IL5 induce successful responses against helminth parasites. Although naïve, uncommitted CD4 T cells can differentiate into Th1 or Th2 phenotypes within a few days of initial stimulation, they can also remain uncommitted. These primed, precursor cells (Thpp) produce IL-2 and proliferate rapidly, allowing expansion of antigen-specific cells during an immune response before commitment to a particular effector phenotype. Cells producing only IL-2 also persist for several weeks after immunization, suggesting that these cells may also provide an expanded pool of uncommitted T cells for subsequent immune responses. In common with Treg cells, Thpp express CD73, which can help to generate adenosine that contributes to immune suppression.

In vivo T cell functions are difficult to evaluate, because cytokine secretion phenotypes in addition to Th1, Th2 and Th0 may occur in vivo; and differentiation and selective growth of T cell subsets in vitro can rapidly obscure patterns that occur in vivo. We are using multicolor flow cytometry and Spot assays to detect the simultaneous expression of two or more cytokines by individual human or mouse T cells, to resolve the contributions of partial differentiation, stochastic variation and environmental effects to the spectrum of cytokines produced by individual cells. Short-term cloning experiments are being used to examine the relationship between T cell phenotypes in vivo, versus in long-term tissue culture. These methods are being applied to define the precise T cell phenotypes induced by vaccination and infection by different influenza strains in infants, adults and the elderly.

A Genechip analysis of T cell gene expression revealed that Amphiregulin, an EGF family member, is selectively expressed in activated mouse Th2 cells, and contributes to Th2-mediated elimination of a helminth parasite. This raises the possibility that Th2 cells could contribute to asthma both by enhancing the allergic response and by increasing tissue remodeling. Initial human experiments suggest that regulation of amhipregulin expression is more complex in humans, but still linked to a Type 2 response. A clinical study has been initiated to compare amphiregulin expression in asthmatic patients and controls.

Patents

Arrayed Detector System For Measurement of Influenza Immune Response

Issue date: July 16, 2013

Patent #: 8,486,619

Country: United States

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Rapid Diagnostic Chips for Detection of Immune Responses to HPV (Human Papilloma Virus)

Issue date: May 28, 2013

Patent #: 8,450,056

Country: United States

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, Robert C Rose

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: March 22, 2017

Patent #: ZL200980125645.5

Country: China, People's Republic of

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: July 06, 2016

Patent #: 2286223

Country: Europe

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Anti-Viral Immune Response

Issue date: May 19, 2015

Patent #: 9,034,638

Country: United States

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, Robert C Rose

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: December 22, 2015

Patent #: 9,217,745

Country: United States

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: July 06, 2016

Patent #: FR2286223

Country: France

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: July 06, 2016

Patent #: 60200903959

Country: Germany

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: July 06, 2016

Patent #: CH2286223

Country: Switzerland/Liechtenstein

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Arrayed Detector System for Measurement of Influenza Immune Response

Issue date: July 06, 2016

Patent #: GB2286223

Country: United Kingdom

Inventors: Charles R Mace, Benjamin Locke Miller, Tim R Mosmann, David J Topham

Publications

Journal Articles

Opportunities and challenges for T cell-based influenza vaccines.

Mosmann TR, McMichael AJ, LeVert A, McCauley JW, Almond JW

Nature reviews. Immunology.. 2024 October 24 (10):736-752. Epub 05/02/2024.

SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses.

Mosmann TR, Rebhahn JA, De Rosa SC, Keefer MC, McElrath MJ, Rouphael NG, Pantaleo G, Gilbert PB, Corey L, Kobie JJ, Thakar J

Frontiers in immunology.. 2024 15 :1347926. Epub 06/06/2024.

Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment.

Simpson EL, Schlievert PM, Yoshida T, Lussier S, Boguniewicz M, Hata T, Fuxench Z, De Benedetto A, Ong PY, Ko J, Calatroni A, Rudman Spergel AK, Plaut M, Quataert SA, Kilgore SH, Peterson L, Gill AL, David G, Mosmann T, Gill SR, Leung DYM, Beck LA

The Journal of allergy and clinical immunology.. 2023 November 152 (5):1179-1195. Epub 06/13/2023.

Rituximab induced cytokine release with high serum IP-10 (CXCL10) concentrations is associated with infusion reactions.

Moore JE, Bloom PC, Chu CC, Bruno JE, Herne CA, Baran AM, Quataert SA, Mosmann TR, Taylor RP, Wallace DS, Elliott MR, Barr PM, Zent CS

Leukemia research.. 2023 June 129 :107072. Epub 03/29/2023.

Comment on: Repositioning T cell polarization from single cytokines to complex help.

Jankovic D, Ciucci T, Coffman RL, Coquet JM, Le Gros G, Mosmann TR, Sher A, Ronchese F

Nature immunology.. 2022 April 23 (4):501-502. Epub 1900 01 01.

SwiftReg cluster registration automatically reduces flow cytometry data variability including batch effects.

Rebhahn JA, Quataert SA, Sharma G, Mosmann TR

Communications biology.. 2020 May 73 (1):218. Epub 05/07/2020.

Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels.

Tourtelot E, Quataert S, Glantz JC, Perlis L, Muthukrishnan G, Mosmann T

Vaccine.. 2020 February 1138 (7):1581-1585. Epub 01/17/2020.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, ?i?in-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A

European journal of immunology.. 2019 October 49 (10):1457-1973. Epub 1900 01 01.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J

European journal of immunology.. 2017 October 47 (10):1584-1797. Epub 1900 01 01.

Reduced T-Helper 17 Responses to Streptococcus pneumoniae in Infection-Prone Children Can Be Rescued by Addition of Innate Cytokines.

Basha S, Kaur R, Mosmann TR, Pichichero ME

The Journal of infectious diseases.. 2017 April 15215 (8):1321-1330. Epub 1900 01 01.

Automated Analysis of Flow Cytometry Data to Reduce Inter-Lab Variation in the Detection of Major Histocompatibility Complex Multimer-Binding T Cells.

Pedersen NW, Chandran PA, Qian Y, Rebhahn J, Petersen NV, Hoff MD, White S, Lee AJ, Stanton R, Halgreen C, Jakobsen K, Mosmann T, Gouttefangeas C, Chan C, Scheuermann RH, Hadrup SR

Frontiers in immunology.. 2017 8 :858. Epub 07/26/2017.

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.

Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A

The Journal of immunology : official journal of the American Association of Immunologists.. 2016 September 1197 (5):1531-8. Epub 1900 01 01.

Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.

Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A

The Journal of immunology : official journal of the American Association of Immunologists.. 2016 September 1197 (5):1539-46. Epub 1900 01 01.

Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.

Pichichero ME, Casey JR, Almudevar A, Basha S, Surendran N, Kaur R, Morris M, Livingstone AM, Mosmann TR

The Journal of infectious diseases.. 2016 June 15213 (12):2014-9. Epub 02/09/2016.

Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.

Finak G, Langweiler M, Jaimes M, Malek M, Taghiyar J, Korin Y, Raddassi K, Devine L, Obermoser G, Pekalski ML, Pontikos N, Diaz A, Heck S, Villanova F, Terrazzini N, Kern F, Qian Y, Stanton R, Wang K, Brandes A, Ramey J, Aghaeepour N, Mosmann T, Scheuermann RH, Reed E, Palucka K, Pascual V, Blomberg BB, Nestle F, Nussenblatt RB, Brinkman RR, Gottardo R, Maecker H, McCoy JP

Scientific reports.. 2016 February 106 :20686. Epub 02/10/2016.

Competitive SWIFT cluster templates enhance detection of aging changes.

Rebhahn JA, Roumanes DR, Qi Y, Khan A, Thakar J, Rosenberg A, Lee FE, Quataert SA, Sharma G, Mosmann TR

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2016 January 89 (1):59-70. Epub 10/06/2015.

A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes.

Aghaeepour N, Chattopadhyay P, Chikina M, Dhaene T, Van Gassen S, Kursa M, Lambrecht BN, Malek M, Qian Y, Qiu P, Saeys Y, Stanton R, Tong D, Vens C, Walkowiak S, Wang K, Finak G, Gottardo R, Mosmann T, Nolan GP, Scheuermann RH, Brinkman RR

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2016 January 89 (1):16-21. Epub 10/08/2015.

Automated analysis of flow cytometry data comes of age.

Brinkman RR, Aghaeepour N, Finak G, Gottardo R, Mosmann T, Scheuermann RH

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2016 January 89 (1):13-5. Epub 1900 01 01.

Optimization of the cytokine secretion assay for human IL-2 in single and combination assays.

Deng N, Mosmann TR

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2015 August 87 (8):777-83. Epub 04/28/2015.

State-of-the-Art in the Computational Analysis of Cytometry Data.

Brinkman RR, Aghaeepour N, Finak G, Gottardo R, Mosmann T, Scheuermann RH

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2015 July 87 (7):591-3. Epub 1900 01 01.

Thinking outside the gate: single-cell assessments in multiple dimensions.

Kvistborg P, Gouttefangeas C, Aghaeepour N, Cazaly A, Chattopadhyay PK, Chan C, Eckl J, Finak G, Hadrup SR, Maecker HT, Maurer D, Mosmann T, Qiu P, Scheuermann RH, Welters MJ, Ferrari G, Brinkman RR, Britten CM

Immunity.. 2015 April 2142 (4):591-2. Epub 1900 01 01.

Microbubble array diffusion assay for the detection of cell secreted factors.

Bobo B, Phelan D, Rebhahn J, Piepenbrink MS, Zheng B, Mosmann TR, Kobie JJ, DeLouise LA

Lab on a chip.. 2014 September 2114 (18):3640-50. Epub 07/31/2014.

An animated landscape representation of CD4+ T-cell differentiation, variability, and plasticity: insights into the behavior of populations versus cells.

Rebhahn JA, Deng N, Sharma G, Livingstone AM, Huang S, Mosmann TR

European journal of immunology.. 2014 August 44 (8):2216-29. Epub 1900 01 01.

SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 2: biological evaluation.

Mosmann TR, Naim I, Rebhahn J, Datta S, Cavenaugh JS, Weaver JM, Sharma G

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2014 May 85 (5):422-33. Epub 02/14/2014.

SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 1: algorithm design.

Naim I, Datta S, Rebhahn J, Cavenaugh JS, Mosmann TR, Sharma G

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2014 May 85 (5):408-21. Epub 02/14/2014.

Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFN?- Thpp cells.

Deng N, Weaver JM, Mosmann TR

PloS one.. 2014 9 (5):e95986. Epub 05/01/2014.

Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.

Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS

PloS one.. 2014 9 (8):e104781. Epub 08/29/2014.

CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens.

Sharma SK, Roumanes D, Almudevar A, Mosmann TR, Pichichero ME

Vaccine.. 2013 June 2631 (30):3090-7. Epub 04/28/2013.

Critical assessment of automated flow cytometry data analysis techniques.

Aghaeepour N, Finak G, , Dougall D, Khodabakhshi AH, Mah P, Obermoser G, Spidlen J, Taylor I, Wuensch SA, Bramson J, Eaves C, Weng AP, Iii ES, Ho K, Kollmann T, Rogers W, De Rosa S, Dalal B, Azad A, Pothen A, Brandes A, Bretschneider H, Bruggner R, Finck R, Jia R, Zimmerman N, Linderman M, Dill D, Nolan G, Chan C, Khettabi FE, O'Neill K, Chikina M, Ge Y, Sealfon S, Sugár I, Gupta A, Shooshtari P, Zare H, De Jager PL, Jiang M, Keilwagen J, Maisog JM, Luta G, Barbo AA, Májek P, Vil?ek J, Manninen T, Huttunen H, Ruusuvuori P, Nykter M, McLachlan GJ, Wang K, Naim I, Sharma G, Nikolic R, Pyne S, Qian Y, Qiu P, Quinn J, Roth A, , Meyer P, Stolovitzky G, Saez-Rodriguez J, Norel R, Bhattacharjee M, Biehl M, Bucher P, Bunte K, Di Camillo B, Sambo F, Sanavia T, Trifoglio E, Toffolo G, Dimitrieva S, Dreos R, Ambrosini G, Grau J, Grosse I, Posch S, Guex N, Keilwagen J, Kursa M, Rudnicki W, Liu B, Maienschein-Cline M, Manninen T, Huttunen H, Ruusuvuori P, Nykter M, Schneider P, Seifert M, Strickert M, Vilar JM, Hoos H, Mosmann TR, Brinkman R, Gottardo R, Scheuermann RH

Nature methods.. 2013 March 10 (3):228-38. Epub 02/10/2013.

Increase in IFNgamma(-)IL-2(+) Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza

Weaver, J. M.; Yang, H.; Roumanes, D.; Lee, F. E.; Wu, H.; Treanor, J. J.; Mosmann, T. R.;.

2013; 8: e57275.

CD4(+) T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens

Sharma, S. K.; Roumanes, D.; Almudevar, A.; Mosmann, T. R.; Pichichero, M. E.;.

2013; 31: 3090-7.

Increase in IFN?(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza.

Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR

PloS one.. 2013 8 (3):e57275. Epub 03/20/2013.

Pillars article: homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990. 248: 1230-1234.

Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 September 1189 (5):2072-6. Epub 1900 01 01.

Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination.

Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR

Vaccine.. 2012 June 2930 (31):4581-4. Epub 04/30/2012.

The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.

Qi Y, Operario DJ, Georas SN, Mosmann TR

PloS one.. 2012 7 (6):e39072. Epub 06/14/2012.

Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors.

Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 November 1187 (9):4474-82. Epub 09/23/2011.

Label-free, arrayed sensing of immune response to influenza antigens.

Mace CR, Topham DJ, Mosmann TR, Quataert SA, Treanor JJ, Miller BL

Talanta.. 2011 January 1583 (3):1000-5. Epub 11/10/2010.

Human basophils express amphiregulin in response to T cell-derived IL-3.

Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR

The Journal of allergy and clinical immunology.. 2010 December 126 (6):1260-6.e4. Epub 10/30/2010.

Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus.

Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ

Journal of virology.. 2010 July 84 (13):6687-98. Epub 04/21/2010.

SWIFT: Scalable weighted iterative sampling for flow cytometry clustering.

Naim, I.; Datta, S.; Sharma, G.; J. Cavenaugh, J.; Mosmann, T.R.

Proc. IEEE Intl. Conf. Acoustics Speech and Sig. Proc. 2010; .

Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data.

Qian Y, Wei C, Eun-Hyung Lee F, Campbell J, Halliley J, Lee JA, Cai J, Kong YM, Sadat E, Thomson E, Dunn P, Seegmiller AC, Karandikar NJ, Tipton CM, Mosmann T, Sanz I, Scheuermann RH

Cytometry. Part B, Clinical cytometry.. 2010 78 Suppl 1 (Suppl 1):S69-82. Epub 1900 01 01.

T helper cytokine patterns: defined subsets, random expression, and external modulation.

Mosmann TR, Kobie JJ, Lee FE, Quataert SA

Immunologic research.. 2009 December 45 (2-3):173-84. Epub 02/06/2009.

Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness.

Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 November 15183 (10):6157-66. Epub 10/28/2009.

Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models.

Lee HY, Hawkins E, Zand MS, Mosmann T, Wu H, Hodgkin PD, Perelson AS

Bulletin of mathematical biology.. 2009 October 71 (7):1649-70. Epub 04/21/2009.

Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division.

Henn AD, Rebhahn J, Brown MA, Murphy AJ, Coca MN, Hyrien O, Pellegrin T, Mosmann T, Zand MS

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 September 1183 (5):3177-87. Epub 08/12/2009.

Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma.

Friedberg JW, Kelly JL, Neuberg D, Peterson DR, Kutok JL, Salloum R, Brenn T, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Sims P, Rothberg PG, Liesveld J, Fisher RI, Coffman R, Mosmann T, Freedman AS

British journal of haematology.. 2009 August 146 (3):282-91. Epub 06/10/2009.

Simulation and prediction of the adaptive immune response to influenza A virus infection.

Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward B, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H

Journal of virology.. 2009 July 83 (14):7151-65. Epub 05/13/2009.

Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab.

Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH

Blood.. 2009 April 16113 (16):3809-12. Epub 02/04/2009.

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.

Seavey MM, Mosmann TR

Vaccine.. 2009 April 1427 (17):2342-9. Epub 02/14/2009.

An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform.

Wang JC, Kobie JJ, Zhang L, Cochran M, Mosmann TR, Ritchlin CT, Quataert SA

Journal of immunological methods.. 2009 February 28341 (1-2):106-16. Epub 12/03/2008.

Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.

Rebhahn JA, Bishop C, Divekar AA, Jiminez-Garcia K, Kobie JJ, Lee FE, Maupin GM, Snyder-Cappione JE, Zaiss DM, Mosmann TR

Computer methods and programs in biomedicine.. 2008 October 92 (1):54-65. Epub 07/21/2008.

Enumeration of cytotoxic CD8 T cells ex vivo during the response to Listeria monocytogenes infection.

Zaiss DM, Sijts AJ, Mosmann TR

Infection and immunity.. 2008 October 76 (10):4609-14. Epub 08/04/2008.

Immunoregulation of fetal and anti-paternal immune responses.

Seavey MM, Mosmann TR

Immunologic research.. 2008 40 (2):97-113. Epub 1900 01 01.

Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection.

Lee FE, Walsh EE, Falsey AR, Lumb ME, Okam NV, Liu N, Divekar AA, Hall CB, Mosmann TR

The Journal of infectious diseases.. 2007 June 15195 (12):1779-88. Epub 05/09/2007.

Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection.

Richter M, Ray SJ, Chapman TJ, Austin SJ, Rebhahn J, Mosmann TR, Gardner H, Kotelianski V, deFougerolles AR, Topham DJ

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 April 1178 (7):4506-16. Epub 1900 01 01.

Amphiregulin, a TH2 cytokine enhancing resistance to nematodes.

Zaiss DM, Yang L, Shah PR, Kobie JJ, Urban JF, Mosmann TR

Science.. 2006 December 15314 (5806):1746. Epub 1900 01 01.

Paternal antigen-bearing cells transferred during insemination do not stimulate anti-paternal CD8+ T cells: role of estradiol in locally inhibiting CD8+ T cell responses.

Seavey MM, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 December 1177 (11):7567-78. Epub 1900 01 01.

T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine.

Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 November 15177 (10):6780-6. Epub 1900 01 01.

HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses.

Snyder-Cappione JE, Divekar AA, Maupin GM, Jin X, Demeter LM, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 February 15176 (4):2662-8. Epub 1900 01 01.

Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.

Divekar AA, Zaiss DM, Lee FE, Liu D, Topham DJ, Sijts AJ, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 February 1176 (3):1465-73. Epub 1900 01 01.

CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells.

Yang L, Kobie JJ, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 November 15175 (10):6458-64. Epub 1900 01 01.

The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects.

Lee FE, Walsh EE, Falsey AR, Liu N, Liu D, Divekar A, Snyder-Cappione JE, Mosmann TR

Mechanisms of ageing and development.. 2005 November 126 (11):1223-9. Epub 1900 01 01.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986.

Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 July 1175 (1):5-14. Epub 1900 01 01.

Design considerations for a web-based database system of ELISpot assay in immunological research.

Ma J, Mosmann T, Wu H

AMIA ... Annual Symposium proceedings. 2005 2005 :1039. Epub 1900 01 01.

Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.

Yang L, Mosmann T

European journal of immunology.. 2004 June 34 (6):1617-26. Epub 1900 01 01.

Dendritic cells: the immune information management experts.

Mosmann TR, Livingstone AM

Nature immunology.. 2004 June 5 (6):564-6. Epub 1900 01 01.

How to "spot" a real killer.

Snyder JE, Mosmann TR

Trends in immunology.. 2003 May 24 (5):231; author reply 231-2. Epub 1900 01 01.

Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.

Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR

Nature medicine.. 2003 February 9 (2):231-5. Epub 01/21/2003.

How to "spot" a real killer

Snyder, J.E.; Mosmann, T.R.;.

Trends Immunol. 2003; 24(5): 231; author reply 231-2.

In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-gamma, and can subsequently differentiate into IL-4- or IFN-gamma-secreting cells.

Wang X, Mosmann T

The Journal of experimental medicine.. 2001 October 15194 (8):1069-80. Epub 1900 01 01.

Measurement of mouse and human interleukin 10.

Mosmann T

Current protocols in immunology / edited by John E. Coligan ... [et

Complexity or coherence? Cytokine secretion by B cells.

Mosmann T

Nature immunology.. 2000 December 1 (6):465-6. Epub 1900 01 01.

Reply to cohen.

Mosmann T

Immunology today.. 2000 April 21 (4):199. Epub 1900 01 01.

Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells.

Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR, Lo D

The Journal of immunology : official journal of the American Association of Immunologists.. 1999 March 1162 (5):2477-87. Epub 1900 01 01.

Mouse IL-13 enhances antibody production in vivo and acts directly on B cells in vitro to increase survival and hence antibody production.

Lai YH, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1999 January 1162 (1):78-87. Epub 1900 01 01.

Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells.

Akai PS, Mosmann TR

Microbes and infection. 1999 January 1 (1):51-8. Epub 1900 01 01.

Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.

Liu MF, Ning Q, Pope M, Mosmann T, Leibowitz J, Ding JW, Fung LS, Rotstein O, Gorczynski R, Levy GA

Advances in experimental medicine and biology.. 1998 440 :415-23. Epub 1900 01 01.

Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and Fas cytotoxicity but compromised long term killing of tumor cells.

Sad S, Li L, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1997 July 15159 (2):606-13. Epub 1900 01 01.

CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions.

Li L, Sad S, Kägi D, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1997 May 1158 (9):4152-61. Epub 1900 01 01.

Cytotoxicity and weak CD40 ligand expression of CD8+ type 2 cytotoxic T cells restricts their potential B cell helper activity.

Sad S, Krishnan L, Bleackley RC, Kägi D, Hengartner H, Mosmann TR

European journal of immunology.. 1997 April 27 (4):914-22. Epub 1900 01 01.

Functions of CD8 T-cell subsets secreting different cytokine patterns.

Mosmann TR, Li L, Sad S

Seminars in immunology.. 1997 April 9 (2):87-92. Epub 1900 01 01.

Differentiation and functions of T cell subsets.

Mosmann TR, Li L, Hengartner H, Kagi D, Fu W, Sad S

Ciba Foundation symposium.. 1997 204 :148-54; discussion 154-8. Epub 1900 01 01.

Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation.

Sad S, Kägi D, Mosmann TR

The Journal of experimental medicine.. 1996 October 1184 (4):1543-7. Epub 1900 01 01.

Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction.

Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A

Diabetes.. 1996 October 45 (10):1350-7. Epub 1900 01 01.

Interleukin 10 modulates ion transport in rat small intestine.

Madsen KL, Tavernini MM, Mosmann TR, Fedorak RN

Gastroenterology.. 1996 October 111 (4):936-44. Epub 1900 01 01.

Continuous administration of Il-13 to mice induces extramedullary hemopoiesis and monocytosis.

Lai YH, Heslan JM, Poppema S, Elliott JF, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1996 May 1156 (9):3166-73. Epub 1900 01 01.

Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.

Pope M, Chung SW, Mosmann T, Leibowitz JL, Gorczynski RM, Levy GA

The Journal of immunology : official journal of the American Association of Immunologists.. 1996 May 1156 (9):3342-9. Epub 1900 01 01.

The expanding universe of T-cell subsets: Th1, Th2 and more.

Mosmann TR, Sad S

Immunology today.. 1996 March 17 (3):138-46. Epub 1900 01 01.

Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines.

Krishnan L, Guilbert LJ, Russell AS, Wegmann TG, Mosmann TR, Belosevic M

The Journal of immunology : official journal of the American Association of Immunologists.. 1996 January 15156 (2):644-52. Epub 1900 01 01.

T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.

Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1996 January 15156 (2):653-62. Epub 1900 01 01.

Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.

Sad S, Mosmann TR

The Journal of experimental medicine.. 1995 November 1182 (5):1505-15. Epub 1900 01 01.

Cytokines, differentiation and functions of subsets of CD4 and CD8 T cells.

Mosmann TR

Behring Institute Mitteilungen. 1995 June (96):1-6. Epub 1900 01 01.

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau.

Chaouat G, Assal Meliani A, Martal J, Raghupathy R, Elliott JF, Elliot J, Mosmann T, Wegmann TG

The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 1154 (9):4261-8. Epub 1900 01 01.

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.

Sad S, Marcotte R, Mosmann TR

Immunity.. 1995 March 2 (3):271-9. Epub 1900 01 01.

Differentiation of subsets of CD4+ and CD8+ T cells.

Mosmann TR, Sad S, Krishnan L, Wegmann TG, Guilbert LJ, Belosevic M

Ciba Foundation symposium.. 1995 195 :42-50; discussion 50-4. Epub 1900 01 01.

IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity.

Li L, Elliott JF, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1994 November 1153 (9):3967-78. Epub 1900 01 01.

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

Sad S, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1994 October 15153 (8):3514-22. Epub 1900 01 01.

In vivo evidence that ultraviolet B-induced suppression of allergic contact sensitivity is associated with functional inactivation of Th1 cells.

Simon JC, Mosmann T, Edelbaum D, Schopf E, Bergstresser PR, Cruz PD

Photodermatology, photoimmunology & photomedicine.. 1994 October 10 (5):206-11. Epub 1900 01 01.

Cytokine patterns during the progression to AIDS.

Mosmann TR

Science.. 1994 July 8265 (5169):193-4. Epub 1900 01 01.

Properties and functions of interleukin-10.

Mosmann TR

Advances in immunology.. 1994 56 :1-26. Epub 1900 01 01.

Synthesis of T helper 2-type cytokines at the maternal-fetal interface.

Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG

The Journal of immunology : official journal of the American Association of Immunologists.. 1993 November 1151 (9):4562-73. Epub 1900 01 01.

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo.

Yang X, Gieni RS, Mosmann TR, HayGlass KT

The Journal of experimental medicine.. 1993 July 1178 (1):349-53. Epub 1900 01 01.

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

Wegmann TG, Lin H, Guilbert L, Mosmann TR

Immunology today.. 1993 July 14 (7):353-6. Epub 1900 01 01.

Interleukin-10.

Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR

Annual review of immunology.. 1993 11 :165-90. Epub 1900 01 01.

Effect of temperature on hybridoma cell cycle and MAb production.

Bloemkolk JW, Gray MR, Merchant F, Mosmann TR

Biotechnology and bioengineering.. 1992 July 40 (3):427-31. Epub 1900 01 01.

Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.

Sher A, Gazzinelli RT, Oswald IP, Clerici M, Kullberg M, Pearce EJ, Berzofsky JA, Mosmann TR, James SL, Morse HC

Immunological reviews.. 1992 June 127 :183-204. Epub 1900 01 01.

Nomenclature for secreted regulatory proteins of the immune system (interleukins). WHO-IUIS Nomenclature Subcommittee on Interleukin Designation.

Paul WE, Kishimoto T, Melchers F, Metcalf D, Mosmann T, Oppenheim J, Ruddle N, Van Snick J

Clinical and experimental immunology.. 1992 May 88 (2):367. Epub 1900 01 01.

T lymphocyte subsets, cytokines, and effector functions.

Mosmann TR

Annals of the New York Academy of Sciences.. 1992 664 :89-92. Epub 1900 01 01.

IL-10 inhibits cytokine production by activated macrophages.

Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A

The Journal of immunology : official journal of the American Association of Immunologists.. 1991 December 1147 (11):3815-22. Epub 1900 01 01.

Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.

Sadick MD, Street N, Mosmann TR, Locksley RM

Infection and immunity.. 1991 December 59 (12):4710-4. Epub 1900 01 01.

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

Sher A, Fiorentino D, Caspar P, Pearce E, Mosmann T

The Journal of immunology : official journal of the American Association of Immunologists.. 1991 October 15147 (8):2713-6. Epub 1900 01 01.

Diversity of cytokine synthesis and function of mouse CD4+ T cells.

Mosmann TR, Schumacher JH, Street NF, Budd R, O'Garra A, Fong TA, Bond MW, Moore KW, Sher A, Fiorentino DF

Immunological reviews.. 1991 October 123 :209-29. Epub 1900 01 01.

Cytokines: is there biological meaning?

Mosmann TR

Current opinion in immunology.. 1991 June 3 (3):311-4. Epub 1900 01 01.

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A

The Journal of immunology : official journal of the American Association of Immunologists.. 1991 May 15146 (10):3444-51. Epub 1900 01 01.

Elevated production of interferon-gamma and interleukin 4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 (CD44) expression.

Budd RC, Schumacher JH, Winslow G, Mosmann TR

European journal of immunology.. 1991 April 21 (4):1081-4. Epub 1900 01 01.

The role of IL-10 in crossregulation of TH1 and TH2 responses.

Mosmann TR, Moore KW

Immunology today.. 1991 March 12 (3):A49-53. Epub 1900 01 01.

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

Vieira P, de Waal-Malefyt R, Dang MN, Johnson KE, Kastelein R, Fiorentino DF, deVries JE, Roncarolo MG, Mosmann TR, Moore KW

Proceedings of the National Academy of Sciences of the United States of America.. 1991 February 1588 (4):1172-6. Epub 1900 01 01.

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

Kupfer A, Mosmann TR, Kupfer H

Proceedings of the National Academy of Sciences of the United States of America.. 1991 February 188 (3):775-9. Epub 1900 01 01.

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

Thompson-Snipes L, Dhar V, Bond MW, Mosmann TR, Moore KW, Rennick DM

The Journal of experimental medicine.. 1991 February 1173 (2):507-10. Epub 1900 01 01.

Functional diversity of T lymphocytes due to secretion of different cytokine patterns.

Street NE, Mosmann TR

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 1991 February 5 (2):171-7. Epub 1900 01 01.

CD4+ T-cell subsets: regulation of differentiation and function.

Coffman RL, Mosmann TR

Research in immunology. 1991 January 142 (1):7-9. Epub 1900 01 01.

Cytokine secretion phenotypes of TH cells: how many subsets, how much regulation?

Mosmann TR

Research in immunology. 1991 January 142 (1):9-13. Epub 1900 01 01.

Role of a new cytokine, interleukin-10, in the cross-regulation of T helper cells.

Mosmann TR

Annals of the New York Academy of Sciences.. 1991 628 :337-44. Epub 1900 01 01.

Regulation of immune responses by T cells with different cytokine secretion phenotypes: role of a new cytokine, cytokine synthesis inhibitory factor (IL10).

Mosmann TR

International archives of allergy and applied immunology.. 1991 94 (1-4):110-5. Epub 1900 01 01.

Cytokine secretion patterns and cross-regulation of T cell subsets.

Mosmann TR

Immunologic research.. 1991 10 (3-4):183-8. Epub 1900 01 01.

IL-10, a novel growth cofactor for mature and immature T cells.

MacNeil IA, Suda T, Moore KW, Mosmann TR, Zlotnik A

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 December 15145 (12):4167-73. Epub 1900 01 01.

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

Go NF, Castle BE, Barrett R, Kastelein R, Dang W, Mosmann TR, Moore KW, Howard M

The Journal of experimental medicine.. 1990 December 1172 (6):1625-31. Epub 1900 01 01.

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.

Hsu DH, de Waal Malefyt R, Fiorentino DF, Dang MN, Vieira P, de Vries J, Spits H, Mosmann TR, Moore KW

Science.. 1990 November 9250 (4982):830-2. Epub 1900 01 01.

Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

Mosmann TR, Schumacher JH, Fiorentino DF, Leverah J, Moore KW, Bond MW

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 November 1145 (9):2938-45. Epub 1900 01 01.

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR

Science.. 1990 June 8248 (4960):1230-4. Epub 1900 01 01.

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

Street NE, Schumacher JH, Fong TA, Bass H, Fiorentino DF, Leverah JA, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 March 1144 (5):1629-39. Epub 1900 01 01.

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

Fong TA, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 March 1144 (5):1744-52. Epub 1900 01 01.

Lymphokine control of in vivo immunoglobulin isotype selection.

Finkelman FD, Holmes J, Katona IM, Urban JF, Beckmann MP, Park LS, Schooley KA, Coffman RL, Mosmann TR, Paul WE

Annual review of immunology.. 1990 8 :303-33. Epub 1900 01 01.

IL4 and IL5: the role of two multifunctional cytokines and their place in the network of cytokine interactions.

Street NE, Mosmann TR

Biotherapy (Dordrecht, Netherlands). 1990 2 (4):347-62. Epub 1900 01 01.

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Fiorentino DF, Bond MW, Mosmann TR

The Journal of experimental medicine.. 1989 December 1170 (6):2081-95. Epub 1900 01 01.

The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones.

Fong TA, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1989 November 1143 (9):2887-93. Epub 1900 01 01.

Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation.

Bass H, Mosmann T, Strober S

The Journal of experimental medicine.. 1989 November 1170 (5):1495-511. Epub 1900 01 01.

Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones.

DeKruyff RH, Ju ST, Hunt AJ, Mosmann TR, Umetsu DT

The Journal of immunology : official journal of the American Association of Immunologists.. 1989 April 15142 (8):2575-82. Epub 1900 01 01.

Specific assays for cytokine production by T cells.

Mosmann TR, Fong TA

Journal of immunological methods.. 1989 January 17116 (2):151-8. Epub 1900 01 01.

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

Brown KD, Zurawski SM, Mosmann TR, Zurawski G

The Journal of immunology : official journal of the American Association of Immunologists.. 1989 January 15142 (2):679-87. Epub 1900 01 01.

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Mosmann TR, Coffman RL

Annual review of immunology.. 1989 7 :145-73. Epub 1900 01 01.

Heterogeneity of cytokine secretion patterns and functions of helper T cells.

Mosmann TR, Coffman RL

Advances in immunology.. 1989 46 :111-47. Epub 1900 01 01.

A single antigen-specific B cell can conjugate to either a type 1 or a type 2 helper T cell.

Sanders VM, Fernandez-Botran R, Coffman RL, Mosmann TR, Vitetta ES

Proceedings of the National Academy of Sciences of the United States of America.. 1988 October 85 (20):7724-8. Epub 1900 01 01.

Directional release of lymphokines from T cells.

Mosmann TR

Immunology today.. 1988 October 9 (10):306-7. Epub 1900 01 01.

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

Schumacher JH, O'Garra A, Shrader B, van Kimmenade A, Bond MW, Mosmann TR, Coffman RL

The Journal of immunology : official journal of the American Association of Immunologists.. 1988 September 1141 (5):1576-81. Epub 1900 01 01.

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

Fernandez-Botran R, Sanders VM, Mosmann TR, Vitetta ES

The Journal of experimental medicine.. 1988 August 1168 (2):543-58. Epub 1900 01 01.

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells.

Stevens TL, Bossie A, Sanders VM, Fernandez-Botran R, Coffman RL, Mosmann TR, Vitetta ES

Nature.. 1988 July 21334 (6179):255-8. Epub 1900 01 01.

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

Finkelman FD, Katona IM, Mosmann TR, Coffman RL

The Journal of immunology : official journal of the American Association of Immunologists.. 1988 February 15140 (4):1022-7. Epub 1900 01 01.

Isotype regulation by helper T cells and lymphokines.

Coffman RL, Mosmann TR

Monographs in allergy.. 1988 24 :96-103. Epub 1900 01 01.

Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes.

Ransom J, Fischer M, Mosmann T, Yokota T, DeLuca D, Schumacher J, Zlotnik A

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 December 15139 (12):4102-8. Epub 1900 01 01.

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

Coffman RL, Shrader B, Carty J, Mosmann TR, Bond MW

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 December 1139 (11):3685-90. Epub 1900 01 01.

A mouse T cell product that preferentially enhances IgA production. II. Physicochemical characterization.

Bond MW, Shrader B, Mosmann TR, Coffman RL

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 December 1139 (11):3691-6. Epub 1900 01 01.

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR

The Journal of experimental medicine.. 1987 November 1166 (5):1229-44. Epub 1900 01 01.

Requirement for BSF-1 in the induction of antigen-specific B cell proliferation by a thymus-dependent antigen and carrier-reactive T cell line.

Dubois P, Stein P, Ennist D, Greenblatt D, Mosmann T, Howard M

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 September 15139 (6):1927-34. Epub 1900 01 01.

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

Cher DJ, Mosmann TR

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 June 1138 (11):3688-94. Epub 1900 01 01.

Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).

Mosmann TR, Yokota T, Kastelein R, Zurawski SM, Arai N, Takebe Y

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 March 15138 (6):1813-6. Epub 1900 01 01.

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

Hu-Li J, Shevach EM, Mizuguchi J, Ohara J, Mosmann T, Paul WE

The Journal of experimental medicine.. 1987 January 1165 (1):157-72. Epub 1900 01 01.

T-cell antigen receptors with identical variable regions but different diversity and joining region gene segments have distinct specificities but cross-reactive idiotypes.

Rupp F, Brecher J, Giedlin MA, Mosmann T, Zinkernagel RM, Hengartner H, Joho RH

Proceedings of the National Academy of Sciences of the United States of America.. 1987 January 84 (1):219-22. Epub 1900 01 01.

Antigen-specific helper factor reacts with antibody to the T-cell receptor.

Deans JP, Krowka JF, Mosmann T, Pilarski LM

Journal of immunogenetics. 1987 14 (2-3):103-7. Epub 1900 01 01.

Two types of mouse helper T-cell clone Implications for immune regulation.

Mosmann TR, Coffman RL

Immunology today.. 1987 8 (7-8):223-7. Epub 1900 01 01.

Alterations in the amino-terminal third of mouse interleukin 2: effects on biological activity and immunoreactivity.

Zurawski SM, Mosmann TR, Benedik M, Zurawski G

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 November 15137 (10):3354-60. Epub 1900 01 01.

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

Yokota T, Otsuka T, Mosmann T, Banchereau J, DeFrance T, Blanchard D, De Vries JE, Lee F, Arai K

Proceedings of the National Academy of Sciences of the United States of America.. 1986 August 83 (16):5894-8. Epub 1900 01 01.

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

Mosmann TR, Bond MW, Coffman RL, Ohara J, Paul WE

Proceedings of the National Academy of Sciences of the United States of America.. 1986 August 83 (15):5654-8. Epub 1900 01 01.

A requirement for physical linkage between determinants recognized by helper molecules and cytotoxic T cell precursors in the induction of cytotoxic T cell responses.

Krowka JF, Singh B, Fotedar A, Mosmann T, Giedlin MA, Pilarski LM

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 May 15136 (10):3561-6. Epub 1900 01 01.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 April 1136 (7):2348-57. Epub 1900 01 01.

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

Lee F, Yokota T, Otsuka T, Meyerson P, Villaret D, Coffman R, Mosmann T, Rennick D, Roehm N, Smith C

Proceedings of the National Academy of Sciences of the United States of America.. 1986 April 83 (7):2061-5. Epub 1900 01 01.

Murine T-cell clones specific for chicken erythrocyte alloantigens.

Giedlin MA, Longenecker BM, Mosmann TR

Cellular immunology.. 1986 February 97 (2):357-70. Epub 1900 01 01.

Production and characterization of monoclonal antibodies to bovine skin proteodermatan sulfate.

Pringle GA, Dodd CM, Osborn JW, Pearson CH, Mosmann TR

Collagen and related research. 1985 January 5 (1):23-39. Epub 1900 01 01.

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

Yokota T, Arai N, Lee F, Rennick D, Mosmann T, Arai K

Proceedings of the National Academy of Sciences of the United States of America.. 1985 January 82 (1):68-72. Epub 1900 01 01.

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

Yokota T, Lee F, Rennick D, Hall C, Arai N, Mosmann T, Nabel G, Cantor H, Arai K

Proceedings of the National Academy of Sciences of the United States of America.. 1984 February 81 (4):1070-4. Epub 1900 01 01.

Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Mosmann T

Journal of immunological methods.. 1983 December 1665 (1-2):55-63. Epub 1900 01 01.

Post-translational fate of variant MOPC 315 lambda chains in Xenopus oocytes and mouse myeloma cells.

Valle G, Besley J, Williamson AR, Mosmann TR, Colman A

European journal of biochemistry. 1983 April 15132 (1):131-8. Epub 1900 01 01.

Characterization of polypeptides serologically and structurally related to hexosaminidase in cultured fibroblasts.

Tsui F, Mahuran DJ, Lowden JA, Mosmann T, Gravel RA

The Journal of clinical investigation.. 1983 April 71 (4):965-73. Epub 1900 01 01.

Specificity of autoimmune monoclonal Fab fragments binding to single-stranded deoxyribonucleic acid.

Lee JS, Dombroski DF, Mosmann TR

Biochemistry.. 1982 September 2821 (20):4940-5. Epub 1900 01 01.

Arrangement of lambda light chain genes in mutant clones of the MOPC 315 mouse myeloma cells.

Hozumi N, Wu G, Murialdo H, Baumal R, Mosmann T, Winberry L, Marks A

The Journal of immunology : official journal of the American Association of Immunologists.. 1982 July 129 (1):260-6. Epub 1900 01 01.

The high background immune reactivity of mice to polymorphic determinants on xenogeneic erythrocytes: theoretical and practical implications.

Mosmann TR, Longenecker BM

The Journal of immunology : official journal of the American Association of Immunologists.. 1982 January 128 (1):100-4. Epub 1900 01 01.

Preference of the early murine immune response for polymorphic determinants on human lymphoid-leukemia cells and the potential use of monoclonal antibodies to these determinants in leukemia-typing panel.

Maclean GD, Mosmann TR, Akabutu JJ, Longenecker BM

Oncodevelopmental biology and medicine : the journal of the

Translation of lymphocyte mRNA into biologically-active Interleukin 2 in oocytes.

Bleackley RC, Caplan B, Havele C, Ritzel RG, Mosmann TR, Farrar JJ, Paetkau V

The Journal of immunology : official journal of the American Association of Immunologists.. 1981 December 127 (6):2432-5. Epub 1900 01 01.

A strong, specific response of mice to serotype-specific antigenic determinants of Neisseria meningitidis, analyzed with mouse monoclonal antibodies.

Mackie EB, Mosmann TR, Bryan LE, Longenecker BM

The Journal of immunology : official journal of the American Association of Immunologists.. 1981 July 127 (1):387-8. Epub 1900 01 01.

Monoclonal antibodies showing sequence specificity in their interaction with single-stranded DNAs.

Lee JS, Lewis JR, Morgan AR, Mosmann TR, Singh B

Nucleic acids research.. 1981 April 109 (7):1707-21. Epub 1900 01 01.

Nomenclature for chicken MHC (B) antigens defined by monoclonal antibodies.

Longenecker BM, Mosmann TR

Immunogenetics.. 1981 13 (1-2):25-8. Epub 1900 01 01.

Structure and properties of the major histocompatibility complex of the chicken. Speculations on the advantages and evolution of polymorphism.

Longenecker BM, Mosmann TR

Immunogenetics.. 1981 13 (1-2):1-23. Epub 1900 01 01.

Alteration of apparent specificity of monoclonal (hybridoma) antibodies recognizing polymorphic histocompatibility and blood group determinants.

Mosmann TR, Gallatin M, Longenecker BM

The Journal of immunology : official journal of the American Association of Immunologists.. 1980 September 125 (3):1152-6. Epub 1900 01 01.

Structural mutations in a mouse immunoglobulin light chain resulting in failure to be secreted.

Mosmann TR, Williamson AR

Cell.. 1980 June 20 (2):283-92. Epub 1900 01 01.

The value of tunicamycin for studies on immunoglobulin biosynthesis.

Williamson AR, Singer HH, Singer PA, Mosmann TR

Biochemical Society transactions.. 1980 April 8 (2):168-70. Epub 1900 01 01.

Restricted expression of an MHC alloantigen in cells of the erythroid series: a specific marker for erythroid differentiation.

Longenecker BM, Mosmann TR

Journal of supramolecular structure.. 1980 13 (3):395-400. Epub 1900 01 01.

"Natural" antibodies to chicken MHC antigens are present in mice, rats, humans, alligators and allogeneic chickens.

Longenecker BM, Mosmann TR

Immunogenetics.. 1980 11 (3):293-302. Epub 1900 01 01.

The ability of the murine placenta to absorb monoclonal anti-fetal H-2K antibody from the maternal circulation.

Wegmann TG, Mosmann TR, Carlson GA, Olijnyk O, Singh B

The Journal of immunology : official journal of the American Association of Immunologists.. 1979 September 123 (3):1020-3. Epub 1900 01 01.

Mutations affecting immunoglobulin light chain secretion by myeloma cells. I. Functional analysis by cell fusion.

Mosmann TR, Baumal R, Williamson AR

European journal of immunology.. 1979 July 9 (7):511-6. Epub 1900 01 01.

Modification and fate of J chain in myeloma cells in the presence and absence of polymeric immunoglobulin secretion.

Mosmann TR, Gravel Y, Williamson AR, Baumal R

European journal of immunology.. 1978 February 8 (2):94-101. Epub 1900 01 01.

Properties of the multicapsid virions of murine cytomegalovirus.

Hudson JB, Misra V, Mosmann TR

Virology.. 1976 July 172 (1):224-34. Epub 1900 01 01.

Cytomegalovirus infectivity: analysis of the phenomenon of centrifugal enhancement of infectivity.

Hudson JB, Misra V, Mosmann TR

Virology.. 1976 July 172 (1):235-43. Epub 1900 01 01.

Macroscopic cloning assay using complement fixation to isolate secretion variants of myeloma cells.

Mosmann T, Baumal R

Journal of immunological methods.. 1976 March 10 (2-3):119-25. Epub 1900 01 01.

Genetic control of immunoglobulin production by individual cell lines.

Singer PA, Mosmann TR, Williamson AR

Annales d'immunologie. 1976 127 (5):667-74. Epub 1900 01 01.

Synthesis but not secretion of J chain by variant mouse myeloma cells which lose alpha-chain-synthesizing ability.

Mosmann T, Baumal R

The Journal of immunology : official journal of the American Association of Immunologists.. 1975 October 115 (4):955-62. Epub 1900 01 01.

Structural and functional heterogeneity of the murine cytomegalovirus genome.

Mosmann TR, Hudson JB

Virology.. 1974 November 62 (1):175-83. Epub 1900 01 01.

Some properties of the genome of murine cytomegalovirus (MCV).

Mosmann TR, Hudson JB

Virology.. 1973 July 54 (1):135-49. Epub 1900 01 01.

Pigmentation and acriflavine resistance in Serratia marcescens.

Woods DR, Mosmann TR, Hanson S, Hendry DA

Journal of bacteriology.. 1971 November 108 (2):765-9. Epub 1900 01 01.