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Bradford C. Berk, M.D., Ph.D.

Bradford C. Berk, M.D., Ph.D.

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About Me

Dr. Berk is Professor of Medicine, Cardiology, and Pharmacology and the Senior Vice President for Health Sciences at the University of Rochester. Dr. Berk received his M.D. and Ph.D. degrees from the University of Rochester. He has served on the faculties of Harvard Medical School, Emory Universit...
Dr. Berk is Professor of Medicine, Cardiology, and Pharmacology and the Senior Vice President for Health Sciences at the University of Rochester. Dr. Berk received his M.D. and Ph.D. degrees from the University of Rochester. He has served on the faculties of Harvard Medical School, Emory University, and the University of Washington. Dr. Berk was previously Chairman of Medicine (1999-2006) and Chief of the Cardiology Unit (1998-2003) at the University of Rochester. In addition he was Director of the Aab Cardiovascular Research Institute. Dr. Berk is a fellow of the American Heart Association and the American College of Cardiology, and a member of the Association of American Physicians. Dr. Berk is past-president of the North American Vascular Biology Organization (NAVBO). He is Consulting Editor for Circulation and Circulation Research and is on the editorial boards of ATVB and the Journal of Clinical Investigation. He serves on the Empire State Stem Cell Board Funding Committee and the National Heart, Lung and Blood Institute (NHLBI), Stem Cell Clinical Trial Network and Gene and Cell-Based Therapies Data and Safety Monitoring Board (DSMB).

His research interests include: molecular biology of renin-angiotensin-aldosterone
system; regulation of endothelial cell function especially by shear stress; the role of oxidative stress in vascular biology and the genetic mechanisms of vascular remodeling. Dr. Berk has published widely – more than 250 articles, chapters, and books.

Listed below is Dr. Berk's affiliation:

Bradford C. Berk, M.D., Ph.D.
Professor of Medicine, Cardiology, and Pharmacology
Senior Vice President for Health Sciences
University of Rochester Medical Center
Rochester, New York

US Postal mail should be sent to:
Bradford C. Berk, M.D., Ph.D.
University of Rochester Medical Center
Office of Vice President for Health Sciences
601 Elmwood Avenue, Box 706
Rochester, New York 14642

FEDEX:
Bradford C. Berk, M.D, Ph.D.
University of Rochester Medical Center
Office of Vice President for Health Sciences
601 Elmwood Avenue, Box 706, Rm. 1-4337
Rochester, NY 14642

Faculty Appointments

Professor - Department of Physical Medicine & Rehabilitation (SMD)

Professor - Department of Medicine, Cardiology (SMD) - Joint

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Distinguished University Professor - President's Office (UR) - Joint

Credentials

Post-doctoral Training & Residency

Fellowship, Cardiology, Brigham & Womens Hospital. 1984 - 1987

Fellowship, Harvard Medical School. 1984 - 1987

Residency, Cardiology, Brigham & Womens Hospital. 1982 - 1984

Residency, Internal Medicine, VA Boston Healthcare System. 1982 - 1984

Internship, Internal Medicine, Brigham & Womens Hospital. 1981 - 1982

Education

MD | University of Rochester School of Medicine/Dentistry. 1981

Awards

Vice-chair. 2004 - 2005

Russell Ross Memorial Lectureship in Vascular Biology. 2003

Theo Tsagaris Memorial Lecture. 2002

Indiana Vascular Society/ICVBM Conference. 2002

Pfizer Visiting Professor. 2002

Borun Visiting Professor in Cardiology. 1999

Annual Pulsifer Lecture, Guest Speaker. 1999

Pfizer Visiting Professor of Cardiovascular Disease. 1995

Marion Young Scholar Award. 1992

Katz Prize Finalist. 1986

Young Investigator's Award. 1985

Robert Kates Memorial Prize in Research, Doran J. Stephens Prize in Medicine. 1981

Phi Beta Kappa, John Albree Jr. Class of 1981 Memorial Fund Award for History. 1975

Medical Scientist Training Program (Pharmacology). 1975 - 1981

Woods Hole Oceanographic Institution Fellowship (Microbiology). 1974

National Science Foundation Undergraduate Research Program (Molecular Biology). 1973

Research

Dr. Berk's laboratory is known for studying signal transduction mechanisms in the vasculature, focusing specifically on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli. The four major research areas ongoing in the laboratory include 1) Mechanis...
Dr. Berk's laboratory is known for studying signal transduction mechanisms in the vasculature, focusing specifically on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli. The four major research areas ongoing in the laboratory include 1) Mechanisms by which blood vessels sense changes in blood flow using protein kinases as targets for signal events. Using cultured endothelial cells and animal models of altered blood flow two projects are underway. The first project investigates the mechanisms by which flow activates the Big MAP kinase (or ERK5) and inhibits inflammation and atherosclerosis. In the second project, the redox-dependent mechanisms that maintain an antioxidant environment are being studied using the apoptosis signal kinase-1 (ASK1) and thioredoxin as targets. The goal of these projects is to identify signal transduction events that confer atheroprotection in the setting of steady laminar flow as opposed to the pro-atherosclerotic effects of disturbed and turbulent flow. 2) The cellular mechanisms that cause hypertension are being investigated by analysis of the role of the renin angiotensin system and the kinases that regulate intracellular sodium. The regulation of smooth muscle cell growth by angiotensin II is focused on the activation of intracellular kinases and phosphatases by the angiotensin II receptor. 3) The mechanisms by which changes in cellular redox state alter blood vessel function are being studied to provide insight into the ways that reactive oxygen species regulate vessel function. Specifically the role of the chaperone molecule cyclophilin A as a mediator of vascular pathology is being studied with several different transgenic models. 4) A genetic model of vascular remodeling in the mouse has been established. A carotid flow reduction model has been characterized and is being used to identify genes responsible for impaired flow-dependent remodeling by positional cloning in inbred strains of mice.

Patents

Thioredoxin Interacting Protein (TXNIP) as a Regulator of Vascular Function

Issue date: April 07, 2015

Patent #: 8,999,944

Country: United States

Inventors: Bradford C Berk

Thioredoxin Interacting Protein (TXNIP as Regulator of Vascular Function

Issue date: June 21, 2012

Patent #: 200606376

Country: Australia

Inventors: Bradford C Berk

Method and Compositions for Treatment or Prevention of Inflammatory Conditions

Issue date: March 11, 2015

Patent #: 1602247

Country: China, People's Republic of

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Method and Compositions For Treatment or Prevention of Inflammatory Conditions

Issue date: January 26, 2016

Patent #: 9,241,932

Country: United States

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Method of Inhibiting Angiogenesis Using Inhibitors of G-Protein -Coupled Receptor Kinase Interacting Protein-1 (GIT1)

Issue date: June 06, 2017

Patent #: 9,670,259

Country: United States

Inventors: Bradford C Berk, Syamantak Majumder, Jinjiang Pang

Method and Compositions For Treatment or Prevention of Inflammatory Conditions

Issue date: June 20, 2017

Patent #: 9,682,070

Country: United States

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Publications

Journal Articles

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.

Maneix L, Iakova P, Lee CG, Moree SE, Lu X, Datar GK, Hill CT, Spooner E, King JCK, Sykes DB, Saez B, Di Stefano B, Chen X, Krause DS, Sahin E, Tsai FTF, Goodell MA, Berk BC, Scadden DT, Catic A

Nature cell biology.. 2024 March 29 Epub 03/29/2024.

A Natural Metabolite and Inhibitor of the NLRP3 Inflammasome: 4-hydroxynonenal.

Zhang J, Berk BC, Hsu CG

Journal of cellular immunology.. 2024 6 (2):76-81. Epub 1900 01 01.

Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages.

Hsu CG, Li W, Sowden M, Chávez CL, Berk BC

Cellular & molecular immunology.. 2023 January 4 Epub 01/04/2023.

MST1 Kinase-Cx43-YAP/TAZ Pathway Mediates Disturbed Flow Endothelial Dysfunction.

Meghwani H, Berk BC

Circulation research.. 2022 October 14131 (9):765-767. Epub 10/13/2022.

Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.

Luo L, Zhang Y, Hsu C, Korshunov VA, Long X, Knight PA, Berk BC, Yan C

Cardiovascular research.. 2022 September 20118 (12):2703-2717. Epub 1900 01 01.

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis.

Hsu CG, Chávez CL, Zhang C, Sowden M, Yan C, Berk BC

Cell death and differentiation.. 2022 September 29 (9):1790-1803. Epub 03/09/2022.

Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation.

Hsu CG, Fazal F, Rahman A, Berk BC, Yan C

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 June 15206 (12):3010-3020. Epub 06/11/2021.

Nck1 is a critical adaptor between proatherogenic blood flow, inflammation, and atherosclerosis.

Wines-Samuelson M, Chowdhury S, Berk BC

The Journal of clinical investigation.. 2020 August 3130 (8):3968-3970. Epub 1900 01 01.

Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.

Korshunov VA, Smolock EM, Wines-Samuelson ME, Faiyaz A, Mickelsen DM, Quinn B, Pan C, Dugbartey GJ, Yan C, Doyley MM, Lusis AJ, Berk BC

Journal of the American Heart Association.. 2020 May 189 (10):e014257. Epub 05/12/2020.

The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

Dugbartey GJ, Quinn B, Luo L, Mickelsen DM, Ture SK, Morrell CN, Czyzyk J, Doyley MM, Yan C, Berk BC, Korshunov VA

The American journal of pathology.. 2019 September 189 (9):1721-1731. Epub 06/18/2019.

Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.

Korshunov VA, Quinn B, Faiyaz A, Ahmed R, Sowden MP, Doyley MM, Berk BC

British journal of pharmacology.. 2019 August 176 (15):2795-2807. Epub 06/24/2019.

NOX5 as a therapeutic target in cerebral ischemic injury.

Carmo LSD, Berk BC, Harrison DG

The Journal of clinical investigation.. 2019 March 18129 (4):1530-1532. Epub 03/18/2019.

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator.

Plekhanova O, Parfyonova Y, Beloglazova I, Berk BC, Tkachuk V

Frontiers in physiology.. 2019 10 :493. Epub 04/30/2019.

Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases.

Xue C, Sowden MP, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2018 May 38 (5):986-993. Epub 03/29/2018.

Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation.

Xue C, Sowden M, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2017 June 37 (6):1138-1146. Epub 04/27/2017.

G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.

Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J

Cell reports.. 2016 December 617 (10):2532-2541. Epub 1900 01 01.

Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events.

Heo KS, Berk B, Abe JI

Antioxidants & redox signaling.. 2016 September 125 (7):435-50. Epub 04/05/2016.

Cyclophilin A modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis.

Perrucci GL, Straino S, Corlianò M, Scopece A, Napolitano M, Berk BC, Lombardi F, Pompilio G, Capogrossi MC, Nigro P

International journal of cardiology.. 2016 June 1212 :324-35. Epub 03/24/2016.

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC

Journal of cardiovascular pharmacology and therapeutics.. 2016 March 21 (2):177-86. Epub 06/30/2015.

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.

Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S

Circulation research.. 2015 May 22116 (11):e99-132. Epub 04/30/2015.

The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.

Burke R, Berk B

Antioxidants & redox signaling.. 2015 May 1022 (14):1243-56. Epub 03/23/2015.

Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

Sheu TJ, Zhou W, Fan J, Zhou H, Zuscik MJ, Xie C, Yin G, Berk BC

Molecular and cellular biochemistry.. 2014 December 397 (1-2):67-74. Epub 08/20/2014.

Novel mechanisms of endothelial mechanotransduction.

Abe JI, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2014 November 34 (11):2378-86. Epub 10/09/2014.

Intima modifier locus 2 controls endothelial cell activation and vascular permeability.

Smolock EM, Burke RM, Wang C, Thomas T, Batchu SN, Qiu X, Zettel M, Fujiwara K, Berk BC, Korshunov VA

Physiological genomics.. 2014 September 146 (17):624-33. Epub 07/01/2014.

Cyclophilin A is an important mediator of platelet function by regulating integrin ?IIb?3 bidirectional signalling.

Wang L, Soe NN, Sowden M, Xu Y, Modjeski K, Baskaran P, Kim Y, Smolock EM, Morrell C, Berk BC

Thrombosis and haemostasis.. 2014 May 5111 (5):873-82. Epub 01/16/2014.

Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.

Spindel ON, Burke RM, Yan C, Berk BC

Circulation research.. 2014 March 28114 (7):1125-32. Epub 02/10/2014.

Acetylation of cyclophilin A is required for its secretion and vascular cell activation.

Soe NN, Sowden M, Baskaran P, Kim Y, Nigro P, Smolock EM, Berk BC

Cardiovascular research.. 2014 March 1101 (3):444-53. Epub 11/29/2013.

G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.

Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J

Arteriosclerosis, thrombosis, and vascular biology.. 2014 February 34 (2):419-26. Epub 11/21/2013.

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC

PloS one.. 2014 9 (2):e89127. Epub 02/19/2014.

Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells.

Soe NN, Sowden M, Baskaran P, Smolock EM, Kim Y, Nigro P, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 September 33 (9):2147-53. Epub 07/11/2013.

Cezanne paints inflammation by regulating ubiquitination.

Abe J, Berk BC

Circulation research.. 2013 June 7112 (12):1526-8. Epub 1900 01 01.

G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration.

Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 May 33 (5):999-1005. Epub 02/21/2013.

Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.

Smolock EM, Machleder DE, Korshunov VA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 May 33 (5):1014-9. Epub 02/28/2013.

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.

Park Y, Park SY, Shi X, Pang J, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 April 33 (4):737-43. Epub 02/07/2013.

p62 binding to protein kinase C ? regulates tumor necrosis factor ?-induced apoptotic pathway in endothelial cells.

Kim GY, Nigro P, Fujiwara K, Abe JI, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2012 December 32 (12):2974-80. Epub 09/27/2012.

Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.

Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk B

Circulation.. 2012 November 13126 (20):2418-27. Epub 10/12/2012.

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV

Nature.. 2012 May 16485 (7399):512-6. Epub 05/16/2012.

Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.

Spindel ON, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2012 May 32 (5):1264-70. Epub 02/16/2012.

Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms.

Spindel ON, World C, Berk B

Antioxidants & redox signaling.. 2012 March 1516 (6):587-96. Epub 12/20/2011.

Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.

Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC

Circulation research.. 2012 February 17110 (4):560-8. Epub 01/19/2012.

Redox redux: protecting the ischemic myocardium.

Spindel ON, Berk BC

The Journal of clinical investigation.. 2012 January 122 (1):30-2. Epub 12/27/2011.

G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart.

Pang J, Xu X, Getman MR, Shi X, Belmonte SL, Michaloski H, Mohan A, Blaxall BC, Berk BC

Journal of molecular and cellular cardiology.. 2011 November 51 (5):769-76. Epub 07/02/2011.

Flow shear stress and atherosclerosis: a matter of site specificity.

Nigro P, Abe JI, Berk B

Antioxidants & redox signaling.. 2011 September 115 (5):1405-14. Epub 04/08/2011.

Vascular-derived reactive oxygen species for homeostasis and diseases.

Satoh K, Berk BC, Shimokawa H

Nitric oxide : biology and chemistry. 2011 August 125 (2):211-5. Epub 05/03/2011.

p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X, Yan C, Nadtochiy SM, Abe JI, Brookes PS, Berk BC

Journal of molecular and cellular cardiology.. 2011 August 51 (2):272-5. Epub 05/14/2011.

PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.

Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J

The Journal of cell biology.. 2011 May 30193 (5):867-84. Epub 1900 01 01.

Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.

Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2011 May 31 (5):1116-23. Epub 02/17/2011.

Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.

Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe JI, Alexis JD, Sparks JD, Berk BC

The Journal of experimental medicine.. 2011 January 17208 (1):53-66. Epub 12/20/2010.

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC

Journal of cellular physiology.. 2010 November 225 (3):777-85. Epub 1900 01 01.

Cyclophilin A: promising new target in cardiovascular therapy.

Satoh K, Shimokawa H, Berk BC

Circulation journal : official journal of the Japanese Circulation Society. 2010 November 74 (11):2249-56. Epub 10/15/2010.

Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.

Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2010 October 30 (10):1976-82. Epub 08/05/2010.

PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.

Nigro P, Abe JI, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC

Blood.. 2010 September 16116 (11):1971-9. Epub 06/10/2010.

Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.

Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC

Hypertension.. 2010 July 56 (1):105-11. Epub 05/17/2010.

Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.

Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe JI, Berk BC, Li JD, Yan C

Proceedings of the National Academy of Sciences of the United States of America.. 2010 May 25107 (21):9795-800. Epub 05/06/2010.

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.

Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC

Brain research.. 2010 March 41317 :218-26. Epub 01/04/2010.

Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A.

Satoh K, Nigro P, Berk B

Antioxidants & redox signaling.. 2010 March 112 (5):675-82. Epub 1900 01 01.

Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.

Massett MP, Fan R, Berk BC

Physiological genomics.. 2009 December 3040 (1):15-22. Epub 09/29/2009.

GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions.

Zhang N, Cai W, Ma Y, Yin G, Nagel DJ, Berk BC

Cell biology international.. 2009 December 1634 (1):41-7. Epub 12/16/2009.

TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.

Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe JI, Berk B, Ho FM, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2009 August 11106 (32):13353-8. Epub 07/28/2009.

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.

Pan S, World CJ, Kovacs CJ, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2009 June 29 (6):895-901. Epub 04/09/2009.

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.

Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe JI, Illig KA, Berk BC

Nature medicine.. 2009 June 15 (6):649-56. Epub 1900 01 01.

G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC

Circulation.. 2009 March 24119 (11):1524-32. Epub 03/09/2009.

GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.

Wang J, Taba Y, Pang J, Yin G, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2009 February 29 (2):202-8. Epub 11/20/2008.

Flow-mediated vascular remodeling in hypertension: relation to hemodyamics.

Ibrahim J, Berk BC

Stroke.. 2009 February 40 (2):582-90. Epub 12/18/2008.

Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.

Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J

Circulation research.. 2009 January 2104 (1):69-78. Epub 11/20/2008.

Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid.

Korshunov VA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2009 January 29 (1):47-53. Epub 10/23/2008.

Flow-Mediated Vascular Remodeling in Hypertension. Relation to Hemodyamics.

Ibrahim, J, Berk BC.

Stroke. 2009; .

Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator.

Plekhanova O, Berk BC, Bashtrykov P, Brooks AI, Tkachuk V, Parfyonova Y

Journal of vascular research.. 2009 46 (3):177-87. Epub 09/24/2008.

An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.

Cavet ME, Pang J, Yin G, Berk BC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 October 22 (10):3607-16. Epub 06/03/2008.

Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC

Circulation.. 2008 June 17117 (24):3088-98. Epub 06/09/2008.

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells.

Li L, Tatake RJ, Natarajan K, Taba Y, Garin G, Tai C, Leung E, Surapisitchat J, Yoshizumi M, Yan C, Abe J, Berk BC

Biochemical and biophysical research communications.. 2008 May 23370 (1):159-63. Epub 03/19/2008.

Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.

Cavet ME, Smolock EM, Ozturk OH, World C, Pang J, Konishi A, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 May 28 (5):886-91. Epub 02/21/2008.

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.

Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 May 28 (5):892-8. Epub 02/21/2008.

Smooth muscle apoptosis and vascular remodeling.

Korshunov VA, Berk BC

Current opinion in hematology.. 2008 May 15 (3):250-4. Epub 1900 01 01.

PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

Mathews MT, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 April 28 (4):711-7. Epub 01/31/2008.

Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells.

Berk BC

Circulation.. 2008 February 26117 (8):1082-9. Epub 1900 01 01.

Circulating smooth muscle progenitor cells: novel players in plaque stability.

Satoh K, Berk BC

Cardiovascular research.. 2008 February 177 (3):445-7. Epub 12/04/2007.

Chapter 2 physiologic stress-mediated signaling in the endothelium.

Reinhart-King, C.; Fujiwara, K.; Berk, B.C.

Methods Enzymology. 2008; 443: 25-44.

Physiologic stress-mediated signaling in the endothelium.

Reinhart-King CA, Fujiwara K, Berk BC

Methods in enzymology.. 2008 443 :25-44. Epub 1900 01 01.

Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension.

Korshunov VA, Daul M, Massett MP, Berk BC

Hypertension.. 2007 December 50 (6):1057-62. Epub 10/08/2007.

Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon.

Korshunov VA, Schwartz SM, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2007 August 27 (8):1722-8. Epub 05/31/2007.

Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.

Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC

Circulation research.. 2007 July 6101 (1):97-105. Epub 05/24/2007.

Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner.

Wang J, Pan S, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2007 June 27 (6):1283-8. Epub 04/12/2007.

ECM remodeling in hypertensive heart disease.

Berk BC, Fujiwara K, Lehoux S

The Journal of clinical investigation.. 2007 March 117 (3):568-75. Epub 1900 01 01.

Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.

Chen C, Korshunov VA, Massett MP, Yan C, Berk BC

Journal of vascular research.. 2007 44 (6):504-12. Epub 07/30/2007.

Novel approaches to treat oxidative stress and cardiovascular diseases.

Berk BC

Transactions of the American Clinical and Climatological Association.. 2007 118 :209-14. Epub 1900 01 01.

Thioredoxin in the cardiovascular system.

World CJ, Yamawaki H, Berk BC

Journal of molecular medicine : official organ of the "Gesellschaft Deutscher Naturforscher und A?rzte".. 2006 December 84 (12):997-1003. Epub 10/05/2006.

Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade.

Barker TA, Massett MP, Korshunov VA, Mohan AM, Kennedy AJ, Berk BC

Hypertension.. 2006 November 48 (5):942-9. Epub 09/18/2006.

HDAC7 supports vascular integrity.

Miano JM, Berk BC

Nature medicine.. 2006 September 12 (9):997-8. Epub 1900 01 01.

Urokinase induces ROS production in vascular smooth muscle cells.

Plekhanova OS, Men'shikov MY, Bashtrykov PP, Berk BC, Tkachuk VA, Parfenova EV

Bulletin of experimental biology and medicine.. 2006 September 142 (3):304-7. Epub 1900 01 01.

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling.

Korshunov VA, Mohan AM, Georger MA, Berk BC

Circulation research.. 2006 June 998 (11):1446-52. Epub 04/20/2006.

Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury.

Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC

Circulation.. 2006 May 30113 (21):2516-23. Epub 05/22/2006.

The multifunctional GIT family of proteins.

Hoefen RJ, Berk BC

Journal of cell science.. 2006 April 15119 (Pt 8):1469-75. Epub 1900 01 01.

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J

Circulation.. 2006 April 11113 (14):1787-98. Epub 04/03/2006.

Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways.

Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2006 April 26 (4):801-7. Epub 02/02/2006.

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.

Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C

Circulation research.. 2006 March 3198 (6):777-84. Epub 03/02/2006.

Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC

Circulation research.. 2006 March 3198 (6):811-7. Epub 03/09/2006.

Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening.

Korshunov VA, Nikonenko TA, Tkachuk VA, Brooks A, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2006 February 26 (2):295-300. Epub 11/17/2005.

Genetic determinants of vascular remodelling.

Berk BC, Korshunov VA

The Canadian journal of cardiology.. 2006 February 22 Suppl B (Suppl B):6B-11B. Epub 1900 01 01.

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.

Shen WL, Gao PJ, Che ZQ, Ji KD, Yin M, Yan C, Berk BC, Zhu DL

Biochemical and biophysical research communications.. 2006 January 6339 (1):337-43. Epub 11/15/2005.

Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats.

Ibrahim J, Berk BC, Hughes AD

Clinical and experimental hypertension : CHE.. 2006 January 28 (1):57-72. Epub 1900 01 01.

Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases.

Natarajan K, Berk BC

Methods in molecular biology.. 2006 332 :51-77. Epub 1900 01 01.

Flow-mediated signaling modulates endothelial cell phenotype.

Garin G, Berk BC

Endothelium : journal of endothelial cell research. 2006 13 (6):375-84. Epub 1900 01 01.

Role of hypertension in the metabolic syndrome: who is affected?

Velarde G, Berk BC

Current hypertension reports.. 2005 December 7 (6):418-26. Epub 1900 01 01.

Tissue-resident bone marrow-derived progenitor cells: key players in hypoxia-induced angiogenesis.

Garin G, Mathews M, Berk BC

Circulation research.. 2005 November 1197 (10):955-7. Epub 1900 01 01.

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.

Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C

Proceedings of the National Academy of Sciences of the United States of America.. 2005 October 11102 (41):14771-6. Epub 09/26/2005.

Expanding the definition and classification of hypertension.

Giles TD, Berk BC, Black HR, Cohn JN, Kostis JB, Izzo JL, Weber MA

The journal of clinical hypertension.. 2005 September 7 (9):505-12. Epub 1900 01 01.

Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2.

Tai LK, Zheng Q, Pan S, Jin ZG, Berk BC

The Journal of biological chemistry.. 2005 August 19280 (33):29620-4. Epub 06/28/2005.

GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

Yin G, Zheng Q, Yan C, Berk BC

The Journal of biological chemistry.. 2005 July 29280 (30):27705-12. Epub 05/27/2005.

BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.

Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC

Circulation research.. 2005 June 1096 (11):1145-51. Epub 05/05/2005.

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.

Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C

Circulation.. 2005 May 17111 (19):2469-2476. Epub 05/02/2005.

Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.

Jin ZG, Wong C, Wu J, Berk BC

The Journal of biological chemistry.. 2005 April 1280 (13):12305-9. Epub 01/21/2005.

Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expression.

Blaxall BC, Miano JM, Berk BC

Circulation research.. 2005 April 196 (6):610-1. Epub 1900 01 01.

Strain-dependent differences in responses to exercise training in inbred and hybrid mice.

Massett MP, Berk BC

American journal of physiology. Regulatory, integrative and comparative physiology.. 2005 April 288 (4):R1006-13. Epub 12/23/2004.

Thioredoxin: a multifunctional antioxidant enzyme in kidney, heart and vessels.

Yamawaki H, Berk BC

Current opinion in nephrology and hypertension.. 2005 March 14 (2):149-53. Epub 1900 01 01.

Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.

Yamawaki H, Pan S, Lee RT, Berk BC

The Journal of clinical investigation.. 2005 March 115 (3):733-8. Epub 1900 01 01.

Angiotensin II and the endothelium: diverse signals and effects.

Watanabe T, Barker TA, Berk BC

Hypertension.. 2005 February 45 (2):163-9. Epub 01/03/2005.

Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling.

Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C

Journal of molecular and cellular cardiology.. 2005 January 38 (1):175-84. Epub 12/08/2004.

VALUE in hypertension treatment.

Berk BC, Bisognano JD

Current hypertension reports.. 2004 December 6 (6):411-3. Epub 1900 01 01.

Role of secreted oxidative stress-induced factors (SOXFs) in the pathogenesis of atherosclerosis.

Jin ZG, Berk BC

Archives des maladies du coeur et des vaisseaux.. 2004 December 97 (12):1256-9. Epub 1900 01 01.

Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae.

Lungu AO, Jin ZG, Yamawaki H, Tanimoto T, Wong C, Berk BC

The Journal of biological chemistry.. 2004 November 19279 (47):48794-800. Epub 09/20/2004.

Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction.

Narins CR, Lin DA, Burton PB, Jin ZG, Berk BC

The American journal of cardiology.. 2004 November 1594 (10):1285-7. Epub 1900 01 01.

Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt.

Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J, Berk BC

Journal of molecular and cellular cardiology.. 2004 October 37 (4):881-7. Epub 1900 01 01.

Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined.

Korshunov VA, Berk BC

Circulation.. 2004 July 13110 (2):220-6. Epub 06/28/2004.

ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation.

Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Marmarosh NL, Che W, Ding B, Yan C, Abe J

The Journal of biological chemistry.. 2004 July 9279 (28):29691-9. Epub 04/12/2004.

Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells.

Konishi A, Aizawa T, Mohan A, Korshunov VA, Berk BC

The Journal of biological chemistry.. 2004 July 2279 (27):28766-70. Epub 04/28/2004.

Cyclophilin A is a proinflammatory cytokine that activates endothelial cells.

Jin ZG, Lungu AO, Xie L, Wang M, Wong C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2004 July 24 (7):1186-91. Epub 05/06/2004.

SOXF: redox mediators of vascular smooth muscle cell growth.

Jin ZG, Berk BC

Heart.. 2004 May 90 (5):488-90. Epub 1900 01 01.

GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.

van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC

Circulation research.. 2004 April 3094 (8):1041-9. Epub 03/11/2004.

Scaffolds direct Src-specific signaling in response to angiotensin II: new roles for Cas and GIT1.

Natarajan K, Yin G, Berk BC

Molecular pharmacology.. 2004 April 65 (4):822-5. Epub 1900 01 01.

14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

Zheng Q, Yin G, Yan C, Cavet M, Berk BC

The Journal of biological chemistry.. 2004 March 5279 (10):8787-91. Epub 12/16/2003.

Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.

Pi X, Yan C, Berk BC

Circulation research.. 2004 February 2094 (3):362-9. Epub 12/11/2003.

GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor.

Yin G, Haendeler J, Yan C, Berk BC

Molecular and cellular biology.. 2004 January 24 (2):875-85. Epub 1900 01 01.

Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling.

Korshunov VA, Massett MP, Carey RM, Berk BC

Journal of vascular research.. 2004 41 (2):148-56. Epub 03/03/2004.

Plasminogen activator expression correlates with genetic differences in vascular remodeling.

Korshunov VA, Solomatina MA, Plekhanova OS, Parfyonova YV, Tkachuk VA, Berk BC

Journal of vascular research.. 2004 41 (6):481-90. Epub 10/28/2004.

GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor.

Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC

The Journal of biological chemistry.. 2003 December 12278 (50):49936-44. Epub 09/30/2003.

Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening.

Korshunov VA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2003 December 23 (12):2185-91. Epub 10/23/2003.

Thioredoxin: a key regulator of cardiovascular homeostasis.

Yamawaki H, Haendeler J, Berk BC

Circulation research.. 2003 November 2893 (11):1029-33. Epub 1900 01 01.

Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation.

Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J

Arteriosclerosis, thrombosis, and vascular biology.. 2003 October 123 (10):1775-81. Epub 08/28/2003.

Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo.

Yamawaki H, Lehoux S, Berk BC

Circulation.. 2003 September 30108 (13):1619-25. Epub 09/08/2003.

Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells.

Konishi A, Berk BC

The Journal of biological chemistry.. 2003 September 12278 (37):35049-56. Epub 06/26/2003.

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.

Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C

Circulation research.. 2003 September 593 (5):406-13. Epub 08/14/2003.

Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase.

Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC

Circulation research.. 2003 August 2293 (4):354-63. Epub 07/31/2003.

Angiotensin II signaling pathways mediated by tyrosine kinases.

Yin G, Yan C, Berk BC

The international journal of biochemistry & cell biology.. 2003 June 35 (6):780-3. Epub 1900 01 01.

14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.

Cavet ME, Lehoux S, Berk BC

The Journal of biological chemistry.. 2003 May 16278 (20):18376-83. Epub 03/04/2003.

Shear stress is differentially regulated among inbred rat strains.

Ibrahim J, Miyashiro JK, Berk BC

Circulation research.. 2003 May 1692 (9):1001-9. Epub 04/03/2003.

Angiotensin type 2 receptor (AT2R): a challenging twin.

Berk BC

Science's STKE : signal transduction knowledge environment. 2003 May 62003 (181):PE16. Epub 05/06/2003.

Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.

Ogata Y, Takahashi M, Ueno S, Takeuchi K, Okada T, Mano H, Ookawara S, Ozawa K, Berk BC, Ikeda U, Shimada K, Kobayashi E

Hypertension.. 2003 May 41 (5):1156-63. Epub 03/31/2003.

Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases.

Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T

Journal of pharmacological sciences.. 2003 March 91 (3):172-6. Epub 1900 01 01.

Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.

Yan C, Kim D, Aizawa T, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2003 January 123 (1):26-36. Epub 1900 01 01.

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway.

Tai LK, Okuda M, Abe J, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2002 November 122 (11):1790-6. Epub 1900 01 01.

Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism.

Hojo Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J, Asmis R, Berk BC

Circulation research.. 2002 October 1891 (8):712-8. Epub 1900 01 01.

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

Haendeler J, Hoffmann J, Tischler V, Berk BC, Zeiher AM, Dimmeler S

Nature cell biology.. 2002 October 4 (10):743-9. Epub 1900 01 01.

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.

Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J

The Journal of biological chemistry.. 2002 August 9277 (32):29330-41. Epub 05/14/2002.

Hypoxia and HIF-1alpha stability: another stress-sensing mechanism for Shc.

Abe J, Berk BC

Circulation research.. 2002 July 1291 (1):4-6. Epub 1900 01 01.

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.

Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC

The Journal of biological chemistry.. 2002 June 28277 (26):23216-22. Epub 04/08/2002.

Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression.

Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J

Circulation research.. 2002 June 1490 (11):1222-30. Epub 1900 01 01.

Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.

Frame MD, Fox RJ, Kim D, Mohan A, Berk BC, Yan C

American journal of physiology. Heart and circulatory physiology.. 2002 June 282 (6):H2377-85. Epub 1900 01 01.

The role of MAP kinases in endothelial activation.

Hoefen RJ, Berk BC

Vascular pharmacology.. 2002 May 38 (5):271-3. Epub 1900 01 01.

Angiotensin II-mediated signal transduction pathways.

Saito Y, Berk BC

Current hypertension reports.. 2002 April 4 (2):167-71. Epub 1900 01 01.

Atheroprotective Mechanisms Activated by Fluid Shear Stress in Endothelial Cells.

Berk BC, Min W, Yan C, Surapisitchat J, Liu Y, Hoefen R

Drug news & perspectives. 2002 April 15 (3):133-139. Epub 1900 01 01.

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy.

Takeishi Y, Huang Q, Abe J, Che W, Lee JD, Kawakatsu H, Hoit BD, Berk BC, Walsh RA

Cardiovascular research.. 2002 January 53 (1):131-7. Epub 1900 01 01.

Differential expression of genes from nitrate-tolerant rat aorta.

Pi X, Yan C, Kim D, Chen J, Berk BC

Journal of vascular research.. 2002 39 (4):304-10. Epub 1900 01 01.

Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr.

Abe JI, Che W, Yoshizumi M, Huang Q, Glassman M, Ohta S, Wu Y, Arlinghaus R, Berk BC

Annals of the New York Academy of Sciences.. 2001 December 947 :341-3. Epub 1900 01 01.

Endothelial atheroprotective and anti-inflammatory mechanisms.

Berk BC, Abe JI, Min W, Surapisitchat J, Yan C

Annals of the New York Academy of Sciences.. 2001 December 947 :93-109; discussion 109-11. Epub 1900 01 01.

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.

Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C

Circulation.. 2001 November 6104 (19):2338-43. Epub 1900 01 01.

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning.

Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines CP, Lee JD, Kawakatsu H, Che W, Lerner-Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J

Journal of molecular and cellular cardiology.. 2001 November 33 (11):1989-2005. Epub 1900 01 01.

Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation.

Saito Y, Haendeler J, Hojo Y, Yamamoto K, Berk BC

Molecular and cellular biology.. 2001 October 21 (19):6387-94. Epub 1900 01 01.

p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.

Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC

Circulation.. 2001 September 18104 (12):1399-406. Epub 1900 01 01.

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.

Takeishi Y, Huang Q, Abe J, Glassman M, Che W, Lee JD, Kawakatsu H, Lawrence EG, Hoit BD, Berk BC, Walsh RA

Journal of molecular and cellular cardiology.. 2001 September 33 (9):1637-48. Epub 1900 01 01.

Vascular smooth muscle growth: autocrine growth mechanisms.

Berk BC

Physiological reviews.. 2001 July 81 (3):999-1030. Epub 1900 01 01.

Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members.

Surapisitchat J, Hoefen RJ, Pi X, Yoshizumi M, Yan C, Berk BC

Proceedings of the National Academy of Sciences of the United States of America.. 2001 May 2298 (11):6476-81. Epub 05/15/2001.

c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.

Chen K, Vita JA, Berk BC, Keaney JF

The Journal of biological chemistry.. 2001 May 11276 (19):16045-50. Epub 02/27/2001.

14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange.

Lehoux S, Abe Ji , Florian JA, Berk BC

The Journal of biological chemistry.. 2001 May 11276 (19):15794-800. Epub 02/13/2001.

Retinoids: new insight into smooth muscle cell growth inhibition.

Miano JM, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2001 May 21 (5):724-6. Epub 1900 01 01.

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains.

Yan C, Luo H, Lee JD, Abe J, Berk BC

The Journal of biological chemistry.. 2001 April 6276 (14):10870-8. Epub 01/03/2001.

Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3.

Liu Y, Yin G, Surapisitchat J, Berk BC, Min W

The Journal of clinical investigation.. 2001 April 107 (7):917-23. Epub 1900 01 01.

Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors.

Saito Y, Berk BC

Journal of molecular and cellular cardiology.. 2001 January 33 (1):3-7. Epub 1900 01 01.

Angiotensin II mediated signal transduction. Important role of tyrosine kinases.

Haendeler J, Berk BC

Regulatory peptides.. 2000 November 2495 (1-3):1-7. Epub 1900 01 01.

Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells.

Ou H, Haendeler J, Aebly MR, Kelly LA, Cholewa BC, Koike G, Kwitek-Black A, Jacob HJ, Berk BC, Miano JM

Circulation research.. 2000 November 1087 (10):881-7. Epub 1900 01 01.

Cyclophilin A is a secreted growth factor induced by oxidative stress.

Jin ZG, Melaragno MG, Liao DF, Yan C, Haendeler J, Suh YA, Lambeth JD, Berk BC

Circulation research.. 2000 October 2787 (9):789-96. Epub 1900 01 01.

Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype.

Miano JM, Berk BC

Circulation research.. 2000 September 187 (5):355-62. Epub 1900 01 01.

Angiotensin II, atherosclerosis, and aortic aneurysms.

Berk BC, Haendeler J, Sottile J

The Journal of clinical investigation.. 2000 June 105 (11):1525-6. Epub 1900 01 01.

Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc.

Heeneman S, Haendeler J, Saito Y, Ishida M, Berk BC

The Journal of biological chemistry.. 2000 May 26275 (21):15926-32. Epub 1900 01 01.

Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species.

Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC

The Journal of biological chemistry.. 2000 April 21275 (16):11706-12. Epub 1900 01 01.

Role of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad.

Abe J, Baines CP, Berk BC

Circulation research.. 2000 March 3186 (6):607-9. Epub 1900 01 01.

Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras.

Abe J, Okuda M, Huang Q, Yoshizumi M, Berk BC

The Journal of biological chemistry.. 2000 January 21275 (3):1739-48. Epub 1900 01 01.

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells.

Liao DF, Jin ZG, Baas AS, Daum G, Gygi SP, Aebersold R, Berk BC

The Journal of biological chemistry.. 2000 January 7275 (1):189-96. Epub 1900 01 01.

The Gas6/Axl system: a novel regulator of vascular cell function.

Melaragno MG, Fridell YW, Berk BC

Trends in cardiovascular medicine.. 1999 November 9 (8):250-3. Epub 1900 01 01.

Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002.

Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell SR, Figeys D, Harrison DG, Berk BC, Aebersold R, Corson MA

The Journal of biological chemistry.. 1999 October 15274 (42):30101-8. Epub 1900 01 01.

NAB2: a transcriptional brake for activated gene expression in the vessel wall?

Miano JM, Berk BC

The American journal of pathology.. 1999 October 155 (4):1009-12. Epub 1900 01 01.

Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation.

Okuda M, Takahashi M, Suero J, Murry CE, Traub O, Kawakatsu H, Berk BC

The Journal of biological chemistry.. 1999 September 17274 (38):26803-9. Epub 1900 01 01.

Redox signals that regulate the vascular response to injury.

Berk BC

Thrombosis and haemostasis.. 1999 August 82 (2):810-7. Epub 1900 01 01.

Fyn and JAK2 mediate Ras activation by reactive oxygen species.

Abe J, Berk BC

The Journal of biological chemistry.. 1999 July 23274 (30):21003-10. Epub 1900 01 01.

Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel.

Traub O, Ishida T, Ishida M, Tupper JC, Berk BC

The Journal of biological chemistry.. 1999 July 16274 (29):20144-50. Epub 1900 01 01.

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1.

Takahashi E, Abe J, Gallis B, Aebersold R, Spring DJ, Krebs EG, Berk BC

The Journal of biological chemistry.. 1999 July 16274 (29):20206-14. Epub 1900 01 01.

Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae.

Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk BC

Circulation research.. 1999 July 985 (1):29-37. Epub 1900 01 01.

Eight years behind the masthead.

Vatner SF, Berk BC, Hintze TH, Leinwand LA, Libby P, Marban E, Schwartz K, Strauss HC, Yazaki Y

Circulation research.. 1999 June 2584 (12):1361-4. Epub 1900 01 01.

If I had an acute coronary syndrome..

Delehanty JM, Ling FS, Berk BC

Lancet.. 1999 June 353 Suppl 2 :SII24-6. Epub 1900 01 01.

Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src.

Ishida T, Ishida M, Suero J, Takahashi M, Berk BC

The Journal of clinical investigation.. 1999 March 103 (6):789-97. Epub 1900 01 01.

Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium.

Yan C, Takahashi M, Okuda M, Lee JD, Berk BC

The Journal of biological chemistry.. 1999 January 1274 (1):143-50. Epub 1900 01 01.

Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases.

Berk BC

Journal of the American Society of Nephrology : JASN.. 1999 January 10 Suppl 11 :S62-8. Epub 1900 01 01.

Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts.

Takeishi Y, Abe J, Lee JD, Kawakatsu H, Walsh RA, Berk BC

Circulation research.. 1999 85 (12):1164-72. Epub 1900 01 01.

MAP kinases and vascular smooth muscle function.

Takahashi E, Berk BC

Acta physiologica Scandinavica. 1998 December 164 (4):611-21. Epub 1900 01 01.

p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2.

Kusuhara M, Takahashi E, Peterson TE, Abe J, Ishida M, Han J, Ulevitch R, Berk BC

Circulation research.. 1998 October 1983 (8):824-31. Epub 1900 01 01.

Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats.

Melaragno MG, Wuthrich DA, Poppa V, Gill D, Lindner V, Berk BC, Corson MA

Circulation research.. 1998 October 583 (7):697-704. Epub 1900 01 01.

Endothelial NO synthase is increased in regenerating endothelium after denuding injury of the rat aorta.

Poppa V, Miyashiro JK, Corson MA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 1998 August 18 (8):1312-21. Epub 1900 01 01.

Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK.

Schmitz U, Ishida T, Ishida M, Surapisitchat J, Hasham MI, Pelech S, Berk BC

Circulation research.. 1998 June 2982 (12):1272-8. Epub 1900 01 01.

Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force.

Traub O, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 1998 May 18 (5):677-85. Epub 1900 01 01.

Reactive oxygen species as mediators of signal transduction in cardiovascular disease.

Abe J, Berk BC

Trends in cardiovascular medicine.. 1998 February 8 (2):59-64. Epub 1900 01 01.

Agonist-mediated changes in intracellular pH: role in vascular smooth muscle cell function.

Berk, B.C.; Canessa, M.; Vallega, G.; Alexander, R.W.

J Cardiovasc Pharmacol. 1998; 12(Suppl 5): S104-14.

Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells.

Ishida M, Ishida T, Thomas SM, Berk BC

Circulation research.. 1998 82 (1):7-12. Epub 1900 01 01.

PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.

Traub O, Monia BP, Dean NM, Berk BC

The Journal of biological chemistry.. 1997 December 12272 (50):31251-7. Epub 1900 01 01.

Vitamins C and E inhibit O2- production in the pig coronary artery.

Nunes GL, Robinson K, Kalynych A, King SB, Sgoutas DS, Berk BC

Circulation.. 1997 November 1896 (10):3593-601. Epub 1900 01 01.

Flow-induced vascular remodeling in the rat carotid artery diminishes with age.

Miyashiro JK, Poppa V, Berk BC

Circulation research.. 1997 September 81 (3):311-9. Epub 1900 01 01.

Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo.

Mondy JS, Lindner V, Miyashiro JK, Berk BC, Dean RH, Geary RL

Circulation research.. 1997 September 81 (3):320-7. Epub 1900 01 01.

Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways.

Schmitz U, Berk BC

Trends in endocrinology and metabolism : TEM.. 1997 September 8 (7):261-6. Epub 1900 01 01.

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

Abe J, Takahashi M, Ishida M, Lee JD, Berk BC

The Journal of biological chemistry.. 1997 August 15272 (33):20389-94. Epub 1900 01 01.

Angiotensin II stimulates p90rsk in vascular smooth muscle cells. A potential Na(+)-H+ exchanger kinase.

Takahashi E, Abe J, Berk BC

Circulation research.. 1997 August 81 (2):268-73. Epub 1900 01 01.

A 90-kD Na(+)-H+ exchanger kinase has increased activity in spontaneously hypertensive rat vascular smooth muscle cells.

Phan VN, Kusuhara M, Lucchesi PA, Berk BC

Hypertension.. 1997 June 29 (6):1265-72. Epub 1900 01 01.

Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases.

Ishida M, Berk BC

The Keio journal of medicine.. 1997 June 46 (2):61-8. Epub 1900 01 01.

Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases.

Berk BC, Corson MA

Circulation research.. 1997 May 80 (5):607-16. Epub 1900 01 01.

A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress.

Wiesner TF, Berk BC, Nerem RM

Proceedings of the National Academy of Sciences of the United States of America.. 1997 April 1594 (8):3726-31. Epub 1900 01 01.

Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses?

Ishida T, Takahashi M, Corson MA, Berk BC

Annals of the New York Academy of Sciences.. 1997 April 15811 :12-23; discussion 23-4. Epub 1900 01 01.

Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells.

Liao DF, Monia B, Dean N, Berk BC

The Journal of biological chemistry.. 1997 March 7272 (10):6146-50. Epub 1900 01 01.

Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages.

Kusuhara M, Chait A, Cader A, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 1997 January 17 (1):141-8. Epub 1900 01 01.

Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress.

Takahashi M, Ishida T, Traub O, Corson MA, Berk BC

Journal of vascular research.. 1997 34 (3):212-9. Epub 1900 01 01.

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase.

Takahashi M, Berk BC

The Journal of clinical investigation.. 1996 December 198 (11):2623-31. Epub 1900 01 01.

Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress.

Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG

Circulation research.. 1996 November 79 (5):984-91. Epub 1900 01 01.

Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf.

Liao DF, Duff JL, Daum G, Pelech SL, Berk BC

Circulation research.. 1996 November 79 (5):1007-14. Epub 1900 01 01.

MAP kinase activation by flow in endothelial cells. Role of beta 1 integrins and tyrosine kinases.

Ishida T, Peterson TE, Kovach NL, Berk BC

Circulation research.. 1996 August 79 (2):310-6. Epub 1900 01 01.

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase.

Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee JD

The Journal of biological chemistry.. 1996 July 12271 (28):16586-90. Epub 1900 01 01.

A second term for the editors. Status and goals for the review process.

Vatner SF, Berk BC, Leinwand LA, Libby P, Schwartz K, Strauss HC

Circulation research.. 1996 July 79 (1):1-3. Epub 1900 01 01.

Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype.

Lucchesi PA, Bell JM, Willis LS, Byron KL, Corson MA, Berk BC

Circulation research.. 1996 June 78 (6):962-70. Epub 1900 01 01.

A mathematical model of cytosolic calcium dynamics in human umbilical vein endothelial cells.

Wiesner TF, Berk BC, Nerem RM

The American journal of physiology.. 1996 May 270 (5 Pt 1):C1556-69. Epub 1900 01 01.

Pulsatile and steady flow-induced calcium oscillations in single cultured endothelial cells.

Helmlinger G, Berk BC, Nerem RM

Journal of vascular research.. 1996 33 (5):360-9. Epub 1900 01 01.

Angiotensin II activates pp60c-src in vascular smooth muscle cells.

Ishida M, Marrero MB, Schieffer B, Ishida T, Bernstein KE, Berk BC

Circulation research.. 1995 December 77 (6):1053-9. Epub 1900 01 01.

Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells.

Tseng H, Peterson TE, Berk BC

Circulation research.. 1995 November 77 (5):869-78. Epub 1900 01 01.

Angiotensin II signal transduction and the mitogen-activated protein kinase pathway.

Duff JL, Marrero MB, Paxton WG, Schieffer B, Bernstein KE, Berk BC

Cardiovascular research.. 1995 October 30 (4):511-7. Epub 1900 01 01.

The role of tyrosine phosphorylation in angiotensin II-mediated intracellular signalling.

Marrero MB, Schieffer B, Paxton WG, Duff JL, Berk BC, Bernstein KE

Cardiovascular research.. 1995 October 30 (4):530-6. Epub 1900 01 01.

Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ.

Helmlinger G, Berk BC, Nerem RM

The American journal of physiology.. 1995 August 269 (2 Pt 1):C367-75. Epub 1900 01 01.

Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells.

Baas AS, Berk BC

Circulation research.. 1995 July 77 (1):29-36. Epub 1900 01 01.

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.

Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE

Nature.. 1995 May 18375 (6528):247-50. Epub 1900 01 01.

Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle.

Fishel RS, Eisenberg S, Shai SY, Redden RA, Bernstein KE, Berk BC

Hypertension.. 1995 March 25 (3):343-9. Epub 1900 01 01.

Regulation of sodium-hydrogen exchange in vascular smooth muscle.

Lucchesi PA, Berk BC

Cardiovascular research.. 1995 February 29 (2):172-7. Epub 1900 01 01.

Combination of vitamins C and E alters the response to coronary balloon injury in the pig.

Nunes GL, Sgoutas DS, Redden RA, Sigman SR, Gravanis MB, King SB, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 1995 January 15 (1):156-65. Epub 1900 01 01.

Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.

Fishel RS, Thourani V, Eisenberg SJ, Shai SY, Corson MA, Nabel EG, Bernstein KE, Berk BC

The Journal of clinical investigation.. 1995 January 95 (1):377-87. Epub 1900 01 01.

The endothelial cell.

Eisenberg, S.; Berk, B.C.

Resident and Staff Physician. 1995; 41: 13-23.

Flow-induced calcium responses in endothelial cells are synergistically modulated by serum.

Helmlinger, G.; Berk, B.C.; Nerem, R.M.

J Cellular Engineering. 1995; 1: 13-20.

Angiotensin II-mediated signal transduction events in vascular smooth muscle cells: kinases and phosphatases.

Duff JL, Berk BC

Blood pressure. Supplement. 1995 2 :55-60. Epub 1900 01 01.

Restenosis after percutaneous transluminal coronary angioplasty: new therapeutic insights from pathogenic mechanisms.

Berk BC, Harris K

Advances in internal medicine.. 1995 40 :445-501. Epub 1900 01 01.

Na(+)-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats.

Lucchesi PA, DeRoux N, Berk BC

Hypertension.. 1994 December 24 (6):734-8. Epub 1900 01 01.

The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases.

Paxton WG, Marrero MB, Klein JD, Delafontaine P, Berk BC, Bernstein KE

Biochemical and biophysical research communications.. 1994 April 15200 (1):260-7. Epub 1900 01 01.

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.

Marrero MB, Paxton WG, Duff JL, Berk BC, Bernstein KE

The Journal of biological chemistry.. 1994 April 8269 (14):10935-9. Epub 1900 01 01.

Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells.

Duff JL, Marrero MB, Paxton WG, Charles CH, Lau LF, Bernstein KE, Berk BC

The Journal of biological chemistry.. 1993 December 15268 (35):26037-40. Epub 1900 01 01.

The biology of angiotensin II receptors.

Bernstein KE, Berk BC

American journal of kidney diseases : the official journal of the National Kidney Foundation.. 1993 November 22 (5):745-54. Epub 1900 01 01.

Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis.

Schneider JE, Berk BC, Gravanis MB, Santoian EC, Cipolla GD, Tarazona N, Lassegue B, King SB

Circulation.. 1993 August 88 (2):628-37. Epub 1900 01 01.

Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells.

Mitsumata M, Fishel RS, Nerem RM, Alexander RW, Berk BC

The American journal of physiology.. 1993 July 265 (1 Pt 2):H3-8. Epub 1900 01 01.

Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells.

Rao GN, Sardet C, Pouysségur J, Berk BC

The American journal of physiology.. 1993 May 264 (5 Pt 1):C1278-84. Epub 1900 01 01.

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.

Rao GN, Lasségue B, Griendling KK, Alexander RW, Berk BC

Nucleic acids research.. 1993 March 1121 (5):1259-63. Epub 1900 01 01.

Angiotensin II-induced vascular smooth muscle cell hypertrophy: PDGF A-chain mediates the increase in cell size.

Berk BC, Rao GN

Journal of cellular physiology.. 1993 February 154 (2):368-80. Epub 1900 01 01.

Endothelial dysfunction in atherosclerosis.

Berk, B.C.

Choice in Cardiology. 1993; 21: 1259-1263.

Growth factors and the vessel wall.

Corson MA, Berk BC

Heart disease and stroke : a journal for primary care physicians.. 1993 2 (2):166-70. Epub 1900 01 01.

Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures.

Rothman A, Kulik TJ, Taubman MB, Berk BC, Smith CW, Nadal-Ginard B

Circulation.. 1992 December 86 (6):1977-86. Epub 1900 01 01.

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells.

Duff JL, Berk BC, Corson MA

Biochemical and biophysical research communications.. 1992 October 15188 (1):257-64. Epub 1900 01 01.

Na+, K(+)-adenosine triphosphatase regulation in hypertrophied vascular smooth muscle cells.

Krug LM, Berk BC

Hypertension.. 1992 August 20 (2):144-50. Epub 1900 01 01.

Bovine angiotensin converting enzyme cDNA cloning and regulation. Increased expression during endothelial cell growth arrest.

Shai SY, Fishel RS, Martin BM, Berk BC, Bernstein KE

Circulation research.. 1992 June 70 (6):1274-81. Epub 1900 01 01.

Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis.

Geiger RV, Berk BC, Alexander RW, Nerem RM

The American journal of physiology.. 1992 June 262 (6 Pt 1):C1411-7. Epub 1900 01 01.

Na+/H+ antiporter gene expression increases during retinoic acid-induced granulocytic differentiation of HL60 cells.

Rao GN, Sardet C, Pouysségur J, Berk BC

Journal of cellular physiology.. 1992 May 151 (2):361-6. Epub 1900 01 01.

The Na/K/2Cl cotransporter is increased in hypertrophied vascular smooth muscle cells.

Tseng H, Berk BC

The Journal of biological chemistry.. 1992 April 25267 (12):8161-7. Epub 1900 01 01.

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

Rao GN, Berk BC

Circulation research.. 1992 March 70 (3):593-9. Epub 1900 01 01.

5-HT2 receptor mRNA is overexpressed in cultured rat aortic smooth muscle cells relative to normal aorta.

Corson MA, Alexander RW, Berk BC

The American journal of physiology.. 1992 February 262 (2 Pt 1):C309-15. Epub 1900 01 01.

JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells.

Taubman MB, Rollins BJ, Poon M, Marmur J, Green RS, Berk BC, Nadal-Ginard B

Circulation research.. 1992 February 70 (2):314-25. Epub 1900 01 01.

Autocrine and paracrine growth mechanisms in vascular smooth muscle.

Berk, B.C.; Corson, M.A.

Current Opinions in Cardiology. 1992; 7: 739-744.

Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells.

Rao GN, de Roux N, Sardet C, Pouysségur J, Berk BC

The Journal of biological chemistry.. 1991 July 25266 (21):13485-8. Epub 1900 01 01.

Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression.

Rao GN, Corson MA, Berk BC

The Journal of biological chemistry.. 1991 May 5266 (13):8604-8. Epub 1900 01 01.

Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty.

Berk BC, Gordon JB, Alexander RW

Journal of the American College of Cardiology.. 1991 May 17 (6 Suppl B):111B-117B. Epub 1900 01 01.

Restenosis following coronary balloon angioplasty Role of smooth muscle cell proliferation.

Liu MW, Berk BC

Trends in cardiovascular medicine.. 1991 April 1 (3):107-11. Epub 1900 01 01.

Thrombin-stimulated events in cultured vascular smooth-muscle cells.

Berk BC, Taubman MB, Griendling KK, Cragoe EJ, Fenton JW, Brock TA

The Biochemical journal.. 1991 March 15274 ( Pt 3) (Pt 3):799-805. Epub 1900 01 01.

Long-term regulation of Na(+)-H+ exchange in vascular smooth muscle cells: role of protein kinase C.

Mitsuka M, Berk BC

The American journal of physiology.. 1991 March 260 (3 Pt 1):C562-9. Epub 1900 01 01.

Restenosis following coronary balloon angioplasty: Role of smooth muscle cell proliferation.

Liu M.W.; Berk, B.C.

Trends in Cardiovascular Medicine. 1991; 1: 107-111.

Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli.

Rao GN, Sardet C, Pouysségur J, Berk BC

The Journal of biological chemistry.. 1990 November 15265 (32):19393-6. Epub 1900 01 01.

Hypertrophy and hyperplasia cause differing effects on vascular smooth muscle cell Na+/H+ exchange and intracellular pH.

Berk BC, Elder E, Mitsuka M

The Journal of biological chemistry.. 1990 November 15265 (32):19632-7. Epub 1900 01 01.

Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.

Berk BC, Taubman MB, Cragoe EJ, Fenton JW, Griendling KK

The Journal of biological chemistry.. 1990 October 5265 (28):17334-40. Epub 1900 01 01.

Elevation of C-reactive protein in "active" coronary artery disease.

Berk BC, Weintraub WS, Alexander RW

The American journal of cardiology.. 1990 January 1565 (3):168-72. Epub 1900 01 01.

Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms.

Griendling KK, Tsuda T, Berk BC, Alexander RW

American journal of hypertension.. 1989 August 2 (8):659-65. Epub 1900 01 01.

Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

Berk BC, Vekshtein V, Gordon HM, Tsuda T

Hypertension.. 1989 April 13 (4):305-14. Epub 1900 01 01.

Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange.

Berk BC, Vallega G, Muslin AJ, Gordon HM, Canessa M, Alexander RW

The Journal of clinical investigation.. 1989 March 83 (3):822-9. Epub 1900 01 01.

Vasoactive effects of growth factors.

Berk BC, Alexander RW

Biochemical pharmacology.. 1989 January 1538 (2):219-25. Epub 1900 01 01.

Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation.

Taubman MB, Berk BC, Izumo S, Tsuda T, Alexander RW, Nadal-Ginard B

The Journal of biological chemistry.. 1989 January 5264 (1):526-30. Epub 1900 01 01.

Angiotensin II stimulation of vascular smooth muscle.

Griendling KK, Tsuda T, Berk BC, Alexander RW

Journal of cardiovascular pharmacology.. 1989 14 Suppl 6 :S27-33. Epub 1900 01 01.

Effects of glucocorticoids on Na+/H+ exchange and growth in cultured vascular smooth muscle cells.

Berk BC, Vallega G, Griendling KK, Gordon JB, Cragoe EJ, Canessa M, Alexander RW

Journal of cellular physiology.. 1988 December 137 (3):391-401. Epub 1900 01 01.

Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells.

Griendling KK, Berk BC, Alexander RW

The Journal of biological chemistry.. 1988 August 5263 (22):10620-4. Epub 1900 01 01.

Vascular smooth muscle Na+-H+ exchanger kinetics and its activation by angiotensin II.

Vallega GA, Canessa ML, Berk BC, Brock TA, Alexander RW

The American journal of physiology.. 1988 June 254 (6 Pt 1):C751-8. Epub 1900 01 01.

Na+-Ca2+ exchange in cultured vascular smooth muscle cells.

Nabel EG, Berk BC, Brock TA, Smith TW

Circulation research.. 1988 March 62 (3):486-93. Epub 1900 01 01.

Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells.

Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW

Clinical and experimental pharmacology & physiology.. 1988 February 15 (2):105-12. Epub 1900 01 01.

Agonist-mediated changes in intracellular pH: role in vascular smooth muscle cell function.

Berk BC, Canessa M, Vallega G, Alexander RW

Journal of cardiovascular pharmacology.. 1988 12 Suppl 5 :S104-14. Epub 1900 01 01.

Protein kinase C-mediated intracellular alkalinization in rat and rabbit aortic smooth muscle cells.

Danthuluri NR, Berk BC, Brock TA, Cragoe EJ, Deth RC

European journal of pharmacology.. 1987 September 23141 (3):503-6. Epub 1900 01 01.

Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State of the art lecture.

Griendling KK, Berk BC, Ganz P, Gimbrone MA, Alexander RW

Hypertension.. 1987 June 9 (6 Pt 2):III181-5. Epub 1900 01 01.

Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.

Berk BC, Aronow MS, Brock TA, Cragoe E, Gimbrone MA, Alexander RW

The Journal of biological chemistry.. 1987 April 15262 (11):5057-64. Epub 1900 01 01.

Early agonist-mediated ionic events in cultured vascular smooth muscle cells. Calcium mobilization is associated with intracellular acidification.

Berk BC, Brock TA, Gimbrone MA, Alexander RW

The Journal of biological chemistry.. 1987 April 15262 (11):5065-72. Epub 1900 01 01.

Vasoconstriction: a new activity for platelet-derived growth factor.

Berk BC, Alexander RW, Brock TA, Gimbrone MA, Webb RC

Science.. 1986 April 4232 (4746):87-90. Epub 1900 01 01.

Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction.

Berk BC, Brock TA, Webb RC, Taubman MB, Atkinson WJ, Gimbrone MA, Alexander RW

The Journal of clinical investigation.. 1985 March 75 (3):1083-6. Epub 1900 01 01.

Purification of a stimulator of microtubule assembly from bovine thyroid.

Berk BC, Hinkle PM

The Journal of biological chemistry.. 1981 November 25256 (22):11859-65. Epub 1900 01 01.

Thyroid and brain microtubules: a comparison.

Berk BC, Hinkle PM

The Journal of biological chemistry.. 1980 April 10255 (7):3186-93. Epub 1900 01 01.

Books

A Handbook of Mouse Models of Cardiovascular Disease (2006)

Authors: Berk BC, Korshunov VA

Publisher: John Wiley & Sons Ltd. 2006

The Kidney (2003)

Chapter: Biology of the Vascular Wall in Hypertension

Authors: Berk BC

Publisher: W. B. Saunders 2003

Cholesterol Lowering, A Practical Guide to Therapy (2003)

Chapter: Lipids and Atherosclerosis

Authors: Berk BC; Wuthrich DA

Publisher: Oxford University Press 2003

Thrombosis and Hemorrhage (2002)

Chapter: Vascular Response to Injury

Authors: Berk BC

Publisher: Lippincott Williams & Wilkins 2002

Vascular Pharmacology (2002)

Chapter: The Role of MAP Kinases in Endothelial Activation

Authors: Hoefen RJ; Berk BC

Publisher: Elsevier Science (US) 2002

Harrison's Advances in Cardiology (2002)

Chapter: Angiotensin II, Oxidative Stress, and Atherosclerosis

Authors: Berk BC

Publisher: McGraw Hill 2002

Cell and Molecular Responses to Stress (2001)

Chapter: Signal Transduction Cascades Responsive to Oxidative Stress in the Vasculature

Authors: Zheng-Gen J; Berk BC

Publisher: Elsevier Science (US) 2001

Vascular Endothelium - Source and Target of Inflammatory Mediators (2001)

Chapter: "Atheroprotective Mechanisms of Fluid Shear Stress: Nitric Oxide Independent Inhibition of Signal Transduction Mediated by Inflammatory Cytokines".

Authors: Berk BC; Surapisitchat J; Yoshizumi M; Yan C; Hoefen R; Abe J

Publisher: IOS Press 2001

Antioxidants and Cardiovascular Disease (2000)

Chapter: Reactive Oxygen Species Mediators Signal Transduction in Cardiovascular Disease

Authors: Abe J; Berk BC

Publisher: Kluwer Academic Publishers 2000

Heart Physiology and Pathophysiology (2000)

Chapter: Kinase Signaling in the Cardiovascular System

Authors: Abe J; Yan C; Surapisitchat J; Berk BC

Publisher: Elsevier Science (US) 2000

Harrison's On Line (1999)

Chapter: Angiotensin II, Oxidative Stress and Atherosclerosis

Authors: Berk BC

Publisher: McGraw Hill 1999

Hypertension Primer (1998)

Chapter: Regulation of Intracelllar pH and Cell Volume

Authors: Berk BC

Publisher: Lippincott Williams & Wilkins 1998

The Kidney (1998)

Chapter: Biology of the Vascular Wall in Hypertension

Authors: Berk BC

Publisher: W. B. Saunders 1998

Mechanical Forces and the Endothelium (1998)

Chapter: In Vitro Stimulation of Shear Stress and Mitogen-activated Protein Kinase Response

Authors: Traub O; Yan C; Berk BC

Publisher: Harwood Academic Publishers, London 1998

The Kidney (1998)

Chapter: Biology of the Vascular Wall in Hypertension

Authors: Berk BC

Publisher: W. B. Saunders 1998

Molecular Biology of Cardiovascular Diseases (1997)

Chapter: Tyrosine Kinases in the Regulation of Vascular Smooth Muscle Function

Authors: Corson MA; Berk BC

Publisher: Marcel Dekker, New York, NY 1997

Vascular Remodeling: A New Approach to Restenosis (1997)

Chapter: Oxidative Stress and Vascular Remodeling

Authors: Berk BC

Publisher: Kluwer Academic Publishers, Boston 1997

The Na+/H+ Exchanger (1996)

Chapter: Regulation of the Na+/H+ Exchanger in Vascular Smooth Muscle

Authors: Berk BC

Publisher: Landes Bioscience 1996

Endocrinology of the Vasculature (1996)

Chapter: Angiotensin II Signal Transduction in Vascular Smooth Muscle

Authors: Berk BC; Duff JL; Marrero MB; Bernstein KE

Publisher: Humana Press 1996

The Kidney (1994)

Chapter: Biology of the Vascular Wall in Hypertension

Authors: Berk BC; Alexander RW

Publisher: W. B. Saunders 1994

Interventional Cardiology: Future Directions (1993)

Chapter: Cell Biology of Restenosis: Role of Angiotensin II in Neointimal Cell Proliferation

Authors: Berk BC

Publisher: Mosby, Littleton, MA 1993

Hypertension Primer (1993)

Chapter: Regulation of Intracellular pH and Cell Volume

Authors: Berk BC; Alexander RW

Publisher: Lippincott Williams & Wilkins 1993

Heart Disease: Review and Assessment (1989)

Authors: Mendelsohn ME; Berk BC

Publisher: W. B. Saunders, Philadelphia, PA 1989

Locations

University of Rochester Medical Center

601 Elmwood Avenue, Box URNI
Rochester, NY 14642