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Chen Yan, Ph.D.

Chen Yan, Ph.D.

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About Me

Dr. Yan was born and grew up in Shanghai, China. She received her Bachelors and Masters degrees in the field of Biochemistry and Genetics, respectively, from Fudan University, Shanghai, China. Her PhD research was done in the lab of Dr. Joseph A. Beavo in Department of Pharmacology at the Universi...
Dr. Yan was born and grew up in Shanghai, China. She received her Bachelors and Masters degrees in the field of Biochemistry and Genetics, respectively, from Fudan University, Shanghai, China. Her PhD research was done in the lab of Dr. Joseph A. Beavo in Department of Pharmacology at the University of Washington in Seattle, WA USA. Her postdoctoral training was done with Dr. Bradford C. Berk in the Cardiology Unit of the University of Washington. Currently Dr. Yan is an associate professor in Aab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry. Her research focuses on a family of enzymes called phosphodiesterases (PDE) that degrade second messengers, diffusible signaling molecules that are rapidly generated and activate proteins within the cell to exert a cellular response. By inhibiting PDEs one can amplify cellular responses. One successful example is Viagra, which inhibits a specific PDE. Altered second messenger signaling and PDE activity/expression have been implicated in a variety of cardiovascular diseases such as hypertension, atherosclerosis and heart failure. Understanding the role of PDEs in cardiovascular diseases may provide new therapeutic information for the treatment of cardiovascular diseases. To date, Dr. Yan has published over 80 research and review articles and has recently received an American Heart Association Established Investigator Award.

Faculty Appointments

Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Credentials

Residency & Fellowship

Division of Cardiology, University of Washington, Seattle, WA, USA
Supervisor: Dr. Bradford Berk 1997 - 1998

Department of Pharmacology, University of Washington, Seattle, WA, USA
Supervisor: Dr. Joseph Beavo 1996 - 1997

Education

Ph.D. | University of Washington. Pharmacology. 1996

MS | Genetic Institute, Fudan University. Genetics. 1986

BS | Department of Biology, Fudan University. Biochemistry. 1983

Awards

American Heart Association Established Investigator Award 2007 - 2011

NIH Postdoctoral Fellowship 1997 - 1998

Fellowship for Advanced Predoctoral Training in Pharmacology/Toxicology of Pharmaceutical Research & Manufactures of America Foundation 1994 - 1996

Shanghai City Honor (Sanhao) Student (top 0.1% students who display the overall well-roundedness).
Received this award for three consecutive years.
1979 - 1982

Honor (Sanhao) Student of Fudan University (top 2% of students who display the best all round development of morality, intelligence, and physique).
Received this award for three consecutive years.
1979 - 1982

Research

General Research Interests: Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. Second messenger cyclic nucleotides (cAMP and cGMP) regulate many signaling pathways in the cardiovascular system. For example, the vascular tone, smooth muscle cell growth, an...
General Research Interests: Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. Second messenger cyclic nucleotides (cAMP and cGMP) regulate many signaling pathways in the cardiovascular system. For example, the vascular tone, smooth muscle cell growth, and cardiac muscle contractility are all regulated by cyclic nucleotide signaling. We are interested in phosphodiesterases (PDEs), the enzymes that break down cyclic nucleotides and thus control the amplitude, duration, and compartmentalization of cyclic nucleotide signaling in the cell. It has become increasingly clear that cyclic nucleotide degradation by PDEs is not a constitutive function of the cell, but rather a highly regulated one controlled by different mechanisms in different physiological and pathological circumstances. PDE regulation and function is further complicated by the fact that there are more than 50 individual PDEs belonging to 11 different PDE families, yet our understanding of the physiological function of each PDE is far from complete. PDEs have been demonstrated to be good pharmacological targets for therapeutic agents due to the presence of multiple structurally different, tissue-specific, differentially regulated, and functionally distinct isozymes. Several drugs, such as Viagra, have been shown to have unique specific effects via selectively inhibit individual PDE isozymes. Our focus has been on determining the regulation and function of individual PDE isozymes in cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and cardiovascular inflammatory diseases. Ongoing and future studies using in vitro and in vivo approaches will focus on the various roles of PDEs in cardiovascular physiology and pathology, which may provide new therapeutic information for tissue specific interventions in cardiovascular diseases.

Research Lab

Research * Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system.

Visit Research Lab Website

Patents

Method and Compositions for Treatment or Prevention of Inflammatory Conditions

Issue date: March 11, 2015

Patent #: 1602247

Country: China, People's Republic of

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Method and Compositions For Treatment or Prevention of Inflammatory Conditions

Issue date: January 26, 2016

Patent #: 9,241,932

Country: United States

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Method and Compositions For Treatment or Prevention of Inflammatory Conditions

Issue date: June 20, 2017

Patent #: 9,682,070

Country: United States

Inventors: Bradford C Berk, Kye-Im Jeon, Jian-Dong Li, Xiangbin Xu, Chen Yan

Publications

Journal Articles

Vinpocetine Suppresses -Induced Inflammation via Inhibition of ERK1 by CYLD.

Komatsu K, Nam DH, Lee JY, Yoneda G, Yan C, Li JD

The Journal of immunology : official journal of the American Association of Immunologists.. 2020 January 3 Epub 01/03/2020.

A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

Chen S, Zhang Y, Lighthouse JK, Mickelsen DM, Wu J, Yao P, Small EM, Yan C

Circulation.. 2019 December 5 Epub 12/05/2019.

The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

Dugbartey GJ, Quinn B, Luo L, Mickelsen DM, Ture SK, Morrell CN, Czyzyk J, Doyley MM, Yan C, Berk BC, Korshunov VA

The American journal of pathology.. 2019 June 17 Epub 06/17/2019.

Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles.

Chen W, Anokhina V, Dieudonne G, Abramowitz MK, Kashyap R, Yan C, Wu TT, de Mesy Bentley KL, Miller BL, Bushinsky DA

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.. 2019 June 134 (6):992-1000. Epub 1900 01 01.

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.

Alvarado FJ, Bos JM, Yuchi Z, Valdivia CR, Hernández JJ, Zhao YT, Henderlong DS, Chen Y, Booher TR, Marcou CA, Van Petegem F, Ackerman MJ, Valdivia HH

JCI insight.. 2019 March 55 Epub 03/05/2019.

Cognitive and physical factors affecting daily function in Alzheimer's disease: A cross-sectional analysis.

Yu F, Chen Y, Mathiason MA, Wan Q, Lin FV

Nursing & health sciences.. 2019 March 21 (1):14-20. Epub 05/07/2018.

The clinicopathologic features of chronic active Epstein-Barr virus infective enteritis.

Liu R, Wang M, Zhang L, Zhou W, Huang Y, Guo H, Gu Y, Chen Y, Li Y, Chen C, Wang Y, Rong L, Li J, Xu J, Cao Q, Jiang Z

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2019 March 32 (3):387-395. Epub 10/08/2018.

Severe Thalassemia Caused by Hb Zunyi [?147(HC3)Stop?Gln; : c.442T>C)] on the ?-Globin Gene.

Su Q, Chen S, Wu L, Tian R, Yang X, Huang X, Chen Y, Peng Z, Chen J

Hemoglobin.. 2019 January 43 (1):7-11. Epub 05/14/2019.

Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.

Lee BC, Susuki-Miyata S, Yan C, Li JD

International journal of molecular sciences.. 2018 November 819 (11)Epub 11/08/2018.

Roles of PDE1 in Pathological Cardiac Remodeling and Dysfunction.

Chen S, Knight WE, Yan C

Journal of cardiovascular development and disease.. 2018 April 235 (2)Epub 04/23/2018.

Vinpocetine Inhibits NF-?B-Dependent Inflammation in Acute Ischemic Stroke Patients.

Zhang F, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, Hao J

Translational stroke research.. 2018 April 9 (2):174-184. Epub 07/09/2017.

Novel multi?kinase inhibitor, T03 inhibits Taxol?resistant breast cancer.

Li Y, Liu C, Tang K, Chen Y, Tian K, Feng Z, Chen J

Molecular medicine reports.. 2018 February 17 (2):2373-2383. Epub 11/28/2017.

An update on vinpocetine: New discoveries and clinical implications.

Zhang YS, Li JD, Yan C

European journal of pharmacology.. 2018 January 15819 :30-34. Epub 11/26/2017.

Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.

Li Y, Ren M, Wang X, Cui X, Zhao H, Zhao C, Zhou J, Guo Y, Hu Y, Yan C, Berk B, Wang J

Scientific reports.. 2017 November 147 (1):15539. Epub 11/14/2017.

??thalassemia caused by compound heterozygous mutations and cured by bone marrow transplantation: A case report.

Wu L, Peng Z, Lu S, Tan M, Rong Y, Tian R, Yang Y, Chen Y, Chen J

Molecular medicine reports.. 2017 November 16 (5):6552-6557. Epub 09/12/2017.

Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.

Korshunov VA, Wang H, Ahmed R, Mickelsen DM, Zhou Q, Yan C, Doyley MM

Scientific reports.. 2017 September 217 (1):12081. Epub 09/21/2017.

Cybersecurity and medical devices: A practical guide for cardiac electrophysiologists.

Ransford B, Kramer DB, Foo Kune D, Auto de Medeiros J, Yan C, Xu W, Crawford T, Fu K

Pacing and clinical electrophysiology : PACE.. 2017 August 40 (8):913-917. Epub 07/12/2017.

Phospholipase C?1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.

Jiang D, Zhuang J, Peng W, Lu Y, Liu H, Zhao Q, Chi C, Li X, Zhu G, Xu X, Yan C, Xu Y, Ge J, Pang J

Journal of the American Heart Association.. 2017 July 116 (7)Epub 07/11/2017.

Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.

Wu MP, Zhang YS, Xu X, Zhou Q, Li JD, Yan C

Cardiovascular drugs and therapy. 2017 April 31 (2):157-166. Epub 1900 01 01.

Phospholipase Cg1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity

Jiang D ; Zhuang J; Peng W; Lu Y; Liu H; Zhao Q; Chi C; Li X; Zhu G; Xu X; Yan C; Xu Y; Ge J; Pang J.

J Am Heart Assoc. pii: e005537. PMCID: PMC5663637. 2017; : 6(7).

Vinpocetine Attenuates Pathological Cardiac Remodeling by inhibiting Cardiac Hypertrophy and Fibrosis.

Wu M, Zhang Y, Xu X, Zhou Q, Li J-D, Yan C.

Cardiovascular Drugs & Therapy. 2017; 31: 157-166.

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

Li J, Chen Y, Zhang L, Xing L, Xu H, Wang Y, Shi Q, Liang Q

Journal of ethnopharmacology.. 2016 December 4193 :293-302. Epub 08/21/2016.

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.

Knight WE, Chen S, Zhang Y, Oikawa M, Wu M, Zhou Q, Miller CL, Cai Y, Mickelsen DM, Moravec C, Small EM, Abe J, Yan C

Proceedings of the National Academy of Sciences of the United States of America.. 2016 November 8113 (45):E7116-E7125. Epub 10/20/2016.

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L

Arthritis research & therapy.. 2016 March 1218 :62. Epub 03/12/2016.

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC

Journal of cardiovascular pharmacology and therapeutics.. 2016 March 21 (2):177-86. Epub 06/30/2015.

Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ?2-AR/PI3K/AKT signaling pathway.

Wu MP, Zhang YS, Zhou QM, Xiong J, Dong YR, Yan C

Pharmacological research.. 2016 February 104 :115-23. Epub 12/30/2015.

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Knight W; Chen S; Zhang Y; Oikawa M; Wu M-; Abe J-I; Yan C.

Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016; .

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.

Knight W; Mickelsen DM; Moravec CS,; Small EM; Abe J-I, and Yan C.

Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016; .

Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ?2-AR/PI3K/AKT signaling.

Wu M-P; Zhang Y-S; Zhou Q-M; Xiong J; Dong Y-R and Yan C.

Pharmacological Research, PMCID: PMC4772856. 2016; 104: 115-123.

Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function.

Chen Y, Li J, Li Q, Wang T, Xing L, Xu H, Wang Y, Shi Q, Zhou Q, Liang Q

Evidence-based complementary and alternative medicine : eCAM.. 2016 2016 :7067691. Epub 04/27/2016.

Cyclic nucleotide phosphodiesterase 1 and vascular aging.

Yan C

Clinical science.. 2015 December 129 (12):1077-81. Epub 09/15/2015.

Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1? and transforming growth factor-?1 expression.

Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C

Hypertension.. 2015 October 66 (4):881-91. Epub 1900 01 01.

Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.

Lee JY, Komatsu K, Lee BC, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li JD

The Journal of immunology : official journal of the American Association of Immunologists.. 2015 June 15194 (12):5990-8. Epub 05/13/2015.

Cross-talk between PKA-C? and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.

Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD

Proceedings of the National Academy of Sciences of the United States of America.. 2015 April 7112 (14):E1800-9. Epub 03/23/2015.

Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.

Cai Y, Nagel DJ, Zhou Q, Li F, Pi X, Knight P, Yan C

Circulation research.. 2015 March 27116 (7):1120-32. Epub 01/21/2015.

Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.

Ruan CC, Ge Q, Li Y, Li XD, Chen DR, Ji KD, Wu YJ, Sheng LJ, Yan C, Zhu DL, Gao PJ

Arteriosclerosis, thrombosis, and vascular biology.. 2015 March 35 (3):598-606. Epub 01/08/2015.

Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1? and transforming growth factor-?1 expression.

Huang C-K; Luo J; Lai K-P; Wang ; Pang H; Chang E; Yan C, Sparks J; Lee A-O; Cho J, and Chang C.

Hypertension,PMCID: PMC4658219. 2015; 66: 881-891.

Vinpocetine inhibits Streptococcus pneumonia-induced up-regulation of mucin MUC5AC expression via induction of MKP-1 phosphatase. The Journal of Immunology, PMCID: PMC4456630. (* Co-corresponding authors).

Lee J-Y; Komatsu K; Lee B-C; Miyata M; Bohn AO; Xu H; Yan C*; and Li J-D*.

2015; 194: 5990-8.

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury

Shi X; O'Neill MM; MacDonnell S; Brookes Paul; Yan C, and Berk BC.

Journal of Cardiovascular Pharmacology and Therapeutics, pii: 1074248415591700. 2015; .

Down regulation of Dynamin-related protein 1 (DRP1) contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells.

Lin JR; Shen WL; Yan C, and Gao PJ.

Arterioscler Thromb Vasc Bio. 2015; 35: 1413-22.

Cross talk between PKA-C? and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.

Susuki-Miyata S; Miyata M; Lee B-C; Xu H; Kai H; Yan C*, and Li J-D* (* Co-corresponding authors).

Proc. Nat. Acad. Sci., USA, 112:E1800-9. PMCID: PMC4394257. 2015; .

Cai Y; Nagel DJ; Zhou Q Li F; Pi X; Knight PA; and Yan C.

Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, and Neointimal Hyperplasia.

Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.

Ruan CC; Ge Q; Li Y; Li XD; Chen DR; Ji KD; Wu YJ; Sheng LJ; Yan C; Zhu DL; and Gao PJ.

Arterioscler Thromb Vasc Bio. 2015; 35: 598-606.

Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.

Spindel ON, Burke RM, Yan C, Berk BC

Circulation research.. 2014 March 28114 (7):1125-32. Epub 02/10/2014.

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, Wang YJ, Chen Y, Wood RW, Li J, Boyce BF, Xing L

Arthritis & rheumatology.. 2014 March 66 (3):657-66. Epub 1900 01 01.

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT-1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC.

PLoS One, 9: e89127. 2014; .

Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulating transforming growth factor-? expression.

Iwaya S; Oikawa M; Yan C; Takeishi Y.

International Heart Journal,. 2014; 55: 165-8.

Thioredoxin-interacting protein is a biomechanical regulator of SRC activity: key role in endothelial cell stress fiber formation.

Spindel ON; Burke RM; Yan C; Berk BC.

Circulation Research PMCID: PMC3981969. 2014; 114: 1125-32.

Biological values of acupuncture and chinese herbal medicine: impact on the life science.

Yang YQ, Yan C, Branford-White CJ, Hou XY

Evidence-based complementary and alternative medicine : eCAM.. 2014 2014 :593921. Epub 01/12/2014.

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC

PloS one.. 2014 9 (2):e89127. Epub 02/19/2014.

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.

Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe JI, Yan C

Journal of molecular and cellular cardiology.. 2013 November 64 :11-9. Epub 08/27/2013.

Therapeutic potential of PDE modulation in treating heart disease.

Knight W, Yan C

Future medicinal chemistry.. 2013 September 5 (14):1607-20. Epub 1900 01 01.

Vinpocetine attenuates lipid accumulation and atherosclerosis formation.

Cai Y, Li JD, Yan C

Biochemical and biophysical research communications.. 2013 May 10434 (3):439-43. Epub 04/10/2013.

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.

Park Y, Park SY, Shi X, Pang J, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 April 33 (4):737-43. Epub 02/07/2013.

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.

Oikawa M; Wu M; Lim S; Knight WE; Miller CL; Cai Y; Lu Y; Blaxall BC; Takeishi Y; Abe J; and Yan C.

J. Mol. Cell. Cardiol. PMCID: PMC3869570. 2013; 64C:(11-19).

Vinpocetine Attenuates Lipid Accumulation and Atherosclerosis Formation.

Cai Y; Li J-D; and Yan C.

Biochem. Biophys. Res. Commun., PMCID: PMC3682500. 2013; 434:: 439-43.

Inhibition of PDE4B suppressed inflammation by increasing expression of the deubiquitinase CYLD.

Komatsu K; Lee JY; Miyata M; Hyang Lim J; Jono H; Koga T; Xu H,; Yan C; Kai H; Li JD.

Nat. Commun. PMCID: PMC3644066. 2013; 4:: 1684.

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.

Park SY; Shi X; Pang J; Yan C; Berk BC.

Arterioscler Thromb Vasc Biol. PMCID: PMC3629821. 2013; 33:: 737-43.

Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.

Silva J, Polesskaya O, Knight W, Zheng JT, Granger M, Lopez T, Ontiveros F, Feng C, Yan C, Kasischke KA, Dewhurst S

Journal of neuroinflammation.. 2012 November 209 :253. Epub 11/20/2012.

Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.

Cai Y, Knight WE, Guo S, Li JD, Knight PA, Yan C

The Journal of pharmacology and experimental therapeutics.. 2012 November 343 (2):479-88. Epub 08/22/2012.

EVI1 acts as an inducible negative-feedback regulator of NF-?B by inhibiting p65 acetylation.

Xu X, Woo CH, Steere RR, Lee BC, Huang Y, Wu J, Pang J, Lim JH, Xu H, Zhang W, Konduru AS, Yan C, Cheeseman MT, Brown SD, Li JD

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 June 15188 (12):6371-80. Epub 05/11/2012.

Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.

Spindel ON, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2012 May 32 (5):1264-70. Epub 02/16/2012.

p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe JI

Circulation research.. 2012 February 17110 (4):536-50. Epub 01/19/2012.

Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.

Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC

Circulation research.. 2012 February 17110 (4):560-8. Epub 01/19/2012.

Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.

Silva J; Polesskaya O; Knight WE; Zheng JT; Granger M; Ontiveros F; Feng C; Yan C; and Dewhurst S.

Journal of Neuroinflammation PMCID: PMC3526511. 2012; 9:: 253.

Phosphoinositide 3-Kinase ? Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A-Mediated Regulation of Distinct Phosphodiesterases.

Ghigo A; Perino A; Mehel H; Zahradnlkova A Jr; Morello F; Leroy J; Nikolaev VO; Damilano F; Cimino J; De Luca E; Richter W; Westenbroek R; Catterall WA; Zhang J,; Yan C; Conti M; Gomez AM,; Vandecasteele G; Hirsch E; Fischmeister R.

CirculationPMCID: PMC3913165. 2012; 126:: 2073-83.

Vinpocetine suppresses pathological vascular remodeling through inhibiting vascular smooth muscle cell proliferation and migration.

Cai Y; Knight W; Guo S; Li J; Knight P; and Yan C.

Journal of Pharmacology and Experimental Therapy. PMID: 22915768; PMCID: PMC3477207. 2012; 343: 479-88.

EVI1 acts as an Inducible Negative-Feedback Regulator of NF-?B by Inhibiting p65 Acetylation. J Immunol. PMCID: PMC3370108.

Xu X; Woo CH; Steere RR; Lee BC; Huang Y; Wu J; Pang J; Lim JH; Xu H,; Zhang W; Konduru AS; Yan C, Cheeseman MT; Brown SD; Li JD.

2012; 188(12):: 6371-80.

PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.

Lee J; Komatsu K; Lee BC; Lim JH; Jono H; Xu H; Kai H; Zhang ZJ; Yan C; Li JD.

J Biol Chem. PMCID: PMC3391144. 2012; 287:: 22799-811.

CYLD negatively regulates transforming growth factor-?-signaling via deubiquitinating Akt.

Lim JH; Jono H; Komatsu K; Woo CH; Lee J; Miyata M; Matsuno T,; Xu X; Huang Y; Zhang W; Park SH; Kim YI; Choi YD; Shen H; Heo KS; Xu H; Bourne P; Koga T; Xu H; Yan C; Wang B; Chen LF; Feng XH; Li JD.

Nat Commun.PMCID: PMC3337989. 2012; 3:: 771.

Thioredoxin Interacting Protein (TXNIP) mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 (VEGFR2) signaling.

Spindel ON; Yan C; and BC Berk.

Arterioscler Thromb Vasc Biol. PMCID: PMC3876410. 2012; 32:: 1264-70.

Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2.

Wang X; Nigro P; World C; Fujiwara K; Yan C; and BC Berk.

Circulation Research. PMCID: PMC3333844. 2012; 110:: 560-8.

p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

Le N; Takei Y; Shishido T; Woo CH; Chang E; Heo KS; Lee H; Lu Y; Morrell C; Oikawa M; McClain C; Wang X; Tournier C; Molina CA; Taunton J; Yan C; Fujiwara K; Patterson C; Yang J; Abe JI.

Circulation Research. PMCID: PMC3306797. 2012; 110:: 536-50.

PDE1 isozymes, key regulators of pathological vascular remodeling.

Chan S, Yan C

Current opinion in pharmacology.. 2011 December 11 (6):720-4. Epub 09/29/2011.

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C

Basic research in cardiology.. 2011 November 106 (6):1023-39. Epub 10/20/2011.

p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X, Yan C, Nadtochiy SM, Abe JI, Brookes PS, Berk BC

Journal of molecular and cellular cardiology.. 2011 August 51 (2):272-5. Epub 05/14/2011.

Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.

Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2011 May 31 (5):1116-23. Epub 02/17/2011.

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.

Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C

Arteriosclerosis, thrombosis, and vascular biology.. 2011 March 31 (3):616-23. Epub 12/09/2010.

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL; Cai Y; Oikawa M; Thomas T; Dostmann WR; Zaccolo M; Fujiwara K; Yan C.

Basic Res. Cardiol. PMCID: PMC4114346. 2011; 106:: 1023-39.

p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X; Yan C; Nadtochiy SM; Abe J; Brookes PS; Berk BC.

J Mol Cell Cardiol. PMCID: PMC3124613. 2011; 51:: 272-5.

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen degradation in vascular smooth muscle cells.

Cai Y; Miller CL; Nagel DJ; Jeon K; Lim S; Gao P; Kinight P; and Yan C.

Arterioscler Thromb Vasc Biol. PMCID: PMC4114343. 2011; 31:: 616-623.

Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice.

Satoh K; Nigro P; Zeidan A; Soe NN; Jaffré F; Oikawa M; O'Dell MR; Cui Z; Menon P; Lu Y; Mohan A; Yan C; Blaxall BC; Berk BC.

Arterioscler Thromb Vasc Biol. PMCID: PMC3085960. 2011; 31: 1: 116-23.

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe JI

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 December 24 (12):4917-28. Epub 08/19/2010.

Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells.

Jeon KI, Jono H, Miller CL, Cai Y, Lim S, Liu X, Gao P, Abe JI, Li JD, Yan C

The FEBS journal.. 2010 December 277 (24):5026-39. Epub 11/16/2010.

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC

Journal of cellular physiology.. 2010 November 225 (3):777-85. Epub 1900 01 01.

Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.

Miller CL, Yan C

Journal of cardiovascular translational research.. 2010 October 3 (5):507-15. Epub 07/15/2010.

Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.

Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2010 October 30 (10):1976-82. Epub 08/05/2010.

Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.

Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe JI, Berk BC, Li JD, Yan C

Proceedings of the National Academy of Sciences of the United States of America.. 2010 May 25107 (21):9795-800. Epub 05/06/2010.

CCN notch signaling in vascular smooth muscle cells: good or bad?

Abe J, Yan C

Arteriosclerosis, thrombosis, and vascular biology.. 2010 April 30 (4):667-8. Epub 1900 01 01.

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.

Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC

Brain research.. 2010 March 41317 :218-26. Epub 01/04/2010.

Ca2+/calmodulin-stimulated Phosphodiesterase 1A regulates the beta-catenin/TCF signal pathway through PP2A B56 gamma subunit in vascular smooth muscle cells.

Jeon K; Jono H; Cai Y; Lim S; Liu X; Gao P; Abe J; Li J; and Yan C.

FEBS Journal PMCID: PMC3059601. 2010; 277:: 5026-39.

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Woo CH; Le NT; Shishido T; Chang E; Lee H; Heo KS; Michelsen DM; Lu Y; McClain C; Spangenberg T; Yan C; Molina CA; Yang J; Patterson C,; Abe JI.

FASEB J. PMCID: PMC2992371. 2010; 24:: 4917-28.

Vinpocetine inhibits NF-?B-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Editorial Commentary: Alexandre E. Medina (2010). Vinpocetine as a potent anti-inflammatory agent Proc. Nat. Acad. Sci., USA. 107:9921-2.

Jeon K; Xu X; Aizawa T; Lim JH,; Jono H; Kwoen D; Abe J; Berk BC; Li J; Yan C.

Proc. Nat. Acad. Sci., USA, PMCID: PMC2906898. 2010; 107: 9795-9800.

Phosphorylation of GIT1 tyrosine-392 is required for PLC??activation and podosome formation in vascular smooth muscle cells.

Wang J: Yin G: Menon P: Pang J: Smolock E: Yan C: and Berk BC.

Arterioscler Thromb Vasc Biol. PMCID: PMC2941990. 2010; 30:: 1976-82.

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

Menon P; Yin G; Smolock E; Zuscik M; Yan C; and Berk BC.

Journal of Cellular Physiology. PMCID: PMC2939960. 2010; : 777-85.

Impaired spine formation and learning in GPCR kinase interacting protein-1 (GIT1) deficient mice.

Menon P; Deane R; Sagare A; Lane SM; Zarcone TJ; O'Dell MR,; Yan C; Zlokovic BV; Berk BC.

Brain Research PMCID: PMC2861918. 2010; 1317:2: 18-26.

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.

Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe JI, Yan C

Circulation research.. 2009 November 6105 (10):956-64. Epub 09/24/2009.

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.

Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe JI, Illig KA, Berk BC

Nature medicine.. 2009 June 15 (6):649-56. Epub 1900 01 01.

G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC

Circulation.. 2009 March 24119 (11):1524-32. Epub 03/09/2009.

GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.

Wang J, Taba Y, Pang J, Yin G, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2009 February 29 (2):202-8. Epub 11/20/2008.

Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation.

Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF, Yan C, Li JD

The Biochemical journal.. 2009 January 15417 (2):583-91. Epub 1900 01 01.

Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.

Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J

Circulation research.. 2009 January 2104 (1):69-78. Epub 11/20/2008.

Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J and Yan C.

Role of Ca2+/calmodulin stimulated cyclic nucleotide phosphodiesterase 1 in cardiomyocyte hypertrophic growth.

Cyclophilin A promotes vascular oxidative stress and accelerates development of angiotensin II-induced aortic aneurysms.

Satoh K; Nigro P; Matoba T; O'Dell MR; Cui Z; Shi X; Mohan A; Yan C; Abe JI; Illig KA; and Berk BC.

Nature Medicine PMCID: PMC2704983. 2009; : 649-56.

The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts.

Zhou H; Chen W; Zhu D; Wu L; Zhang J; Han W; Li J; Yan C; and Gao P.

J. Vasc. Res. PMCID: PMC2855283. 2009; 47:: 9-15.

Perivascular gene transfer of dominant-negative N19RhoA attenuates neointimal formation via inhibition of TGF-beta1-Smad2 signaling in rats after carotid artery balloon injury.

Chen W; Chu Y; Zhu D; Yan C; Liu J; Ji K; Gao P.

Biochem Biophys Res Commun. 2009; : 763-768.

GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLC.

Wang J; Taba Y; Pang J; Yin G; Yan C; and Berk B.

Arterioscler Thromb Vasc Biol. PMCID: PMC2735351. 2009; 29:: 202-8.

Synergistic induction of NF-kappaB by TGF-beta and TNF-alpha is mediated by PKA-dependent RelA acetylation.

Ishinaga H; Jono H; Lim JH; Komatsu K; Xu X; Lee J; Woo CH; Xu H; Feng XH; Chen LF; Yan C*; and Li JD* (* Co-corresponding author).

Biochem J. 2009; 417:: 583-591.

G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

Pang J; Hoefen R; Pryhuber GS; Wang J; Yin G; White JR; Xu X; O'Dell MR; Mohan A; Michaloski H; Massett; MP; Yan C; and Berk BC.

Circulation PMCID: PMC2732662. 2009; 119:: 1524-1532.

Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor {gamma} Transcriptional Activity in Vascular Smooth Muscle Cells.

Alexis JD; Wang N; Che W; Lerner-Marmarosh N; Sahni A; Korshunov VA; Zou Y; Ding B; Yan C; Berk BC; Abe JI.

Circulation Research PMCID: PMC2642522. 2009; : 69-78.

Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK.

Komatsu K, Jono H, Lim JH, Imasato A, Xu H, Kai H, Yan C, Li JD

Biochemical and biophysical research communications.. 2008 December 19377 (3):763-8. Epub 10/26/2008.

Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.

Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H

Circulation research.. 2008 August 1103 (3):269-78. Epub 07/03/2008.

Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC

Circulation.. 2008 June 17117 (24):3088-98. Epub 06/09/2008.

Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction.

Shishido T, Woo CH, Ding B, McClain C, Molina CA, Yan C, Yang J, Abe J

Circulation research.. 2008 June 6102 (11):1416-25. Epub 05/08/2008.

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells.

Li L, Tatake RJ, Natarajan K, Taba Y, Garin G, Tai C, Leung E, Surapisitchat J, Yoshizumi M, Yan C, Abe J, Berk BC

Biochemical and biophysical research communications.. 2008 May 23370 (1):159-63. Epub 03/19/2008.

Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.

Koga T, Lim JH, Jono H, Ha UH, Xu H, Ishinaga H, Morino S, Xu X, Yan C, Kai H, Li JD

The Journal of biological chemistry.. 2008 May 2283 (18):12546-54. Epub 03/10/2008.

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.

Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 May 28 (5):892-8. Epub 02/21/2008.

Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells.

Woo CH, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J

Circulation research.. 2008 March 14102 (5):538-45. Epub 01/24/2008.

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.

Pang J; Yan C; Natarajan K; Cavet ME; Massett MP; Yin G; Berk BC.

Arterioscler Thromb Vasc Biol. PMCID: PMC2735338. 2008; : 892-8.

Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced anti-inflammatory response and endothelial nitric oxide synthase expression in endothelial cells.

Woo CH; Shishido T; McClain C; Lim JH; Li JD; Yang J; Yan C; and Abe JI.

Circulation Research. 2008; : 538-45.

Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation.

Satoh K; Matoba T; Suzuki J; O'Dell MR; Nigro P; Cui Z; Mohan A; Pan S; Li L; Jin ZG; Yan C; Abe JI; and Berk BC.

Circulation PMCID: PMC2775430. 2008; 117:: 3088-3098.

Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. PMCID: PMC2614366

Shishido T; Woo CH; Ding B; McClain C; Molina CA; Yan C; Yang J; Abe J.

Circulation Research. 2008; 102:: 1416-25.

Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.

Lu Z; Abe J; Taunton J; Lu Y; Shishido T; McClain C; Yan C; Xu SP; Spangenberg TM; and Xu H.

Circulation Research PMCID: PMC2631445. 2008; : 269-78.

Tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for streptococcus pneumoniae-induced NFAT signaling.

Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD.

J. Biol. Chem. PMCID: PMC2335367. 2008; : 12546-54.

Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK.

Komatsu K; Jono H; Hyanglim J; Imasato A; Xu H; Kai H; Yan C; and Li J-D.

Biochem Biophys Res Commun. 2008; 377:: 763-768.

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells.

Li L; Tatake RJ; Natarajan K; Taba Y; Garin G; Tai C; Leung E; Surapisitchat J; Yoshizumi M; Yan C; Abe J; and Berk BC.

Biochem Biophys Res Commun PMCID: PMC2435412. 2008; 370:: 159-63.

In cardiac myocytes; cAMP elevation triggers that down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase 4A10 (PDE4A10).

McCahill A; Campbell L; McSorley T; Sood A; Lynch MJ; Li X; Yan C; Baillie GS; Houslay MD.

Cell Signaling. 2008; 20:: 2071-83.

Functional Role of Phosphodiesterase 3 in Cardiomyocyte Apoptosis: Implication in Heart Failure. PMCID: PMC4108189

Ding B; Abe J; Wei H; Huang Q; Walsh RA; Molina; CA; Zhao A; Sadoshima J; Blaxall BC; Berk BC; Yan C.

Circulation. 1. 2008; : 2469-76.

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.

Surapisitchat J, Jeon KI, Yan C, Beavo JA

Circulation research.. 2007 October 12101 (8):811-8. Epub 08/17/2007.

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

Huang Y, Mikami F, Jono H, Zhang W, Weng X, Koga T, Xu H, Yan C, Kai H, Li JD

Biochemical and biophysical research communications.. 2007 August 3359 (3):691-6. Epub 06/04/2007.

Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.

Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD

Immunity.. 2007 August 27 (2):349-60. Epub 1900 01 01.

Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.

Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC

Circulation research.. 2007 July 6101 (1):97-105. Epub 05/24/2007.

Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop.

Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J

Circulation research.. 2007 March 2100 (4):510-9. Epub 02/01/2007.

Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart.

Yan C, Miller CL, Abe J

Circulation research.. 2007 March 2100 (4):489-501. Epub 1900 01 01.

TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation.

Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Koga T, Yan C, Feng XH, Chen LF, Li JD

The EMBO journal.. 2007 February 2126 (4):1150-62. Epub 02/01/2007.

Expression and function of vascular endothelial growth factor receptors (Flt-1 and Flk-1) in vascular adventitial fibroblasts. J.

Jin X; Ge X; Zhu DL; Yan C; Chu YF; Chen WD; Liu J; Gao PJ.

Mol. Cell. Cardiol. 2007; 43:: 292-300.

Activation of ERK5 reduces cardiac apoptosis and dysfunction via inhibition of a PDE3A-ICER feedback loop. Circulation Research 100(4): 510-9. PMCID: PMC4115673. (* Co-corresponding author)

Yan C*; Ding B; Shishido T; Woo C-H; Itoh S; Jeon K; Liu W; Xu H; McClain C; Molina CA; Blaxall BC; and Abe JI * (* Co-corresponding author).

Circulation Research PMCID: PMC4115673. 2007; 100(4):: 510-9.

Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.

Chen C; Korshunov VA; Massett MP; Yan C; and Berk BC.

J Vasc Res. 2007; : 504-512.

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. PMID: 17555715. PMCID: PMC3345029.

Huang Y; Mikami F; Jono H; Zhang W; Weng X; Koga T; Xu H; Yan C; Kai H; Li JD.

Biochem. Biophys. Res. Commun. 2007; : 691-6.

Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.

Chen C; Korshunov VA; Massett MP; Yan C; and Berk BC.

J Vasc Res. 2007; : 504-512.

Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.

Chen C, Korshunov VA, Massett MP, Yan C, Berk BC

Journal of vascular research.. 2007 44 (6):504-12. Epub 07/30/2007.

ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.

Woo CH, Massett MP, Shishido T, Itoh S, Ding B, McClain C, Che W, Vulapalli SR, Yan C, Abe J

The Journal of biological chemistry.. 2006 October 27281 (43):32164-74. Epub 08/30/2006.

Stimulation of HIV-1 minus strand strong stop DNA transfer by genomic sequences 3' of the primer binding site.

Song M, Balakrishnan M, Chen Y, Roques BP, Bambara RA

The Journal of biological chemistry.. 2006 August 25281 (34):24227-35. Epub 06/15/2006.

Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction.

Qin F, Yan C, Patel R, Liu W, Dong E

Free radical biology & medicine.. 2006 May 1540 (10):1827-42. Epub 02/08/2006.

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J

Circulation.. 2006 April 11113 (14):1787-98. Epub 04/03/2006.

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.

Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C

Circulation research.. 2006 March 3198 (6):777-84. Epub 03/02/2006.

NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin.

Qin F, Patel R, Yan C, Liu W

Free radical biology & medicine.. 2006 January 1540 (2):236-46. Epub 11/10/2005.

ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta) stimulation.

Woo, CH.; Massett, MP.; Shishido, T.; Itoh, S.; Ding, B.; McClain, C.; Che, W.; Vulapalli, SR.; Yan, C.; Abe, J.

J. Bio. Chem. 2006; 281: 32164-32174.

Role of Nuclear Ca2+/calmodulin-stimulated Phosphodiesterase 1A in Vascular Smooth Muscle Cell Growth and Survival. PMCID: PMC4114760. Editorial Commentary: Bornfeldt KE (2006). Nuclear signaling in smooth muscle cells: cyclic nucleotide phosphodiesterase 1A moves in. Circulation Research 98: 720-722.

Nagel DJ; Aizawa T; Jeon K; Liu W; Mohan A; Wei H; Miano JM; Florio VA; Gao P; Korshunov VA; Berk BC; and Yan C.

Circulation Research. 2006; : 777-784.

Role of p90 ribosome s6 kinase (p90RSK)-mediated pro-renin converting enzyme (PRECE) in ischemic and diabetic myocardium

Itoh S; Ding B; Shishido T; Lerner-Marmarosh N; Wang N; Maekawa N; Berk BC; Takeishi Y; Yan C; Blaxall BC; Abe J.

Circulation. 2006; 113:: 1787-1798.

ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta) stimulation.

Woo CH; Massett MP; Shishido T; Itoh S; Ding B; McClain C; Che W; Vulapalli SR; Yan C; Abe JI (2006).

J. Bio. Chem. 2006; 281:: 32164-74.

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochem. Biophys.

Shen WL; Gao PJ; Che ZQ; Ji KD; Yin M; Yan C; Berk BC; Zhu DL.

Res. Commun.,. 2006; : 337-43.

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.

Shen WL; Gao PJ; Che ZQ; Ji KD; Yin M; Yan C; Berk BC; Zhu DL.

Biochem. Biophys. Res. Commun.,. 2006; : 337-43.

Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction.

Qin F; Yan C; Patel R; Liu W; Dong E.

Free Radical Biology and Medicine. 2006; 40:: 1827-1842.

NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac cells: Effects of apocynin.

Qin F; Patel R; Yan C; Liu W.

Free Radical Biology and Medicine. 2006; 40:(236-246).

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.

Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C

Proceedings of the National Academy of Sciences of the United States of America.. 2005 October 11102 (41):14771-6. Epub 09/26/2005.

Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.

Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M, Beavo JA

Biology of reproduction.. 2005 October 73 (4):598-609. Epub 05/18/2005.

GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

Yin G, Zheng Q, Yan C, Berk BC

The Journal of biological chemistry.. 2005 July 29280 (30):27705-12. Epub 05/27/2005.

Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.

Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J

The Journal of biological chemistry.. 2005 June 24280 (25):24135-42. Epub 04/19/2005.

BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.

Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC

Circulation research.. 2005 June 1096 (11):1145-51. Epub 05/05/2005.

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.

Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C

Circulation.. 2005 May 17111 (19):2469-2476. Epub 05/02/2005.

Acceptor RNA cleavage profile supports an invasion mechanism for HIV-1 minus strand transfer.

Chen Y, Balakrishnan M, Roques BP, Bambara RA

The Journal of biological chemistry.. 2005 April 15280 (15):14443-52. Epub 01/18/2005.

Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling.

Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C

Journal of molecular and cellular cardiology.. 2005 January 38 (1):175-84. Epub 12/08/2004.

BMK1/ERK5 Is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1{alpha}.

Pi, X.; Garin, G.; Xie, L.; Zheng, Q.; Wei, H.; Abe, J.; Yan, C.; Berk, BC.

Circulation Research. 2005; 96(1145-1151).

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.

Shen, W.; Gao, P.; Che, Z.; Ji, K.; Yin, M.; Yan, C.; Berk, BC.; Zhu, D.

Biochemical and Biophysical Research Communication. 2005; 339: 337-343.

GIT1 is a scaffold for ERK1/2 activation in focal adhesion.

Yin G; Zheng Q; Yan C; Berk; BC.

J. Biol. Chem. 2005; : 27705-12.

Identification of a New Cyclic Nucleotide Phosphodiesterase Expressed in Mouse Sperm.

Vasta V; Sonnenburg WK; Yan C; Sodeling SH; Shimizu-Albergine M; Beavo JA.

Biol. Reprod. 2005; : 598-609.

Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells.

Yan C

Methods in molecular biology.. 2005 307 :85-92. Epub 1900 01 01.

Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt.

Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J, Berk BC

Journal of molecular and cellular cardiology.. 2004 October 37 (4):881-7. Epub 1900 01 01.

ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation.

Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Marmarosh NL, Che W, Ding B, Yan C, Abe J

The Journal of biological chemistry.. 2004 July 9279 (28):29691-9. Epub 04/12/2004.

Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion.

Cameron SJ, Itoh S, Baines CP, Zhang C, Ohta S, Che W, Glassman M, Lee JD, Yan C, Yang J, Abe J

FEBS letters.. 2004 May 21566 (1-3):255-60. Epub 1900 01 01.

14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

Zheng Q, Yin G, Yan C, Cavet M, Berk BC

The Journal of biological chemistry.. 2004 March 5279 (10):8787-91. Epub 12/16/2003.

Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.

Pi X, Yan C, Berk BC

Circulation research.. 2004 February 2094 (3):362-9. Epub 12/11/2003.

GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor.

Yin G, Haendeler J, Yan C, Berk BC

Molecular and cellular biology.. 2004 January 24 (2):875-85. Epub 1900 01 01.

ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation.

Osawa, M.; Itoh, S.; Ohta, S.; Huang, Q.; Berk, BC.; Marmarosh, NL.; Che, W.; Ding, B.; Yan, C.; Abe, J.

J Biol. Chem. 2004; 79(28): 29691-29699.

Big Mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.

Pi X; Yan C; and Berk BC.

Circulation Research, PMID: 15879308. 2004; 94:: 362-9.

GIT1 functions as a scaffold for MEK1-ERK1/2 activation by angiotensin II and EGF.

Yin G; Haendeler J; Yan C; Berk BC.

Mol. Cell. Biol.,. 2004; : 875-85.

Hinge-helix1 region of PPAR?1 mediates interaction with ERK5 and PPAR?1 transcriptional activation: Involvement in flow-induced PPAR? activation in endothelial cells. PMCID: PMC516745

Akaike M; Wei C; Lerner-Marmarosh N; Osawa S; Bo D; Berk BC; Yan C; Abe J.

Mol Cell Biol. 2004; : 8691-704.

Activation of big MAP kinase 1, (BMK1/ERK5) inhibits cardiac injury, after myocardial ischemia and reperfusion. FEBS Lett 566: 255-260.

Cameron SJ; Itoh S; Baines CP; Zhang C; Ohta S; Che W; Glassman M; Lee JD; Yan C; Yang J; and Abe JI.

FEBS Lett. 2004; : 255-260.

14-3-3beta binds to big mitogen activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

Zheng Q; Yin G; Yan C; Cavet M; and Berk BC.

J. Biol. Chem. 2004; : 8787-91.

Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt.

Melaragno MG; Cavet ME; Yan C; Tai L; Jin Z; Haendeler J; Berk BC.

J. Mol. Cell. Cardiol. 2004; : 881-887.

ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation.

Osawa M; Itoh S; Ohta S; Huang Q; Berk BC; Marmarosh NL; Che W; Ding B; Yan C; Abe JI.

J Biol. Chem. 2004; : 29691-9.

GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor.

Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC

The Journal of biological chemistry.. 2003 December 12278 (50):49936-44. Epub 09/30/2003.

Steps of the acceptor invasion mechanism for HIV-1 minus strand strong stop transfer.

Chen Y, Balakrishnan M, Roques BP, Bambara RA

The Journal of biological chemistry.. 2003 October 3278 (40):38368-75. Epub 07/22/2003.

Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation.

Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J

Arteriosclerosis, thrombosis, and vascular biology.. 2003 October 123 (10):1775-81. Epub 08/28/2003.

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.

Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C

Circulation research.. 2003 September 593 (5):406-13. Epub 08/14/2003.

Cyclic GMP phosphodiesterases and regulation of smooth muscle function.

Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA

Circulation research.. 2003 August 2293 (4):280-91. Epub 1900 01 01.

Angiotensin II signaling pathways mediated by tyrosine kinases.

Yin G, Yan C, Berk BC

The international journal of biochemistry & cell biology.. 2003 June 35 (6):780-3. Epub 1900 01 01.

Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.

Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J

The Journal of biological chemistry.. 2003 May 16278 (20):18682-8. Epub 03/12/2003.

Mechanism of minus strand strong stop transfer in HIV-1 reverse transcription.

Chen Y, Balakrishnan M, Roques BP, Fay PJ, Bambara RA

The Journal of biological chemistry.. 2003 March 7278 (10):8006-17. Epub 12/23/2002.

Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.

Yan C, Kim D, Aizawa T, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2003 January 123 (1):26-36. Epub 1900 01 01.

Anti-inflammatory effects of NO/cGMP are mediated by PDE3 inhibition in vascular smooth muscle cell.

Aizawa T; Wei H; Miano JM; Abe J; Berk BC; and Yan C.

Circulation Research,. 2003; : 406-413.

Inhibition of Tumor Necrosis Factor-{alpha}-Induced SHP-2 Phosphatase Activity by Shear Stress. A Mechanism to Reduce Endothelial Inflammation.

Lerner-Marmarosh N; Yoshizumi M; Che W; Surapisitchat J; Kawakatsu H; Akaike M; Ding B; Huang Q; Yan C; Berk BC; Abe J.

Arterioscler Thromb Vasc Biol. 2003; : 1775-1781.

GIT1 Mediates Src-dependent Activation of PLCgamma by Angiotensin II and EGF.

Haendeler J; Yin Y; Hojo Y; Saito Y; Melaragno M; Yan C; Heller M; Aebersold R; and Berk BC.

J. Biol. Chem. 2003; : 49936-44.

Regulation of EGF-induced connexin 43 gap junction communication by BMK1/ERK5 but not ERK1/2 kinase activation.

Cameron SJ; Malik; Lerner-Marmarosh N; Yan C; Akaike M; Lee J-D; Abe J; and Yang J;.

J. Biol. Chem. 2003; 278(20):: 18682-8.

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway.

Tai LK, Okuda M, Abe J, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2002 November 122 (11):1790-6. Epub 1900 01 01.

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.

Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J

The Journal of biological chemistry.. 2002 August 9277 (32):29330-41. Epub 05/14/2002.

Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H.

Wisniewski M, Chen Y, Balakrishnan M, Palaniappan C, Roques BP, Fay PJ, Bambara RA

The Journal of biological chemistry.. 2002 August 9277 (32):28400-10. Epub 05/21/2002.

Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression.

Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J

Circulation research.. 2002 June 1490 (11):1222-30. Epub 1900 01 01.

Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.

Frame MD, Fox RJ, Kim D, Mohan A, Berk BC, Yan C

American journal of physiology. Heart and circulatory physiology.. 2002 June 282 (6):H2377-85. Epub 1900 01 01.

Atheroprotective Mechanisms Activated by Sheer Stress in Endothelial Cells.

Berk, BC.; Wang, M.; Yan, C.; Surapisitchat, J.; Hoefen, R.

Drug News Perspect. 2002; 15: 1-7.

Differential expression of genes from nitrate tolerant rat aortas.

Pi, X.; Yan, C.; Kim, D-S.; Chen, J.; Berk, BC. ( * Contributed equally to this manuscript).

Journal of Vascular Research. 2002; 39: 304-310.

Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.

Frame, MD.; Fox, RJ.; Kim, D-S.; Mohan, A.; Berk, BC.; Chen, Y.

Am. J. Physiol. 2002; 282: H2377-H2385.

Differential expression of genes from nitrate tolerant rat aorta.

Pi X.*; Yan C*; Kim D-S; Chen J; and Berk BC ( * Contributed equally to this manuscript).

Journal of Vascular Research. 2002; : 304-310.

Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.

Frame MD; Fox RJ; Kim D-S; Mohan A; Berk BC; and Yan C.

Am. J. Physiol. 2002; : H2377-H2385.

Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-a induced c-Jun and NF-kB activation and adhesion molecule expression.

Che W; Lerner-Marmarosh N; Huang Q; Osawa M; Ohta S; Yoshizumi M; Glassman M; Lee J-D; Yan C; Berk BC; and Abe J.

Circulation Research;. 2002; : 1222-1230.

The novel role of C-terminal region of SHP-2 : Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. J. Biol. Chem, 277(32): 29330-29341.

Huang Q; Lerner-Marmarosh N; Che W; Ohta S; Osawa M; Yoshizumi M; Glassman M; Yan C; Berk BC; and Abe J.

J. Biol. Chem,. 2002; : 29330-29341.

Fluid shear stress activates Pyk2 via a reactive oxygen species dependent pathway.

Tai L; Okada M; Abe J; Yan C; and Berk BC.

Arterioscler. Thromb. Vasc. Biol. 2002; : 1790-1796.

Differential expression of genes from nitrate-tolerant rat aorta.

Pi X, Yan C, Kim D, Chen J, Berk BC

Journal of vascular research.. 2002 39 (4):304-10. Epub 1900 01 01.

Endothelial atheroprotective and anti-inflammatory mechanisms.

Berk BC, Abe JI, Min W, Surapisitchat J, Yan C

Annals of the New York Academy of Sciences.. 2001 December 947 :93-109; discussion 109-11. Epub 1900 01 01.

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.

Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C

Circulation.. 2001 November 6104 (19):2338-43. Epub 1900 01 01.

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning.

Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines CP, Lee JD, Kawakatsu H, Che W, Lerner-Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J

Journal of molecular and cellular cardiology.. 2001 November 33 (11):1989-2005. Epub 1900 01 01.

p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.

Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC

Circulation.. 2001 September 18104 (12):1399-406. Epub 1900 01 01.

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.

Yan C, Zhao AZ, Sonnenburg WK, Beavo JA

Biology of reproduction.. 2001 June 64 (6):1746-54. Epub 1900 01 01.

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains.

Yan C, Luo H, Lee JD, Abe J, Berk BC

The Journal of biological chemistry.. 2001 April 6276 (14):10870-8. Epub 01/03/2001.

Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons.

Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2001 January 1521 (2):434-43. Epub 1900 01 01.

Fluid shear stress inhibits TNF-a activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : inhibitory crosstalk among MAPK family members.

Surapisitcht, J.; Hoefen, JR.; Pi, X.; Yoshizumi, M.; Yan, C.; Berk, BC.

Proc. Nat. Acad, Sci. USA. 2001; 98: 6476-6481.

Kim D-S; Rebulkin S; Pi X; Zhang C; Munzel T; Beavo JA; Berk BC; Yan C.

Upregulation of phosphodiestrase 1A1 expression is associated with the development of nitrate tolerance.

Stage and Cell–Specific Expression of CaM-PDEs in Mouse Testis.

Yan C; Zhao AZ; Sonnenburg WK; and Beavo JA.

Biology of Reproduction,. 2001; : 1746-1754.

Molecular Cloning of Mouse ERK5/BMK1 Splice Variants and Characterization of ERK5 Functional Domains.

Yan C; Luo H; Lee J-D; Abe J; and Berk BC.

J. Biol. Chem. 2001; : 10870-10878.

Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons.

Cavanaugh JE; Ham J; Hetman M; Poser S; Yan C; and Xia Z.

J. Neuroscience. 2001; : 434-443.

Fluid shear stress inhibits TNF-a activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: inhibitory crosstalk among MAPK family members.

Surapisitcht J; Hoefen JR; Pi X; Yoshizumi M; Yan C; Berk BC.

Proc. Nat. Acad. Sci. USA. 2001; : 6476-6481.

p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.

Che W; Abe J; Yoshizumi M; Huang Q-H; Glassman M; Ohta S; Melaragno MG; Poppa V; Yan C; Lerner-Marmarosh N; Zhang C; Wu Y; Arlinhaus R; Berk BC.

Circulation. 2001; : 1399-1406.

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: Modulation of MAP kinases activation by ischemic preconditioning.

Takeishi Y; Hang Q; Wang T; Glassman M; Yoshizumi M; Baines CP; Lee J-D; Kawakatsu H; Che W; Lerner-Marmarosh N; Zhang C; Yan C; Ohta S; Walsh RA; Berk BC; and Abe J.

J. Mol. Cell. Cardiol. 2001; 33:: 1989-2005.

Cyclophilin A is a Secreted Growth Factor Induced by Oxidative Stress

Jin Z-G; Melaragno MG; Liao D-F; Yan C; Haendelaer J; Suh Y-A; Lambeth JD; and Berk BC.

Circulation Research. 2000; : 789-796.

Fluid shear stress stimulates big MAP kinase 1 (BMK1) activity in endothelial cells: roles of tyrosine kinases and Ca2+.

Yan C; Takahashi M; Lee JD; Ulevitch RJ; and Berk BC.

J. Biol. Chem. 1999; : 143-150.

Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae.

Peterson TE; Poppa V; Ueba H; Wu A; Yan C; and Berk BC.

Circulation Research. 1999; : 29-37.

The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue specific manner.

Yan C; Zhao AZ; Bentley JK; and Beavo JA.

J. Biol. Chem. 1996; : 25699-25706.

Molecular cloning and characterization of a novel calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

Yan C; Zhao AZ; Bentley JK; Loughney K; Ferguson K; and Beavo JA.

Proc. Nat. Acad. Sci. USA. 1995; : 9677-9681.

Developmentally expressed Ca2+-sensitive adenylyl cyclase activity is disrupted in the brain of type I adenylyl cyclase mutant mice.

Villacres EC; Wu Z; Hua W; Nielsen MD; Watters JJ; Yan C; Beavo JA; and Storm DR.

J. Biochem. 1995; 270: 14352-14357.

Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain.

Yan C; Bentley JK; Sonnenburg WK; and Beavo JA.

J. Neuroscience (Cover article). 1994; : 973-984.

Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.

Yan C; Costa RH; Darnell JE; Chen J; and Van Dyke TA.

EMBO J. 1990; : 869-878.

Hepatocyte nuclear factor binding correlates with the transcription of the transthyretin gene.

Costa RH; Van Dyke TA; Yan C; Kuo F; and Darnell JE.

Proc. Nat. Acad. Sci., USA. 1990; 87: 6589-6593.

Studies on the systematic status of a new species of Drosophila (Sophophora)--from morphological to molecular level.

Chen HZ; Yan C; and Liu ZD.

I-Chuan-Hsueh-Pao. 1990; 17(3):: 189-210.

Introduction of a sensitive rapid silver staining method.

Yan C.

Heredity and Disease. 1986; 3: 185-186.

Isolation and characterization of ouabain-resistant mutants of Chinese hamster cell.

Qi M; Qiu XF; Xiu XL.; and Yan C.

Acta Biologiae Experimentalis Sinica. 1986; 19: 161-171.

Model-based vascular elastograph improves the detection of flow-induced carotid artery remodeling in mice. Scientific Report, Sep 21;7(1):12081. doi: 10.1038/s41598-017-12321-7. PMCID: PMC5608712. (* Co-corresponding authors).

Korshunov VA*: Wang H: Ahmed R: Mickelsen DM: Zhou Q: Yan C*: Doyley MM* (2017).

Books

Cyclic Nucleotide Phosphodiesterases in Health and Disease (2006)

Chapter: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases.

Authors: Yan C, Nagel DJ, Jeon K

Publisher: CRC Press 2006

Methods Mol Biol (2005)

Chapter: Determination of Ca2+/Calmodulin-Stimulated Phosphodiesterase Activity in Intact Cells

Authors: Yan C.

Publisher: N/A 2005

In Proteomic and Genomic Analysis of Cardiovascular Disease (2003)

Chapter: Identification of secreted oxidative stress-induced factors (SOXF) and associated proteins: proteomics in vascular biology

Authors: Jin Z-G, Liao D-F, Yan C, and Berk BC

Publisher: Wiley-VCH publishers 2003

Vascular Endothelium-Source and Target of Inflammatory Mediators (2001)

Chapter: Atheroprotective mechanisms of fluid shear stress: nitric oxide independent inhibition of signal transduction mediated by inflammatory cytokine

Authors: Berk BC, Surapisitchat J, Yoshizumi M, Yan C. Hoefen R, and Abe J

Publisher: IOS Press 2001

Vascular Protection: Molecular Mechanisms, Novel Therapeutic Principles, and Cli (2001)

Chapter: Flow-mediated Activation of MAP Kinase

Authors: Surapisitchat J, Yan C, and Berk BC

Publisher: N/A 2001

Heart Physiology and Pathophysiology (2000)

Chapter: Kinase Signaling in the Cardiovascular System

Authors: Abe J, Yan C, Surapisitchat J, and Berk BC

Publisher: Academic Press 2000

Mechanical Forces and the Endothelium (1998)

Chapter: In Vitro stimulation of shear stress and mitogen-activated protein kinase responses to shear stress in endothelial cells

Authors: Traub O, Yan C, and Berk BC

Publisher: Hardwood Academic Publishers. 1998

Signal Transduction in Health and Disease, Advances in Second Messenger and P... (1997)

Chapter: Recent advances in the study of Ca2+/CaM activated phosphodiesterases: Expression and physiological functions

Authors: Zhao AZ, Yan C, Sonnenburg WK, and Beavo JA

Publisher: Raven Press 1997

Calcium as a Cellular Regulator (1997)

Chapter: cAMP Phosphodiesterase / Adenylate Cyclase

Authors: Yan C, Chan GC, Storm DR, and Beavo JA

Publisher: Oxford University Press 1997