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Hartmut K. Land, Ph.D.

Hartmut K. Land, Ph.D.


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About Me

Faculty Appointments

Professor - Department of Biomedical Genetics (SMD)

Chair - Department of Biomedical Genetics (SMD)

Robert and Dorothy Markin Professorship - Department of Biomedical Genetics (SMD)


Post-doctoral Training & Residency

MIT/Whitehead Institute for Biomed. Research, Molecular Cell Biology 1982 - 1985


PhD | University of Heidelberg. Biochem. Mol. Biol. 1981


Selected ISI highly cited Investigator ( 2003

Elected Member of the European Molecular Biology Organization (EMBO). 1996

Postdoctoral Fellow of the Deutsche Forschungsgemeinschaft. 1982 - 1985



Journal Articles

Correction: Multiple imputation and direct estimation for qPCR data with non-detects.

Sherina V, McMurray HR, Powers W, Land H, Love TMT, McCall MN

BMC bioinformatics.. 2024 February 725 (1):63. Epub 02/07/2024.

Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments.

McMurray HR, Stern HA, Ambeskovic A, Land H, McCall MN

STAR protocols.. 2022 December 163 (4):101737. Epub 09/30/2022.

The global spread of misinformation on spiders.

Mammola S, Malumbres-Olarte J, Arabesky V, Barrales-Alcalá DA, Barrion-Dupo AL, Benamú MA, Bird TL, Bogomolova M, Cardoso P, Chatzaki M, Cheng RC, Chu TA, Classen-Rodríguez LM, ?upi? I, Dhiya'ulhaq NU, Drapeau Picard AP, El-Hennawy HK, Elverici M, Fukushima CS, Ganem Z, Gavish-Regev E, Gonnye NT, Hacala A, Haddad CR, Hesselberg T, Tian Ho TA, Into T, Isaia M, Jayaraman D, Karuaera N, Khalap R, Khalap K, Kim D, Korhonen T, Kralj-Fišer S, Land H, Lin SW, Loboda S, Lowe E, Lubin Y, Martínez A, Mbo Z, Mili?i? M, Kioko GM, Nanni V, Norma-Rashid Y, Nwankwo D, Painting CJ, Pang A, Pantini P, Pavlek M, Pearce R, Petcharad B, Pétillon J, Raberahona OC, Russo P, Saarinen JA, Segura-Hernández L, Sentenská L, Uhl G, Walker L, Warui CM, Wi?niewski K, Zamani A, Chuang A, Scott C

Current biology : CB.. 2022 August 2232 (16):R871-R873. Epub 1900 01 01.

Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes.

McMurray HR, Ambeskovic A, Newman LA, Aldersley J, Balakrishnan V, Smith B, Stern HA, Land H, McCall MN

Cell reports.. 2021 December 2137 (12):110136. Epub 1900 01 01.

Multiple imputation and direct estimation for qPCR data with non-detects.

Sherina V, McMurray HR, Powers W, Land H, Love TMT, McCall MN

BMC bioinformatics.. 2020 November 2621 (1):545. Epub 11/26/2020.

A four gene signature predictive of recurrent prostate cancer.

Komisarof J, McCall M, Newman L, Bshara W, Mohler JL, Morrison C, Land H

Oncotarget.. 2017 January 108 (2):3430-3440. Epub 1900 01 01.

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.

Smith B, Schafer XL, Ambeskovic A, Spencer CM, Land H, Munger J

Cell reports.. 2016 October 1117 (3):821-836. Epub 1900 01 01.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J

Oncotarget.. 2015 June 206 (17):14796-813. Epub 1900 01 01.

On non-detects in qPCR data.

McCall MN, McMurray H, Land H, Almudevar A

Bioinformatics.. 2014 August 1530 (16):2310-6. Epub 04/23/2014.

Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.

Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H

Cell reports.. 2014 May 227 (4):1143-55. Epub 05/01/2014.

Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery.

Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, Land H

Oncogene.. 2013 August 1532 (33):3809-18. Epub 09/10/2012.

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth.

Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li WX

Proceedings of the National Academy of Sciences of the United States of America.. 2013 June 18110 (25):10213-8. Epub 06/03/2013.

The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis.

Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li WX

Human molecular genetics.. 2013 January 1522 (2):284-99. Epub 10/16/2012.

Anticancer activity of the cholesterol exporter ABCA1 gene.

Smith B, Land H

Cell reports.. 2012 September 272 (3):580-90. Epub 09/13/2012.

Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT

Cell stem cell.. 2012 September 711 (3):359-72. Epub 08/02/2012.

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.

O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF

Cancer research.. 2012 March 1572 (6):1557-67. Epub 01/20/2012.

Fitting Boolean networks from steady state perturbation data.

Almudevar A, McCall MN, McMurray H, Land H

Statistical applications in genetics and molecular biology. 2011 October 510 (1)Epub 10/05/2011.

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype.

McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, Chen SR, Klebanov L, Salzman P, Yakovlev A, Land H

Nature.. 2008 June 19453 (7198):1112-6. Epub 05/25/2008.

Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.

Xia M, Land H

Nature structural & molecular biology.. 2007 March 14 (3):215-23. Epub 02/18/2007.

A permutation test motivated by microarray data analysis

Klebanov, L.; Gordon, A.; Xiao, Y.; Land, H.; Yakovlev, A.

Computational Statistics and Data Analysis. 2005; 50: 3619-3628.

Recruitment of TRRAP required for oncogenic transformation by E1A.

Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H

Oncogene.. 2001 December 1320 (57):8270-5. Epub 1900 01 01.

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes.

Roper E, Weinberg W, Watt FM, Land H

EMBO reports.. 2001 February 2 (2):145-50. Epub 1900 01 01.

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H

The EMBO journal.. 1999 October 118 (19):5310-20. Epub 1900 01 01.

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

Sewing A, Wiseman B, Lloyd AC, Land H

Molecular and cellular biology.. 1997 September 17 (9):5588-97. Epub 1900 01 01.

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H

Genes & development.. 1997 March 111 (5):663-77. Epub 1900 01 01.

Immortalization and transformation are associated with specific alterations in choline metabolism.

Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD

Cancer research.. 1996 October 1556 (20):4630-5. Epub 1900 01 01.

Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts.

Solomon DL, Philipp A, Land H, Eilers M

Oncogene.. 1995 November 211 (9):1893-7. Epub 1900 01 01.

Transformation of primary rat embryo cells.

Land H

Methods in enzymology.. 1995 254 :37-41. Epub 1900 01 01.

Integrated control of cell proliferation and cell death by the c-myc oncogene.

Evan G, Harrington E, Fanidi A, Land H, Amati B, Bennett M

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 1994 August 30345 (1313):269-75. Epub 1900 01 01.

Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

Amati B, Land H

Current opinion in genetics & development.. 1994 February 4 (1):102-8. Epub 1900 01 01.

Integrated control of cell proliferation and cell death by the c-myc oncogene

Evan,G.; Harrington,E.; Fanidi,A.; Land,H.; Amati,B.; Bennett,M.;.

Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 1994; 345(1313): 269-275.

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

Amati B, Littlewood TD, Evan GI, Land H

The EMBO journal.. 1993 December 1512 (13):5083-7. Epub 1900 01 01.

Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers.

Solomon DL, Amati B, Land H

Nucleic acids research.. 1993 November 2521 (23):5372-6. Epub 1900 01 01.

Oncogenic activity of the c-Myc protein requires dimerization with Max.

Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H

Cell.. 1993 January 2972 (2):233-45. Epub 1900 01 01.

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H

Nature.. 1992 October 1359 (6394):423-6. Epub 1900 01 01.

Max and c-Myc/Max DNA-binding activities in cell extracts.

Littlewood TD, Amati B, Land H, Evan GI

Oncogene.. 1992 September 7 (9):1783-92. Epub 1900 01 01.

Induction of apoptosis in fibroblasts by c-myc protein.

Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC

Cell.. 1992 April 369 (1):119-28. Epub 1900 01 01.

Choice and manipulation of retroviral vectors.

Morgenstern JP, Land H

Methods in molecular biology.. 1991 7 :181-206. Epub 1900 01 01.

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

Penn LJ, Brooks MW, Laufer EM, Littlewood TD, Morgenstern JP, Evan GI, Lee WM, Land H

Molecular and cellular biology.. 1990 September 10 (9):4961-6. Epub 1900 01 01.

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

Bögler O, Wren D, Barnett SC, Land H, Noble M

Proceedings of the National Academy of Sciences of the United States of America.. 1990 August 87 (16):6368-72. Epub 1900 01 01.

Establishment of rat endometrial cell lines by retroviral mediated transfer of immortalizing and transforming oncogenes.

Wiehle RD, Helftenbein G, Land H, Neumann K, Beato M

Oncogene.. 1990 June 5 (6):787-94. Epub 1900 01 01.

Negative autoregulation of c-myc transcription.

Penn LJ, Brooks MW, Laufer EM, Land H

The EMBO journal.. 1990 April 9 (4):1113-21. Epub 1900 01 01.

C-MYC: evidence for multiple regulatory functions.

Penn LJ, Laufer EM, Land H

Seminars in cancer biology.. 1990 February 1 (1):69-80. Epub 1900 01 01.

[Induction of primitive neuroectodermal tumors by oncogene complementation].

von Deimling A, Aguzzi A, Kleihues P, Land H, Wiestler OD

Verhandlungen der Deutschen Gesellschaft für Pathologie. 1990 74 :432-6. Epub 1900 01 01.

Control of division and differentiation in oligodendrocyte-type-2 astrocyte progenitor cells.

Noble M, Barnett SC, Bögler O, Land H, Wolswijk G, Wren D

Ciba Foundation symposium.. 1990 150 :227-43; discussion 244-9. Epub 1900 01 01.

Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells.

Ridley AJ, Davis JB, Stroobant P, Land H

The Journal of cell biology.. 1989 December 109 (6 Pt 2):3419-24. Epub 1900 01 01.

An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis.

Beddington RS, Morgernstern J, Land H, Hogan A

Development.. 1989 May 106 (1):37-46. Epub 1900 01 01.

The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R

Proceedings of the National Academy of Sciences of the United States of America.. 1989 April 86 (7):2224-8. Epub 1900 01 01.

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

Thompson TC, Southgate J, Kitchener G, Land H

Cell.. 1989 March 2456 (6):917-30. Epub 1900 01 01.

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

Ridley AJ, Paterson HF, Noble M, Land H

The EMBO journal.. 1988 June 7 (6):1635-45. Epub 1900 01 01.

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

Land H, Chen AC, Morgenstern JP, Parada LF, Weinberg RA

Molecular and cellular biology.. 1986 June 6 (6):1917-25. Epub 1900 01 01.

Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts.

Parada LF, Land H, Chen A, Morganstern J, Weinberg RA

Progress in medical virology. Fortschritte der medizinischen

Activated oncogenes in Burkitt's lymphoma.

Lenoir GM, Land H, Parada LF, Cunningham JM, Weinberg RA

Current topics in microbiology and immunology.. 1984 113 :6-14. Epub 1900 01 01.

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

Parada LF, Land H, Weinberg RA, Wolf D, Rotter V

Nature.. 1984 312 (5995):649-51. Epub 1900 01 01.

Cellular oncogenes and multistep carcinogenesis.

Land H, Parada LF, Weinberg RA

Science.. 1983 November 18222 (4625):771-8. Epub 1900 01 01.

Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences.

Land H, Grez M, Hauser H, Lindenmaier W, Schütz G

Methods in enzymology.. 1983 100 :285-92. Epub 1900 01 01.

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Land H, Parada LF, Weinberg RA

Nature.. 1983 304 (5927):596-602. Epub 1900 01 01.

Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA.

Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schütz G

Nature.. 1983 302 (5906):342-4. Epub 1900 01 01.

Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor.

Land H, Schütz G, Schmale H, Richter D

Nature.. 1982 January 28295 (5847):299-303. Epub 1900 01 01.

Multiple mRNAs are generated from the chicken lysozyme gene.

Grez M, Land H, Giesecke K, Schütz G, Jung A, Sippel AE

Cell.. 1981 September 25 (3):743-52. Epub 1900 01 01.

5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency.

Land H, Grez M, Hauser H, Lindenmaier W, Schütz G

Nucleic acids research.. 1981 May 259 (10):2251-66. Epub 1900 01 01.

Structure of the lysozyme gene and expression in the oviduct and macrophages.

Hauser H, Graf T, Beug H, Greiser-Wilke I, Lindenmaier W, Grez M, Land H, Giesecke K, Schütz G

Haematology and blood transfusion.. 1981 26 :175-8. Epub 1900 01 01.

The isolation and characterization of the chicken lysozyme and ovomucoid gene.

Lindenmaier W, Nguyen-Huu MC, Stratmann LM, Blin N, Wurtz T, Hauser HJ, Giesecke K, Land H, Jeep S, Grez M, Sippel AE, Schütz G

Journal of steroid biochemistry.. 1980 January 12 :211-8. Epub 1900 01 01.

Isolation and characterization of the chicken ovomucoid gene.

Lindenmaier W, Nguyen-Huu MC, Lurz R, Blin N, Stratmann M, Land H, Jeep S, Sippel AE, Schütz G

Nucleic acids research.. 1979 November 107 (5):1221-32. Epub 1900 01 01.

Chicken lysozyme gene contains several intervening sequences.

Nguyen-Huu MC, Stratmann M, Groner B, Wurtz T, Land H, Giesecke K, Sippel AE, Schütz G

Proceedings of the National Academy of Sciences of the United States of America.. 1979 January 76 (1):76-80. Epub 1900 01 01.

Cloning of chicken lysozyme structural gene sequences synthesized in vitro.

Sippel AE, Land H, Lindenmaier W, Nguyen-Huu MC, Wurtz T, Timmis KN, Giesecke K, Schütz G

Nucleic acids research.. 1978 September 5 (9):3275-94. Epub 1900 01 01.

Differential behavior of two dexamethasone induced mRNA activities in HTC cells in response to cordycepin and to withdrawal of hormone.

Land H, Hofer E, Sekeris CE

Biochemical and biophysical research communications.. 1978 July 2883 (2):607-15. Epub 1900 01 01.

In vitro synthesis and stability of RNA in isolated nuclei from bovine lymphocytes.

Land H, Schäfer KP

Biochemical and biophysical research communications.. 1977 December 779 (3):947-57. Epub 1900 01 01.