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Joseph M. Miano, Ph.D.

Joseph M. Miano, Ph.D.

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About Me

Dr. Joseph Miano grew up in Chili, a suburb of Rochester, New York. He graduated from Gates-Chili High School in 1980 and, following one year of playing junior hockey in Western New York and Southern Ontario, he attended SUNY Cortland and graduated in 1986 with dual degrees in Biology and Physical ...
Dr. Joseph Miano grew up in Chili, a suburb of Rochester, New York. He graduated from Gates-Chili High School in 1980 and, following one year of playing junior hockey in Western New York and Southern Ontario, he attended SUNY Cortland and graduated in 1986 with dual degrees in Biology and Physical Education (Exercise Science). His undergraduate research, performed in 1983-86 under the tutelage of David Berger and Jim Starzec, investigated the effects of psychological stress or voluntary exercise on fatty streak formation in the aorta of spontaneously hypertensive rats. His PhD research, in Experimental Pathology at New York Medical College under the mentorship of Michael Stemerman, involved the identification of genes rapidly turned on following experimental balloon angioplasty. His post-doctoral training was done with Eric Olson at the MD Anderson Cancer Center in Houston Texas where he cloned and characterized several smooth muscle-restricted promoters and initiated the study of retinoids in the blood vessel wall. He was recruited to the University of Rochester in 1999 following a three year appointment at the Medical College of Wisconsin where he developed a passion for the human genome. A major research aim in the Miano Lab has been to decipher the small snippets of codes in our genome that dictate how genes involved in cardiovascular disease are either turned up or down. Much like a thermostat controlling the heat in a home, cells normally have exquisite control over the level of gene activity. Diseases of the heart and blood vessels occur when this 'geneostat' control runs awry. Thus, identifying and understanding how certain genetic codes control genes turning on and off is a foundation for developing novel methods of predicting and perhaps treating various diseases of the body. Dr. Miano's lab was among the first wave of labs in 2013 to exploit the revolutionary CRISPR genome editing technology for purposes of altering the mouse genome and, within a year, the lab generated the first CRISPR animal model carrying subtle mutations in a control element that turns on a gene (Cnn1). To date, Dr. Miano has published over 100 research papers that focus on the control of gene expression in smooth muscle cells of the blood vessel wall. He previously served as Associate Editor of ATVB and Consulting Editor of Circulation Research. He is a Fellow of the American Heart Association and a member of the Vascular Cell and Molecular Biology Study Section at NIH.

Links of interest for the lay public:

Research Gate https://www.researchgate.net/home

Faculty Appointments

Adjunct Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Credentials

Residency & Fellowship

Department of Biochemistry & Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston Texas. (Eric Olson, Mentor) 1992 - 1995

Education

PhD | New York Medical College. Experimental Pathology. 1992

MS | New York Medical College. Experimental Pathology. 1988

BS | SUNY Coll at Cortland. Biology. 1986

Awards

Vascular Biology Special Recognition Award. 2014

Established Investigator Award American Heart Association. 2003 - 2007

Who's Who in Medicine and Healthcare. 2003

Manitowoc Heart-A-Rama Research for Life. 1997

Post-Doctoral National Research Service, Smooth Muscle Cell Differentiation. 1993

Helen S. Page Memorial Ph.D.. 1992

Research

The human genome is replete with functional information, including millions of transcription factor binding sites (TFBS) that bind some 1400 transcription factors and several classes of non-coding RNA genes, particularly the rapidly growing class of long non-coding RNA (lncRNA). Thus, the long-held ...
The human genome is replete with functional information, including millions of transcription factor binding sites (TFBS) that bind some 1400 transcription factors and several classes of non-coding RNA genes, particularly the rapidly growing class of long non-coding RNA (lncRNA). Thus, the long-held notion that the human genome is made up largely of "junk DNA" has been debunked and a new era has emerged to elucidate the functionality of the non-protein coding genome which comprises 98% of our blueprint of life.

Though the ENCODE Consortium and other big genome projects have been a magnificent kick-start for this new endeavor, much remains to be learned across the ~250 distinct cell types that make up the human body, especially under stress conditions that simulate disease processes. Accordingly, research in the Miano Lab is focused broadly on the vascular smooth muscle cell (VSMC) and how this cell type's differentiation program is controlled through both key TFBS and lncRNAs. Much of the work revolves around a DNA-binding transcription factor called serum response factor (SRF), its TFBS known as a CArG box, and an SRF cofactor called Myocardin (MYOCD), which his lab first showed to be a potent stimulus for the VSMC differentiation program. Current funded projects involve the study of a protein-coding gene (AKAP12A) that is a direct target of the SRF-Myocardin switch; the regulation of MYOCD and its role in vascular diseases; and the elucidation of the CArGome (all functional CArG boxes in the genome).

The latter project is also aimed to gain insight into CArG-SNPs that may be linked to human diseases. Since the vast majority of the >3.6 million CArG boxes punctuating the human genome fall in intergenic or intronic sequence space where "pervasive transcription" is known to occur, the lab initiated several screens to define known and novel lncRNAs in human VSMC. A major focus of the lab is obtaining functional insight into a novel lncRNA (SENCR) enriched in vascular cells as well as a number of known and novel lncRNAs that are regulated by SRF and/or MYOCD. The project pipeline involves a systematic series of experiments to define expression of lncRNAs in human tissues and cell lines; elucidating full length transcripts by RACE; defining spatial localization of lncRNAs by RNA-FISH; ascertaining potential regulatory sequences within lncRNAs (e.g., microRNA binding site, TFBS, etc); defining lncRNA promoters and the signaling molecules that converge upon regulatory sequences therein; defining altered transcriptomes by RNA-seq following loss-of-function with dicer substrate siRNAs directed to several regions of a lncRNA; and lncRNA interaction studies with other RNAs or proteins to begin understanding mechanistic aspects of lncRNAs. The Miano Lab utilizes state-of-the-art tools in genetics (e.g., HDR-mediated genome editing with CRISPR-Cas9), genomics, bioinformatics, and molecular biology to elucidate regulatory element and lncRNA biology in experimental and clinically relevant settings.

Publications

Journal Articles

Prime editing in mice with an engineered pegRNA.

Salem AR, Bryant WB, Doja J, Griffin SH, Shi X, Han W, Su Y, Verin AD, Miano JM

Vascular pharmacology.. 2023 December 27 :107269. Epub 12/27/2023.

Calponin 1 inhibits agonist-induced ERK activation and decreases calcium sensitization in vascular smooth muscle.

Kajuluri LP, Lyu QR, Doja J, Kumar A, Wilson MP, Sgrizzi SR, Rezaeimanesh E, Miano JM, Morgan KG

Journal of cellular and molecular medicine.. 2023 December 26 Epub 12/26/2023.

HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells.

Thevkar Nagesh P, Nishi H, Rawal S, Zahr T, Miano JM, Sorci-Thomas M, Xu H, Akbar N, Choudhury RP, Misra A, Fisher EA

bioRxiv : the preprint server for biology.. 2023 October 19 Epub 10/19/2023.

A New "Lnc" to Brake Inflammation.

Long X, Miano JM, Zhou J

Arteriosclerosis, thrombosis, and vascular biology.. 2023 May 25 Epub 05/25/2023.

is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10.

Zhang W, Zhao J, Deng L, Ishimwe N, Pauli J, Wu W, Shan S, Kempf W, Ballantyne MD, Kim D, Lyu Q, Bennett M, Rodor J, Turner AW, Lu YW, Gao P, Choi M, Warthi G, Kim HW, Barroso MM, Bryant WB, Miller CL, Weintraub NL, Maegdefessel L, Miano JM, Baker AH, Long X

Circulation.. 2023 May 18 Epub 05/18/2023.

CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome.

Bryant WB, Yang A, Griffin SH, Zhang W, Rafiq AM, Han W, Deak F, Mills MK, Long X, Miano JM

The CRISPR journal.. 2023 April 6 (2):163-175. Epub 1900 01 01.

PGC-1? senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.

Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE

Molecular cell.. 2023 January 1983 (2):186-202.e11. Epub 1900 01 01.

is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10.

Zhang W, Zhao J, Deng L, Ishimwe N, Pauli J, Wu W, Shan S, Kempf W, Ballantyne MD, Kim D, Lyu Q, Bennett M, Rodor J, Turner AW, Lu YW, Gao P, Choi M, Warthi G, Kim HW, Barroso MM, Bryant WB, Miller CL, Weintraub NL, Maegdefessel L, Miano JM, Baker AH, Long X

bioRxiv : the preprint server for biology.. 2023 January 9 Epub 01/09/2023.

Generation and Comparative Analysis of an Mouse with Preferential Activity in Vascular Smooth Muscle Cells.

Warthi G, Faulkner JL, Doja J, Ghanam AR, Gao P, Yang AC, Slivano OJ, Barris CT, Kress TC, Zawieja SD, Griffin SH, Xie X, Ashworth A, Christie CK, Bryant WB, Kumar A, Davis MJ, Long X, Gan L, de Chantemèle EJB, Lyu Q, Miano JM

Nature cardiovascular research.. 2022 November 1 (11):1084-1100. Epub 11/11/2022.

Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.

Matsumura S, D'Addiaro C, Slivano OJ, De Miguel C, Stier C, Gupte R, Miano JM, Gupte SA

Vascular pharmacology.. 2022 May 24 :107002. Epub 05/24/2022.

Of mice and human-specific long noncoding RNAs.

Ghanam AR, Bryant WB, Miano JM

Mammalian genome : official journal of the International Mammalian Genome Society.. 2022 February 1 Epub 02/01/2022.

Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.

Miano JM, Fisher EA, Majesky MW

Circulation.. 2021 May 25143 (21):2110-2116. Epub 05/24/2021.

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb K, Eudy JD, Gan L, Gao J, Gonzales A, Guntur A, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majeweska L, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford A, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G

Genome biology.. 2021 April 722 (1):99. Epub 04/07/2021.

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.

Gao P, Lyu Q, Ghanam AR, Lazzarotto CR, Newby GA, Zhang W, Choi M, Slivano OJ, Holden K, Walker JA, Kadina AP, Munroe RJ, Abratte CM, Schimenti JC, Liu DR, Tsai SQ, Long X, Miano JM

Genome biology.. 2021 March 1622 (1):83. Epub 03/16/2021.

The miR-378/PGC1?/mTOR axis as an alternative mechanism to promote autophagy during adipogenesis.

Lyu QR, Huang N, Dong K, Xie W, He J, Miano JM, Xu N, Zhang Y

Biochimica et biophysica acta. Molecular and cell biology of lipids.. 2021 March 11 :158921. Epub 03/11/2021.

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm.

Gao P, Gao P, Zhao J, Shan S, Luo W, Slivano OJ, Zhang W, Tabuchi A, LeMaire SA, Maegdefessel L, Shen YH, Miano JM, Singer HA, Long X

Redox biology.. 2021 February 2041 :101903. Epub 02/20/2021.

Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary tale.

Lyu QR, Yao P, Miano JM

Journal of biomedical research.. 2020 December 2535 (2):174-178. Epub 1900 01 01.

CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean Variant.

Kitagawa A, Kizub I, Jacob C, Michael K, D'Alessandro A, Reisz JA, Grzybowski M, Geurts AM, Rocic P, Gupte R, Miano JM, Gupte SA

Hypertension.. 2020 June 8 :HYPERTENSIONAHA12014772. Epub 06/08/2020.

Coronary Disease Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.

Nagao M, Lyu Q, Zhao Q, Wirka RC, Bagga J, Nguyen T, Cheng P, Kim JB, Pjanic M, Miano JM, Quertermous T

Circulation research.. 2019 December 9 Epub 12/09/2019.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G

Genome biology.. 2019 August 2620 (1):171. Epub 08/26/2019.

CRISPR links to long noncoding RNA function in mice: A practical approach.

Miano JM, Long X, Lyu Q

Vascular pharmacology.. 2019 February 26 Epub 02/26/2019.

CRISPR-tagging mice in aging research.

Miano JM, Long X

Aging.. 2018 September 1910 (9):2226-2227. Epub 1900 01 01.

CRISPR-Cas9-Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin-Brief Report.

Lyu Q, Dhagia V, Han Y, Guo B, Wines-Samuelson ME, Christie CK, Yin Q, Slivano OJ, Herring P, Long X, Gupte SA, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2018 September 38 (9):2184-2190. Epub 1900 01 01.

Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.

Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM

Journal of the American Society of Nephrology : JASN.. 2018 February 29 (2):416-422. Epub 11/07/2017.

Testosterone Rescues the De-Differentiation of Smooth Muscle Cells Through Serum Response Factor/Myocardin.

Leimgruber C, Quintar AA, Peinetti N, Scalerandi MV, Nicola JP, Miano JM, Maldonado CA

Journal of cellular physiology.. 2017 October 232 (10):2806-2817. Epub 04/10/2017.

What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine?

Musunuru K, Lagor WR, Miano JM

Circulation. Cardiovascular genetics.. 2017 October 10 (5)Epub 1900 01 01.

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM

Proceedings of the National Academy of Sciences of the United States of America.. 2017 March 28114 (13):E2739-E2747. Epub 03/14/2017.

Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques.

de Campo DM, Cameron JL, Miano JM, Lewis DA, Mirnics K, Fudge JL

Developmental psychobiology.. 2017 March 59 (2):235-249. Epub 12/04/2016.

Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.

Zhu QM, Ko KA, Ture S, Mastrangelo MA, Chen MH, Johnson AD, O'Donnell CJ, Morrell CN, Miano JM, Lowenstein CJ

Arteriosclerosis, thrombosis, and vascular biology.. 2017 February 37 (2):264-270. Epub 12/29/2016.

Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases.

Freedman JE, Miano JM,

Arteriosclerosis, thrombosis, and vascular biology.. 2017 January 37 (1):21-25. Epub 11/17/2016.

Serum response factor regulates smooth muscle contractility via myotonic dystrophy protein kinases and L-type calcium channels.

Lee MY, Park C, Ha SE, Park PJ, Berent RM, Jorgensen BG, Corrigan RD, Grainger N, Blair PJ, Slivano OJ, Miano JM, Ward SM, Smith TK, Sanders KM, Ro S

PloS one.. 2017 12 (2):e0171262. Epub 02/02/2017.

Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency.

Chettimada S, Joshi SR, Dhagia V, Aiezza A, Lincoln TM, Gupte R, Miano JM, Gupte SA

American journal of physiology. Heart and circulatory physiology.. 2016 October 1311 (4):H904-H912. Epub 08/12/2016.

MYOSLID Is a Novel Serum Response Factor-Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program.

Zhao J, Zhang W, Lin M, Wu W, Jiang P, Tou E, Xue M, Richards A, Jourd'heuil D, Asif A, Zheng D, Singer HA, Miano JM, Long X

Arteriosclerosis, thrombosis, and vascular biology.. 2016 October 36 (10):2088-99. Epub 07/21/2016.

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research.

Miano JM, Zhu QM, Lowenstein CJ

Arteriosclerosis, thrombosis, and vascular biology.. 2016 June 36 (6):1058-75. Epub 04/21/2016.

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation.

Ballantyne MD, Pinel K, Dakin R, Vesey AT, Diver L, Mackenzie R, Garcia R, Welsh P, Sattar N, Hamilton G, Joshi N, Dweck MR, Miano JM, McBride MW, Newby DE, McDonald RA, Baker AH

Circulation.. 2016 May 24133 (21):2050-65. Epub 04/06/2016.

A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells.

Boulberdaa M, Scott E, Ballantyne M, Garcia R, Descamps B, Angelini GD, Brittan M, Hunter A, McBride M, McClure J, Miano JM, Emanueli C, Mills NL, Mountford JC, Baker AH

Molecular therapy : the journal of the American Society of Gene Therapy.. 2016 May 24 (5):978-90. Epub 02/22/2016.

Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells.

Park C, Lee MY, Slivano OJ, Park PJ, Ha S, Berent RM, Fuchs R, Collins NC, Yu TJ, Syn H, Park JK, Horiguchi K, Miano JM, Sanders KM, Ro S

Cell death & disease.. 2015 December 36 (12):e2011. Epub 12/03/2015.

Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype.

Park C, Lee MY, Park PJ, Ha SE, Berent RM, Fuchs R, Miano JM, Becker LS, Sanders KM, Ro S

Journal of neurogastroenterology and motility.. 2015 October 121 (4):589-602. Epub 1900 01 01.

The short and long of noncoding sequences in the control of vascular cell phenotypes.

Miano JM, Long X

Cellular and molecular life sciences : CMLS.. 2015 September 72 (18):3457-88. Epub 05/29/2015.

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.

Ackers-Johnson M, Talasila A, Sage AP, Long X, Bot I, Morrell NW, Bennett MR, Miano JM, Sinha S

Arteriosclerosis, thrombosis, and vascular biology.. 2015 April 35 (4):817-28. Epub 01/22/2015.

Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.

Vengrenyuk Y, Nishi H, Long X, Ouimet M, Savji N, Martinez FO, Cassella CP, Moore KJ, Ramsey SA, Miano JM, Fisher EA

Arteriosclerosis, thrombosis, and vascular biology.. 2015 March 35 (3):535-46. Epub 01/08/2015.

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report.

Han Y, Slivano OJ, Christie CK, Cheng AW, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2015 February 35 (2):312-5. Epub 12/23/2014.

Myocardin in biology and disease.

Miano JM

Journal of biomedical research.. 2015 January 29 (1):3-19. Epub 12/25/2014.

Smooth Muscle Cell Genome Browser: Enabling the Identification of Novel Serum Response Factor Target Genes.

Lee MY, Park C, Berent RM, Park PJ, Fuchs R, Syn H, Chin A, Townsend J, Benson CC, Redelman D, Shen TW, Park JK, Miano JM, Sanders KM, Ro S

PloS one.. 2015 10 (8):e0133751. Epub 08/04/2015.

Myocardin Family Members Drive Formation of Caveolae.

Krawczyk KK, Yao Mattisson I, Ekman M, Oskolkov N, Grantinge R, Kotowska D, Olde B, Hansson O, Albinsson S, Miano JM, Rippe C, Swärd K

PloS one.. 2015 10 (8):e0133931. Epub 08/05/2015.

Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.

Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2014 June 34 (6):1249-59. Epub 02/27/2014.

Don't judge books by their covers: vascular smooth muscle cells in arterial pathologies.

Fisher EA, Miano JM

Circulation.. 2014 April 15129 (15):1545-7. Epub 1900 01 01.

Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism.

Shi F, Long X, Hendershot A, Miano JM, Sottile J

PloS one.. 2014 9 (4):e94988. Epub 04/21/2014.

Myocardin: new therapeutic agent in vascular disease?

Long X, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2013 October 33 (10):2284-5. Epub 1900 01 01.

Myocardin and microRNA-1 modulate bladder activity through connexin 43 expression during post-natal development.

Imamura M, Sugino Y, Long X, Slivano OJ, Nishikawa N, Yoshimura N, Miano JM

Journal of cellular physiology.. 2013 September 228 (9):1819-26. Epub 1900 01 01.

Platelet factor 4 mediates vascular smooth muscle cell injury responses.

Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN

Blood.. 2013 May 23121 (21):4417-27. Epub 04/08/2013.

Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program.

Long X, Cowan SL, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2013 February 33 (2):378-86. Epub 11/21/2012.

Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.

Kitchen CM, Cowan SL, Long X, Miano JM

Gene.. 2013 January 15513 (1):82-9. Epub 11/08/2012.

Smooth muscle cell plasticity: fact or fiction?

Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK

Circulation research.. 2013 January 4112 (1):17-22. Epub 10/23/2012.

Testosterone and 17?-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.

Nicholson TM, Ricke EA, Marker PC, Miano JM, Mayer RD, Timms BG, Vom Saal FS, Wood RW, Ricke WA

Endocrinology.. 2012 November 153 (11):5556-65. Epub 09/04/2012.

Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research.

Davis J, Maillet M, Miano JM, Molkentin JD

Circulation research.. 2012 August 31111 (6):761-77. Epub 1900 01 01.

Serum response factor regulates bone formation via IGF-1 and Runx2 signals.

Chen J, Yuan K, Mao X, Miano JM, Wu H, Chen Y

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 August 27 (8):1659-68. Epub 1900 01 01.

Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.

Nanda V, Miano JM

The Journal of biological chemistry.. 2012 January 20287 (4):2459-67. Epub 12/07/2011.

Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.

Long X, Slivano OJ, Cowan SL, Georger MA, Lee TH, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2011 October 31 (10):2172-80. Epub 08/04/2011.

MicroRNA133a: a new variable in vascular smooth muscle cell phenotypic switching.

Miano JM, Small EM

Circulation research.. 2011 September 30109 (8):825-7. Epub 1900 01 01.

Identifying functional single nucleotide polymorphisms in the human CArGome.

Benson CC, Zhou Q, Long X, Miano JM

Physiological genomics.. 2011 September 2243 (18):1038-48. Epub 07/19/2011.

Serum response factor-dependent MicroRNAs regulate gastrointestinal smooth muscle cell phenotypes.

Park C, Hennig GW, Sanders KM, Cho JH, Hatton WJ, Redelman D, Park JK, Ward SM, Miano JM, Yan W, Ro S

Gastroenterology.. 2011 July 141 (1):164-75. Epub 04/05/2011.

Smad3-mediated myocardin silencing: a novel mechanism governing the initiation of smooth muscle differentiation.

Xie WB, Li Z, Miano JM, Long X, Chen SY

The Journal of biological chemistry.. 2011 April 29286 (17):15050-7. Epub 03/14/2011.

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC

PloS one.. 2011 April 226 (4):e18869. Epub 04/22/2011.

Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells.

Streb JW, Long X, Lee TH, Sun Q, Kitchen CM, Georger MA, Slivano OJ, Blaner WS, Carr DW, Gelman IH, Miano JM

PloS one.. 2011 April 56 (4):e18538. Epub 04/05/2011.

Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages.

Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK

Molecular and cellular biology.. 2011 February 31 (4):861-75. Epub 12/06/2010.

Expression and functional activity of four myocardin isoforms.

Imamura M, Long X, Nanda V, Miano JM

Gene.. 2010 September 15464 (1-2):1-10. Epub 04/09/2010.

Role of serum response factor in the pathogenesis of disease.

Miano JM

Laboratory investigation; a journal of technical methods and pathology.. 2010 September 90 (9):1274-84. Epub 05/24/2010.

Dicing up microRNA gene expression profiles in normal and neoplastic smooth muscle cells.

Miano JM

The American journal of pathology.. 2010 August 177 (2):541-3. Epub 06/21/2010.

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function.

Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC

Arteriosclerosis, thrombosis, and vascular biology.. 2010 June 30 (6):1118-26. Epub 04/08/2010.

Vascular smooth muscle cell differentiation-2010.

Miano JM

Journal of biomedical research.. 2010 May 24 (3):169-80. Epub 1900 01 01.

What is truth? Standards of scientific integrity in American Heart Association journals.

Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2010 January 30 (1):1-4. Epub 1900 01 01.

The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.

Long X, Tharp DL, Georger MA, Slivano OJ, Lee MY, Wamhoff BR, Bowles DK, Miano JM

The Journal of biological chemistry.. 2009 November 27284 (48):33671-82. Epub 10/01/2009.

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.

Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM

The Journal of biological chemistry.. 2009 November 20284 (47):32582-90. Epub 09/21/2009.

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D

Nature.. 2009 August 6460 (7256):705-10. Epub 07/05/2009.

Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells.

Lee TH, Chen J, Miano JM

Circulation research.. 2009 July 31105 (3):271-8. Epub 07/02/2009.

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.

Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV

Nature cell biology.. 2009 February 11 (2):143-53. Epub 12/21/2008.

Myocardin is sufficient for a smooth muscle-like contractile phenotype.

Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM

Arteriosclerosis, thrombosis, and vascular biology.. 2008 August 28 (8):1505-10. Epub 05/01/2008.

Deck of CArGs.

Miano JM

Circulation research.. 2008 July 3103 (1):13-5. Epub 1900 01 01.

SRF'ing the actin cytoskeleton with no destrin.

Miano JM

Physiological genomics.. 2008 June 1234 (1):6-8. Epub 05/13/2008.

Expression and comparative genomics of two serum response factor genes in zebrafish.

Davis JL, Long X, Georger MA, Scott IC, Rich A, Miano JM

The International journal of developmental biology.. 2008 52 (4):389-96. Epub 1900 01 01.

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation.

Long X, Creemers EE, Wang DZ, Olson EN, Miano JM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 October 16104 (42):16570-5. Epub 10/10/2007.

Remote control of gene expression.

Long X, Miano JM

The Journal of biological chemistry.. 2007 June 1282 (22):15941-5. Epub 04/02/2007.

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.

Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV

Proceedings of the National Academy of Sciences of the United States of America.. 2007 January 16104 (3):823-8. Epub 01/10/2007.

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus.

Miano JM, Long X, Fujiwara K

American journal of physiology. Cell physiology.. 2007 January 292 (1):C70-81. Epub 08/23/2006.

HDAC7 supports vascular integrity.

Miano JM, Berk BC

Nature medicine.. 2006 September 12 (9):997-8. Epub 1900 01 01.

Tissue expression of the novel serine carboxypeptidase Scpep1.

Lee TH, Streb JW, Georger MA, Miano JM

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.. 2006 June 54 (6):701-11. Epub 02/06/2006.

Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins.

Rensen SS, Niessen PM, Long X, Doevendans PA, Miano JM, van Eys GJ

Cardiovascular research.. 2006 April 170 (1):136-45. Epub 01/31/2006.

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.

Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C

Circulation research.. 2006 March 3198 (6):777-84. Epub 03/02/2006.

Fishing for function in zebrafish.

Miano JM

Circulation research.. 2006 March 3198 (6):723-6. Epub 1900 01 01.

Defining the mammalian CArGome.

Sun Q, Chen G, Streb JW, Long X, Yang Y, Stoeckert CJ, Miano JM

Genome research.. 2006 February 16 (2):197-207. Epub 12/19/2005.

Ultrastructure of zebrafish dorsal aortic cells.

Miano JM, Georger MA, Rich A, De Mesy Bentley KL

Zebrafish.. 2006 3 (4):455-63. Epub 1900 01 01.

Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo.

Qiu P, Ritchie RP, Fu Z, Cao D, Cumming J, Miano JM, Wang DZ, Li HJ, Li L

Circulation research.. 2005 November 1197 (10):983-91. Epub 10/13/2005.

Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expression.

Blaxall BC, Miano JM, Berk BC

Circulation research.. 2005 April 196 (6):610-1. Epub 1900 01 01.

AKAP12alpha, an atypical serum response factor-dependent target gene.

Streb JW, Miano JM

The Journal of biological chemistry.. 2005 February 11280 (6):4125-34. Epub 12/07/2004.

Neurovascular pathways and Alzheimer amyloid beta-peptide.

Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM

Brain pathology.. 2005 January 15 (1):78-83. Epub 1900 01 01.

Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles.

Streb JW, Kitchen CM, Gelman IH, Miano JM

The Journal of biological chemistry.. 2004 December 31279 (53):56014-23. Epub 10/20/2004.

Restricted inactivation of serum response factor to the cardiovascular system.

Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP

Proceedings of the National Academy of Sciences of the United States of America.. 2004 December 7101 (49):17132-7. Epub 11/29/2004.

Channeling to myocardin.

Miano JM

Circulation research.. 2004 August 2095 (4):340-2. Epub 1900 01 01.

Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP.

Hogarth DK, Sandbo N, Taurin S, Kolenko V, Miano JM, Dulin NO

American journal of physiology. Cell physiology.. 2004 August 287 (2):C449-56. Epub 04/14/2004.

Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner.

Zhang R, Al-Lamki R, Bai L, Streb JW, Miano JM, Bradley J, Min W

Circulation research.. 2004 June 1194 (11):1483-91. Epub 04/29/2004.

Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels.

Jiang M, Mezentsev A, Kemp R, Byun K, Falck JR, Miano JM, Nasjletti A, Abraham NG, Laniado-Schwartzman M

Circulation research.. 2004 February 694 (2):167-74. Epub 12/11/2003.

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.

Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C

Circulation research.. 2003 September 593 (5):406-13. Epub 08/14/2003.

Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.

Chen J, Chada S, Mhashilkar A, Miano JM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 August 8 (2):220-9. Epub 1900 01 01.

Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.

Davis A, Hogarth K, Fernandes D, Solway J, Niu J, Kolenko V, Browning D, Miano JM, Orlov SN, Dulin NO

Cellular signalling.. 2003 June 15 (6):597-604. Epub 1900 01 01.

Serum response factor: toggling between disparate programs of gene expression.

Miano JM

Journal of molecular and cellular cardiology.. 2003 June 35 (6):577-93. Epub 1900 01 01.

Retinoids: pleiotropic agents of therapy for vascular diseases?

Streb JW, Miano JM

Current drug targets. Cardiovascular & haematological disorders. 2003 March 3 (1):31-57. Epub 1900 01 01.

Cardiac-specific gene expression: a HANDful of factors.

Miano JM

Journal of molecular and cellular cardiology.. 2002 October 34 (10):1287-91. Epub 1900 01 01.

Myocardin: a component of a molecular switch for smooth muscle differentiation.

Chen J, Kitchen CM, Streb JW, Miano JM

Journal of molecular and cellular cardiology.. 2002 October 34 (10):1345-56. Epub 1900 01 01.

Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosome.

Miano JM, Kitchen CM, Chen J, Maltby KM, Kelly LA, Weiler H, Krahe R, Ashworth LK, Garcia E

American journal of physiology. Heart and circulatory physiology.. 2002 May 282 (5):H1793-803. Epub 1900 01 01.

Mammalian smooth muscle differentiation: origins, markers and transcriptional control.

Miano JM

Results and problems in cell differentiation.. 2002 38 :39-59. Epub 1900 01 01.

Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouch.

Frame MD, Miano JM, Yang J, Rivers RJ

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2001 December 8 (6):403-13. Epub 1900 01 01.

Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells.

Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM

The Journal of biological chemistry.. 2001 September 7276 (36):34175-81. Epub 07/10/2001.

G-protein-coupled-receptor activation of the smooth muscle calponin gene.

Dulin NO, Orlov SN, Kitchen CM, Voyno-Yasenetskaya TA, Miano JM

The Biochemical journal.. 2001 July 15357 (Pt 2):587-92. Epub 1900 01 01.

Retinoids: new insight into smooth muscle cell growth inhibition.

Miano JM, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2001 May 21 (5):724-6. Epub 1900 01 01.

Expression and chromosomal mapping of the mouse smooth muscle calponin gene.

Miano JM, Thomas S, Disteche CM

Mammalian genome : official journal of the International Mammalian Genome Society.. 2001 March 12 (3):187-91. Epub 1900 01 01.

A novel retinoid-response gene set in vascular smooth muscle cells.

Chen J, Maltby KM, Miano JM

Biochemical and biophysical research communications.. 2001 February 23281 (2):475-82. Epub 1900 01 01.

Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells.

Ou H, Haendeler J, Aebly MR, Kelly LA, Cholewa BC, Koike G, Kwitek-Black A, Jacob HJ, Berk BC, Miano JM

Circulation research.. 2000 November 1087 (10):881-7. Epub 1900 01 01.

Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.

Camoretti-Mercado B, Liu HW, Halayko AJ, Forsythe SM, Kyle JW, Li B, Fu Y, McConville J, Kogut P, Vieira JE, Patel NM, Hershenson MB, Fuchs E, Sinha S, Miano JM, Parmacek MS, Burkhardt JK, Solway J

The Journal of biological chemistry.. 2000 September 29275 (39):30387-93. Epub 1900 01 01.

Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype.

Miano JM, Berk BC

Circulation research.. 2000 September 187 (5):355-62. Epub 1900 01 01.

Serum response factor-dependent regulation of the smooth muscle calponin gene.

Miano JM, Carlson MJ, Spencer JA, Misra RP

The Journal of biological chemistry.. 2000 March 31275 (13):9814-22. Epub 1900 01 01.

Gene structure and chromosomal mapping of the rat smooth muscle calponin gene.

Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM

Mammalian genome : official journal of the International Mammalian Genome Society.. 2000 February 11 (2):115-9. Epub 1900 01 01.

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.

Molkentin JD, Antos C, Mercer B, Taigen T, Miano JM, Olson EN

Developmental biology.. 2000 January 15217 (2):301-9. Epub 1900 01 01.

NAB2: a transcriptional brake for activated gene expression in the vessel wall?

Miano JM, Berk BC

The American journal of pathology.. 1999 October 155 (4):1009-12. Epub 1900 01 01.

EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature.

Kowal RC, Richardson JA, Miano JM, Olson EN

Circulation research.. 1999 May 2884 (10):1166-76. Epub 1900 01 01.

Radiation Hybrid (RH) Mapping of Human Smooth Muscle-Restricted Genes.

Miano JM, Garcia E, Krahe R

Methods in molecular medicine.. 1999 30 :25-35. Epub 1900 01 01.

all-Trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury.

Miano JM, Kelly LA, Artacho CA, Nuckolls TA, Piantedosi R, Blaner WS

Circulation.. 1998 September 2298 (12):1219-27. Epub 1900 01 01.

Evolutionarily conserved promoter region containing CArG*-like elements is crucial for smooth muscle myosin heavy chain gene expression.

Zilberman A, Dave V, Miano J, Olson EN, Periasamy M

Circulation research.. 1998 March 2382 (5):566-75. Epub 1900 01 01.

A comparative molecular analysis of four rat smooth muscle cell lines.

Firulli AB, Han D, Kelly-Roloff L, Koteliansky VE, Schwartz SM, Olson EN, Miano JM

In vitro cellular & developmental biology. Animal.. 1998 March 34 (3):217-26. Epub 1900 01 01.

Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy.

Koike G, Miano JM, Vanvooren P, Shiozawa M, Szpirer C, Jacob HJ

Mammalian genome : official journal of the International Mammalian Genome Society.. 1998 January 9 (1):76-7. Epub 1900 01 01.

The A10 cell line: a model for neonatal, neointimal, or differentiated vascular smooth muscle cells?

Rao RS, Miano JM, Olson EN, Seidel CL

Cardiovascular research.. 1997 October 36 (1):118-26. Epub 1900 01 01.

Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene.

Miano JM, Krahe R, Garcia E, Elliott JM, Olson EN

Gene.. 1997 September 15197 (1-2):215-24. Epub 1900 01 01.

Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells.

Miano JM, Topouzis S, Majesky MW, Olson EN

Circulation.. 1996 May 1593 (10):1886-95. Epub 1900 01 01.

Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis.

Miano JM, Olson EN

The Journal of biological chemistry.. 1996 March 22271 (12):7095-103. Epub 1900 01 01.

SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis.

Li L, Miano JM, Cserjesi P, Olson EN

Circulation research.. 1996 February 78 (2):188-95. Epub 1900 01 01.

Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype.

Firulli AB, Miano JM, Bi W, Johnson AD, Casscells W, Olson EN, Schwarz JJ

Circulation research.. 1996 February 78 (2):196-204. Epub 1900 01 01.

Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells.

Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM

Proceedings of the National Academy of Sciences of the United States of America.. 1996 January 2393 (2):900-5. Epub 1900 01 01.

Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

Miano JM, Cserjesi P, Ligon KL, Periasamy M, Olson EN

Circulation research.. 1994 November 75 (5):803-12. Epub 1900 01 01.

Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

Pritchard KA, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB

The Journal of biological chemistry.. 1994 March 18269 (11):8504-9. Epub 1900 01 01.

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

Martin JF, Miano JM, Hustad CM, Copeland NG, Jenkins NA, Olson EN

Molecular and cellular biology.. 1994 March 14 (3):1647-56. Epub 1900 01 01.

Localization of Fos and Jun proteins in rat aortic smooth muscle cells after vascular injury.

Miano JM, Vlasic N, Tota RR, Stemerman MB

The American journal of pathology.. 1993 March 142 (3):715-24. Epub 1900 01 01.

Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth.

Miano JM, Vlasic N, Tota RR, Stemerman MB

Arteriosclerosis and thrombosis : a journal of vascular biology. 1993 February 13 (2):211-9. Epub 1900 01 01.

Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal.

Miano JM, Tota RR, Vlasic N, Danishefsky KJ, Stemerman MB

The American journal of pathology.. 1990 October 137 (4):761-5. Epub 1900 01 01.

Books

Vascular smooth muscle cell phenotypic adaptation (2012)

Chapter: Muscle: Fundamental Biology and Mechanisms of Disease

Authors: Miano JM

Publisher: Academic Press 2012

Antiangiogenic Agents in Cancer (1999)

Chapter: Retinoids and interferons as antiangiogenic cancer drugs

Authors: Clifford, J.L., Miano, J.M., and Lippman, S.M

Publisher: Humana Press 1999

Molecular Biology of Vascular Disease. (1999)

Chapter: Radiation hybrid (RH) mapping of human smooth muscle-restricted genes.

Authors: Miano, J.M.*, Garcia, E. and Krahe, R.

Publisher: Humana Press 1999

Advances in Prostaglandin, Thromboxane and Leukotriene Research (1989)

Chapter: Low density lipoprotein-mediated endothelial cell perturbation: Effects on endothelial cell eicosanoid metabolism.

Authors: Miano, J.M., Holland, J.A., Pritchard, K.A., Jr., Rogers, N.J. and Stemerman, M.B.

Publisher: Raven Press, New York 1989