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Dirk P. Bohmann, Ph.D.

Dirk P. Bohmann, Ph.D.

Contact

About Me

Faculty Appointments

Professor (Part-Time) - Department of Biomedical Genetics (SMD)

Credentials

Residency & Fellowship

Postdoctoral Fellow in laboratory of Professor Robert Tjian at the University of California, Berkeley, CA 1986 - 1989

Education

Habilitation | University of Heidelberg. Molecular Biology. 1997

PhD | University of Tübingen. Biology. 1986

Awards

German Research Foundation Post-doctoral Fellowship Award. 1986 - 1988

German Cancer Center Predoctoral Fellowship Award. 1983 - 1986

Publications

Journal Articles

Walter Keller (1938-2023): a tribute from his mentees.

Bohmann D, O'Connell M, Frendewey D, Gerber A, Hernandez N, Krämer A, Minvielle-Sebastia L, Shaw P, Wahle E, Zavolan M

RNA.. 2023 September 29 (9):v-xiii. Epub 06/27/2023.

Preserving transcriptional stress responses as an anti-aging strategy.

Cheng Y, Pitoniak A, Wang J, Bohmann D

Aging cell.. 2021 January 20 :e13297. Epub 01/20/2021.

Counting the Minutes.

Mello S, Bohmann D

eLife.. 2020 January 79 Epub 01/07/2020.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V

Cell.. 2019 April 18177 (3):622-638.e22. Epub 1900 01 01.

BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.

Chatterjee N, Bohmann D

BioEssays : news and reviews in molecular, cellular and developmental biology.. 2018 May 40 (5):e1800007. Epub 03/30/2018.

Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.

Li X, Eberhardt A, Hansen JN, Bohmann D, Li H, Schor NF

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2017 June 31 (6):2327-2339. Epub 02/17/2017.

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D

PLoS genetics.. 2016 May 12 (5):e1006072. Epub 05/27/2016.

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.

Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D

Scientific reports.. 2016 February 256 :21455. Epub 02/25/2016.

Mechanisms and functions of Nrf2 signaling in Drosophila.

Pitoniak A, Bohmann D

Free radical biology & medicine.. 2015 November 88 (Pt B):302-313. Epub 06/25/2015.

Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann.

Bohmann D, Dhillon P

Disease models & mechanisms.. 2014 May 7 (5):499-502. Epub 1900 01 01.

Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.

Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP

Aging cell.. 2013 October 12 (5):802-13. Epub 06/28/2013.

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D

Aging cell.. 2013 August 12 (4):554-62. Epub 05/16/2013.

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Tsakiri EN, Sykiotis GP, Papassideri IS, Gorgoulis VG, Bohmann D, Trougakos IP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2013 June 27 (6):2407-20. Epub 03/01/2013.

Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.

Barone MC, Bohmann D

Journal of visualized experiments : JoVE.. 2013 April 24 (74):e50339. Epub 04/24/2013.

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

Barone MC, Sykiotis GP, Bohmann D

Disease models & mechanisms.. 2011 September 4 (5):701-7. Epub 06/30/2011.

c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.

Schreck I, Al-Rawi M, Mingot JM, Scholl C, Diefenbacher ME, O'Donnell P, Bohmann D, Weiss C

Biochemical and biophysical research communications.. 2011 April 22407 (4):735-40. Epub 03/31/2011.

Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.

Hochmuth CE, Biteau B, Bohmann D, Jasper H

Cell stem cell.. 2011 February 48 (2):188-99. Epub 1900 01 01.

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.

Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D

Current opinion in clinical nutrition and metabolic care.. 2011 January 14 (1):41-8. Epub 1900 01 01.

Computational systems biology of aging.

Kriete A, Lechner M, Clearfield D, Bohmann D

Wiley interdisciplinary reviews. Systems biology and medicine.. 2011 3 (4):414-28. Epub 12/31/2010.

Stress-activated cap'n'collar transcription factors in aging and human disease.

Sykiotis GP, Bohmann D

Science signaling.. 2010 March 93 (112):re3. Epub 03/09/2010.

Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.

Wang Q, Uhlirova M, Bohmann D

Developmental cell.. 2010 January 1918 (1):157-64. Epub 1900 01 01.

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.

Sekyrova P, Bohmann D, Jindra M, Uhlirova M

Development.. 2010 January 137 (1):141-50. Epub 1900 01 01.

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy.

Wu H, Wang MC, Bohmann D

Mechanisms of development.. 2009 126 (8-9):624-37. Epub 06/18/2009.

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila.

Sykiotis GP, Bohmann D

Developmental cell.. 2008 January 14 (1):76-85. Epub 1900 01 01.

Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.

Luo X, Puig O, Hyun J, Bohmann D, Jasper H

The EMBO journal.. 2007 January 2426 (2):380-90. Epub 12/21/2006.

Stress-Activated Protein Kinase Signaling in Drosophila

Sykiotis, G.P.; Bohmann, D.

Topics in Current Genetics. 2007; .

JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.

Uhlirova M, Bohmann D

The EMBO journal.. 2006 November 1525 (22):5294-304. Epub 11/02/2006.

Control of G2/M transition by Drosophila Fos.

Hyun J, Bécam I, Yanicostas C, Bohmann D

Molecular and cellular biology.. 2006 November 26 (22):8293-302. Epub 09/11/2006.

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.

Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D

Developmental dynamics : an official publication of the American Association of Anatomists.. 2006 February 235 (2):427-34. Epub 1900 01 01.

Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.

Miotto B, Sagnier T, Berenger H, Bohmann D, Pradel J, Graba Y

Genes & development.. 2006 January 120 (1):101-12. Epub 1900 01 01.

Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.

Uhlirova M, Jasper H, Bohmann D

Proceedings of the National Academy of Sciences of the United States of America.. 2005 September 13102 (37):13123-8. Epub 09/06/2005.

DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.

Hyun J, Jasper H, Bohmann D

Molecular and cellular biology.. 2005 July 25 (13):5590-8. Epub 1900 01 01.

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons.

Etter PD, Narayanan R, Navratilova Z, Patel C, Bohmann D, Jasper H, Ramaswami M

BMC neuroscience.. 2005 June 26 :39. Epub 06/02/2005.

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.

Wang MC, Bohmann D, Jasper H

Cell.. 2005 April 8121 (1):115-25. Epub 1900 01 01.

Small flies--big discoveries: nearly a century of Drosophila genetics and development.

Letsou A, Bohmann D

Developmental dynamics : an official publication of the American Association of Anatomists.. 2005 March 232 (3):526-8. Epub 1900 01 01.

Toward the computable transcriptome.

Portman DS, Bohmann D

Molecular cell.. 2004 June 1814 (6):693-4. Epub 1900 01 01.

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.

Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J

The EMBO journal.. 2004 March 1023 (5):1133-43. Epub 02/19/2004.

Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis.

Weiss C, Bohmann D

Cell cycle.. 2004 February 3 (2):111-3. Epub 1900 01 01.

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.

Wang MC, Bohmann D, Jasper H

Developmental cell.. 2003 November 5 (5):811-6. Epub 1900 01 01.

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.

Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D

The EMBO journal.. 2003 July 1522 (14):3686-95. Epub 1900 01 01.

Drosophila innate immunity: a genomic view of pathogen defense.

Jasper H, Bohmann D

Molecular cell.. 2002 November 10 (5):967-9. Epub 1900 01 01.

A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.

Jasper H, Benes V, Atzberger A, Sauer S, Ansorge W, Bohmann D

Developmental cell.. 2002 October 3 (4):511-21. Epub 1900 01 01.

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation.

Gallo A, Cuozzo C, Esposito I, Maggiolini M, Bonofiglio D, Vivacqua A, Garramone M, Weiss C, Bohmann D, Musti AM

Oncogene.. 2002 September 1921 (42):6434-45. Epub 1900 01 01.

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, Rodrigues JP, Tavanez JP, Carmo-Fonseca M

Molecular biology of the cell.. 2002 August 13 (8):2771-82. Epub 1900 01 01.

An essential function of AP-1 heterodimers in Drosophila development.

Ciapponi L, Bohmann D

Mechanisms of development.. 2002 July 115 (1-2):35-40. Epub 1900 01 01.

Transrepression of AP-1 by nuclear receptors in Drosophila.

Gritzan U, Weiss C, Brennecke J, Bohmann D

Mechanisms of development.. 2002 July 115 (1-2):91-100. Epub 1900 01 01.

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.

Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D

The EMBO journal.. 2002 February 121 (3):451-60. Epub 1900 01 01.

The genomic response of the Drosophila embryo to JNK signaling.

Jasper H, Benes V, Schwager C, Sauer S, Clauder-Münster S, Ansorge W, Bohmann D

Developmental cell.. 2001 October 1 (4):579-86. Epub 1900 01 01.

Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells.

Leppä S, Eriksson M, Saffrich R, Ansorge W, Bohmann D

Molecular and cellular biology.. 2001 July 21 (13):4369-78. Epub 1900 01 01.

Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites.

Ciapponi L, Jackson DB, Mlodzik M, Bohmann D

Genes & development.. 2001 June 1515 (12):1540-53. Epub 1900 01 01.

Drosophila AP-1: lessons from an invertebrate.

Kockel L, Homsy JG, Bohmann D

Oncogene.. 2001 April 3020 (19):2347-64. Epub 1900 01 01.

The role of the Drosophila TAK homologue dTAK during development.

Mihaly J, Kockel L, Gaengel K, Weber U, Bohmann D, Mlodzik M

Mechanisms of development.. 2001 April 102 (1-2):67-79. Epub 1900 01 01.

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G

The EMBO journal.. 2000 January 1719 (2):273-81. Epub 1900 01 01.

Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.

Valcárcel R, Weber U, Jackson DB, Benes V, Ansorge W, Bohmann D, Mlodzik M

Journal of cell science.. 1999 December 112 ( Pt 23) :4389-96. Epub 1900 01 01.

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis.

Leppä S, Bohmann D

Oncogene.. 1999 November 118 (45):6158-62. Epub 1900 01 01.

Thorax closure in Drosophila: involvement of Fos and the JNK pathway.

Zeitlinger J, Bohmann D

Development.. 1999 September 126 (17):3947-56. Epub 1900 01 01.

Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

Leppä S, Saffrich R, Ansorge W, Bohmann D

The EMBO journal.. 1998 August 317 (15):4404-13. Epub 1900 01 01.

Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants.

Zeitlinger J, Kockel L, Peverali FA, Jackson DB, Mlodzik M, Bohmann D

The EMBO journal.. 1997 December 1516 (24):7393-401. Epub 1900 01 01.

The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development.

Isaksson A, Peverali FA, Kockel L, Mlodzik M, Bohmann D

Mechanisms of development.. 1997 November 68 (1-2):59-67. Epub 1900 01 01.

Connecting up the pathways in Drosophila development.

Riesgo-Escovar JR, Hafen E, Hou XS, Goldstein ES, Perrimon N, Glise B, Noselli S, Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D

Trends in cell biology.. 1997 November 7 (11):421-2. Epub 1900 01 01.

Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways.

Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D

Genes & development.. 1997 July 111 (13):1748-58. Epub 1900 01 01.

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

Kockel L, Vorbrüggen G, Jäckle H, Mlodzik M, Bohmann D

Genes & development.. 1997 May 111 (9):1140-7. Epub 1900 01 01.

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction.

Eresh S, Riese J, Jackson DB, Bohmann D, Bienz M

The EMBO journal.. 1997 April 1516 (8):2014-22. Epub 1900 01 01.

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases.

Musti AM, Treier M, Bohmann D

Science.. 1997 January 17275 (5298):400-2. Epub 1900 01 01.

Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation.

Musti AM, Treier M, Peverali FA, Bohmann D

Biological chemistry.. 1996 October 377 (10):619-24. Epub 1900 01 01.

Ubiquitin in signal transduction and cell transformation.

Isaksson A, Musti AM, Bohmann D

Biochimica et biophysica acta.. 1996 August 81288 (1):F21-9. Epub 1900 01 01.

Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation.

Peverali FA, Isaksson A, Papavassiliou AG, Plastina P, Staszewski LM, Mlodzik M, Bohmann D

The EMBO journal.. 1996 August 115 (15):3943-50. Epub 1900 01 01.

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye.

Treier M, Bohmann D, Mlodzik M

Cell.. 1995 December 183 (5):753-60. Epub 1900 01 01.

Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.

Davydov IV, Bohmann D, Krammer PH, Li-Weber M

Gene.. 1995 August 19161 (2):271-5. Epub 1900 01 01.

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells.

Jenkins F, Cockerill PN, Bohmann D, Shannon MF

The Journal of immunology : official journal of the American Association of Immunologists.. 1995 August 1155 (3):1240-51. Epub 1900 01 01.

Intramolecular signal transduction in c-Jun.

Papavassiliou AG, Treier M, Bohmann D

The EMBO journal.. 1995 May 114 (9):2014-9. Epub 1900 01 01.

Drosophila Jun mediates Ras-dependent photoreceptor determination.

Bohmann D, Ellis MC, Staszewski LM, Mlodzik M

Cell.. 1994 September 2378 (6):973-86. Epub 1900 01 01.

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.

Treier M, Staszewski LM, Bohmann D

Cell.. 1994 September 978 (5):787-98. Epub 1900 01 01.

Repression of AP-1-stimulated transcription by c-Ets-1.

Goldberg Y, Treier M, Ghysdael J, Bohmann D

The Journal of biological chemistry.. 1994 June 17269 (24):16566-73. Epub 1900 01 01.

Structure and regulation of the growth arrest-specific (gas-1) promoter.

de Martin R, Cowled PA, Smith SE, Papavassiliou AG, Sorrentino V, Philipson L, Bohmann D

The Journal of biological chemistry.. 1993 October 25268 (30):22788-93. Epub 1900 01 01.

Different TRE-related elements are distinguished by sets of DNA-binding proteins with overlapping sequence specificity.

Smith SE, Papavassiliou AG, Bohmann D

Nucleic acids research.. 1993 April 1121 (7):1581-5. Epub 1900 01 01.

Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun.

Papavassiliou AG, Treier M, Chavrier C, Bohmann D

Science.. 1992 December 18258 (5090):1941-4. Epub 1900 01 01.

Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites.

Papavassiliou AG, Chavrier C, Bohmann D

Proceedings of the National Academy of Sciences of the United States of America.. 1992 December 189 (23):11562-5. Epub 1900 01 01.

Optimization of the signal-to-noise ratio in south-western assays by using lipid-free BSA as blocking reagent.

Papavassiliou AG, Bohmann D

Nucleic acids research.. 1992 August 2520 (16):4365-6. Epub 1900 01 01.

Functional dissection of AP-1 transcription factors using the Gal4 adaptor assay.

Smith SE, Bohmann D

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.. 1992 August 3 (8):523-9. Epub 1900 01 01.

Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors.

Papavassiliou AG, Bohmann K, Bohmann D

Analytical biochemistry.. 1992 June 203 (2):302-9. Epub 1900 01 01.

Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression.

Bohmann D

Cancer cells (Cold Spring Harbor, N.Y. : 1989). 1990 November 2 (11):337-44. Epub 1900 01 01.

Biochemical analysis of transcriptional activation by Jun: differential activity of c- and v-Jun.

Bohmann D, Tjian R

Cell.. 1989 November 1759 (4):709-17. Epub 1900 01 01.

Fos-associated protein p39 is the product of the jun proto-oncogene.

Rauscher FJ, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza BR

Science.. 1988 May 20240 (4855):1010-6. Epub 1900 01 01.

v-jun encodes a nuclear protein with enhancer binding properties of AP-1.

Bos TJ, Bohmann D, Tsuchie H, Tjian R, Vogt PK

Cell.. 1988 March 1152 (5):705-12. Epub 1900 01 01.

Transcriptional regulation by the AP-1 family of enhancer-binding proteins: a nuclear target for signal transduction.

Bohmann D, Admon A, Turner DR, Tjian R

Cold Spring Harbor symposia on quantitative biology.. 1988 53 Pt 2 :695-700. Epub 1900 01 01.

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R

Science.. 1987 December 4238 (4832):1386-92. Epub 1900 01 01.

Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription.

Tebb G, Bohmann D, Mattaj IW

Nucleic acids research.. 1987 August 2515 (16):6437-53. Epub 1900 01 01.

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes.

Bohmann D, Keller W, Dale T, Schöler HR, Tebb G, Mattaj IW

Nature.. 1987 325 (6101):268-72. Epub 1900 01 01.

Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements.

Schlokat U, Bohmann D, Schöler H, Gruss P

The EMBO journal.. 1986 December 15 (12):3251-8. Epub 1900 01 01.

The SV40 enhancer influences viral late transcription in vitro and in vivo but not on replicating templates.

Shaw PE, Bohmann D, Sergeant A

The EMBO journal.. 1985 December 14 (12):3247-52. Epub 1900 01 01.

A transcription enhancer acts in vitro over distances of hundreds of base-pairs on both circular and linear templates but not on chromatin-reconstituted DNA.

Sergeant A, Bohmann D, Zentgraf H, Weiher H, Keller W

Journal of molecular biology.. 1984 December 15180 (3):577-600. Epub 1900 01 01.