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Carol L. Miller-Graziano, Ph.D.

Carol L. Miller-Graziano, Ph.D.

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About Me

Dr. Miller-Graziano's laboratory has 3 NIH supported projects to assess different aspects of immunopathology in burn and trauma patients. A dysfunction in patient monocyte (MO) to dendritic (DC) cell differentiation has been identified along with a decrease in the immune stimulatory capacity of pati...
Dr. Miller-Graziano's laboratory has 3 NIH supported projects to assess different aspects of immunopathology in burn and trauma patients. A dysfunction in patient monocyte (MO) to dendritic (DC) cell differentiation has been identified along with a decrease in the immune stimulatory capacity of patients' MO. The current MO experiments focus on the tolerogenic capacity of patients' DC in mediating their immunodepression. Microarray analysis of DC derived from patients' dysfunctional, patients' immunostimulatory, controls' immunostimulatory and in vitro induced controls' tolerogenic populations is under way. Altered signaling proteins and receptor expression in these 2 patient and 2 control DC populations is being characterized by multicolor flow cytometry, Luminex, and RealTime PCR technology. These DC experiments particularly emphasize increases in co-inhibitory receptors like PD-L1+2, ILT3+4, and HEMV concomitant to decreases in costimulatory receptors like CD40, CD86, and CD80 as mechanisms behind dysfunctional MO/DC antigen presenting function in the immunodepressed patients. Autocrine inhibitory signaling by SIPR(alpha), CD47 and thrombospondin in patients' DC is also being assessed for their role in mediating MO driven decreased immune function post injury. The ability of patient DC to alter the responses of an HLA unrestricted, tetanus toxoid responsive, human T cell clone provides an additional assay for patient DC tolerogenic function.
A complimentary project investigates induction and maintenance of T cell adaptive tolerance as a contributor to post injury immunosuppression. An increased threshold of inhibitory signal transduction molecules and negative costimulation molecules appears to mediate some of the patients' T cell immunodepression. The induction of DC tolerogenic capacity by post injury apoptotic T cells and hyporesponsive T cells is also a focus of laboratory experiments. These 3 projects offer students an opportunity to apply fundamental immunologic principles and systems to the study of human immunopathology.

Faculty Appointments

Professor Emeritus - Department of Surgery, Research (SMD)

Credentials

Education

PhD | Univ of Utah Coll Medicine. Microbiology, All Other. 1972

MS | University of Utah. Zoology. 1969

BS | San Diego State Univ. Zoology. 1966

Awards

Star Award for Excellence in Graduate School Teaching
University of Massachusetts
2000 - 2000

Research

Dr. Miller-Graziano's laboratory has 3 NIH supported projects to assess different aspects of immunopathology in burn and trauma patients. A dysfunction in patient monocyte (MO) to dendritic (DC) cell differentiation has been identified along with a decrease in the immune stimulatory capacity of pati...
Dr. Miller-Graziano's laboratory has 3 NIH supported projects to assess different aspects of immunopathology in burn and trauma patients. A dysfunction in patient monocyte (MO) to dendritic (DC) cell differentiation has been identified along with a decrease in the immune stimulatory capacity of patients' MO. The current MO experiments focus on the tolerogenic capacity of patients' DC in mediating their immunodepression. Microarray analysis of DC derived from patients' dysfunctional, patients' immunostimulatory, controls' immunostimulatory and in vitro induced controls' tolerogenic populations is under way. Altered signaling proteins and receptor expression in these 2 patient and 2 control DC populations is being characterized by multicolor flow cytometry, Luminex, and RealTime PCR technology. These DC experiments particularly emphasize increases in co-inhibitory receptors like PD-L1+2, ILT3+4, and HEMV concomitant to decreases in costimulatory receptors like CD40, CD86, and CD80 as mechanisms behind dysfunctional MO/DC antigen presenting function in the immunodepressed patients. Autocrine inhibitory signaling by SIPR(alpha), CD47 and thrombospondin in patients' DC is also being assessed for their role in mediating MO driven decreased immune function post injury. The ability of patient DC to alter the responses of an HLA unrestricted, tetanus toxoid responsive, human T cell clone provides an additional assay for patient DC tolerogenic function.
A complimentary project investigates induction and maintenance of T cell adaptive tolerance as a contributor to post injury immunosuppression. An increased threshold of inhibitory signal transduction molecules and negative costimulation molecules appears to mediate some of the patients' T cell immunodepression. The induction of DC tolerogenic capacity by post injury apoptotic T cells and hyporesponsive T cells is also a focus of laboratory experiments. These 3 projects offer students an opportunity to apply fundamental immunologic principles and systems to the study of human immunopathology.

Publications

Journal Articles

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG

Proceedings of the National Academy of Sciences of the United States of America.. 2006 October 17103 (42):15564-9. Epub 10/10/2006.

Negative Signaling Contributes to T Cell Anergy in Trauma Patients

Bandyopadhyay, G.; De, A.; Laudanski, K.; Li F.; Lentz, C.; Bankey, P.; Miller-Graziano, C.

Crit. Care Med. 2006; .

Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome: a possible faulty IL-13 feedback loop.

Laudanski K, De A, Pellegrini J, Miller-Graziano C

Clinical immunology : the official journal of the Clinical Immunology Society.. 2006 118 (2-3):332-41. Epub 11/21/2005.

Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.

De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 November 1175 (9):6155-62. Epub 1900 01 01.

A network-based analysis of systemic inflammation in humans.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF,

Nature.. 2005 October 13437 (7061):1032-7. Epub 08/31/2005.

Application of genome-wide expression analysis to human health and disease.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V,

Proceedings of the National Academy of Sciences of the United States of America.. 2005 March 29102 (13):4801-6. Epub 03/21/2005.

Development of a simple method for rapid isolation of polymorphonuclear leukocytes from human blood.

De AK, Roach SE, De M, Minielly RC, Laudanski K, Miller-Graziano CL, Bankey PE

Journal of immunoassay & immunochemistry. 2005 26 (1):35-42. Epub 1900 01 01.

Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG,

Physiological genomics.. 2004 November 1719 (3):247-54. Epub 1900 01 01.

Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotype.

Laudanski K, De A, Brouxhon S, Kyrkanides S, Miller-Graziano C

Shock.. 2004 September 22 (3):204-12. Epub 1900 01 01.

Two Third-Year Medical Student-Level Laboratory Shock Exercises without Large Animals

Koniaris, L.G.; Kaufman, D.; Zimmers, T.A.; Wang, N.; Spitalnik, P.F.; Henson, L.; Miller-Graziano, C.; Sitzmann, J.V.

Surgical Infections. 2004; 5 (4): 34.

Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colony-stimulating factor-driven macrophage differentiation.

De AK, Laudanski K, Miller-Graziano CL

The Journal of immunology : official journal of the American Association of Immunologists.. 2003 June 15170 (12):6355-62. Epub 1900 01 01.

Down-regulated circulating PMN function after injury despite enhanced p38 MAPK activity.

Sheth K, Friel J, Nolan B, Miller-Graziano C, Bankey P

Surgical infections.. 2002 3 (2):151-7,discussion 157-8. Epub 1900 01 01.

Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus.

De AK, Kodys KM, Yeh BS, Miller-Graziano C

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 October 1165 (7):3951-8. Epub 1900 01 01.

Induction of Global Anergy Rather than Inhibitory Th2 Lymphokines Mediate Post-Trauma T Cell Immunodepression

De, A.; Kodys, K.; Pellegrini, J.; Yeh, B.; Furse, R.; Bankey, P.; Miller-Graziano, C.

Clin. Immun. 2000; 96(1): 52-66.

Relationships Between T Lymphocyte Apoptosis and Anergy Following Trauma

Pellegrini, J.D.; De, A.K.; Kodys, K.; Puyana, J.C.; Furse, R.K.; Miller-Graziano, C.

J. of Surgical Research. 1999; 88: 200-206.

Failure of GM-CSF/IL-4 Induced MØ to Become Dendritic Cells Reflects Altered Signal Transduction and Altered TNF(alpha) and CD64 Levels

Miller, C.; De, A.; Yeh, B.; Kodys, K.

J. Leuk. Biol. 1999; Suppl.: 18.

Maximal T cell IL-13 production requires monocyte or monokine participation.

De AK, Kodys K, Miller-Graziano C

Cytokine.. 1998 December 10 (12):911-9. Epub 1900 01 01.

Both T Helper-1 and T Helper-2 Type Lymphokines are Depressed in Post Trauma Anergy

Puyana, J.C.; Pellegrini, J.D.; De, A.K.; Kodys, K.; Silva, W.E.; Miller, C.L.

J. of Trauma. 1998; 44(6): 1037-1046.

Anergy of T Cells Induced by Trauma and Sepsis

De, A.K.; Kodys, K.; Furse, R.K.; Pellegrini, J.; Puyana, J.C.; Miller-Graziano, C.L.

Surgery & Critical Care. 1998; : 30-31.

Only a subset of trauma patients with depressed mitogen responses have true T cell dysfunctions.

De AK, Kodys K, Puyana JC, Fudem G, Pellegrini J, Miller-Graziano CL

Clinical immunology and immunopathology.. 1997 January 82 (1):73-82. Epub 1900 01 01.

Increased MØ TNF(alpha) Message Stability Contributes to Trauma Patients' Increased TNF Production

Furse, R.K.; Kodys, K.; Zhu, D.; Miller-Graziano, C.L.

J. Leuk. Biol. 1997; 62: 524-534.

A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality.

Pellegrini JD, Puyana JC, Lapchak PH, Kodys K, Miller-Graziano CL

Shock.. 1996 December 6 (6):389-96. Epub 1900 01 01.

A Trauma Induced T Cell Defect is Associated with Deregulated Monokine Production and is Truly Predictive of Poor Clinical Outcome

Pellegrini, J.; Puyana, J.C.; De, A.K.; Fudem, G.; Kodys, K.; and Lapchak, P.H.; Miller, C.

Surgical Forum. 1996; XLVII: 64-66.

Post-Trauma Depressed IFN(gamma) Production Result from Elevated MØ PGE2 Production and/or a True T Cell Dysfunction

Miller-Graziano, C.; De, A.K.; Kodys, K.

Clinical Immunol & Immunopath. 1995; 75(3): 292.

Altered IL-10 Levels in Trauma Patients' Monocytes (MØ) and T Lymphocytes

Miller-Graziano, C.; De, A.K.; Kodys, K.

J Clinical Immunology. 1995; 15(2): 93-104.

Continued tumor necrosis factor receptor expression by trauma patients' monocytes (Mphi) despite TNF alpha secretion.

Miller-Graziano CL, Kodys K, Gonzalez F, Fudem GM

Shock.. 1994 May 1 (5):317-24. Epub 1900 01 01.

Differential induction of human monocyte transforming growth factor beta 1 production and its regulation by interleukin 4.

Miller-Graziano CL, Zhu D, Kodys K

Journal of clinical immunology.. 1994 January 14 (1):61-72. Epub 1900 01 01.

Normal MØ Cell-Associated TNFa is Resistant to PGE2 as well as TGF-beta Downregulation

Miller-Graziano, C.L.; Kodys, K.; Jhaver, K.

Annals of the NY Academy of Sciences, Microbial Pathogenesis and Immune Response. 1994; 730: 307-309.

Dibutyryl-cAMP Modulation of Receptor Expression and Antigen Presentation Capacity in MØ Subpopulations

Szabo, G.; Kodys, K.; Miller-Graziano, C.L.

Intl J. Immunopharm., England. 1994; 16(2): 151-16.

Role of elevated monocyte transforming growth factor beta (TGF beta) production in posttrauma immunosuppression.

Miller-Graziano CL, Szabo G, Griffey K, Mehta B, Kodys K, Catalano D

Journal of clinical immunology.. 1991 March 11 (2):95-102. Epub 1900 01 01.

Downregulation of TNFR by Fc(gamma)RI Crosslinking and Relationship to Cell Associated Bioactivity

Miller-Graziano, C.; Pajor, L.; Kodys, K.

Journal of Leukocyte Biology. 1991; (2): 96-97.

Elevated MØ IL-6 Production in Immunosuppressed Trauma Patients. I. Role of Fc(gamma)RI Crosslinking Stimulation

Szabo, G.; Kodys, K.; Miller-Graziano, C.L.

J. Clinical Immunol. 1991; 11(6): 326-335.

Elevated MØ IL-6 Production in Immunosuppressed Trauma Patients. II. Downregulation by IL-4

Szabo, G.; Kodys, K.; Miller-Graziano, C.L.

J. Clinical Immunology. 1991; 11(6): 336-344.28.

Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome.

Miller-Graziano CL, Szabo G, Kodys K, Griffey K

The Journal of trauma.. 1990 December 30 (12 Suppl):S86-96. Epub 1900 01 01.

Induction and regulation of monocyte procoagulant activity.

Szabo G, Miller-Graziano CL

Transplantation.. 1990 August 50 (2):301-9. Epub 1900 01 01.

Differential tumor necrosis factor production by human monocyte subsets.

Szabo G, Miller-Graziano CL, Wu JY, Takayama T, Kodys K

Journal of leukocyte biology.. 1990 March 47 (3):206-16. Epub 1900 01 01.

Antigen presentation by the CD4 positive monocyte subset.

Szabo G, Miller CL, Kodys K

Journal of leukocyte biology.. 1990 February 47 (2):111-20. Epub 1900 01 01.

Elevated tumor necrosis factor alpha production concomitant to elevated prostaglandin E2 production by trauma patients' monocytes.

Takayama TK, Miller C, Szabo G

Archives of surgery.. 1990 January 125 (1):29-35. Epub 1900 01 01.

Evaluation of MØ Procoagulant Activity as a Parameter for Immunological Monitoring in Renal Transplantation

Zappala, S.; Khauli, R.; Miller-Graziano, C., et al.

Transplant. 1989; 21: 1844.

Mechanisms of Altered Monocyte Prostaglandin E2 Production in Severely Injured Patients

Miller-Graziano, C.; Fink, M.; Wu, J.; Szabo, G.; Kodys, K.

Arch. Surgery. 1988; 123: 293-299.

Mechanisms of Altered Monocyte Prostaglandin E2 Production in Severely Injured Patients

Miller-Graziano, C.; Fink, M.; Wu, J.; Szabo, G.; Kodys, K.

Arch. Surgery. 1988; 123: 293-299.

Post-Ischemia Immunosuppression in a Mini-Swine Model

Miller-Graziano, C.; Lim, R.

Journal of Lab Animal Science. 1986; 36: 375-380.

Dextran as Modulator of Immune Function in Trauma Patients

Miller-Graziano, C.; Lim, R.

Journal of Surgery Res. 1985; 39: 183-191.

Soluble Non-Cross Linked Peptidoglycan Polymers Stimulate Monocyte/Macrophage Inflammatory Function

Gold, M.; Miller-Graziano, C.; Mishell, R.

Infect. and Immun. 1985; 49: 731-741.

Soluble Non-Cross Linked Peptidoglycan Polymers Stimulate Monocyte/Macrophage Inflammatory Function

Gold, M.; Miller-Graziano, C.; Mishell, R.

Infect. And Immun. 1985; 49: 731-741.

Adrenalectomy in the guinea pig: operative and perioperative management.

Kudsk KA, Miller CL, Sheldon GF

Laboratory animal science.. 1983 April 33 (2):177-80. Epub 1900 01 01.

Human monocyte plasminogen activator production: correlation to altered M phi-T lymphocyte interaction.

Miller CL, Graziano CJ, Lim RC

The Journal of immunology : official journal of the American Association of Immunologists.. 1982 May 128 (5):2194-200. Epub 1900 01 01.

Production of Tissue Procoagulant Factor by Patient MØ. Correlation to Thromboembolic Complication

Miller-Graziano, C.; Graziano, C.; Lim, R.; Chin, M.

Thrombosis and Hemostasis. 1981; 46(2): 489.

The Immune Response of Burn Injury

Miller-Graziano, C.

Journal of Trauma. 1981; 21(8): 677.

Effect of Nutrition on Nonspecific Inflammatory and Specific Immune Host Defense Systems

Miller, C.

J Medicine. 1980; 11(4): 267.

The Role of Monocyte Function in Alteration of the Thrombo-fibrinolytic System After Shock

Graziano, C.; Miller, C.; Lim, R.

Surgical Forum. 1980; XXXI: 24.

Burns and the immune network.

Miller CL

The Journal of trauma.. 1979 November 19 (11 Suppl):880-3. Epub 1900 01 01.

Development of inhibitory macrophage (phi) after splenectomy.

Miller CL, Baker CC

Transplantation proceedings.. 1979 June 11 (2):1460. Epub 1900 01 01.

Identity of mononuclear cells which compromise the resistance of trauma patients.

Baker CC, Miller CL, Trunkey DD, Lim RC

The Journal of surgical research.. 1979 May 26 (5):478-87. Epub 1900 01 01.

Suppressor T Cells Induced by Thermal Injury

Miller, C.; Claudy, B.

Cellular Immunol. 1979; 44: 201.

Changes in Lymphocyte Activity After Thermal Injury: Role of Suppressor Cells

Miller, C.; Baker, C.

Journal of Clinical Investigations. 1979; 63: 202.

Immunological Assays as Measurements of Nutritional Status. A Review

Miller, C.

Journal of Parenteral and Enteral Nutrition. 1979; 2: 554.

Predicting Sepsis in Burn Patients

Baker, C.; Miller, C.; Trunkey, D.

Journal of Trauma. 1979; 19: 20.

Correlation of traumatic shock with immunocompetence and sepsis.

Baker CC, Miller CL, Trunkey DD

Surgical forum.. 1979 30 :20-1. Epub 1900 01 01.

Alterations in monocyte function following trauma.

Miller CL, Graziano C, Lim RC

Surgical forum.. 1979 30 :43-5. Epub 1900 01 01.

Effect of protein-sparing therapy on immunocompetence in normal and protein-depleted rats.

Miller C, Petersen S, Sheldon GF, Carpenter G, Fuchs R, Claudy B

Surgical forum.. 1978 29 :63-5. Epub 1900 01 01.

Thermal injury: defects in immune response induction.

Miller CL, Trunkey DD

The Journal of surgical research.. 1977 June 22 (6):621-5. Epub 1900 01 01.

Evaluation of total parenteral nutrition by in vitro measurement of immune capacity.

Miller C, Sheldon GF, Claudy B, Carpenter G

Surgical forum.. 1977 28 :81-2. Epub 1900 01 01.

Inhibition of Cell Mediated Cytotoxicity by an Adherent Accessory Cell

Miller, C.; Mishell, R.

Journal of Immunology. 1975; 114: 792.

The effect of neonatal thymectomy on antibody responses to histocompatibility antigens in the rat.

Miller CL, DeWitt CW

Cellular immunology.. 1974 August 13 (2):278-87. Epub 1900 01 01.

Cellular and Humoral Response to Major and Minor Histocompatibility Antigens

Miller, C.; DeWitt, C.

Transplantation Proceedings. 1974; 1: 303.

Rat alloantibody responses against strong and weak histocompatibility antigens.

Miller C, DeWitt C

The Journal of immunology : official journal of the American Association of Immunologists.. 1972 November 109 (5):919-26. Epub 1900 01 01.

Spatial relationships of rat histocompatibility antigens.

DeWitt CW, McDonald JH, Miller C

Transplantation proceedings.. 1971 March 3 (1):198-201. Epub 1900 01 01.

Exogenous heat shock protein (Hsp-27) uniquely blocks in vitro IL-4+GM-CSF stimulated MO differentiation to dendritic cells

Laudanski, K., De, A., Miller-Graziano, C.

European Journal of Immunology. .

Books

Molecular Chaperones and Cell Signalling (2005)

Chapter: HSP-27 As an Anti-Inflammatory Protein

Authors: Laudanski K, De A, Miller-Graziano C

Publisher: Cambridge Univ Press, New York, NY 2005

Update in Intensive Care and Emergency Medicine (2000)

Chapter: Trauma Mediators Favor Differentiation of Monocytes to Macrophage Rather Than to Dendritic Cells

Authors: Miller-Graziano, C.L.; De, A.K.; Kodys, K.

Publisher: Springer-Verlag, Berlin, Germany 2000

The Immune Consequences of Trauma, Shock & Sepsis - Mechanisms & Therapeutic App (1996)

Chapter: Relationship of Post-Trauma Altered IL-12 and IL-10 to Depressed Patient Mitogen Responses

Authors: De, A.K.; Kodys, K.; Fairfield, S.; Miller-Graziano, C.

Publisher: Springer-Verlag, Berlin, Germany 1996

Shock and Resuscitation (1993)

Chapter: Immunology of Shock and Injury

Authors: Miller-Graziano, C.L.

Publisher: McGraw-Hill, Inc., New York. 1993

Host Defense Dysfunction in Trauma, Shock and Sepsis (1993)

Chapter: Interactions of Immunopathological Mediators (TNF-alpha, TGF-beta, PGE2) in Traumatized Individuals

Authors: Miller-Graziano, C.L.; Szabo, G.; Kodys, K.; et al

Publisher: Springer-Verlag, Berlin, Germany 1993

Medicolegal Controversies of Trauma (1992)

Chapter: Trauma and the Immune System

Authors: Romain, P.L.; Miller-Graziano, C.L.; Zurier, R.B.

Publisher: Marcel Dekker, Inc., New York 1992

Alterations of Monocyte Function Following Major Injury (1989)

Chapter: The Immune Consequences of Trauma, Shock and Sepsis

Authors: Miller-Graziano, C.; Szabo, G.; Takayama, T.; Wu

Publisher: JSpringer-Verlag, Berlin, Germany 1989

Immunologic Consequences (1989)

Chapter: Splanchnic Ischemia and Multiple Organ Failure

Authors: Miller-Graziano, C.; et al

Publisher: Edward Arnold Co., Inc., Baltimore 1989

Infection in Massively Injured Patients. (1982)

Chapter: Massive Transfusion in Surgery and Trauma

Authors: Miller-Graziano, C.

Publisher: Alan R. Liss, Inc., New York 1982

Surgical Infections (1982)

Chapter: Immunobiology of Sepsis

Authors: Miller-Graziano, C.; Trunkey, D.

Publisher: Medical Examination Publishing Co., Inc., New York. 1982

Surgical Infections (1982)

Chapter: Post-Splenectomy Sepsis

Authors: Trunkey, D.; Miller-Graziano, C.

Publisher: Medical Examination Publishing Co.,, New York 1982

Emergency Surgery (1982)

Chapter: Multiple Organ Failure and Sepsis

Authors: Trunkey, D.; Miller-Graziano, C.

Publisher: Year Book Publishers, Chicago 1982

Surgical Clinics of North America: Trauma (1982)

Chapter: Immune Consequences of Trauma

Authors: Miller, S.; Miller-Graziano, C.; Trunkey, D.

Publisher: WB Saunders Co. 1982

Clinics in Immunology and Allergy (1981)

Chapter: Secondary Immunodeficiency in Burns and After Surgical Trauma

Authors: Miller-Graziano, C.

Publisher: WB Saunders Co., Ltd.,, Philadelphia 1981

Immune Consequences of Thermal Injury (1980)

Chapter: Alteration in Macrophage Function Following Thermal Injury

Authors: Miller, C.

Publisher: Williams and Wilkins, Maryland 1980

Lymphocytes and Their Interaction. (1974)

Chapter: Effects of Accessory Cells on the Generation of Immune Responses

Authors: Mishell, R.; Miller, C.

Publisher: Raven Press, New York 1974