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Jeffrey Michael Purkerson, Ph.D.

Jeffrey Michael Purkerson, Ph.D.

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About Me

Faculty Appointments

Research Associate Professor - Department of Pediatrics, Neonatology (SMD)

Credentials

Residency & Fellowship

Molecular Genetics and Microbiology Postdoctoral Fellowship, University of Massachusetts Medical Center, Worcester, MA 1994 - 1995

Immunoinflammatory Diseases Research Postdoctoral Fellowship, Searle Research and Development, Monsanto Company. 1991 - 1993

Education

PhD | University of Virginia. Pharmacology. 1991

BS | California Polytechnic State University. Biochemistry. 1986

Research

Dr. Purkerson's research interests are:
1) Cell biology and physiology of the carbonic anhydrases
2) The response of renal epithelial cells to acid-base disturbances or injury.

Publications

Journal Articles

Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct.

Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL

American journal of physiology. Renal physiology.. 2018 October 1315 (4):F812-F823. Epub 05/03/2017.

Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine.

Peng H, Purkerson JM, Schwaderer AL, Schwartz GJ

American journal of physiology. Renal physiology.. 2017 November 1313 (5):F1061-F1067. Epub 07/26/2017.

SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution.

Schwartz GJ, Gao X, Tsuruoka S, Purkerson JM, Peng H, D'Agati V, Picard N, Eladari D, Al-Awqati Q

The Journal of clinical investigation.. 2015 October 26125 (12):4365-74. Epub 10/26/2015.

Distinct ?-intercalated cell morphology and its modification by acidosis define regions of the collecting duct.

Purkerson JM, Schwaderer AL, Nakamori A, Schwartz GJ

American journal of physiology. Renal physiology.. 2015 September 1309 (5):F464-73. Epub 06/17/2015.

Renal Intercalated cells are rather energized by a proton than a sodium-pump.

Chambrey, R.; Kurth. I.;Peti-Peterdi J.;Houillier, P.;Purkerson, J.;Leviel,F.;Zbedik, A.;Schwartz,G.J.;Huebner,C.;Eladari, D.

PNAS. 2013; .

Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct

Purkerson JM; Tsuruoka S; Suter DZ; Nakamori A; Schwartz GJ.

Kindney International. 2010; 78(10): 993-1005.

Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation.

Peng H, Vijayakumar S, Schiene-Fischer C, Li H, Purkerson JM, Malesevic M, Liebscher J, Al-Awqati, Schwartz GJ.

Journal of Biological Chemistry. 2009; 284(10): 6465-75.

Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation.

Peng H; Vijayakumar S; Schiene-Fischer C; Li H; Purkerson JM; Malesevic M; Liebscher J; Al-Awqati Q; Schwartz GJ.

Journal of Biological Chemistry. 2008; 284(10): 6465-75.

Basolateral carbonic anhydrase IV in the proximal tubule is a glycosylphosphatidylinositol-anchored protein.

Purkerson JM, Kittelberger AM, Schwartz GJ

Kidney international.. 2007 March 71 (5):407-16. Epub 01/17/2007.

Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.

Tsuruoka S, Watanabe S, Purkerson JM, Fujimura A, Schwartz GJ

American journal of physiology. Renal physiology.. 2006 October 291 (4):F866-73. Epub 05/16/2006.

The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts.

Purkerson JM, Smith RS, Pollock SJ, Phipps RP

European journal of immunology.. 2005 October 35 (10):2920-8. Epub 1900 01 01.

Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX during maturation.

Purkerson JM, Schwartz GJ

American journal of physiology. Regulatory, integrative and comparative physiology.. 2005 May 288 (5):R1256-63. Epub 1900 01 01.

Nitric oxide production modulates cyclosporin A-induced distal renal tubular acidosis in the rat.

Tsuruoka S, Schwartz GJ, Wakaumi M, Nishiki K, Yamamoto H, Purkerson JM, Fujimura A

The Journal of pharmacology and experimental therapeutics.. 2003 June 305 (3):840-5. Epub 03/06/2003.

Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L.

Hwang Y, Nahm MH, Briles DE, Thomas D, Purkerson JM

Infection and immunity.. 2000 February 68 (2):511-7. Epub 1900 01 01.

Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40.

Evans DE, Munks MW, Purkerson JM, Parker DC

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 January 15164 (2):688-97. Epub 1900 01 01.

Differential coupling of membrane Ig and CD40 to the extracellularly regulated kinase signaling pathway.

Purkerson JM, Parker DC

The Journal of immunology : official journal of the American Association of Immunologists.. 1998 March 1160 (5):2121-9. Epub 1900 01 01.

IL-5 receptor expression and Ig secretion from murine B lymphocytes requires coordinated signaling by membrane Ig , IL-4, and IL-5.

Weber JD; Isakson PC; Purkerson JM.

Journal of Immunology. 1996; 157(10): 4428-35.

Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE.

Purkerson JM, Isakson PC

The Journal of experimental medicine.. 1994 June 1179 (6):1877-83. Epub 1900 01 01.

A two-signal model for regulation of immunoglobulin isotype switching.

Purkerson J, Isakson P

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 1992 November 6 (14):3245-52. Epub 1900 01 01.

Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.

Purkerson JM, Isakson PC

The Journal of experimental medicine.. 1992 April 1175 (4):973-82. Epub 1900 01 01.

Constitutive versus cell cycle regulation of c-myb mRNA expression correlates with developmental stages in murine B lymphoid tumors.

Catron KM; Purkerson JM; Isakson PC; Bender TP.

Journal of Immunology. 1992; 148(3): 934-42.

A novel method for synchronizing a B cell lymphoma.

Isakson PC, Purkerson J, Catron K, Bender TP

Journal of immunological methods.. 1991 December 15145 (1-2):137-42. Epub 1900 01 01.

Constitutive and cell cycle regulated expression of c-myc mRNA is related to the state of differentiation in murine B-lymphoid tumors.

Catron KM, Toth CR, Purkerson J, Isakson P, Bender TP

Current topics in microbiology and immunology.. 1990 166 :197-202. Epub 1900 01 01.

Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

Purkerson JM, Newberg M, Wise G, Lynch KR, Isakson PC

The Journal of experimental medicine.. 1988 September 1168 (3):1175-80. Epub 1900 01 01.

Books

Trends in Atherosclerosis Research (2004)

Chapter: Targeting of the CD40-CD40 (CD154) Ligand System as Therapeutic Intervention for the Treatment of Atherosclerosis

Authors: Carolyn J. Baglole, Richard P. Phipps, Jeffrey M. Purkerson, Patricia J. Sime

Publisher: Nova Science Publishers Inc., New York, NY 2004

Cytokine regulation of humoral immunity: Basic and clinical aspects (1996)

Chapter: B-cell activation and maturation to immunoglobulin secretion

Authors: Parker DC, Purkerson JM

Publisher: John Wiley & Sons, New York, NY 1996