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Marc W. Halterman, M.D., Ph.D.

Marc W. Halterman, M.D., Ph.D.

Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Adjunct Professor - Department of Neurology, Stroke Division (SMD)

Credentials

Education

PhD | Univ Rochester Sch Med/Dent. Microbiology. 2002

MD | Univ Rochester Sch Med/Dent. Medicine. 2002

MS | Univ Rochester Sch Med/Dent. Microbiology. 1999

BS | Georgetown University. Chemistry. 1992

Awards

K99/R00 Fellowship. 2008

Henry C. Buswell Fellowship Award. 2007

Doctor of Medicine with Distinction in Research. 2002

NIH Individual Pre-doctoral Combined MD PhD Fellowship. 1998

Gilbert B. Forbes Prize in Pediatric Research. 1994

Alpha Omega Alpha.

Publications

Journal Articles

Evolving Clinical-Translational Investigations of Cerebroprotection in Ischemic Stroke.

Journal of clinical medicine.. 2023 October 2412 (21)Epub 10/24/2023.

The transcription factor C/EBP? promotes vascular endothelial growth factor A expression and neural stem cell expansion.

Li Y, Schor J, Bartko J, Albert G, Halterman MW

FEBS letters.. 2022 May 20 Epub 05/20/2022.

The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy.

Li Y, Halterman MW

Biomolecules.. 2021 December 1411 (12)Epub 12/14/2021.

Effects of 9-t-butyl doxycycline on the innate immune response to CNS ischemia-reperfusion injury.

Mai N, Knowlden SA, Miller-Rhodes K, Prifti V, Sims M, Grier M, Nelson M, Halterman MW

Experimental and molecular pathology.. 2020 December 29 :104601. Epub 12/29/2020.

Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care.

Simpkins AN, Busl KM, Amorim E, Barnett-Tapia C, Cervenka MC, Dhakar MB, Etherton MR, Fung C, Griggs R, Holloway RG, Kelly AG, Khan IR, Lizarraga KJ, Madagan HG, Onweni CL, Mestre H, Rabinstein AA, Rubinos C, Dionisio-Santos DA, Youn TS, Merck LH, Maciel CB,

Neurocritical care.. 2020 September 21 Epub 09/21/2020.

Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia.

Mai N, Prifti V, Lim K, O'Reilly MA, Kim M, Halterman MW

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2020 September 29 (9):104942. Epub 05/14/2020.

Phosphorylation within the bipartite NLS alters the localization and toxicity of the ER stress response factor DDIT3/CHOP.

Bartko JC, Li Y, Sun Z, Halterman MW

Cellular signalling.. 2020 July 13 :109713. Epub 07/13/2020.

Characterization of neutrophil-neuronal co-cultures to investigate mechanisms of post-ischemic immune-mediated neurotoxicity.

Mai N, Prifti V, Kim M, Halterman MW

Journal of neuroscience methods.. 2020 May 20 :108782. Epub 05/20/2020.

Legal and ethical issues surrounding the use of crowdsourcing among healthcare providers.

Sims MH, Hodges Shaw M, Gilbertson S, Storch J, Halterman MW

Health informatics journal.. 2019 December 25 (4):1618-1630. Epub 09/07/2018.

Long-Term Microgliosis Driven by Acute Systemic Inflammation.

Trzeciak A, Lerman YV, Kim TH, Kim MR, Mai N, Halterman MW, Kim M

The Journal of immunology : official journal of the American Association of Immunologists.. 2019 October 16 Epub 10/16/2019.

Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia.

Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW

Journal of the American Heart Association.. 2019 May 78 (9):e011801. Epub 1900 01 01.

The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection.

Mai N, Miller-Rhodes K, Knowlden S, Halterman MW

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2019 March 13 :271678X19835552. Epub 03/13/2019.

Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia.

Buczynski BW, Mai N, Yee M, Allen JL, Prifti L, Cory-Slechta DA, Halterman MW, O'Reilly MA

Frontiers in medicine.. 2018 5 :334. Epub 12/10/2018.

Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche.

Mills BN, Albert GP, Halterman MW

Cancer microenvironment : official journal of the International Cancer Microenvironment Society.. 2017 December 10 (1-3):57-68. Epub 08/18/2017.

Endotoxemia induces lung-brain coupling and multi-organ injury following cerebral ischemia-reperfusion.

Mai N, Prifti L, Rininger A, Bazarian H, Halterman MW

Experimental neurology.. 2017 November 297 :82-91. Epub 07/28/2017.

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.

Pröschel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR

European journal of human genetics : EJHG.. 2017 February 25 (2):216-221. Epub 12/14/2016.

Provider impressions of the use of a mobile crowdsourcing app in medical practice.

Sims MH, Fagnano M, Halterman JS, Halterman MW

Health informatics journal.. 2016 June 22 (2):221-31. Epub 08/28/2014.

De novo mutations in SIK1 cause a spectrum of developmental epilepsies.

Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR

American journal of human genetics.. 2015 April 296 (4):682-90. Epub 1900 01 01.

Crowdsourcing medical expertise in near real time.

Sims MH, Bigham J, Kautz H, Halterman MW

Journal of hospital medicine.. 2014 July 9 (7):451-6. Epub 04/17/2014.

Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia.

Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K

Brain research.. 2014 January 161543 :28-37. Epub 11/23/2013.

MKP-1 antagonizes C/EBP? activity and lowers the apoptotic threshold after ischemic injury.

Rininger A, Dejesus C, Totten A, Wayland A, Halterman MW

Cell death and differentiation.. 2012 October 19 (10):1634-43. Epub 04/20/2012.

Assessment of CA1 injury after global ischemia using supervised 2D analyses of nuclear pyknosis.

Rininger A, Wayland A, Prifti V, Halterman MW

Journal of neuroscience methods.. 2012 June 15207 (2):181-8. Epub 04/21/2012.

The paradox of the neutrophil's role in tissue injury.

Segel GB, Halterman MW, Lichtman MA

Journal of leukocyte biology.. 2011 March 89 (3):359-72. Epub 11/19/2010.

An improved method for the study of apoptosis-related genes using the tet-on system.

Halterman MW

Journal of biomolecular screening.. 2011 March 16 (3):332-7. Epub 02/18/2011.

Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress.

Qazi A, Halterman MW, Mi Z, Zhang T, Schor NF

Oxidative medicine and cellular longevity.. 2011 2011 :391659. Epub 09/05/2011.

The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.

Halterman MW, Gill M, Dejesus C, Ogihara M, Schor NF, Federoff HJ

The Journal of biological chemistry.. 2010 July 9285 (28):21329-40. Epub 05/06/2010.

In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures.

Halterman MW, Giuliano R, Dejesus C, Schor NF

Journal of neuroscience methods.. 2009 March 15177 (2):348-54. Epub 10/30/2008.

Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons.

Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ

Molecular and cellular neurosciences.. 2008 June 38 (2):125-37. Epub 02/13/2008.

Teaching NeuroImage: tremor in aqueductal stenosis and response to endoscopic third ventriculostomy.

Halterman MW, Vates GE, Riggs G

Neurology.. 2007 May 868 (19):E29-31. Epub 1900 01 01.

Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity.

Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ

The journal of gene medicine.. 2006 November 8 (11):1320-8. Epub 1900 01 01.

The role of the THY1 gene in human ovarian cancer suppression based on transfection studies.

Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N

Cancer genetics and cytogenetics.. 2004 February 149 (1):1-10. Epub 1900 01 01.

Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer.

Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y

Annals of surgery.. 2002 September 236 (3):337-42; discussion 342-3. Epub 1900 01 01.

Reporter gene transfer induces apoptosis in primary cortical neurons.

Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK

Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 June 5 (6):723-30. Epub 1900 01 01.

A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes.

Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y

Molecular therapy : the journal of the American Society of Gene Therapy.. 2001 September 4 (3):250-6. Epub 1900 01 01.

Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer.

Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y

Molecular medicine.. 2001 August 7 (8):561-8. Epub 1900 01 01.

Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia.

Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD

Blood.. 2001 July 1598 (2):287-95. Epub 1900 01 01.

Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers.

Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ

Gene therapy.. 2001 January 8 (2):111-20. Epub 1900 01 01.

Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer.

Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y

Journal of molecular medicine : official organ of the "Gesellschaft Deutscher Naturforscher und A?rzte".. 2000 78 (3):166-74. Epub 1900 01 01.

Gene therapy in the inner ear. Mechanisms and clinical implications.

Van de Water TR, Staecker H, Halterman MW, Federoff HJ

Annals of the New York Academy of Sciences.. 1999 November 28884 :345-60. Epub 1900 01 01.

HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia.

Halterman MW, Federoff HJ

Experimental neurology.. 1999 September 159 (1):65-72. Epub 1900 01 01.

Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity.

D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y

Molecular medicine.. 1999 September 5 (9):606-16. Epub 1900 01 01.

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

Halterman MW, Miller CC, Federoff HJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 August 1519 (16):6818-24. Epub 1900 01 01.

Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207).

Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 1999 August 13 (11):1325-34. Epub 1900 01 01.

Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207).

Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y

Human gene therapy.. 1999 July 110 (10):1599-606. Epub 1900 01 01.

Lentivirus vectors using human and simian immunodeficiency virus elements.

White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V

Journal of virology.. 1999 April 73 (4):2832-40. Epub 1900 01 01.

Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization.

Brooks AI, Halterman MW, Federoff HJ

Neuroreport.. 1999 February 510 (2):337-44. Epub 1900 01 01.

Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors.

Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD

Blood.. 1999 January 1593 (2):643-54. Epub 1900 01 01.

In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.

D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y

Cancer immunology, immunotherapy : CII.. 1999 January 47 (5):265-71. Epub 1900 01 01.

Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector.

Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y

American journal of surgery.. 1998 November 176 (5):404-8. Epub 1900 01 01.

Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry.

Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF

The American journal of pathology.. 1998 June 152 (6):1521-9. Epub 1900 01 01.

Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector.

Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ

Journal of neuroscience methods.. 1998 April 3080 (2):137-47. Epub 1900 01 01.

Use of the herpes amplicon system as a vehicle for somatic gene transfer.

Federoff HJ, Halterman MW, Brooks AI

Advanced drug delivery reviews.. 1997 August 1127 (1):29-39. Epub 1900 01 01.