Arshad Rahman, Ph.D.
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Arshad Rahman, Ph.D.
About Me
Faculty Appointments
Professor - Department of Pediatrics, Neonatology (SMD)
Professor - Department of Pharmacology and Physiology (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Senior Research Associate, Department of Pharmacology, Rush Medical Center, Chicago, IL 1993 - 1995
Research Associate, Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, IL 1992 - 1993
Education
PhD | AM University. Biochemistry. 1988
MSc | AM University. Biochemistry. 1984
BSc | AM University. Chemistry. 1981
Research
More recently, we have been focusing on Spleen Tyrosine Kinase (Syk) and Mechanistic/Mammalian Target of Rapamycin (MTOR) as critical mechanistic targets for modulation of ALI pathogenesis. The Syk project seeks to clarify the mechanism by which Syk regulates EC dysfunction (permeability and inflammation) in ALI and evaluate the therapeutic efficacy of Syk inhibition against evolving ALI in mice with sepsis. The MTOR project builds logically on our prior work and seeks to clarify the role of MTOR in ALI and evaluate the preventive and therapeutic efficacy of modulation of MTOR signaling against ALI. In a nutshell, the research in my lab uses genetically modified mice, primary cell cultures, and multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery (cell-specific transfer of genes and shRNA to endothelial cells in the lung) and multiple mouse models of ALI to identify viable therapeutic targets and mechanisms to limit ALI.
Publications
Journal Articles
Vandewouw MM, Norris-Brilliant A, Rahman A, Assimopoulos S, Morton SU, Kushki A, Cunningham S, King E, Goldmuntz E, Miller TA, Thomas NH, Adams HR, Cleveland J, Cnota JF, Ellen Grant P, Goldberg CS, Huang H, Li JS, McQuillen P, Porter GA, Roberts AE, Russell MW, Seidman CE, Tivarus ME, Chung WK, Hagler DJ, Newburger JW, Panigrahy A, Lerch JP, Gelb BD, Anagnostou E
NeuroImage.. 2024 July 4297 :120721. Epub 07/04/2024.
Schartz DA, Ismail RF, Rahman AA, Bender MT, Westesson PL, Mesfin A, Kessler A
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.. 2024 February 30 (1):137-142. Epub 07/11/2022.
Jagrosse ML, Baliga UK, Jones CW, Russell JJ, García CI, Najar RA, Rahman A, Dean DA, Nilsson BL
Molecular pharmaceutics.. 2023 December 420 (12):6090-6103. Epub 11/14/2023.
Shadab M, Slavin SA, Mahamed Z, Millar MW, Najar RA, Leonard A, Pietropaoli A, Dean DA, Fazal F, Rahman A
The Journal of biological chemistry.. 2023 December 299 (12):105408. Epub 10/28/2023.
Millar MW, Fazal F, Rahman A
Cells.. 2022 October 2111 (20)Epub 10/21/2022.
Shadab M, Najar RA, Fazal F, Rahman A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2022 May 36 Suppl 1 Epub 1900 01 01.
McRae HL, Millar MW, Slavin SA, Blumberg N, Rahman A, Refaai MA
Biomedicines.. 2021 December 79 (12)Epub 12/07/2021.
Hsu CG, Fazal F, Rahman A, Berk BC, Yan C
The Journal of immunology : official journal of the American Association of Immunologists.. 2021 June 15206 (12):3010-3020. Epub 06/11/2021.
Shadab M, Millar MW, Slavin SA, Leonard A, Fazal F, Rahman A
Scientific reports.. 2020 August 1310 (1):13708. Epub 08/13/2020.
Leonard A, Su PY, Yule DI, Rahman A, Fazal F
Shock.. 2020 August 54 (2):245-255. Epub 1900 01 01.
Jagrosse ML, Dean DA, Rahman A, Nilsson BL
Translational research : the journal of laboratory and clinical medicine.. 2019 December 214 :30-49. Epub 07/27/2019.
Leonard A, Millar MW, Slavin SA, Bijli KM, Dionisio Santos, Dean DA, Fazal F, Rahman A
Cellular signalling.. 2019 September 61 :120-129. Epub 05/01/2019.
Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG
European heart journal.. 2019 August 140 (29):2398-2408. Epub 1900 01 01.
Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F
Scientific reports.. 2019 February 149 (1):2096. Epub 02/14/2019.
Lyu Q, Xu S, Lyu Y, Choi M, Christie CK, Slivano OJ, Rahman A, Jin ZG, Long X, Xu Y, Miano JM
Proceedings of the National Academy of Sciences of the United States of America.. 2019 January 8116 (2):546-555. Epub 12/24/2018.
Leonard A, Rahman A, Fazal F
Cellular signalling.. 2018 April 44 :103-117. Epub 01/11/2018.
Slavin SA, Leonard A, Grose V, Fazal F, Rahman A
American journal of physiology. Lung cellular and molecular physiology.. 2018 March 1314 (3):L388-L396. Epub 10/26/2017.
Angara S, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V
American journal of respiratory cell and molecular biology.. 2016 November 55 (5):722-735. Epub 1900 01 01.
Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A
American journal of physiology. Lung cellular and molecular physiology.. 2016 August 1311 (2):L517-24. Epub 07/01/2016.
Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 July 30 (7):2615-26. Epub 04/08/2016.
Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation. FASEB J. 30:2615-26
Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ.
2016; .
Inhibition of RPTOR Prevents Hyperoxia-induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.
Sureshbabu. A.; Syed, M.; Das, P.; Janér, C.; Pryhuber, G.; Rahman, A.; Andersson, S.; Homer, R.J.; Bhandari, V.
Am J Respir Cell Mol Biol. 2016; 55: 722-735.
Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ
American journal of physiology. Lung cellular and molecular physiology.. 2015 August 1309 (3):L293-304. Epub 05/29/2015.
Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A
Shock.. 2014 December 42 (6):562-9. Epub 1900 01 01.
Thrombin selectively engages LIM kinase1 and slingshot-1L phosphatase to regulate NF-?B activation and endothelial cell inflammation.
Leonard A, Marando C, Rahman A, Fazal F.
Am J Physiol: Lung Cell Mol Physiol. 2013; 305: L651-64.
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A
PloS one.. 2013 8 (3):e59965. Epub 03/21/2013.
Bijli KM, Fazal F, Rahman A
American journal of respiratory cell and molecular biology.. 2012 November 47 (5):660-8. Epub 07/27/2012.
Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L
Cancer research.. 2011 August 1571 (16):5558-68. Epub 07/01/2011.
Blocking NF-?B: An Inflammatory Issue.
Rahman A and Fazal F.
Proc Am Thorac Soc 8:497-503. 2011; .
Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A
The Journal of biological chemistry.. 2009 July 31284 (31):21047-56. Epub 05/29/2009.
Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A
The Journal of biological chemistry.. 2009 February 13284 (7):4052-61. Epub 12/13/2008.
Hug tightly and say goodbye: Role of endothelial ICAM-1 in leukocyte transmigration.
Rahman A and Fazal F.
Antioxid Redox Signal 11:823-829. 2009; .
Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 July 22 (7):2297-310. Epub 02/08/2008.
Bijli KM, Fazal F, Minhajuddin M, Rahman A
The Journal of biological chemistry.. 2008 May 23283 (21):14674-84. Epub 03/24/2008.
Fazal F, Minhajuddin M, Bijli KM, McGrath JL, Rahman A
The Journal of biological chemistry.. 2007 February 9282 (6):3940-50. Epub 12/08/2006.
Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A
American journal of physiology. Lung cellular and molecular physiology.. 2007 February 292 (2):L396-404. Epub 09/29/2006.
Berk BC. Flow antagonizes TNF? signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.
Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC.
Circ Res. 2007; 101(1): 97-105.
Orrington-Myers J, Gao X, Kouklis P, Broman M, Rahman A, Vogel SM, Malik AB
American journal of physiology. Lung cellular and molecular physiology.. 2006 October 291 (4):L764-71. Epub 06/16/2006.
Staversky RJ, Vitiello PF, Gehen SC, Helt CE, Rahman A, Keng PC, O'Reilly MA
Free radical biology & medicine.. 2006 August 1541 (4):601-9. Epub 05/23/2006.
Frey RS, Gao X, Javaid K, Siddiqui SS, Rahman A, Malik AB
The Journal of biological chemistry.. 2006 June 9281 (23):16128-38. Epub 03/09/2006.
Minhajuddin M, Fazal F, Bijli KM, Amin MR, Rahman A
The Journal of immunology : official journal of the American Association of Immunologists.. 2005 May 1174 (9):5823-9. Epub 1900 01 01.
Anwar KN, Fazal F, Malik AB, Rahman A
The Journal of immunology : official journal of the American Association of Immunologists.. 2004 December 1173 (11):6965-72. Epub 1900 01 01.
Rahman A, Anwar KN, Minhajuddin M, Bijli KM, Javaid K, True AL, Malik AB
American journal of physiology. Lung cellular and molecular physiology.. 2004 November 287 (5):L1017-24. Epub 07/09/2004.
Ong ES, Gao XP, Xu N, Predescu D, Rahman A, Broman MT, Jho DH, Malik AB
American journal of physiology. Lung cellular and molecular physiology.. 2003 October 285 (4):L879-88. Epub 06/20/2003.
Paria BC, Malik AB, Kwiatek AM, Rahman A, May MJ, Ghosh S, Tiruppathi C
The Journal of biological chemistry.. 2003 September 26278 (39):37195-203. Epub 07/10/2003.
Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC
The Journal of biological chemistry.. 2003 August 29278 (35):32544-51. Epub 06/12/2003.
Deb DK, Sassano A, Lekmine F, Majchrzak B, Verma A, Kambhampati S, Uddin S, Rahman A, Fish EN, Platanias LC
The Journal of immunology : official journal of the American Association of Immunologists.. 2003 July 1171 (1):267-73. Epub 1900 01 01.
Javaid K, Rahman A, Anwar KN, Frey RS, Minshall RD, Malik AB
Circulation research.. 2003 May 3092 (10):1089-97. Epub 04/24/2003.
Babcock TA, Kurland A, Helton WS, Rahman A, Anwar KN, Espat NJ
JPEN. Journal of parenteral and enteral nutrition.. 2003 27 (3):176-80; discussion 181. Epub 1900 01 01.
Rahman A, True AL, Anwar KN, Ye RD, Voyno-Yasenetskaya TA, Malik AB
Circulation research.. 2002 September 691 (5):398-405. Epub 1900 01 01.
Skidgel RA, Gao XP, Brovkovych V, Rahman A, Jho D, Predescu S, Standiford TJ, Malik AB
The Journal of immunology : official journal of the American Association of Immunologists.. 2002 August 15169 (4):2093-101. Epub 1900 01 01.
Frey RS, Rahman A, Kefer JC, Minshall RD, Malik AB
Circulation research.. 2002 May 1790 (9):1012-9. Epub 1900 01 01.
Uddin S, Sassano A, Deb DK, Verma A, Majchrzak B, Rahman A, Malik AB, Fish EN, Platanias LC
The Journal of biological chemistry.. 2002 April 26277 (17):14408-16. Epub 02/11/2002.
Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB
The Journal of immunology : official journal of the American Association of Immunologists.. 2002 April 15168 (8):3974-82. Epub 1900 01 01.
Xu N, Gao XP, Minshall RD, Rahman A, Malik AB
American journal of physiology. Lung cellular and molecular physiology.. 2002 April 282 (4):L796-802. Epub 1900 01 01.
Fan J, Frey RS, Rahman A, Malik AB
The Journal of biological chemistry.. 2002 February 1277 (5):3404-11. Epub 11/29/2001.
Gao X, Xu N, Sekosan M, Mehta D, Ma SY, Rahman A, Malik AB
The Journal of immunology : official journal of the American Association of Immunologists.. 2001 September 1167 (5):2895-901. Epub 1900 01 01.
Rahman A, Anwar KN, Uddin S, Xu N, Ye RD, Platanias LC, Malik AB
Molecular and cellular biology.. 2001 August 21 (16):5554-65. Epub 1900 01 01.
Mehta D, Rahman A, Malik AB
The Journal of biological chemistry.. 2001 June 22276 (25):22614-20. Epub 04/17/2001.
Yang M, Sang H, Rahman A, Wu D, Malik AB, Ye RD
The Journal of immunology : official journal of the American Association of Immunologists.. 2001 June 1166 (11):6885-92. Epub 1900 01 01.
Kefer J, Rahman A, Anwar KN, Malik AB
Shock.. 2001 January 15 (1):11-5. Epub 1900 01 01.
Rahman A, Anwar KN, Malik AB
American journal of physiology. Cell physiology.. 2000 October 279 (4):C906-14. Epub 1900 01 01.
Xu N, Rahman A, Minshall RD, Tiruppathi C, Malik AB
Circulation research.. 2000 August 487 (3):254-60. Epub 1900 01 01.
Activation of NF-kB induced by H2O2 and TNFa in endothelial cells and effect on ICAM-1 expression.
True, A.L., Rahman, A., Malik, A.B.
Am. J. Physiol: Lung Mol. Cell. Physiolol. 2000; 279: L302-L311.
Lo SK, Rahman A, Xu N, Zhou MY, Nagpala P, Jaffe HA, Malik AB
Molecular pharmacology.. 1999 November 56 (5):926-32. Epub 1900 01 01.
Rahman A, Anwar KN, True AL, Malik AB
The Journal of immunology : official journal of the American Association of Immunologists.. 1999 May 1162 (9):5466-76. Epub 1900 01 01.
Rahman A, Bando M, Kefer J, Anwar KN, Malik AB
Molecular pharmacology.. 1999 March 55 (3):575-83. Epub 1900 01 01.
E-selectin expression in human endothelial cells by TNFa-induced oxidant generation and NF-kB activation.
Rahman, A., Kefer, J., Bando, M., Niles, W.D., Malik, A.B.
Am. J. Physiol. 1998; 19: L533-L544.
Roebuck KA, Rahman A, Lakshminarayanan V, Janakidevi K, Malik AB
The Journal of biological chemistry.. 1995 August 11270 (32):18966-74. Epub 1900 01 01.
Rahman A, Malhotra P, Dhar R, Kewalramani T, Thimmapaya B
Journal of virology.. 1995 July 69 (7):4299-307. Epub 1900 01 01.
Generation of superoxide anion and hydroxyl radical by methylglyoxal.
Fazal, F., Rahman, A., Hadi, S.M.
Med. Sci. Res. 1994; 22: 21-24.
Said Ahmad M, Fazal F, Rahman A, Hadi SM, Parish JH
Carcinogenesis.. 1992 April 13 (4):605-8. Epub 1900 01 01.
Rahman A, Fazal F, Greensill J, Ainley K, Parish JH, Hadi SM
Molecular and cellular biochemistry.. 1992 April 111 (1-2):3-9. Epub 1900 01 01.
Shahabuddin , Rahman A, Hadi SM
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.. 1991 October 29 (10):719-21. Epub 1900 01 01.
Anticancer drugs and DNA degradation.
Rahman, A.; Hadi, S.M.
Med Sci Res. 1991; 19: 627-631.
Fazal F, Rahman A, Greensill J, Ainley K, Hadi SM, Parish JH
Carcinogenesis.. 1990 November 11 (11):2005-8. Epub 1900 01 01.
Rahman A, Shahabuddin , Hadi SM, Parish JH
Carcinogenesis.. 1990 November 11 (11):2001-3. Epub 1900 01 01.
Shahabuddin , Rahman A, Hadi SM
Mutagenesis.. 1990 March 5 (2):131-6. Epub 1900 01 01.
Rahman A, Shahabuddin , Hadi SM
Journal of biochemical toxicology.. 1990 5 (3):161-6. Epub 1900 01 01.
Rahman A, Shahabuddin , Hadi SM, Parish JH, Ainley K
Carcinogenesis.. 1989 October 10 (10):1833-9. Epub 1900 01 01.
Hadi SM, Shahabuddin , Rehman A
Mutation research.. 1989 March 225 (3):101-6. Epub 1900 01 01.
Dietary mutagens and carcinogens
Hadi, SM.; Rizvi, RY.; Rahman, A.; Uddin, S.
J Sc Ind Res. 1987; 46: 54-60.
Effect of alkylation with streptozotocin on the secondary structure of DNA.
Rizvi, R.Y., Uddin, S., Rahman, A., Hadi, S. M.
Biosc. Rep. 1986; 6: 557-564.
SENCR Stabilizes Vascular Endothelial Cell Adherens Junction through Interaction with CKAP4.
Lyu, Q.; Xu, S.W.; Lyu, Y.Y.; Choi, M.; Christie, C.K.; Slivano, O.J.; Rahman, A.; Jin, Z.G.; Long, X.C.; Xu, Y.W.; Miano, J.M.
Proc Natl Acad Sci USA. .
Endoplasmic Reticulum Chaperone and Signaling Regulator BiP/GRP78 is Critical to Endothelial Dysfunction in Acute Lung Injury.
Leonard, A.; Grose, V.; Paton, A.W.; Paton, J.C.; Yule, D.I.; Rahman, A.; Fazal, F.
Scientific Reports. .
Essential Role of Beclin1-Autopahgy Axis in Endothelial Cell Inflammation and Permeability
Leonard, A.; Millar, M.; Slavin, S.A.; Bijli, K.M.; Dionisio-Santos, DA.; Dean, DA.; Fazal, F.; *Rahman, A.
J Immunol. .
Occludin is indispensable for alveolar barrier function and serves as a therapeutic target for treating ARDS.
Lin, X.; Bai, H.; Barravecchia, M.; Norman, R.; Rahman, A.; Young, JL.; Dean, DA.
JCI Insight. .
Deficiency of a novel coronary artery disease risk gene JCAD/KIAA1462 reduces atherosclerosis.
Xu, Y.; Xu, S.; Liu, P.; Zhang, S.; Slavin, S.; Koroleva, M.; Rahman, A.; Si, S.; Jin, ZG.
European Heart Journal. .
Books
Endothelial Biomedicine (2007)
Chapter: Nuclear Factor-kappaB Signaling in Endothelium
Authors: Bijli KM, Rahman A
Publisher: Cambridge University Press 2007
Nitric Oxide and Radicals in the Pulmonary Vasculature. Proceedings of the VII (1996)
Chapter: Transcriptional regulation of endothelial adhesion molecule gene expression by oxidants and cytokines.
Authors: Rahman A, Roebuck KA, Malik AB
Publisher: Futura Publishing Co., New York, NY 1996
Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research-Part 2 (1993)
Chapter: Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals.
Authors: Rahman A, Fazal F, Hadi SM
Publisher: Today and Tomorrow's Printers and Publishers, New Delhi, India 1993