Ian M. Dickerson, Ph.D.
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Ian M. Dickerson, Ph.D.
About Me
Humboldt State University, Arcata, CA, 1980 BA Biology
Purdue University, West Lafayette, IN, 1985 PhD Molecular Biology
The Johns Hopkins School of Medicine, Baltimore, MD, 1989 Post Doc Neuroscience
POSITIONS:
1989-1997: Assistant Professor, Univer...
Humboldt State University, Arcata, CA, 1980 BA Biology
Purdue University, West Lafayette, IN, 1985 PhD Molecular Biology
The Johns Hopkins School of Medicine, Baltimore, MD, 1989 Post Doc Neuroscience
POSITIONS:
1989-1997: Assistant Professor, University of Miami School of Medicine, Department of Physiology and Biophysics
1997-2003: Assoc. Professor, University of Miami School of Medicine, Department of Physiology and Biophysics
1990-2003: Faculty Member, Neuroscience Program, University of Miami School of Medicine
1991-2003: Secondary Appointment, Department of Biochemistry and Molecular Biology, University of Miami School of Medicine
2000-2003: Member, University of Miami School of Medicine Cancer Center, Tumor Cell Biology Program
2003-present: Associate Professor, University of Rochester School of Medicine, Department of Neurobiology and Anatomy
2003-present: Secondary Appointment, University of Rochester School of Medicine, Department of Physiology and Pharmacology
HONORS:
1987-1989 NIH NRSA Individual Postdoctoral Fellowship Award
1994-1995 Stanley Glaser Research Award, University of Miami School of Medicine
1996 UM Dean's Award for Excellence in Research and Creativity; Outstanding Graduate Mentor
Faculty Appointments
Associate Professor - Department of Neuroscience (SMD)
Associate Professor - Department of Biomedical Engineering (RC) - Joint
Associate Professor - Department of Pharmacology and Physiology (SMD) - Joint
Credentials
Post-doctoral Training & Residency
The Johns Hopkins School of Medicine
Neuroscience, Department of Neuroscience 1985 - 1989
Education
PhD | Purdue University. Molecular Biology. 1985
BA | Humboldt State Univ. Biology. 1980
Awards
Dean's Award for Excellence in Research and Creativity; Outstanding Graduate Mentor. 1996
Stanley Glaser Research Award. 1994
NIH NRSA Individual Postdoctoral Fellowship Award. 1987 - 1989
David Ross Graduate Research Fellowship. 1983 - 1985
Research
Our laboratory studies the neuropeptide calcitonin gene-related peptide (CGRP). Originally discovered as an alternatively-spliced variant of the calcitonin mRNA, CGRP is one of the most potent vasodilators known. As a vasodilator, CGRP has both...
Our laboratory studies the neuropeptide calcitonin gene-related peptide (CGRP). Originally discovered as an alternatively-spliced variant of the calcitonin mRNA, CGRP is one of the most potent vasodilators known. As a vasodilator, CGRP has both peripheral and central effects. One of the most notable effects of CGRP is its causative effect of migraine on the cerebral vasculature, and stable synthetic antagonists have been recently developed and are in Stage III clinical trials for migraine treatment. CGRP also suppresses immune function, is involved in pain perception, and has further central role in the development of tolerance to opiates.
Recently, we have discovered that CGRP is a potent stimulator of glioma and metastatic breast cancer tumor cell growth. In collaboration with Dr. Edward Brown (Biomedical Engineering) we have observed remarkable increases in tumor cell growth rates in response to CGRP incubation. These data suggest that the CGRP receptor system represents an important new target for these types of cancer for which therapy is currently limited.
The CGRP receptor is unique for G protein-coupled receptors (GPCR) in that it requires three proteins for function: calcitonin-like receptor (CLR), a stereotypical GPCR with 7 hydrophobic transmembrane domains; receptor activity modifying protein (RAMP1), a single transmembrane accessory protein that targets CLR to the cell surface and confers pharmacologic specificity, and CGRP receptor component protein (RCP) which couples the CLR/RAMP1 complex to the cellular signaling pathway.
Our laboratory is investigating the mechanism of RCP action by: (1) determining the molecular/ biochemical requirements for RCP function, (2) determining the proteins that interact with RCP in a functional receptor complex using proteomic strategies, (3) determining the role of RCP and CGRP in vivo, using targeted homologous recombination to generate transgenic RCP knockout mice.
In addition, we are applying the biochemical reagents made in the first three areas of interest to directly test the role of the CGRP receptor in glioma and breast cancer proliferation, with the long-term goal of identifying novel protein interactions required for CGRP receptor function as targets for future anti-cancer drug development.
Patents
Methods of Treating Cancer Using The Calcitonin-Gene Related Peptide ("CGRP") Receptor Antagonist CGRP8-37
Issue date: March 12, 2013
Patent #: 8,394,767
Country: United States
Inventors: Edward Brown III, Ian Dickerson
Delivery of Biomolecules into Cells Through Carbon Nanotube Arrays
Issue date: October 12, 2021
Patent #: 11,142,776
Country: United States
Inventors: Ian Dickerson, Masoud Golshadi, Michael G Schrlau
Publications
Journal Articles
Wee NK, Novak S, Ghosh D, Root SH, Dickerson IM, Kalajzic I
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 June 41 (6):1228-1239. Epub 10/31/2022.
McQuaid C, Solorzano A, Dickerson I, Deane R
Frontiers in neuroscience.. 2023 17 :1117845. Epub 02/16/2023.
Brouxhon SM, O'Banion MK, Dickerson IM, Kyrkanides S
Clinical and experimental dental research.. 2022 October 8 (5):1158-1166. Epub 06/14/2022.
Lown M, Miles EA, Fisk HL, Smith KA, Muller I, Maund E, Rogers K, Becque T, Hayward G, Moore M, Little P, Glogowska M, Hay AD, Stuart B, Mantzourani E, Butler C, Bostock J, Davies F, Dickerson I, Thompson N, Francis N
Frontiers in immunology.. 2022 13 :1016181. Epub 10/06/2022.
Golshadi M,; Nguyen L.; Dickerson I.M.; Schrlau M.G.
Journal of Multidisciplinary Engineering Science and Technology. 2021; 8(1): 13358-13369.
Routledge SJ, Simms J, Clark A, Yeung HY, Wigglesworth MJ, Dickerson IM, Kitchen P, Ladds G, Poyner DR
Biochimica et biophysica acta. Biomembranes.. 2020 March 11862 (3):183174. Epub 12/27/2019.
Kubrin K; Ahmed A; Demiri S; Majid M; Dickerson IM; Schrlau MG.
ASME 2017 International Mechanical Engineering Congress and Exposition. 2017; 14: V014T07A011.
Dickerson IM, Bussey-Gaborski R, Holt JC, Jordan PM, Luebke AE
Physiological reports.. 2016 July 4 (14)Epub 1900 01 01.
Golshadi M, Wright LK, Dickerson IM, Schrlau MG
Small.. 2016 June 12 (22):3014-20. Epub 04/05/2016.
Bawa Z, Routledge SJ, Jamshad M, Clare M, Sarkar D, Dickerson I, Ganzlin M, Poyner DR, Bill RM
Microbial cell factories.. 2014 September 413 (1):127. Epub 09/04/2014.
Shapovalov Y, Zettel M, Spielman SC, Amico-Ruvio SA, Kelly EA, Sipe GO, Dickerson IM, Majewska AK, Brown EB
BMC cancer.. 2014 August 1614 :598. Epub 08/16/2014.
Bullock CM, Wookey P, Bennett A, Mobasheri A, Dickerson I, Kelly S
Arthritis & rheumatology.. 2014 August 66 (8):2188-200. Epub 1900 01 01.
Sardi C, Zambusi L, Finardi A, Ruffini F, Tolun AA, Dickerson IM, Righi M, Zacchetti D, Grohovaz F, Provini L, Furlan R, Morara S
Journal of neuroimmunology.. 2014 June 15271 (1-2):18-29. Epub 03/19/2014.
Dickerson IM
Current protein & peptide science.. 2013 August 14 (5):407-15. Epub 1900 01 01.
Egea SC, Dickerson IM
Endocrinology.. 2012 April 153 (4):1850-60. Epub 02/07/2012.
Supowit SC, Katki KA, Hein TW, Gupta P, Kuo L, Dickerson IM, Dipette DJ
American journal of physiology. Heart and circulatory physiology.. 2011 September 301 (3):H683-8. Epub 06/10/2011.
Morara S, Wang LP, Filippov V, Dickerson IM, Grohovaz F, Provini L, Kettenmann H
The European journal of neuroscience.. 2008 December 28 (11):2213-20. Epub 1900 01 01.
Glaser SS, Ueno Y, DeMorrow S, Chiasson VL, Katki KA, Venter J, Francis HL, Dickerson IM, DiPette DJ, Supowit SC, Alpini GD
Laboratory investigation; a journal of technical methods and pathology.. 2007 September 87 (9):914-26. Epub 07/09/2007.
Tolun AA, Dickerson IM, Malhotra A
Protein expression and purification.. 2007 March 52 (1):167-74. Epub 09/20/2006.
Zhang Z, Dickerson IM, Russo AF
Endocrinology.. 2006 April 147 (4):1932-40. Epub 12/22/2005.
Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S
Arthritis and rheumatism.. 2006 April 54 (4):1184-97. Epub 1900 01 01.
Rossi SG, Dickerson IM, Rotundo RL
The Journal of biological chemistry.. 2003 July 4278 (27):24994-5000. Epub 04/21/2003.
Hay DL, Poyner D, Dickerson I
Trends in endocrinology and metabolism : TEM.. 2003 January 14 (1):3-4; author reply 4-6. Epub 1900 01 01.
Ma W, Chabot JG, Powell KJ, Jhamandas K, Dickerson IM, Quirion R
Neuroscience.. 2003 120 (3):677-94. Epub 1900 01 01.
Prado MA, Evans-Bain B, Dickerson IM
Biochemical Society transactions.. 2002 August 30 (4):460-4. Epub 1900 01 01.
Pokabla MJ, Dickerson IM, Papka RE
Peptides.. 2002 March 23 (3):507-14. Epub 1900 01 01.
CGRP receptor heterogeneity: a role for receptor component protein?
Hay, DL; Poyner, D; Dickerson, I.
Trends Endocrinol Metab. 2002; 14: 3-4.
Prado MA, Evans-Bain B, Oliver KR, Dickerson IM
Peptides.. 2001 November 22 (11):1773-81. Epub 1900 01 01.
Krajewski JL, Dickerson IM, Potter LT
Molecular pharmacology.. 2001 October 60 (4):725-31. Epub 1900 01 01.
Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M, Dickerson IM, Hill RG
The European journal of neuroscience.. 2001 August 14 (4):618-28. Epub 1900 01 01.
Evans BN, Rosenblatt MI, Mnayer LO, Oliver KR, Dickerson IM
The Journal of biological chemistry.. 2000 October 6275 (40):31438-43. Epub 1900 01 01.
Rosenblatt MI, Dahl GP, Dickerson IM
Investigative ophthalmology & visual science.. 2000 April 41 (5):1159-67. Epub 1900 01 01.
Lindberg I, Tu B, Muller L, Dickerson IM
DNA and cell biology.. 1998 August 17 (8):727-34. Epub 1900 01 01.
Naghashpour M, Rosenblatt MI, Dickerson IM, Dahl GP
Endocrinology.. 1997 October 138 (10):4207-14. Epub 1900 01 01.
Sarkar A, Dickerson IM
Journal of neurochemistry.. 1997 August 69 (2):455-64. Epub 1900 01 01.
Gómez-Saladín E, Luebke AE, Wilson DL, Dickerson IM
DNA and cell biology.. 1997 May 16 (5):663-9. Epub 1900 01 01.
Rosenblatt MI, Dickerson IM
Peptides.. 1997 18 (4):567-76. Epub 1900 01 01.
Luebke AE, Dahl GP, Roos BA, Dickerson IM
Proceedings of the National Academy of Sciences of the United States of America.. 1996 April 1693 (8):3455-60. Epub 1900 01 01.
Luebke AE, Dickerson IM, Muller KJ
Journal of neurobiology.. 1995 May 27 (1):1-14. Epub 1900 01 01.
Amin J, Dickerson IM, Weiss DS
Molecular pharmacology.. 1994 February 45 (2):317-23. Epub 1900 01 01.
Gómez-Saladín E, Wilson DL, Dickerson IM
Cellular and molecular neurobiology.. 1994 February 14 (1):9-25. Epub 1900 01 01.
Dickerson IM, Mains RE
Endocrinology.. 1990 July 127 (1):133-40. Epub 1900 01 01.
Andres DA, Dickerson IM, Dixon JE
The Journal of biological chemistry.. 1990 April 15265 (11):5952-5. Epub 1900 01 01.
Dickerson IM, Dixon JE, Mains RE
The Journal of biological chemistry.. 1990 February 15265 (5):2462-9. Epub 1900 01 01.
Cellular and molecular aspects of peptide hormone biosynthesis.
Mains RE; Dickerson IM; May V; Stoffers DA; Perkins SN; Ouafik L; Husten EJ; Eipper BA.
Frontiers in Neuroendocrinology. 1990; : 1-38.
Dickerson IM, Peden KW, Mains RE
Molecular and cellular endocrinology.. 1989 July 64 (2):205-12. Epub 1900 01 01.
Eipper BA, Park LP, Dickerson IM, Keutmann HT, Thiele EA, Rodriguez H, Schofield PR, Mains RE
Molecular endocrinology.. 1987 November 1 (11):777-90. Epub 1900 01 01.
Dickerson IM, Dixon JE, Mains RE
The Journal of biological chemistry.. 1987 October 5262 (28):13646-53. Epub 1900 01 01.
Books
The Calcitonin Gene-related Peptide Family: Form, Function & Future Perspective (2010)
Chapter: "The CGRP Receptor Component Protein: A Regulator for CLR Signaling"
Authors: Dickerson, I.M.
Publisher: Springer Science, New York 2010
The Calcitonin Gene-Related Peptide Family; Form, Function And Future Perspective (2009)
Chapter: "The CGRP Receptor Component Protein (RCP): A Regulator for CLR Signaling",
Authors: Dickerson, I.M.
Publisher: Springer 2009
Handbook of Neurochemistry and Molecular Neurobiology (2006)
Chapter: "CGRP: A Multifunctional Neuropeptide"
Authors: Russo, A.F.; Dickerson, I.M.
Publisher: Kluwer Academic/Plenum 2006
The CGRP family: calcitonin gene-related peptide (CGRP), amylin, and adrenomedul (2000)
Chapter: The CGRP-receptor component protein: A novel signal transduction protein.
Authors: M.I. Rosenblatt; B.N. Evans; M. Nagashpour; L.O. Mnayer; A.E. Luebke; G.P. Dahl; I.M.Dickerson
Publisher: Landes Bioscience, Georgetown, USA 2000
Peptide Biosynthesis and Processing (1991)
Chapter: Tissue-specificity of peptide processing.
Authors: Dickerson, I.M.; Noel, G.
Publisher: CRC Press, Boston, USA 1991
Neuropeptides and Their Receptors, Alfred Benzon Symposium 29 (1990)
Chapter: Probing the specificity of biosynthetic endoproteases with transfected cDNA for proNeuropeptide Y.
Authors: Dickerson, I.M., and R.E. Mains
Publisher: Munksgaard,Copenhagen 1990
Highlights on Endocrinologyed (1987)
Chapter: Cloning of cDNA Encoding Bovine Peptidyl-glycine a-Amidating Monooxygenase (PAM).
Authors: Park, L.P.; Thiele, E.A.; Dickerson, I.M.; R.E. Mains
Publisher: Norhaven Bogtrykkeri 1987