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Paul Spencer Brookes, Ph.D.

Paul Spencer Brookes, Ph.D.

Contact

Call Center (585) 276-3000

Research Lab

About Me

Faculty Appointments

Professor - Department of Anesthesiology and Perioperative Medicine, Research (SMD)

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Education

PhD | UK-Cambridge U Med Sch. Biochemistry. 1997

BS | UK - Non-Medical School. Biochemistry. 1993

Awards

Anthony Linnane Award for outstanding contribution to mitochondrial research. 2006 - 2006

Young Investigator Award. 1999

Research

Patents

Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use

Issue date: June 25, 2013

Patent #: 8,470,861

Country: United States

Inventors: Marion W Anders, Paul S Brookes, Leif Olson, Richard L Parton, James L Robotham, Shey-Shing Sheu, Jalai Shojaie

Publications

Journal Articles

Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions.

Tabata Fukushima C, Dancil IS, Clary H, Shah N, Nadtochiy SM, Brookes PS

Redox biology.. 2024 January 2770 :103047. Epub 01/27/2024.

Reactive Oxygen Species Generation by Reverse Electron Transfer at Mitochondrial Complex I Under Simulated Early Reperfusion Conditions.

Fukushima CT, Dancil IS, Clary H, Shah N, Nadtochiy SM, Brookes PS

bioRxiv : the preprint server for biology.. 2023 November 21 Epub 11/21/2023.

A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.

Faniyan TS, Zhang X, Morgan DA, Robles J, Bathina S, Brookes PS, Rahmouni K, Perry RJ, Chhabra KH

bioRxiv : the preprint server for biology.. 2023 September 5 Epub 09/05/2023.

Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.

Mia S, Sonkar R, Williams L, Latimer MN, Rawnsley DR, Rana S, He J, Dierickx P, Kim T, Xie M, Habegger KM, Kubo M, Zhou L, Thomsen MB, Prabhu SD, Frank SJ, Brookes PS, Lazar MA, Diwan A, Young ME

JACC. Basic to translational science.. 2023 September 8 (9):1141-1156. Epub 06/14/2023.

ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING.

Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2023 February 13 Epub 02/13/2023.

Distinct effects of intracellular vs. extracellular acidic pH on the cardiac metabolome during ischemia and reperfusion.

Milliken AS, Ciesla JH, Nadtochiy SM, Brookes PS

Journal of molecular and cellular cardiology.. 2022 December 5174 :101-114. Epub 12/05/2022.

Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites.

Paine A, Brookes PS, Bhattacharya S, Li D, Garcia-Hernandez ML, Tausk F, Ritchlin C

Arthritis & rheumatology.. 2022 July 11 Epub 07/11/2022.

Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.

Milliken AS, Nadtochiy SM, Brookes PS

Journal of the American Heart Association.. 2022 June 29 :e026135. Epub 06/29/2022.

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.

Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI

Redox biology.. 2021 September 2047 :102132. Epub 09/20/2021.

Metabolomics of aging in primary fibroblasts from small and large breed dogs.

Brookes PS, Jimenez AG

GeroScience.. 2021 June 16 Epub 06/16/2021.

Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.

Cohen ED, Yee M, Porter GA, Ritzer EE, McDavid AN, Brookes PS, Pryhuber GS, O'Reilly MA

JCI insight.. 2021 January 28 Epub 01/28/2021.

FNDC-1-Mediated Mitophagy and ATFS-1 Coordinate to Protect Against Hypoxia-Reoxygenation.

Lim Y, Berry B, Viteri S, McCall M, Park EC, Rongo C, Brookes PS, Nehrke K

Autophagy.. 2021 January 8 Epub 01/08/2021.

Modified Blue Native Gel Approach for Analysis of Respiratory Supercomplexes.

Nadtochiy SM, Ngai M, Brookes PS

Methods in molecular biology.. 2021 2276 :227-234. Epub 1900 01 01.

Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity.

Trippier PC, Huwaimel BI, Bhakta M, Kulkarni CA, Milliken AS, Wang F, Peng A, Brookes PS

ChemMedChem.. 2020 December 16 Epub 12/16/2020.

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.

Kulkarni CA, Nadtochiy SM, Kennedy L, Zhang J, Chhim S, Alwaseem H, Murphy E, Fu D, Brookes PS

eLife.. 2020 August 149 Epub 08/14/2020.

Amber Alert: Getting to the Heart of Succinate Efflux in Reperfusion Injury.

Milliken AS, Brookes PS

Cardiovascular research.. 2020 July 14 Epub 07/14/2020.

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.

Bennett JA, Mastrangelo MA, Ture SK, Smith CO, Loelius SG, Berg RA, Shi X, Burke RM, Spinelli SL, Cameron SJ, Carey TE, Brookes PS, Gerszten RE, Sabater-Lleal M, de Vries PS, Huffman JE, Smith NL, Morrell CN, Lowenstein CJ

Nature communications.. 2020 July 1311 (1):3479. Epub 07/13/2020.

Cardiac metabolism as a driver and therapeutic target of myocardial infarction.

Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T

Journal of cellular and molecular medicine.. 2020 May 8 Epub 05/08/2020.

Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes.

Chapa-Dubocq XR, Rodríguez-Graciani KM, Guzmán-Hernández RA, Jang S, Brookes PS, Javadov S

International journal of molecular sciences.. 2020 February 2521 (5)Epub 02/25/2020.

Swapping mitochondria: A key to understanding susceptibility to neonatal chronic lung disease.

Dylag AM, Brookes PS, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2019 October 9 Epub 10/09/2019.

Fndc-1 contributes to paternal mitochondria elimination in C. elegans.

Lim Y, Rubio-Peña K, Sobraske PJ, Molina PA, Brookes PS, Galy V, Nehrke K

Developmental biology.. 2019 October 1454 (1):15-20. Epub 06/21/2019.

Cellular Compartmentation and the Redox/Nonredox Functions of NAD.

Kulkarni CA, Brookes PS

Antioxidants & redox signaling.. 2019 September 2031 (9):623-642. Epub 03/26/2019.

Early life exposures shape the CD4 T cell transcriptome, influencing proliferation, differentiation, and mitochondrial dynamics later in life.

Burke CG, Myers JR, Boule LA, Post CM, Brookes PS, Lawrence BP

Scientific reports.. 2019 August 79 (1):11489. Epub 08/07/2019.

Cardioprotection by the mitochondrial unfolded protein response requires ATF5.

Wang YT, Lim Y, McCall MN, Huang KT, Haynes CM, Nehrke K, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2019 August 1317 (2):H472-H478. Epub 07/05/2019.

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS

Journal of molecular and cellular cardiology.. 2018 August 121 :155-162. Epub 06/26/2018.

Cardiac metabolic effects of K1.2 channel deletion and evidence for its mitochondrial localization.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 June 4 :fj201800139R. Epub 06/04/2018.

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.

Zhang J, Wang YT, Miller JH, Day MM, Munger JC, Brookes PS

Cell reports.. 2018 May 2923 (9):2617-2628. Epub 1900 01 01.

Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.

Peoples JNR, Maxmillian T, Le Q, Nadtochiy SM, Brookes PS, Porter GA, Davidson VL, Ebert SN

The Journal of biological chemistry.. 2018 May 4293 (18):6925-6941. Epub 03/14/2018.

Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice.

Sahni PV, Zhang J, Sosunov S, Galkin A, Niatsetskaya Z, Starkov A, Brookes PS, Ten VS

Pediatric research.. 2018 February 83 (2):491-497. Epub 12/06/2017.

Metabolism: A Direct Link Between Cardiac Structure and Function.

Brookes PS, Taegtmeyer H

Circulation.. 2017 November 28136 (22):2158-2161. Epub 1900 01 01.

Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS

The Biochemical journal.. 2017 August 10474 (16):2829-2839. Epub 08/10/2017.

Synthesis and Antineoplastic Evaluation of Mitochondrial Complex?II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin?A5.

Wang H, Huwaimel B, Verma K, Miller J, Germain TM, Kinarivala N, Pappas D, Brookes PS, Trippier PC

ChemMedChem.. 2017 July 612 (13):1033-1044. Epub 06/12/2017.

The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.

Smith CO, Nehrke K, Brookes PS

The Biochemical journal.. 2017 June 9474 (12):2067-2094. Epub 06/09/2017.

SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.

Resseguie EA, Brookes PS, O'Reilly MA

Experimental lung research.. 2017 43 (6-7):229-239. Epub 07/27/2017.

Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK

Cell metabolism.. 2016 October 1124 (4):582-592. Epub 09/22/2016.

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS

The Journal of biological chemistry.. 2016 September 16291 (38):20188-97. Epub 08/10/2016.

Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K

Anesthesiology.. 2016 May 124 (5):1065-76. Epub 1900 01 01.

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.

Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T

Circulation research.. 2016 March 4118 (5):898-906. Epub 1900 01 01.

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC

Journal of cardiovascular pharmacology and therapeutics.. 2016 March 21 (2):177-86. Epub 06/30/2015.

The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy.

Zhang J, Nadtochiy SM, Urciuoli WR, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2016 January 1310 (1):H29-38. Epub 10/30/2015.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM, Doran KS, D'Orazi G, Dorn GW, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe KI, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, 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Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.

Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA

Redox biology.. 2015 August 5 :176-85. Epub 05/02/2015.

Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.

Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Maggirwar SB, Bernstein SH

Experimental hematology.. 2015 February 43 (2):89-99. Epub 10/22/2014.

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Chouchani ET, Pell VR, Gaude E, Aksentijevi? D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord EN, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa AS, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP

Nature.. 2014 November 20515 (7527):431-435. Epub 11/05/2014.

DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells.

Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O'Reilly MA

Free radical biology & medicine.. 2014 October 75 :30-9. Epub 07/15/2014.

Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease.

Galloway CA, Lee H, Brookes PS, Yoon Y

American journal of physiology. Gastrointestinal and liver physiology.. 2014 September 15307 (6):G632-41. Epub 07/31/2014.

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.

Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM

American journal of physiology. Heart and circulatory physiology.. 2014 June 15306 (12):H1602-9. Epub 04/18/2014.

Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection.

Nadtochiy SM, Madukwe J, Hagen F, Brookes PS

British journal of pharmacology.. 2014 April 171 (8):2091-8. Epub 1900 01 01.

Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.

Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2013 June 1304 (11):H1439-45. Epub 04/12/2013.

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS

Biochimica et biophysica acta.. 2013 May 1827 (5):598-611. Epub 01/02/2013.

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.

Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT

Cell stem cell.. 2013 March 712 (3):329-41. Epub 01/17/2013.

Role of p90(RSK) in regulating the Crabtree effect: implications for cancer.

Redman EK, Brookes PS, Karcz MK

Biochemical Society transactions.. 2013 February 141 (1):124-6. Epub 1900 01 01.

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS

PeerJ.. 2013 1 :e48. Epub 03/05/2013.

Mitochondria as a drug target in ischemic heart disease and cardiomyopathy.

Walters AM, Porter GA, Brookes PS

Circulation research.. 2012 October 12111 (9):1222-36. Epub 1900 01 01.

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.

Bernstein SH, Venkatesh S, Li M, Lee J, Lu B, Hilchey SP, Morse KM, Metcalfe HM, Skalska J, Andreeff M, Brookes PS, Suzuki CK

Blood.. 2012 April 5119 (14):3321-9. Epub 02/08/2012.

A cell-based phenotypic assay to identify cardioprotective agents.

Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS

Circulation research.. 2012 March 30110 (7):948-57. Epub 03/06/2012.

Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.

Wojtovich AP, Distefano P, Sherman T, Brookes PS, Nehrke K

FEBS letters.. 2012 February 17586 (4):428-34. Epub 01/21/2012.

Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.

Nadtochiy SM, Zhu QM, Zhu Q, Urciuoli W, Rafikov R, Black SM, Brookes PS

The Journal of biological chemistry.. 2012 January 27287 (5):3573-80. Epub 12/09/2011.

Ischemic preconditioning: the role of mitochondria and aging.

Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K

Experimental gerontology.. 2012 January 47 (1):1-7. Epub 11/10/2011.

SIRT1-mediated acute cardioprotection.

Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente LP, Rahman I, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2011 October 301 (4):H1506-12. Epub 08/19/2011.

p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X, Yan C, Nadtochiy SM, Abe JI, Brookes PS, Berk BC

Journal of molecular and cellular cardiology.. 2011 August 51 (2):272-5. Epub 05/14/2011.

Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.

Nadtochiy SM, Redman E, Rahman I, Brookes PS

Cardiovascular research.. 2011 February 1589 (3):643-9. Epub 09/07/2010.

The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction.

Ding B, Gibbs PE, Brookes PS, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2011 January 25 (1):301-13. Epub 09/27/2010.

SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.

Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K

PloS one.. 2011 6 (12):e28287. Epub 12/01/2011.

An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays.

Gunter TE, Gerstner B, Lester T, Wojtovich AP, Malecki J, Swarts SG, Brookes PS, Gavin CE, Gunter KK

Toxicology and applied pharmacology.. 2010 November 15249 (1):65-75. Epub 08/26/2010.

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress.

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 September 24 (9):3145-59. Epub 04/12/2010.

A novel mitochondrial K(ATP) channel assay.

Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS

Circulation research.. 2010 April 16106 (7):1190-6. Epub 02/25/2010.

Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria.

Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, Anders MW

Bioorganic & medicinal chemistry.. 2010 February 1518 (4):1441-8. Epub 01/15/2010.

The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.

Wojtovich AP, Nehrke KW, Brookes PS

Acta biochimica Polonica. 2010 57 (4):431-4. Epub 11/19/2010.

Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

Skalska J, Brookes PS, Nadtochiy SM, Hilchey SP, Jordan CT, Guzman ML, Maggirwar SB, Briehl MM, Bernstein SH

PloS one.. 2009 December 24 (12):e8115. Epub 12/02/2009.

Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.

Hoffman DL, Brookes PS

The Journal of biological chemistry.. 2009 June 12284 (24):16236-45. Epub 04/14/2009.

Cardioprotection by metabolic shut-down and gradual wake-up.

Burwell LS, Nadtochiy SM, Brookes PS

Journal of molecular and cellular cardiology.. 2009 June 46 (6):804-10. Epub 03/10/2009.

In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine.

Nadtochiy SM, Burwell LS, Ingraham CA, Spencer CM, Friedman AE, Pinkert CA, Brookes PS

Journal of molecular and cellular cardiology.. 2009 June 46 (6):960-8. Epub 02/03/2009.

NDUFS4: creation of a mouse model mimicking a Complex I disorder.

Ingraham CA, Burwell LS, Skalska J, Brookes PS, Howell RL, Sheu SS, Pinkert CA

Mitochondrion.. 2009 June 9 (3):204-10. Epub 02/11/2009.

Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection.

Nadtochiy SM, Baker PR, Freeman BA, Brookes PS

Cardiovascular research.. 2009 May 182 (2):333-40. Epub 12/02/2008.

The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.

Wojtovich AP, Brookes PS

Basic research in cardiology.. 2009 March 104 (2):121-9. Epub 02/26/2009.

The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning.

Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS

Biochemical and biophysical research communications.. 2008 November 21376 (3):625-8. Epub 09/20/2008.

Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury.

Burwell LS, Brookes PS

Antioxidants & redox signaling.. 2008 March 10 (3):579-99. Epub 1900 01 01.

Purine release: a protective signaling mechanism of the mitochondrial permeability transition pore in ischemia.

Nadtochiy SM, Nauduri D, Shimanskaya TV, Sagach VF, Brookes PS

Fiziolohichny? zhurnal.. 2008 54 (6):5-14. Epub 1900 01 01.

Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury.

Nadtochiy SM, Burwell LS, Brookes PS

Journal of molecular and cellular cardiology.. 2007 April 42 (4):812-25. Epub 01/31/2007.

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore.

Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH

Cancer research.. 2007 February 1567 (4):1793-802. Epub 1900 01 01.

Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling.

Hoffman DL, Salter JD, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2007 January 292 (1):H101-8. Epub 09/08/2006.

A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress".

Brookes PS, Freeman RS, Barone MC

Free radical biology & medicine.. 2006 July 141 (1):41-5. Epub 04/01/2006.

Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection.

Nadtochiy SM, Tompkins AJ, Brookes PS

The Biochemical journal.. 2006 May 1395 (3):611-8. Epub 1900 01 01.

Direct evidence for S-nitrosation of mitochondrial complex I.

Burwell LS, Nadtochiy SM, Tompkins AJ, Young S, Brookes PS

The Biochemical journal.. 2006 March 15394 (Pt 3):627-34. Epub 1900 01 01.

Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition.

Tompkins AJ, Burwell LS, Digerness SB, Zaragoza C, Holman WL, Brookes PS

Biochimica et biophysica acta.. 2006 February 1762 (2):223-31. Epub 10/21/2005.

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.

Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ

The Biochemical journal.. 2005 December 1392 (Pt 2):353-62. Epub 1900 01 01.

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.

Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, Abe J

The Journal of biological chemistry.. 2005 July 15280 (28):26383-96. Epub 04/26/2005.

Mitochondrial H(+) leak and ROS generation: an odd couple.

Brookes PS

Free radical biology & medicine.. 2005 January 138 (1):12-23. Epub 1900 01 01.

Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS

American journal of physiology. Cell physiology.. 2004 October 287 (4):C817-33. Epub 1900 01 01.

Mechanisms of the interaction of nitroxyl with mitochondria.

Shiva S, Crawford JH, Ramachandran A, Ceaser EK, Hillson T, Brookes PS, Patel RP, Darley-Usmar VM

The Biochemical journal.. 2004 April 15379 (Pt 2):359-66. Epub 1900 01 01.

Mitochondrial nitric oxide synthase.

Brookes PS

Mitochondrion.. 2004 March 3 (4):187-204. Epub 1900 01 01.

Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition.

Brookes PS, Darley-Usmar VM

American journal of physiology. Heart and circulatory physiology.. 2004 January 286 (1):H39-46. Epub 08/21/2003.

Redox signalling: from nitric oxide to oxidized lipids.

Shiva S, Moellering D, Ramachandran A, Levonen AL, Landar A, Venkatraman A, Ceaser E, Ulasova E, Crawford JH, Brookes PS, Patel RP, Darley-Usmar VM

Biochemical Society symposium. 2004 (71):107-20. Epub 1900 01 01.

Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion.

Davies JE, Digerness SB, Goldberg SP, Killingsworth CR, Katholi CR, Brookes PS, Holman WL

The Annals of thoracic surgery.. 2003 October 76 (4):1252-8; discussion 1258. Epub 1900 01 01.

Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state.

Brookes PS, Kraus DW, Shiva S, Doeller JE, Barone MC, Patel RP, Lancaster JR, Darley-Usmar V

The Journal of biological chemistry.. 2003 August 22278 (34):31603-9. Epub 06/04/2003.

Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide.

Barone MC, Darley-Usmar VM, Brookes PS

The Journal of biological chemistry.. 2003 July 25278 (30):27520-4. Epub 05/12/2003.

Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.

Venkatraman A, Shiva S, Davis AJ, Bailey SM, Brookes PS, Darley-Usmar VM

Hepatology : official journal of the American Association for the Study of Liver Diseases.. 2003 July 38 (1):141-7. Epub 1900 01 01.

Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury.

Digerness SB, Brookes PS, Goldberg SP, Katholi CR, Holman WL

The Journal of thoracic and cardiovascular surgery.. 2003 April 125 (4):863-71. Epub 1900 01 01.

Mitochondria, nitric oxide, and cardiovascular dysfunction.

Ramachandran A, Levonen AL, Brookes PS, Ceaser E, Shiva S, Barone MC, Darley-Usmar V

Free radical biology & medicine.. 2002 December 133 (11):1465-74. Epub 1900 01 01.

Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species.

Cooper CE, Patel RP, Brookes PS, Darley-Usmar VM

Trends in biochemical sciences.. 2002 October 27 (10):489-92. Epub 1900 01 01.

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.

Brookes PS, Levonen AL, Shiva S, Sarti P, Darley-Usmar VM

Free radical biology & medicine.. 2002 September 1533 (6):755-64. Epub 1900 01 01.

High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes.

Brookes PS, Pinner A, Ramachandran A, Coward L, Barnes S, Kim H, Darley-Usmar VM

Proteomics.. 2002 August 2 (8):969-77. Epub 1900 01 01.

Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin.

Brookes PS, Digerness SB, Parks DA, Darley-Usmar V

Free radical biology & medicine.. 2002 June 132 (11):1220-8. Epub 1900 01 01.

Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.

Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP

The Journal of biological chemistry.. 2002 May 10277 (19):17048-56. Epub 02/22/2002.

Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide.

Brookes PS, Shiva S, Patel RP, Darley-Usmar VM

Methods in enzymology.. 2002 359 :305-19. Epub 1900 01 01.

Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO*.

Dai L, Brookes PS, Darley-Usmar VM, Anderson PG

American journal of physiology. Heart and circulatory physiology.. 2001 December 281 (6):H2261-9. Epub 1900 01 01.

Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase.

Shiva S, Brookes PS, Patel RP, Anderson PG, Darley-Usmar VM

Proceedings of the National Academy of Sciences of the United States of America.. 2001 June 1998 (13):7212-7. Epub 1900 01 01.

Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy.

Brookes PS, Zhang J, Dai L, Zhou F, Parks DA, Darley-Usmar VM, Anderson PG

Journal of molecular and cellular cardiology.. 2001 January 33 (1):69-82. Epub 1900 01 01.

Mechanisms of cell signaling by nitric oxide and peroxynitrite: implications for the modulation of cellular oxidative and nitrosative stress

Levonen, A-L; Patel, RP; Brookes, P; Go, Y-M; Jo, H; Parthasarathy, S; Darley-Usmar, VM.

Antiox. Redox Signaling. (review). 2001; 3: 215-229.

Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release.

Brookes PS, Salinas EP, Darley-Usmar K, Eiserich JP, Freeman BA, Darley-Usmar VM, Anderson PG

The Journal of biological chemistry.. 2000 July 7275 (27):20474-9. Epub 1900 01 01.

The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct.

Brookes PS, Bolaños JP, Heales SJ

FEBS letters.. 1999 March 12446 (2-3):261-3. Epub 1900 01 01.

Nitric oxide, mitochondria and neurological disease.

Heales SJ, Bolaños JP, Stewart VC, Brookes PS, Land JM, Clark JB

Biochimica et biophysica acta.. 1999 February 91410 (2):215-28. Epub 1900 01 01.

Peroxynitrite and brain mitochondria: evidence for increased proton leak.

Brookes PS, Land JM, Clark JB, Heales SJ

Journal of neurochemistry.. 1998 May 70 (5):2195-202. Epub 1900 01 01.

The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition.

Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.. 1998 February 119 (2):325-34. Epub 1900 01 01.

Depression of liver mitochondrial complex II-linked respiration following cooling: beneficial effects of using a prostacyclin analogue during hypothermia

Changani, KK; Bell, JD; Brooks, KJ; Fuller, BJ; Taylor-Robinson, SD; Davidson, BR; Brookes, PS; Bates, TE.

Cryo-Letters. 1998; 19: 71-78.

The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: no effect of fatty acid composition.

Brookes PS, Hulbert AJ, Brand MD

Biochimica et biophysica acta.. 1997 December 41330 (2):157-64. Epub 1900 01 01.

Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin.

Brookes PS, Land JM, Clark JB, Heales SJ

FEBS letters.. 1997 October 13416 (1):90-2. Epub 1900 01 01.

The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: comparison with isolated mitochondria.

Brookes PS, Rolfe DF, Brand MD

The Journal of membrane biology.. 1997 January 15155 (2):167-74. Epub 1900 01 01.

Books

Free Radical Effects on Membranes (2008)

Chapter: The interaction of mitochondrial membranes with reactive oxygen and nitrogen species

Authors: Brookes PS, Wojtovich AP, Burwell LS, Hoffman DL, Nadtochiy SM

Publisher: Elsevier, NY 2008

Oxidative Stress in Aging: From Model Systems to Human Diseases (2008)

Chapter: Aging & Cardiac Ischemia: Mitochondrial Free Radical Considerations

Authors: Brookes PS, Hoffman DL

Publisher: Springer Verlag, NY 2008

Mitochondria - Methods in Cell Biology Series (2006)

Chapter: Methods for measuring the regulation of respiration by nitric oxide

Authors: Shiva, S; Brookes, PS; Darley-Usmar, VM

Publisher: Press/Elsevier, San Diego 2006

"Handbook of Neurochemistry and Molecular Neurobiology" "Brain Energy Metabolis (2005)

Chapter: Mitochondrial production of oxidants and their role in the regulation of cellular processes

Authors: Brookes, PS

Publisher: New York, Kluwer 2005

Free Radicals in Chemistry, Biology and Medicine (2000)

Chapter: Cytoprotective mechanisms of nitric oxide: the role of cell signaling

Authors: Brookes, PS; Patel, RP; Levonen, A-L; Shiva, S; Moellering, D; Anderson, PG; Jo, H; Darley-Usmar, VM

Publisher: OICA International, London, UK 2000

Biothermokinetics of the living cell (1996)

Chapter: Proton leak of mitochondrial inner membrane phospholipid liposomes

Authors: Brookes, PS; Rolfe, DFS; Brand, MD

Publisher: BTK Press, Amsterdam, NL 1996