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Maiken Nedergaard, M.D., D.M.Sc.

Maiken Nedergaard, M.D., D.M.Sc.

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About Me

Faculty Appointments

Professor (Part-Time) - Department of Neurology, Center for Translational Neuromedicine (SMD)

Co-Director - Department of Neurology, Center for Translational Neuromedicine (SMD)

Professor (Part-Time) - Department of Neurosurgery (SMD) - Joint

Connect with Maiken Nedergaard, M.D., D.M.Sc.

Credentials

Residency & Fellowship

Post-Doctoral Training;
Neuroscience;
Cornell University Medical School 1987 - 1988

Post-Doctoral Training;
Neuropathology / Physiology
University of Copenhagen 1984 - 1987

Rigshospitalet;
University of Copenhagen;
Neurology / Neurosurgery 1983 - 1984

Education

DMSc | University of Copenhagen. Neuroscience. 1988

MD | University of Copenhagen. Medicine. 1983

Awards

Research to Prevent Blindness Stein Innovation Award. 2018 - 2019

China Medical University, Shenyang, China, Honorary Professorship. 2018

Jeppe Juhl Prize. 2016

Tagea Brandt Prize. 2016

Olav Thon Alzheimer Prize. 2016

Alzheimer Prize. 2015

Newcomb Cleveland Prize. 2015

1 of 10 most important science discoveries. 2013

Elected Member Academia Europaea. 2012

Elected Member Royal Academy of Pharmacy of Spain. 2011

Elected Member of the Royal Danish Academy of Sciences. 2008

Research

Patents

Adenosine as a Therapeutic Tool to Improve the Efficacy of Deep Brain Stimulation

Issue date: October 01, 2014

Patent #: 2180916

Country: Europe

Inventors: Maiken Nedergaard

Adenosine and Its Mimetics, Modulators, Transport Inhibitors, and Receptor Agonists as a Therapeutic Tool to Replace or Improve the Efficacy of Deep Brain Stimulation

Issue date: October 01, 2014

Patent #: DE2180916

Country: Germany

Inventors: Maiken Nedergaard

Adenosine and Its Mimetics, Modulators, Transport Inhibitors, and Receptor Agonists as a Therapeutic Tool to Replace or Improve the Efficacy of Deep Brain Stimulation

Issue date: October 01, 2014

Patent #: GB2180916

Country: United Kingdom

Inventors: Maiken Nedergaard

Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors

Issue date: November 13, 2019

Patent #: 2887806

Country: Europe

Inventors: Maiken Nedergaard, Vinita Rangroo Thrane, Alexander Stanley Thrane

Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors

Issue date: April 11, 2017

Patent #: 9,616,075

Country: United States

Inventors: Maiken Nedergaard, Vinita Rangroo Thrane, Alexander Stanley Thrane

Methods for Evaluating Brain-Wide Paravascular Pathway for Waste Clearance Function and Methods for Treating Neurodegenerative Disorders Based Thereon

Issue date: August 10, 2018

Patent #: 6382232

Country: Japan

Inventors: Helene Benveniste, Rashid Deane, Jeffrey J Iliff, Maiken Nedergaard

Methods for Evaluating Brain-Wide Paravascular Pathway for Waste Clearance Function and Methods for Treating Neurodegenerative Disorders Based Thereon

Issue date: February 27, 2018

Patent #: 9,901,650

Country: United States

Inventors: Helene Benveniste, Rashid Deane, Jeffrey J Iliff, Maiken Nedergaard

Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors

Issue date: November 13, 2019

Patent #: FR2887806

Country: France

Inventors: Maiken Nedergaard, Vinita Rangroo Thrane, Alexander Stanley Thrane

Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors

Issue date: November 13, 2019

Patent #: DE2887806

Country: Germany

Inventors: Maiken Nedergaard, Vinita Rangroo Thrane, Alexander Stanley Thrane

Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors

Issue date: November 13, 2019

Patent #: GB2887806

Country: United Kingdom

Inventors: Maiken Nedergaard, Vinita Rangroo Thrane, Alexander Stanley Thrane

Publications

Journal Articles

Astrocyte chloride, excitatory-inhibitory balance and epilepsy.

Untiet V, Nedergaard M, Verkhratsky A

Neural regeneration research.. 2024 September 119 (9):1887. Epub 12/15/2023.

In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.".

Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K

Fluids and barriers of the CNS.. 2024 June 321 (1):49. Epub 06/03/2024.

Mouse Brain Elastography Changes with Sleep/Wake Cycles, Aging, and Alzheimer's Disease.

Ge GR, Song W, Giannetto MJ, Rolland JP, Nedergaard M, Parker KJ

NeuroImage.. 2024 May 30 :120662. Epub 05/30/2024.

Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.

Persson NDÅ, Lohela TJ, Mortensen KN, Rosenholm M, Li Q, Weikop P, Nedergaard M, Lilius TO

Anesthesiology.. 2024 May 24 Epub 05/24/2024.

Mapping glymphatic solute transportation through the perivascular space of hippocampal arterioles with 14 Tesla MRI.

Zhou XA, Man W, Liu X, Choi S, Jiang Y, Hike D, Cid LG, Lin C, Nedergaard M, Yu X

bioRxiv : the preprint server for biology.. 2024 May 20 Epub 05/20/2024.

Enlargement of Perivascular Spaces as a Downstream Consequence of Spaceflight Analog-Induced Alterations in Cerebral Venous Hemodynamics.

Mader TH, Gibson CR, Wostyn P, Nedergaard M

AJNR. American journal of neuroradiology.. 2024 May 945 (5):E6. Epub 05/09/2024.

A new look at ocular glymphatic transport in space.

Wostyn P, Nedergaard M

Journal of applied physiology.. 2024 May 1136 (5):1129-1130. Epub 1900 01 01.

Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice.

Deng S, Hu Y, Chen S, Xue Y, Yao D, Sun Q, Nedergaard M, Wang W, Ding F

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2024 April 19 :271678X241230188. Epub 04/19/2024.

Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood.

van Osch MJP, Wåhlin A, Scheyhing P, Mossige I, Hirschler L, Eklund A, Mogensen K, Gomolka R, Radbruch A, Qvarlander S, Decker A, Nedergaard M, Mori Y, Eide PK, Deike K, Ringstad G

NMR in biomedicine.. 2024 April 18 :e5159. Epub 04/18/2024.

Modeling of brain efflux: Constraints of brain surfaces.

Bork PAR, Hauglund NL, Mori Y, Møllgård K, Hjorth PG, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2024 April 16121 (16):e2318444121. Epub 04/10/2024.

Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.

Beinlich FRM, Asiminas A, Untiet V, Bojarowska Z, Plá V, Sigurdsson B, Timmel V, Gehrig L, Graber MH, Hirase H, Nedergaard M

Science.. 2024 March 29383 (6690):1471-1478. Epub 03/28/2024.

Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.

Delle C, Wang X, Giannetto M, Newbold E, Peng W, Gomolka RS, Ladrón-de-Guevara A, Cankar N, Schiøler Nielsen E, Kjaerby C, Weikop P, Mori Y, Nedergaard M

Fluids and barriers of the CNS.. 2024 March 1221 (1):26. Epub 03/12/2024.

Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.

Ding F, Sun Q, Long C, Rasmussen RN, Peng S, Xu Q, Kang N, Song W, Weikop P, Goldman SA, Nedergaard M

Brain : a journal of neurology.. 2024 March 11 Epub 03/11/2024.

Synchronized neuronal activity drives waste fluid flow.

Hablitz L, Nedergaard M

Nature.. 2024 February 28 Epub 02/28/2024.

Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.

Giannetto MJ, Gomolka RS, Gahn-Martinez D, Newbold EJ, Bork PAR, Chang E, Gresser M, Thompson T, Mori Y, Nedergaard M

Glia.. 2024 February 16 Epub 02/16/2024.

Glymphatic system dysfunction in neurodegenerative diseases.

Beschorner N, Nedergaard M

Current opinion in neurology.. 2024 February 13 Epub 02/13/2024.

THE GLYMPHATIC SYSTEM AND AMYOTROPHIC LATERAL SCLEROSIS.

Eisen A, Nedergaard M, Gray E, Kiernan MC

Progress in neurobiology.. 2024 January 22 :102571. Epub 01/22/2024.

Managing noradrenaline after traumatic brain injury.

Hussain R, Nedergaard M

Clinical and translational medicine.. 2024 January 14 (1):e1562. Epub 1900 01 01.

Structural characterization of SLYM-a 4th meningeal membrane.

Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K

Fluids and barriers of the CNS.. 2023 December 1420 (1):93. Epub 12/14/2023.

Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.

Hussain R, Tithof J, Wang W, Cheetham-West A, Song W, Peng W, Sigurdsson B, Kim D, Sun Q, Peng S, Plá V, Kelley DH, Hirase H, Castorena-Gonzalez JA, Weikop P, Goldman SA, Davis MJ, Nedergaard M

Nature.. 2023 November 15 Epub 11/15/2023.

Corrigendum: Theory of sleep/wake cycles affecting brain elastography (2022225013).

Ge GR, Song W, Nedergaard M, Rolland JP, Parker KJ

Physics in medicine and biology.. 2023 November 268 (21)Epub 11/02/2023.

Structural characterization of SLYM - a 4th meningeal membrane.

Plá V, Bitsika S, Giannetto M, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K

Research square.. 2023 October 31 Epub 10/31/2023.

Structural characterization of SLYM - a 4 meningeal membrane.

Plá V, Bitsika S, Giannetto M, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K

bioRxiv : the preprint server for biology.. 2023 October 28 Epub 10/28/2023.

Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging.

Nature communications.. 2023 October 2714 (1):6598. Epub 10/27/2023.

Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging.

Esmail T, Nedergaard M, Beinlich FRM

STAR protocols.. 2023 October 254 (4):102652. Epub 10/25/2023.

Age- and glaucoma-induced changes to the ocular glymphatic system.

Wang X, Delle C, Peng W, Plá V, Giannetto M, Kusk P, Sigurdsson B, Sakurai S, Sweeney A, Sun Q, Du T, Libby RT, Nedergaard M

Neurobiology of disease.. 2023 October 11 :106322. Epub 10/11/2023.

Local extracellular K in cortex regulates norepinephrine levels, network state, and behavioral output.

Dietz AG, Weikop P, Hauglund N, Andersen M, Petersen NC, Rose L, Hirase H, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2023 October 3120 (40):e2305071120. Epub 09/29/2023.

Air pollution, glymphatic impairment, and Alzheimer's disease.

Hussain R, Graham U, Elder A, Nedergaard M

Trends in neurosciences.. 2023 September 28 Epub 09/28/2023.

Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.

Holstein-Rønsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M

Nature neuroscience.. 2023 September 4 Epub 09/04/2023.

Astrocytic GPCR-Induced Ca Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.

Ozawa K, Nagao M, Konno A, Iwai Y, Vittani M, Kusk P, Mishima T, Hirai H, Nedergaard M, Hirase H

International journal of molecular sciences.. 2023 September 224 (17)Epub 09/02/2023.

Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.

Gan Y, Holstein-Rønsbo S, Nedergaard M, Boster KAS, Thomas JH, Kelley DH

Journal of the Royal Society, Interface. 2023 September 20 (206):20230288. Epub 09/20/2023.

Development of C-labeled CRANAD-102 for positron emission tomography imaging of soluble A?-species.

Staudt M, Shalgunov V, Nedergaard M, Herth MM

Journal of labelled compounds & radiopharmaceuticals.. 2023 August 31 Epub 08/31/2023.

Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.

Andersen M, Tsopanidou A, Radovanovic T, Compere VN, Hauglund N, Nedergaard M, Kjaerby C

Bio-protocol.. 2023 August 513 (15):e4734. Epub 08/05/2023.

Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.

Kim D, Gan Y, Nedergaard M, Kelley DH, Tithof J

bioRxiv : the preprint server for biology.. 2023 July 24 Epub 07/24/2023.

The state of brain activity modulates cerebrospinal fluid transport.

Miyakoshi LM, Stæger FF, Li Q, Pan C, Xie L, Kang H, Pavan C, Dang J, Sun Q, Ertürk A, Nedergaard M

Progress in neurobiology.. 2023 July 21 :102512. Epub 07/21/2023.

Sizes and shapes of perivascular spaces surrounding murine pial arteries.

Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K

Fluids and barriers of the CNS.. 2023 July 1720 (1):56. Epub 07/17/2023.

Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.

Vittani M, Knak PAG, Fukuda M, Nagao M, Wang X, Kjaerby C, Konno A, Hirai H, Nedergaard M, Hirase H

bioRxiv : the preprint server for biology.. 2023 July 10 Epub 07/10/2023.

Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.

Bork PAR, Ladrón-de-Guevara A, Christensen AH, Jensen KH, Nedergaard M, Bohr T

Journal of the Royal Society, Interface. 2023 July 20 (204):20230050. Epub 07/12/2023.

Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.

Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B

Science translational medicine.. 2023 June 2815 (702):eabq3916. Epub 06/28/2023.

Glymphatic influx and clearance are accelerated by neurovascular coupling.

Holstein-Rønsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M

Nature neuroscience.. 2023 June 26 (6):1042-1053. Epub 06/01/2023.

Beyond the Symptom: The Biology of Fatigue.

Raizen DM, Mullington J, Anaclet C, Clarke G, Critchley H, Dantzer R, Davis R, Drew KL, Fessel J, Fuller PM, Gibson EM, Harrington M, Lipkin WI, Klerman EB, Klimas N, Komaroff AL, Koroshetz W, Krupp L, Kuppuswamy A, Lasselin J, Lewis LD, Magistretti PJ, Matos HY, Miaskowski C, Miller AH, Nath A, Nedergaard M, Opp MR, Ritchie MD, Rogulja D, Rolls A, Salamone JD, Saper C, Whittemore V, Wylie G, Younger J, Zee PC, Heller HC

Sleep.. 2023 May 24 Epub 05/24/2023.

Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.

Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Carare RO, Wells J, Bakker ENTP, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJP

Journal of magnetic resonance imaging : JMRI.. 2023 May 4 Epub 05/04/2023.

Reply to: 'Do all norepinephrine surges disrupt sleep?'.

Kjaerby C, Andersen M, Hauglund N, Untiet V, Dall C, Ding F, Hirase H, Nedergaard M

Nature neuroscience.. 2023 April 20 Epub 04/20/2023.

Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.

Boster KAS, Cai S, Ladrón-de-Guevara A, Sun J, Zheng X, Du T, Thomas JH, Nedergaard M, Karniadakis GE, Kelley DH

Proceedings of the National Academy of Sciences of the United States of America.. 2023 April 4120 (14):e2217744120. Epub 03/29/2023.

Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.

Untiet V, Beinlich FRM, Kusk P, Kang N, Ladrón-de-Guevara A, Song W, Kjaerby C, Andersen M, Hauglund N, Bojarowska Z, Sigurdsson B, Deng S, Hirase H, Petersen NC, Verkhratsky A, Nedergaard M

Nature communications.. 2023 April 414 (1):1871. Epub 04/04/2023.

Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model.

Parka A, Volbracht C, Hall B, Bastlund JF, Nedergaard M, Laursen B, Botta P, Sotty F

Journal of Alzheimer's disease : JAD.. 2023 March 31 Epub 03/31/2023.

Fluid compartments influence elastography of the aging mouse brain.

Ge GR, Rolland JP, Song W, Nedergaard M, Parker KJ

Physics in medicine and biology.. 2023 March 30 Epub 03/30/2023.

Pretargeted imaging beyond the blood-brain barrier.

Shalgunov V, Lopes van den Broek S, Vang Andersen I, García Vázquez R, Raval NR, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, Moos Knudsen G, Battisti UM, Herth MM

RSC medicinal chemistry.. 2023 March 2214 (3):444-453. Epub 12/02/2022.

Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice.

Delle C, Cankar N, Digebjerg Holgersson C, Hvorup Knudsen H, Schiøler Nielsen E, Kjaerby C, Mori Y, Nedergaard M, Weikop P

Scientific reports.. 2023 March 1313 (1):4137. Epub 03/13/2023.

A SPECT-based method for dynamic imaging of the glymphatic system in rats.

Sigurdsson B, Hauglund NL, Lilius TO, Mogensen FL, Mortensen KN, Beschorner N, Klinger L, Bærentzen SL, Rosenholm MP, Shalgunov V, Herth M, Mori Y, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2023 February 21 :271678X231156982. Epub 02/21/2023.

Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.

Raicevic N, Forer JM, Ladron-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster KAS

Research square.. 2023 February 17 Epub 02/17/2023.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.

Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y

eLife.. 2023 February 912 Epub 02/09/2023.

Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles.

Lilius TO, Mortensen KN, Deville C, Lohela TJ, Stæger FF, Sigurdsson B, Fiordaliso EM, Rosenholm M, Kamphuis C, Beekman FJ, Jensen AI, Nedergaard M

Journal of controlled release : official journal of the Controlled Release Society.. 2023 January 30 Epub 01/30/2023.

Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model.

Parka A, Degel C, Dreyer J, Richter U, Hall B, Bastlund JF, Laursen B, Nedergaard M, Sotty F, Botta P

Neurobiology of disease.. 2023 January 23178 :106012. Epub 01/23/2023.

A mesothelium divides the subarachnoid space into functional compartments.

Møllgård K, Beinlich FRM, Kusk P, Miyakoshi LM, Delle C, Plá V, Hauglund NL, Esmail T, Rasmussen MK, Gomolka RS, Mori Y, Nedergaard M

Science.. 2023 January 6379 (6627):84-88. Epub 01/05/2023.

Locomotion Induces Fundamentally Different Patterns of Ca Signaling in Astrocytes and Neurons.

Hirase H, Nedergaard M

Function.. 2023 4 (4):zqad028. Epub 06/05/2023.

Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations.

Helakari H, Järvelä M, Väyrynen T, Tuunanen J, Piispala J, Kallio M, Ebrahimi SM, Poltojainen V, Kananen J, Elabasy A, Huotari N, Raitamaa L, Tuovinen T, Korhonen V, Nedergaard M, Kiviniemi V

Frontiers in neuroscience.. 2023 17 :1275184. Epub 12/01/2023.

Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.

Liu G, Ladrón-de-Guevara A, Izhiman Y, Nedergaard M, Du T

Fluids and barriers of the CNS.. 2022 December 1519 (1):101. Epub 12/15/2022.

B lymphocytes ameliorate Alzheimer's disease-like neuropathology via interleukin-35.

Feng W, Zhang Y, Ding S, Chen S, Wang T, Wang Z, Zou Y, Sheng C, Chen Y, Pang Y, Marshall C, Shi J, Nedergaard M, Li Q, Xiao M

Brain, behavior, and immunity.. 2022 November 22 Epub 11/22/2022.

Theory of sleep/wake cycles affecting brain elastography.

Ge GR, Song W, Nedergaard M, Rolland JP, Parker KJ

Physics in medicine and biology.. 2022 October 27 Epub 10/27/2022.

Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.

Wang X, Delle C, Asiminas A, Akther S, Vittani M, Brøgger P, Kusk P, Vo CT, Radovanovic T, Konno A, Hirai H, Fukuda M, Weikop P, Goldman SA, Nedergaard M, Hirase H

Cell reports methods.. 2022 October 242 (10):100302. Epub 09/21/2022.

SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.

Lilius TO, Rosenholm M, Klinger L, Mortensen KN, Sigurdsson B, Mogensen FL, Hauglund NL, Nielsen MSN, Rantamäki T, Nedergaard M

iScience.. 2022 October 2125 (10):105250. Epub 09/29/2022.

Could dexmedetomidine be repurposed as a glymphatic enhancer?

Persson NDÅ, Uusalo P, Nedergaard M, Lohela TJ, Lilius TO

Trends in pharmacological sciences.. 2022 October 21 Epub 10/21/2022.

Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

Lopes van den Broek S, Shalgunov V, García Vázquez R, Beschorner N, Bidesi NSR, Nedergaard M, Knudsen GM, Sehlin D, Syvänen S, Herth MM

Pharmaceuticals.. 2022 September 2715 (10)Epub 09/27/2022.

The glymphatic system: Current understanding and modeling.

Bohr T, Hjorth PG, Holst SC, Hrab?tová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M

iScience.. 2022 September 1625 (9):104987. Epub 08/20/2022.

Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice.

Carlsen EMM, Nedergaard M, Rasmussen RN

STAR protocols.. 2022 September 143 (4):101701. Epub 09/14/2022.

A real-time in vivo clearance assay for quantification of glymphatic efflux.

Plá V, Bork P, Harnpramukkul A, Olveda G, Ladrón-de-Guevara A, Giannetto MJ, Hussain R, Wang W, Kelley DH, Hablitz LM, Nedergaard M

Cell reports.. 2022 September 1340 (11):111320. Epub 1900 01 01.

A sensitive and specific genetically encoded potassium ion biosensor for in vivo applications across the tree of life.

Wu SY, Wen Y, Serre NBC, Laursen CCH, Dietz AG, Taylor BR, Drobizhev M, Molina RS, Aggarwal A, Rancic V, Becker M, Ballanyi K, Podgorski K, Hirase H, Nedergaard M, Fendrych M, Lemieux MJ, Eberl DF, Kay AR, Campbell RE, Shen Y

PLoS biology.. 2022 September 620 (9):e3001772. Epub 09/06/2022.

The glymphatic system: implications for drugs for central nervous system diseases.

Lohela TJ, Lilius TO, Nedergaard M

Nature reviews. Drug discovery.. 2022 August 10 Epub 08/10/2022.

The effect of long-duration spaceflight on perivascular spaces within the brain.

Wostyn P, Mader TH, Gibson CR, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2022 August 9119 (32):e2207724119. Epub 07/18/2022.

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.

Kjaerby C, Andersen M, Hauglund N, Untiet V, Dall C, Sigurdsson B, Ding F, Feng J, Li Y, Weikop P, Hirase H, Nedergaard M

Nature neuroscience.. 2022 July 7 Epub 07/07/2022.

Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.

Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI

Nature communications.. 2022 July 613 (1):3897. Epub 07/06/2022.

A network model of glymphatic flow under different experimentally-motivated parametric scenarios.

Tithof J, Boster KAS, Bork PAR, Nedergaard M, Thomas JH, Kelley DH

iScience.. 2022 May 2025 (5):104258. Epub 04/14/2022.

Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.

Kananen J, Järvelä M, Korhonen V, Tuovinen T, Huotari N, Raitamaa L, Helakari H, Väyrynen T, Raatikainen V, Nedergaard M, Ansakorpi H, Jacobs J, LeVan P, Kiviniemi V

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2022 May 14 :271678X221099703. Epub 05/14/2022.

Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.

Ladrón-de-Guevara A, Shang JK, Nedergaard M, Kelley DH

Journal of theoretical biology.. 2022 March 23 :111103. Epub 03/23/2022.

Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

Monai H, Koketsu S, Shinohara Y, Ueki T, Kusk P, Hauglund NL, Samson AJ, Nedergaard M, Hirase H

Scientific reports.. 2022 March 1812 (1):4741. Epub 03/18/2022.

Blood-brain barrier permeable ?-blockers linked to lower risk of Alzheimer's disease in hypertension.

Beaman EE, Bonde AN, Ulv Larsen SM, Ozenne B, Lohela TJ, Nedergaard M, Gíslason GH, Knudsen GM, Holst SC

Brain : a journal of neurology.. 2022 February 23 Epub 02/23/2022.

Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.

Helakari H, Korhonen V, Holst SC, Piispala J, Kallio M, Väyrynen T, Huotari N, Raitamaa L, Tuunanen J, Kananen J, Järvelä M, Tuovinen T, Raatikainen V, Borchardt V, Kinnunen H, Nedergaard M, Kiviniemi V

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2022 February 7 Epub 02/07/2022.

Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?

Wostyn P, Mader TH, Gibson CR, Nedergaard M

Eye and brain.. 2022 14 :49-58. Epub 05/04/2022.

Physiological Mechanisms and Significance of Intracranial B Waves.

Newell DW, Nedergaard M, Aaslid R

Frontiers in neurology. 2022 13 :872701. Epub 05/16/2022.

TUBE Project: Transport-Derived Ultrafines and the Brain Effects.

Martikainen MV, Aakko-Saksa P, van den Broek L, Cassee FR, Carare RO, Chew S, Dinnyes A, Giugno R, Kanninen KM, Malm T, Muala A, Nedergaard M, Oudin A, Oyola P, Pfeiffer TV, Rönkkö T, Saarikoski S, Sandström T, Schins RPF, Topinka J, Yang M, Zeng X, Westerink RHS, Jalava PI

International journal of environmental research and public health.. 2021 December 2819 (1)Epub 12/28/2021.

Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.

Battistella R, Kritsilis M, Matuskova H, Haswell D, Cheng AX, Meissner A, Nedergaard M, Lundgaard I

International journal of molecular sciences.. 2021 October 2622 (21)Epub 10/26/2021.

The glymphatic system.

Hablitz LM, Nedergaard M

Current biology : CB.. 2021 October 2531 (20):R1371-R1375. Epub 1900 01 01.

Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.

Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M

Brain : a journal of neurology.. 2021 September 28 Epub 09/28/2021.

The Glymphatic System: A Novel Component of Fundamental Neurobiology.

Hablitz LM, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2021 September 1541 (37):7698-7711. Epub 1900 01 01.

DNase treatment prevents CSF block in early experimental pneumococcal meningitis.

Pavan C, Xavier AL, Ramos M, Fisher J, Kritsilis M, Linder A, Bentzer P, Nedergaard M, Lundgaard I

Annals of neurology.. 2021 August 16 Epub 08/16/2021.

Cerebral small vessel disease: A glymphopathy?

Benveniste H, Nedergaard M

Current opinion in neurobiology.. 2021 August 1572 :15-21. Epub 08/15/2021.

The Glymphatic System (En)during Inflammation.

Mogensen FL, Delle C, Nedergaard M

International journal of molecular sciences.. 2021 July 1322 (14)Epub 07/13/2021.

Reply to: Rethink the classical view of cerebrospinal fluid production.

Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Charpak S, Smith KJ, Black SE

Nature reviews. Neurology.. 2021 July 12 Epub 07/12/2021.

Fluid Transport in the Brain.

Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews.. 2021 May 5 Epub 05/05/2021.

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

Monai H, Koketsu S, Shinohara Y, Ueki T, Kusk P, Hauglund NL, Samson AJ, Nedergaard M, Hirase H

Scientific reports.. 2021 April 1411 (1):8150. Epub 04/14/2021.

Cardiovascular brain impulses in Alzheimer's disease.

Rajna Z, Mattila H, Huotari N, Tuovinen T, Krüger J, Holst SC, Korhonen V, Remes AM, Seppänen T, Hennig J, Nedergaard M, Kiviniemi V

Brain : a journal of neurology.. 2021 March 31 Epub 03/31/2021.

Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.

Yuste R, Hawrylycz M, Aalling N, Aguilar-Valles A, Arendt D, Armañanzas R, Ascoli GA, Bielza C, Bokharaie V, Bergmann TB, Bystron I, Capogna M, Chang Y, Clemens A, de Kock CPJ, DeFelipe J, Dos Santos SE, Dunville K, Feldmeyer D, Fiáth R, Fishell GJ, Foggetti A, Gao X, Ghaderi P, Goriounova NA, Güntürkün O, Hagihara K, Hall VJ, Helmstaedter M, Herculano-Houzel S, Hilscher MM, Hirase H, Hjerling-Leffler J, Hodge R, Huang J, Huda R, Khodosevich K, Kiehn O, Koch H, Kuebler ES, Kühnemund M, Larrañaga P, Lelieveldt B, Louth EL, Lui JH, Mansvelder HD, Marin O, Martinez-Trujillo J, Chameh HM, Mohapatra AN, Munguba H, Nedergaard M, N?mec P, Ofer N, Pfisterer UG, Pontes S, Redmond W, Rossier J, Sanes JR, Scheuermann RH, Serrano-Saiz E, Staiger JF, Somogyi P, Tamás G, Tolias AS, Tosches MA, García MT, Wozny C, Wuttke TV, Liu Y, Yuan J, Zeng H, Lein E

Nature neuroscience.. 2021 March 19 Epub 03/19/2021.

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.

Raghunandan A, Ladron-de-Guevara A, Tithof J, Mestre H, Du T, Nedergaard M, Thomas JH, Kelley DH

eLife.. 2021 March 910 Epub 03/09/2021.

Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia.

Stanton EH, Persson NDÅ, Gomolka RS, Lilius T, Sigurðsson B, Lee H, Xavier ALR, Benveniste H, Nedergaard M, Mori Y

Magnetic resonance in medicine.. 2021 January 11 Epub 01/11/2021.

Direct Measurement of Cerebrospinal Fluid Production in Mice.

Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports.. 2020 December 2233 (12):108524. Epub 1900 01 01.

The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.

Tuovinen T, Kananen J, Rajna Z, Lieslehto J, Korhonen V, Rytty R, Mattila H, Huotari N, Raitamaa L, Helakari H, Elseoud AA, Krüger J, LeVan P, Tervonen O, Hennig J, Remes AM, Nedergaard M, Kiviniemi V

Scientific reports.. 2020 December 910 (1):21559. Epub 12/09/2020.

Publisher Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.

Yuste R, Hawrylycz M, Aalling N, Aguilar-Valles A, Arendt D, Arnedillo RA, Ascoli GA, Bielza C, Bokharaie V, Bergmann TB, Bystron I, Capogna M, Chang Y, Clemens A, de Kock CPJ, DeFelipe J, Dos Santos SE, Dunville K, Feldmeyer D, Fiáth R, Fishell GJ, Foggetti A, Gao X, Ghaderi P, Goriounova NA, Güntürkün O, Hagihara K, Hall VJ, Helmstaedter M, Herculano S, Hilscher MM, Hirase H, Hjerling-Leffler J, Hodge R, Huang J, Huda R, Khodosevich K, Kiehn O, Koch H, Kuebler ES, Kühnemund M, Larrañaga P, Lelieveldt B, Louth EL, Lui JH, Mansvelder HD, Marin O, Martinez-Trujillo J, Moradi Chameh H, Nath A, Nedergaard M, N?mec P, Ofer N, Pfisterer UG, Pontes S, Redmond W, Rossier J, Sanes JR, Scheuermann R, Serrano-Saiz E, Steiger JF, Somogyi P, Tamás G, Tolias AS, Tosches MA, García MT, Vieira HM, Wozny C, Wuttke TV, Yong L, Yuan J, Zeng H, Lein E

Nature neuroscience.. 2020 December 4 Epub 12/04/2020.

The Glymphatic System and Pain.

Goldman N, Hablitz LM, Mori Y, Nedergaard M

Medical acupuncture.. 2020 December 132 (6):373-376. Epub 12/16/2020.

Surface periarterial spaces of the mouse brain are open, not porous.

Min Rivas F, Liu J, Martell BC, Du T, Mestre H, Nedergaard M, Tithof J, Thomas JH, Kelley DH

Journal of the Royal Society, Interface. 2020 November 17 (172):20200593. Epub 11/11/2020.

Glymphatic failure as a final common pathway to dementia.

Nedergaard M, Goldman SA

Science.. 2020 October 2370 (6512):50-56. Epub 1900 01 01.

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports.. 2020 September 3010 (1):16073. Epub 09/30/2020.

Circadian control of brain glymphatic and lymphatic fluid flow.

Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications.. 2020 September 211 (1):4411. Epub 09/02/2020.

A community-based transcriptomics classification and nomenclature of neocortical cell types.

Yuste R, Hawrylycz M, Aalling N, Aguilar-Valles A, Arendt D, Arnedillo RA, Ascoli GA, Bielza C, Bokharaie V, Bergmann TB, Bystron I, Capogna M, Chang Y, Clemens A, de Kock CPJ, DeFelipe J, Dos Santos SE, Dunville K, Feldmeyer D, Fiáth R, Fishell GJ, Foggetti A, Gao X, Ghaderi P, Goriounova NA, Güntürkün O, Hagihara K, Hall VJ, Helmstaedter M, Herculano S, Hilscher MM, Hirase H, Hjerling-Leffler J, Hodge R, Huang J, Huda R, Khodosevich K, Kiehn O, Koch H, Kuebler ES, Kühnemund M, Larrañaga P, Lelieveldt B, Louth EL, Lui JH, Mansvelder HD, Marin O, Martinez-Trujillo J, Moradi Chameh H, Nath A, Nedergaard M, N?mec P, Ofer N, Pfisterer UG, Pontes S, Redmond W, Rossier J, Sanes JR, Scheuermann R, Serrano-Saiz E, Steiger JF, Somogyi P, Tamás G, Tolias AS, Tosches MA, García MT, Vieira HM, Wozny C, Wuttke TV, Yong L, Yuan J, Zeng H, Lein E

Nature neuroscience.. 2020 August 24 Epub 08/24/2020.

Defining novel functions for cerebrospinal fluid in ALS pathophysiology.

Ng Kee Kwong KC, Mehta AR, Nedergaard M, Chandran S

Acta neuropathologica communications.. 2020 August 208 (1):140. Epub 08/20/2020.

Twists and turns of ocular glymphatic clearance - new study reveals surprising findings in glaucoma.

Rangroo Thrane V, Hynnekleiv L, Wang X, Thrane AS, Krohn J, Nedergaard M

Acta ophthalmologica.. 2020 July 24 Epub 07/24/2020.

A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices.

Stæger FF, Mortensen KN, Nielsen MSN, Sigurdsson B, Kaufmann LK, Hirase H, Nedergaard M

Scientific data.. 2020 July 137 (1):235. Epub 07/13/2020.

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.

Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, Lu Y, Mariani JN, Goldman SA

Cell reports.. 2020 May 1931 (7):107658. Epub 1900 01 01.

The Brain's Glymphatic System: Current Controversies.

Mestre H, Mori Y, Nedergaard M

Trends in neurosciences.. 2020 May 15 Epub 05/15/2020.

Interstitial ions: A key regulator of state-dependent neural activity?

Rasmussen R, O'Donnell J, Ding F, Nedergaard M

Progress in neurobiology.. 2020 May 12 :101802. Epub 05/12/2020.

Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.

Ulv Larsen SM, Landolt HP, Berger W, Nedergaard M, Knudsen GM, Holst SC

PLoS biology.. 2020 May 18 (5):e3000623. Epub 05/05/2020.

Mechanisms of cognitive dysfunction in CKD.

Viggiano D, Wagner CA, Martino G, Nedergaard M, Zoccali C, Unwin R, Capasso G

Nature reviews. Nephrology.. 2020 March 31 Epub 03/31/2020.

An ocular glymphatic clearance system removes ?-amyloid from the rodent eye.

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M

Science translational medicine.. 2020 March 2512 (536)Epub 1900 01 01.

Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.

Hauglund NL, Kusk P, Kornum BR, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2020 March 1140 (11):2371-2380. Epub 02/11/2020.

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.

Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT

Nature reviews. Neurology.. 2020 March 9 Epub 03/09/2020.

Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus.

Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, Alper SL, Lundgaard I, Nedergaard M, Kahle KT

Trends in molecular medicine.. 2020 March 26 (3):285-295. Epub 01/18/2020.

Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.

Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Nostrand WV, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A

Scientific reports.. 2020 February 2710 (1):3934. Epub 02/27/2020.

Perivascular spaces in the brain: anatomy, physiology and pathology.

Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE,

Nature reviews. Neurology.. 2020 February 24 Epub 02/24/2020.

Aquaporin 1 and the Na/K/2Cl cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.

Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS.. 2020 February 1117 (1):15. Epub 02/11/2020.

Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.

Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Van Nostrand W, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A

Scientific reports.. 2020 February 610 (1):1990. Epub 02/06/2020.

Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science.. 2020 January 30 Epub 01/30/2020.

Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study.

Kananen J, Helakari H, Korhonen V, Huotari N, Järvelä M, Raitamaa L, Raatikainen V, Rajna Z, Tuovinen T, Nedergaard M, Jacobs J, LeVan P, Ansakorpi H, Kiviniemi V

Brain communications.. 2020 2 (2):fcaa076. Epub 06/08/2020.

Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.

Yoon C, Qi Y, Mestre H, Canavesi C, Marola OJ, Cogliati A, Nedergaard M, Libby RT, Rolland JP

Biomedical optics express.. 2019 December 110 (12):6242-6257. Epub 11/14/2019.

Glial cells in schizophrenia: a unified hypothesis.

Dietz AG, Goldman SA, Nedergaard M

The lancet. Psychiatry.. 2019 November 5 Epub 11/05/2019.

Astrocytes in chronic pain and itch.

Ji RR, Donnelly CR, Nedergaard M

Nature reviews. Neuroscience.. 2019 November 20 (11):667-685. Epub 09/19/2019.

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.

Mortensen KN, Sanggaard S, Mestre H, Lee H, Kostrikov S, Xavier ALR, Gjedde A, Benveniste H, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2019 August 739 (32):6365-6377. Epub 06/17/2019.

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Grutzendler J, Nedergaard M

Trends in neurosciences.. 2019 August 42 (8):528-536. Epub 06/26/2019.

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice.

Rasmussen R, Nicholas E, Petersen NC, Dietz AG, Xu Q, Sun Q, Nedergaard M

Cell reports.. 2019 July 3028 (5):1182-1194.e4. Epub 1900 01 01.

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

Sweeney AM, Plá V, Du T, Liu G, Sun Q, Peng S, Plog BA, Kress BT, Wang X, Mestre H, Nedergaard M

Journal of visualized experiments : JoVE.. 2019 July 29 (149)Epub 07/29/2019.

Longitudinal shear waves for elastic characterization of tissues in optical coherence elastography.

Zvietcovich F, Ge GR, Mestre H, Giannetto M, Nedergaard M, Rolland JP, Parker KJ

Biomedical optics express.. 2019 July 110 (7):3699-3718. Epub 07/01/2019.

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Stæger FF, Bærentzen S, Du T, Ahlström F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M

Journal of controlled release : official journal of the Controlled Release Society.. 2019 June 28304 :29-38. Epub 05/05/2019.

Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.

Smith NA, Bekar LK, Nedergaard M

Neurochemical research.. 2019 June 28 Epub 06/28/2019.

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA

Cell reports.. 2019 June 2527 (13):3832-3843.e6. Epub 1900 01 01.

Hydraulic resistance of periarterial spaces in the brain.

Tithof J, Kelley DH, Mestre H, Nedergaard M, Thomas JH

Fluids and barriers of the CNS.. 2019 June 2016 (1):19. Epub 06/20/2019.

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.

Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H

Proceedings of the National Academy of Sciences of the United States of America.. 2019 May 28116 (22):11010-11019. Epub 05/16/2019.

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.

Plog BA, Lou N, Pierre CA, Cove A, Kenney HM, Hitomi E, Kang H, Iliff JJ, Zeppenfeld DM, Nedergaard M, Vates GE

Journal of neurosurgery.. 2019 May 17 :1-14. Epub 05/17/2019.

Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.

Zhou S, Giannetto M, DeCourcey J, Kang H, Kang N, Li Y, Zheng S, Zhao H, Simmons WR, Wei HS, Bodine DM, Low PS, Nedergaard M, Wan J

Science advances.. 2019 May 5 (5):eaaw4466. Epub 05/29/2019.

Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.

Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, Benveniste H, Lee H

Neuroscience.. 2019 April 15404 :14-26. Epub 01/26/2019.

PDGF-B Is Required for Development of the Glymphatic System.

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B, Benraiss A, Mäe MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard I

Cell reports.. 2019 March 1226 (11):2955-2969.e3. Epub 1900 01 01.

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.

Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Ertürk A

Nature neuroscience.. 2019 February 22 (2):317-327. Epub 12/31/2018.

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Hablitz LM, Vinitsky HS, Sun Q, Stæger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M

Science advances.. 2019 February 5 (2):eaav5447. Epub 02/27/2019.

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV

Alzheimer's & dementia : the journal of the Alzheimer's Association.. 2019 January 15 (1):158-167. Epub 1900 01 01.

Cisterna Magna Injection in Rats to Study Glymphatic Function.

Ramos M, Burdon Bechet N, Battistella R, Pavan C, Xavier ALR, Nedergaard M, Lundgaard I

Methods in molecular biology.. 2019 1938 :97-104. Epub 1900 01 01.

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.

Wang M, Qin C, Luo X, Wang J, Wang X, Xie M, Hu J, Cao J, Hu T, Goldman SA, Nedergaard M, Wang W

Theranostics.. 2019 9 (15):4474-4493. Epub 06/09/2019.

State-Dependent Changes in Brain Glycogen Metabolism.

DiNuzzo M, Walls AB, Öz G, Seaquist ER, Waagepetersen HS, Bak LK, Nedergaard M, Schousboe A

Advances in neurobiology.. 2019 23 :269-309. Epub 1900 01 01.

Editorial: Sleep and Mood Disorders.

Verkhratsky A, Nedergaard M, Steardo L, Li B

Frontiers in psychiatry.. 2019 10 :981. Epub 01/16/2020.

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M

eLife.. 2018 December 187 Epub 12/18/2018.

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M

JCI insight.. 2018 December 63 (23)Epub 12/06/2018.

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH

Nature communications.. 2018 November 199 (1):4878. Epub 11/19/2018.

The glymphatic pathway in neurological disorders.

Rasmussen MK, Mestre H, Nedergaard M

The Lancet. Neurology.. 2018 November 17 (11):1016-1024. Epub 1900 01 01.

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M

JCI insight.. 2018 October 183 (20)Epub 10/18/2018.

VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance.

Michaelsen SR, Staberg M, Pedersen H, Jensen KE, Majewski W, Broholm H, Nedergaard MK, Meulengracht C, Urup T, Villingshøj M, Lukacova S, Skjøth-Rasmussen J, Brennum J, Kjær A, Lassen U, Stockhausen MT, Poulsen HS, Hamerlik P

Neuro-oncology.. 2018 October 920 (11):1462-1474. Epub 1900 01 01.

Understanding the role of the perivascular space in cerebral small vessel disease.

Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM

Cardiovascular research.. 2018 September 1114 (11):1462-1473. Epub 1900 01 01.

Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.

Obara-Michlewska M, Ding F, Popek M, Verkhratsky A, Nedergaard M, Zielinska M, Albrecht J

Neurochemistry international.. 2018 September 118 :286-291. Epub 05/14/2018.

Altered physiological brain variation in drug-resistant epilepsy.

Kananen J, Tuovinen T, Ansakorpi H, Rytky S, Helakari H, Huotari N, Raitamaa L, Raatikainen V, Rasila A, Borchardt V, Korhonen V, LeVan P, Nedergaard M, Kiviniemi V

Brain and behavior.. 2018 September 8 (9):e01090. Epub 08/15/2018.

Cerebral Metabolic Changes During Sleep.

Aalling NN, Nedergaard M, DiNuzzo M

Current neurology and neuroscience reports.. 2018 July 1618 (9):57. Epub 07/16/2018.

Cannula Implantation into the Cisterna Magna of Rodents.

Xavier ALR, Hauglund NL, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M

Journal of visualized experiments : JoVE.. 2018 May 23 (135)Epub 05/23/2018.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM

Clinical science.. 2018 April 30132 (8):851-868. Epub 04/30/2018.

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.

Lee H, Mortensen K, Sanggaard S, Koch P, Brunner H, Quistorff B, Nedergaard M, Benveniste H

Magnetic resonance in medicine.. 2018 March 79 (3):1568-1578. Epub 06/19/2017.

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M

Scientific reports.. 2018 February 28 (1):2246. Epub 02/02/2018.

Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss A, Nedergaard M

Science signaling.. 2018 January 3011 (515)Epub 01/30/2018.

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.

Plog BA, Nedergaard M

Annual review of pathology.. 2018 January 2413 :379-394. Epub 1900 01 01.

Voluntary running enhances glymphatic influx in awake behaving, young mice.

Holstein-Rathlou SV, Petersen NC, Nedergaard M

Neuroscience letters.. 2018 January 1662 :253-258. Epub 10/25/2017.

Physiology of Astroglia.

Verkhratsky A, Nedergaard M

Physiological reviews.. 2018 January 198 (1):239-389. Epub 1900 01 01.

Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.

Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, Lu H

Anesthesiology.. 2017 December 127 (6):976-988. Epub 1900 01 01.

Brain energetics during the sleep-wake cycle.

DiNuzzo M, Nedergaard M

Current opinion in neurobiology.. 2017 December 47 :65-72. Epub 10/09/2017.

Perivascular spaces, glymphatic dysfunction, and small vessel disease.

Mestre H, Kostrikov S, Mehta RI, Nedergaard M

Clinical science.. 2017 September 1131 (17):2257-2274. Epub 08/10/2017.

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J

The Journal of clinical investigation.. 2017 September 1127 (9):3210-3219. Epub 09/01/2017.

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H

Journal of nuclear medicine : official publication, Society of Nuclear Medicine.. 2017 September 58 (9):1471-1476. Epub 03/16/2017.

Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?

Oberheim Bush NA, Nedergaard M

Neurochemical research.. 2017 September 42 (9):2577-2587. Epub 08/19/2017.

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA

Cell stem cell.. 2017 August 321 (2):195-208.e6. Epub 07/20/2017.

Glymphatic clearance controls state-dependent changes in brain lactate concentration.

Lundgaard I, Lu ML, Yang E, Peng W, Mestre H, Hitomi E, Deane R, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2017 June 37 (6):2112-2124. Epub 01/01/2016.

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Kjaerby C, Rasmussen R, Andersen M, Nedergaard M

Neurochemical research.. 2017 June 42 (6):1810-1822. Epub 02/16/2017.

Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.

Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A

NeuroImage.. 2017 May 15152 :530-537. Epub 03/18/2017.

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Su Wanga NA, Benraiss A, Lou N, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 April 2637 (17):4493-4507. Epub 03/23/2017.

Impairment of the glymphatic system after diabetes.

Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sadry N, Nedergaard M, Chopp M, Zhang Z

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2017 April 37 (4):1326-1337. Epub 01/01/2016.

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.

Wang F, Wang X, Shapiro LA, Cotrina ML, Liu W, Wang EW, Gu S, Wang W, He X, Nedergaard M, Huang JH

Brain structure & function.. 2017 April 222 (3):1543-1556. Epub 09/01/2016.

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 March 1537 (11):2870-2877. Epub 02/10/2017.

Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.

Cotrina ML, Lou N, Tome-Garcia J, Goldman J, Nedergaard M

Neuroscience.. 2017 February 20343 :483-494. Epub 12/18/2016.

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2017 January 1212 (1):3. Epub 01/12/2017.

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2016 December 811 (1):74. Epub 12/08/2016.

"Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.

Bosetti F, Galis ZS, Bynoe MS, Charette M, Cipolla MJ, Del Zoppo GJ, Gould D, Hatsukami TS, Jones TL, Koenig JI, Lutty GA, Maric-Bilkan C, Stevens T, Tolunay HE, Koroshetz W,

Journal of the American Heart Association.. 2016 November 45 (11)Epub 11/04/2016.

Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2016 September 36 (9):1537-52. Epub 10/14/2015.

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benveniste H, Nedergaard M, Deane R

Neurobiology of disease.. 2016 September 93 :215-25. Epub 05/24/2016.

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.

Wei HS, Kang H, Rasheed ID, Zhou S, Lou N, Gershteyn A, McConnell ED, Wang Y, Richardson KE, Palmer AF, Xu C, Wan J, Nedergaard M

Neuron.. 2016 August 1791 (4):851-862. Epub 08/04/2016.

The homeostatic astroglia emerges from evolutionary specialization of neural cells.

Verkhratsky A, Nedergaard M

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2016 August 5371 (1700)Epub 1900 01 01.

Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.

Rasmussen R, Nedergaard M, Petersen NC

Scientific reports.. 2016 July 266 :30433. Epub 07/26/2016.

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA

Nature communications.. 2016 June 77 :11758. Epub 06/07/2016.

Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?

Kiviniemi V, Wang X, Korhonen V, Keinänen T, Tuovinen T, Autio J, LeVan P, Keilholz S, Zang YF, Hennig J, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2016 June 36 (6):1033-45. Epub 12/21/2015.

Changes in the composition of brain interstitial ions control the sleep-wake cycle.

Ding F, O'Donnell J, Xu Q, Kang N, Goldman N, Nedergaard M

Science.. 2016 April 29352 (6285):550-5. Epub 1900 01 01.

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.

Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK

Cell death and differentiation.. 2016 April 23 (4):596-607. Epub 10/09/2015.

BRAIN DRAIN.

Nedergaard M, Goldman SA

Scientific American.. 2016 March 314 (3):44-9. Epub 1900 01 01.

Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2016 January 26113 (4):1074-9. Epub 01/11/2016.

Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro.

Staberg M, Michaelsen SR, Olsen LS, Nedergaard MK, Villingshøj M, Stockhausen MT, Hamerlik P, Poulsen HS

Cancer cell international.. 2016 16 :34. Epub 04/26/2016.

A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.

Xie L, Kang H, Nedergaard M

Journal of nature and science.. 2016 2 (2)Epub 1900 01 01.

The Glymphatic System: A Beginner's Guide.

Jessen NA, Munk AS, Lundgaard I, Nedergaard M

Neurochemical research.. 2015 December 40 (12):2583-99. Epub 05/07/2015.

Implications of the discovery of brain lymphatic pathways.

Iliff JJ, Goldman SA, Nedergaard M

The Lancet. Neurology.. 2015 October 14 (10):977-9. Epub 1900 01 01.

Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals.

Benveniste H, Hof PR, Nedergaard M, Bechter K

The Journal of comparative neurology.. 2015 September 1523 (13):2017-8. Epub 1900 01 01.

External Dentin Stimulation Induces ATP Release in Human Teeth.

Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT

Journal of dental research.. 2015 September 94 (9):1259-66. Epub 06/30/2015.

Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia.

Makaryus R, Lee H, Feng T, Park JH, Nedergaard M, Jacob Z, Enikolopov G, Benveniste H

Anesthesiology.. 2015 September 123 (3):557-68. Epub 1900 01 01.

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.

Ribeiro Xavier AL, Kress BT, Goldman SA, Lacerda de Menezes JR, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 August 2635 (34):11848-61. Epub 1900 01 01.

Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals.

Benveniste H, Hof PR, Nedergaard M, Bechter K

The Journal of comparative neurology.. 2015 August 15523 (12):1748-55. Epub 05/12/2015.

The Effect of Body Posture on Brain Glymphatic Transport.

Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 August 535 (31):11034-44. Epub 1900 01 01.

Modeling cognition and disease using human glial chimeric mice.

Goldman SA, Nedergaard M, Windrem MS

Glia.. 2015 August 63 (8):1483-93. Epub 05/24/2015.

156?Capillary-Level Control of Cerebrovascular Tone.

Wei HS, Rasheed ID, Takano T, Kang H, Reitz KM, Gershteyn A, Vates GE, Nedergaard M

Neurosurgery.. 2015 August 62 Suppl 1 :216-7. Epub 1900 01 01.

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC

Alzheimer's & dementia : the journal of the Alzheimer's Association.. 2015 June 11 (6):710-7. Epub 12/12/2014.

Filtering the muddied waters of brain edema.

Thrane AS, Rangroo Thrane V, Plog BA, Nedergaard M

Trends in neurosciences.. 2015 June 38 (6):333-5. Epub 05/22/2015.

Why have we not yet developed a simple blood test for TBI?

Plog BA, Nedergaard M

Expert review of neurotherapeutics.. 2015 May 15 (5):465-8. Epub 03/30/2015.

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M

Nature communications.. 2015 April 236 :6807. Epub 04/23/2015.

Distinct functional states of astrocytes during sleep and wakefulness: Is norepinephrine the master regulator?

O'Donnell J, Ding F, Nedergaard M

Current sleep medicine reports.. 2015 March 1 (1):1-8. Epub 01/29/2015.

Optimal-mass-transfer-based estimation of glymphatic transport in living brain.

Ratner V, Zhu L, Kolesov I, Nedergaard M, Benveniste H, Tannenbaum A

Proceedings of SPIE--the International Society for Optical Engineering.. 2015 February 219413 Epub 03/20/2015.

Why are astrocytes important?

Verkhratsky A, Nedergaard M, Hertz L

Neurochemical research.. 2015 February 40 (2):389-401. Epub 08/12/2014.

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 January 1435 (2):518-26. Epub 1900 01 01.

18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma.

Nedergaard MK, Michaelsen SR, Urup T, Broholm H, El Ali H, Poulsen HS, Stockhausen MT, Kjaer A, Lassen U

PloS one.. 2015 10 (2):e0115315. Epub 02/13/2015.

Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone.

Xavier AL, Lima FR, Nedergaard M, Menezes JR

Frontiers in cellular neuroscience.. 2015 9 :37. Epub 02/17/2015.

How do astrocytes participate in neural plasticity?

Haydon PG, Nedergaard M

Cold Spring Harbor perspectives in biology.. 2014 December 117 (3):a020438. Epub 12/11/2014.

Neuronal transgene expression in dominant-negative SNARE mice.

Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 December 1034 (50):16594-604. Epub 1900 01 01.

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 December 334 (49):16180-93. Epub 1900 01 01.

Impairment of paravascular clearance pathways in the aging brain.

Kress BT, Iliff JJ, Xia M, Wang M, Wei H, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew J, Plog BA, Ding F, Deane R, Nedergaard M

Annals of neurology.. 2014 December 76 (6):845-61. Epub 09/26/2014.

Drowning stars: reassessing the role of astrocytes in brain edema.

Thrane AS, Rangroo Thrane V, Nedergaard M

Trends in neurosciences.. 2014 November 37 (11):620-8. Epub 09/15/2014.

Fine-tuning the central nervous system: microglial modelling of cells and synapses.

Xavier AL, Menezes JR, Goldman SA, Nedergaard M

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2014 October 19369 (1654):20130593. Epub 1900 01 01.

Astroglial cradle in the life of the synapse.

Verkhratsky A, Nedergaard M

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2014 October 19369 (1654):20130595. Epub 1900 01 01.

Glial biology in learning and cognition.

Fields RD, Araque A, Johansen-Berg H, Lim SS, Lynch G, Nave KA, Nedergaard M, Perez R, Sejnowski T, Wake H

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.. 2014 October 20 (5):426-31. Epub 10/11/2013.

Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease.

Cotrina ML, Chen M, Han X, Iliff J, Ren Z, Sun W, Hagemann T, Goldman J, Messing A, Nedergaard M

Brain research.. 2014 September 251582 :211-9. Epub 07/25/2014.

White matter astrocytes in health and disease.

Lundgaard I, Osório MJ, Kress B, Sanggaard S, Nedergaard M

Neuroscience.. 2014 September 12276 :161-73. Epub 11/11/2013.

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR

Brain : a journal of neurology.. 2014 August 137 (Pt 8):2193-209. Epub 06/11/2014.

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH

Journal of neurotrauma.. 2014 July 131 (13):1211-24. Epub 06/12/2014.

Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury.

Tong J, Ren Y, Wang X, Dimopoulos VG, Kesler HN, Liu W, He X, Nedergaard M, Huang JH

Neurosurgery.. 2014 July 75 (1):51-60. Epub 1900 01 01.

Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature.

Kristoffersen K, Nedergaard MK, Villingshøj M, Borup R, Broholm H, Kjær A, Poulsen HS, Stockhausen MT

Cancer biology & therapy.. 2014 July 15 (7):862-77. Epub 04/22/2014.

A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation.

Plog BA, Moll KM, Kang H, Iliff JJ, Nedergaard M, Vates GE, Dashnaw ML

Journal of neuroscience methods.. 2014 May 30229 :44-52. Epub 04/13/2014.

Contributions of the Na?/K?-ATPase, NKCC1, and Kir4.1 to hippocampal K? clearance and volume responses.

Larsen BR, Assentoft M, Cotrina ML, Hua SZ, Nedergaard M, Kaila K, Voipio J, Macaulay N

Glia.. 2014 April 62 (4):608-22. Epub 01/30/2014.

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices.

Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M

Glia.. 2014 January 62 (1):78-95. Epub 11/06/2013.

The use of longitudinal 18F-FET MicroPET imaging to evaluate response to irinotecan in orthotopic human glioblastoma multiforme xenografts.

Nedergaard MK, Kristoffersen K, Michaelsen SR, Madsen J, Poulsen HS, Stockhausen MT, Lassen U, Kjaer A

PloS one.. 2014 9 (2):e100009. Epub 06/11/2014.

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M

Surgical neurology international.. 2014 5 :184. Epub 12/23/2014.

Glia and pain: is chronic pain a gliopathy?

Ji RR, Berta T, Nedergaard M

Pain.. 2013 December 154 Suppl 1 (0 1):S10-S28. Epub 06/20/2013.

?1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.

Ding F, O'Donnell J, Thrane AS, Zeppenfeld D, Kang H, Xie L, Wang F, Nedergaard M

Cell calcium.. 2013 December 54 (6):387-94. Epub 09/24/2013.

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering.

Thrane VR, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M

Nature medicine.. 2013 December 19 (12):1643-8. Epub 11/17/2013.

Is potassium a ubiquitous mediator of vasodilation in the central nervous system?

Bekar LK, Nedergaard M

Biophysical journal.. 2013 November 19105 (10):2238-9. Epub 1900 01 01.

Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.

Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 November 1333 (46):18190-9. Epub 1900 01 01.

Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.

Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 October 3033 (44):17404-12. Epub 1900 01 01.

Sleep drives metabolite clearance from the adult brain.

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M

Science.. 2013 October 18342 (6156):373-7. Epub 1900 01 01.

Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling.

Langevin H, Fujita T, Bouffard N, Takano T, Koptiuch C, Badger G, Nedergaard M

Journal of cellular physiology.. 2013 September 228 (9):1922-6. Epub 1900 01 01.

Cellular control of connective tissue matrix tension.

Langevin HM, Nedergaard M, Howe A

Journal of cellular biochemistry.. 2013 August 114 (8):1714-9. Epub 1900 01 01.

In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 July 33 (7):996-9. Epub 04/24/2013.

Neuroscience. Garbage truck of the brain.

Nedergaard M

Science.. 2013 June 28340 (6140):1529-30. Epub 1900 01 01.

Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter.

Chen X, Yang J, Kress BT, Tong J, Liu H, Takano T, Zhao Y, Nedergaard M, Ren Z

Neuroscience.. 2013 June 25241 :89-99. Epub 03/19/2013.

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA

Cell stem cell.. 2013 June 612 (6):787-99. Epub 1900 01 01.

'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation.

Ren Z, Iliff JJ, Yang L, Yang J, Chen X, Chen MJ, Giese RN, Wang B, Shi X, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 June 33 (6):834-45. Epub 02/27/2013.

Is there a cerebral lymphatic system?

Iliff JJ, Nedergaard M

Stroke.. 2013 June 44 (6 Suppl 1):S93-5. Epub 1900 01 01.

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer.

Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M

Journal of translational medicine.. 2013 May 111 :107. Epub 05/01/2013.

Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.

Goldman N, Chandler-Militello D, Langevin HM, Nedergaard M, Takano T

Cell calcium.. 2013 April 53 (4):297-301. Epub 02/22/2013.

Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M

Cell stem cell.. 2013 March 712 (3):342-53. Epub 1900 01 01.

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI.

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H

The Journal of clinical investigation.. 2013 March 123 (3):1299-309. Epub 02/22/2013.

A link between glial Ca2+ signaling and hypoxia in aging?

Iliff JJ, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 February 33 (2):170. Epub 12/05/2012.

Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.

Sun W, McConnell E, Pare JF, Xu Q, Chen M, Peng W, Lovatt D, Han X, Smith Y, Nedergaard M

Science.. 2013 January 11339 (6116):197-200. Epub 1900 01 01.

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M

Scientific reports.. 2013 3 :2582. Epub 1900 01 01.

Glia and pain: Is chronic pain a gliopathy?

Ji RR, Berta T, Nedergaard M

Pain.. 2013 154 Suppl 1 Epub 1900 01 01.

Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts.

Wang M, Iliff JJ, Liao Y, Chen MJ, Shinseki MS, Venkataraman A, Cheung J, Wang W, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 December 1232 (50):17948-60. Epub 1900 01 01.

Brain connexins in demyelinating diseases: therapeutic potential of glial targets.

Cotrina ML, Nedergaard M

Brain research.. 2012 December 31487 :61-8. Epub 07/10/2012.

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons.

Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC

Brain research.. 2012 December 31487 :3-15. Epub 09/10/2012.

The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand.

Bekar LK, Wei HS, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2012 December 32 (12):2135-45. Epub 08/08/2012.

Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse.

Enger R, Gundersen GA, Haj-Yasein NN, Eilert-Olsen M, Thoren AE, Vindedal GF, Petersen PH, Skare O, Nedergaard M, Ottersen OP, Nagelhus EA

Glia.. 2012 December 60 (12):2018-26. Epub 09/17/2012.

Traditional acupuncture triggers a local increase in adenosine in human subjects.

Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M

The journal of pain.. 2012 December 13 (12):1215-23. Epub 1900 01 01.

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex.

Thrane AS, Thrane VR, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 November 13109 (46):18974-9. Epub 10/29/2012.

Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance.

O'Donnell J, Zeppenfeld D, McConnell E, Pena S, Nedergaard M

Neurochemical research.. 2012 November 37 (11):2496-512. Epub 06/21/2012.

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury.

Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR, Nedergaard M

Glia.. 2012 November 60 (11):1660-70. Epub 08/01/2012.

Glial progenitor cell-based treatment and modeling of neurological disease.

Goldman SA, Nedergaard M, Windrem MS

Science.. 2012 October 26338 (6106):491-5. Epub 1900 01 01.

Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy.

Thrane VR, Thrane AS, Chang J, Alleluia V, Nagelhus EA, Nedergaard M

Neuroscience.. 2012 September 18220 :247-55. Epub 06/21/2012.

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid ?.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M

Science translational medicine.. 2012 August 154 (147):147ra111. Epub 1900 01 01.

Artifact versus reality--how astrocytes contribute to synaptic events.

Nedergaard M, Verkhratsky A

Glia.. 2012 July 60 (7):1013-23. Epub 01/06/2012.

Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake.

Wang F, Xu Q, Wang W, Takano T, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 May 15109 (20):7911-6. Epub 04/30/2012.

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.

Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 April 17109 (16):6265-70. Epub 03/15/2012.

Alexander disease.

Messing A, Brenner M, Feany MB, Nedergaard M, Goldman JE

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 April 1132 (15):5017-23. Epub 1900 01 01.

Neurological diseases as primary gliopathies: a reassessment of neurocentrism.

Verkhratsky A, Sofroniew MV, Messing A, Delanerolle NC, Rempe D, Rodriguez Arellano JJ, Nedergaard M

ASN neuro.. 2012 April 54 (3)Epub 04/05/2012.

Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.

Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M

Science signaling.. 2012 April 35 (218):ra26. Epub 04/03/2012.

Targeting the epidermal growth factor receptor in solid tumor malignancies.

Nedergaard MK, Hedegaard CJ, Poulsen HS

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.. 2012 April 126 (2):83-99. Epub 1900 01 01.

Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.

Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 March 732 (10):3333-8. Epub 1900 01 01.

Extracellular Ca²? acts as a mediator of communication from neurons to glia.

Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M

Science signaling.. 2012 January 245 (208):ra8. Epub 01/24/2012.

Cultured astrocytes do not release adenosine during hypoxic conditions.

Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2012 January 32 (1):e1-7. Epub 10/12/2011.

Random access multiphoton (RAMP) microscopy for investigation of cerebral blood flow regulation mechanisms.

Christensen DJ, Nedergaard M

Proceedings of SPIE--the International Society for Optical Engineering.. 2012 January 8226 Epub 02/09/2012.

Heterogeneity of astrocytic form and function.

Oberheim NA, Goldman SA, Nedergaard M

Methods in molecular biology.. 2012 814 :23-45. Epub 1900 01 01.

P2X receptors in neuroglia.

Verkhratsky A, Pankratov Y, Lalo U, Nedergaard M

Wiley interdisciplinary reviews. Membrane transport and signaling. 2012 1 (2)Epub 1900 01 01.

Two-photon in vivo imaging of cells.

Christensen DJ, Nedergaard M

Pediatric nephrology : journal of the International Pediatric Nephrology Association.. 2011 September 26 (9):1483-9. Epub 03/15/2011.

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA

Proceedings of the National Academy of Sciences of the United States of America.. 2011 January 11108 (2):846-51. Epub 12/27/2010.

Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions.

Kasischke KA, Lambert EM, Panepento B, Sun A, Gelbard HA, Burgess RW, Foster TH, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2011 January 31 (1):68-81. Epub 09/22/2010.

Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i.

Hertz L, Lovatt D, Goldman SA, Nedergaard M

Neurochemistry international.. 2010 November 57 (4):411-20. Epub 04/07/2010.

Targeting glia for treatment of neurological disease.

Rempe DA, Nedergaard M

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2010 October 7 (4):335-7. Epub 1900 01 01.

Functions of astrocytes and their potential as therapeutic targets.

Kimelberg HK, Nedergaard M

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2010 October 7 (4):338-53. Epub 1900 01 01.

Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons.

Kang J, Kang N, Yu Y, Zhang J, Petersen N, Tian GF, Nedergaard M

Neuroscience.. 2010 September 15169 (4):1601-9. Epub 06/19/2010.

Pericyte constriction after stroke: the jury is still out.

Vates GE, Takano T, Zlokovic B, Nedergaard M

Nature medicine.. 2010 September 16 (9):959; author reply 960. Epub 1900 01 01.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M

Nature neuroscience.. 2010 July 13 (7):883-8. Epub 05/30/2010.

5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'.

Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L

Neuron glia biology. 2010 May 6 (2):113-25. Epub 09/16/2010.

Glial calcium and diseases of the nervous system.

Nedergaard M, Rodríguez JJ, Verkhratsky A

Cell calcium.. 2010 February 47 (2):140-9. Epub 12/31/2009.

Calcium dyshomeostasis and pathological calcium signalling in neurological diseases.

Nedergaard M, Verkhratsky A

Cell calcium.. 2010 February 47 (2):101-2. Epub 01/15/2010.

TR(I)Pping towards treatment for ischemia.

Rempe DA, Takano T, Nedergaard M

Nature neuroscience.. 2009 October 12 (10):1215-6. Epub 1900 01 01.

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury.

Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2009 July 28106 (30):12489-93. Epub 07/27/2009.

Physiological and pathological functions of P2X7 receptor in the spinal cord.

Cotrina ML, Nedergaard M

Purinergic signalling.. 2009 June 5 (2):223-32. Epub 02/11/2009.

Uniquely hominid features of adult human astrocytes.

Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 March 1129 (10):3276-87. Epub 1900 01 01.

Astrocytes and ischemic injury.

Takano T, Oberheim N, Cotrina ML, Nedergaard M

Stroke.. 2009 March 40 (3 Suppl):S8-12. Epub 12/08/2008.

Hyaline protoplasmic astrocytopathy of neocortex.

Hedley-Whyte ET, Goldman JE, Nedergaard M, Friedman A, Han X, Schmidt RE, Powers JM

Journal of neuropathology and experimental neurology.. 2009 February 68 (2):136-47. Epub 1900 01 01.

Deciphering migraine.

Takano T, Nedergaard M

The Journal of clinical investigation.. 2009 January 119 (1):16-9. Epub 1900 01 01.

Astrocytic calcium signaling: mechanism and implications for functional brain imaging.

Wang X, Takano T, Nedergaard M

Methods in molecular biology.. 2009 489 :93-109. Epub 1900 01 01.

Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo.

Bekar LK, He W, Nedergaard M

Cerebral cortex.. 2008 December 18 (12):2789-95. Epub 03/27/2008.

Adhesive properties of connexin hemichannels.

Cotrina ML, Lin JH, Nedergaard M

Glia.. 2008 December 56 (16):1791-8. Epub 1900 01 01.

Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.

Windrem MS, Schanz SJ, Guo M, Tian GF, Washco V, Stanwood N, Rasband M, Roy NS, Nedergaard M, Havton LA, Wang S, Goldman SA

Cell stem cell.. 2008 June 52 (6):553-65. Epub 1900 01 01.

Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone.

Xu H, Hu F, Sado Y, Ninomiya Y, Borza DB, Ungvari Z, Lagamma EF, Csiszar A, Nedergaard M, Ballabh P

Journal of neuroscience research.. 2008 May 1586 (7):1482-500. Epub 1900 01 01.

Connexin 43 hemichannels are permeable to ATP.

Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 April 3028 (18):4702-11. Epub 1900 01 01.

Loss of astrocytic domain organization in the epileptic brain.

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 March 2628 (13):3264-76. Epub 1900 01 01.

A central role of connexin 43 in hypoxic preconditioning.

Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 January 1628 (3):681-95. Epub 1900 01 01.

Strategies to advance translational research into brain barriers.

Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, Engelhardt B, Grammas P, Nedergaard M, Nutt J, Pardridge W, Rosenberg GA, Smith Q, Drewes LR

The Lancet. Neurology.. 2008 January 7 (1):84-96. Epub 1900 01 01.

Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor.

Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M

Nature medicine.. 2008 January 14 (1):75-80. Epub 12/23/2007.

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.

Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 November 727 (45):12255-66. Epub 1900 01 01.

Glial regulation of the cerebral microvasculature.

Iadecola C, Nedergaard M

Nature neuroscience.. 2007 November 10 (11):1369-76. Epub 1900 01 01.

Paucity of pericytes in germinal matrix vasculature of premature infants.

Braun A, Xu H, Hu F, Kocherlakota P, Siegel D, Chander P, Ungvari Z, Csiszar A, Nedergaard M, Ballabh P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 October 3127 (44):12012-24. Epub 1900 01 01.

Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes.

Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 August 28104 (35):14151-6. Epub 08/21/2007.

Cortical spreading depression causes and coincides with tissue hypoxia.

Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M

Nature neuroscience.. 2007 June 10 (6):754-62. Epub 04/29/2007.

DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+.

Takano T, Nedergaard M

Cell calcium.. 2007 May 41 (5):503-4. Epub 10/19/2006.

Angiogenic inhibition reduces germinal matrix hemorrhage.

Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M

Nature medicine.. 2007 April 13 (4):477-85. Epub 04/01/2007.

Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.

Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M

Developmental biology.. 2007 February 1302 (1):356-66. Epub 09/16/2006.

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.

Takano T, Han X, Deane R, Zlokovic B, Nedergaard M

Annals of the New York Academy of Sciences.. 2007 February 1097 :40-50. Epub 1900 01 01.

Astrocytic complexity distinguishes the human brain.

Oberheim NA, Wang X, Goldman S, Nedergaard M

Trends in neurosciences.. 2006 October 29 (10):547-53. Epub 08/30/2006.

Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain.

Tian GF, Takano T, Lin JH, Wang X, Bekar L, Nedergaard M

Advanced drug delivery reviews.. 2006 September 1558 (7):773-87. Epub 08/04/2006.

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M

Nature neuroscience.. 2006 June 9 (6):816-23. Epub 05/14/2006.

Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons.

Anderson CM, Nedergaard M

Trends in neurosciences.. 2006 May 29 (5):257-62. Epub 03/27/2006.

Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants.

El-Khoury N, Braun A, Hu F, Pandey M, Nedergaard M, Lagamma EF, Ballabh P

Pediatric research.. 2006 May 59 (5):673-9. Epub 1900 01 01.

Astrocyte-mediated control of cerebral blood flow.

Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M

Nature neuroscience.. 2006 February 9 (2):260-7. Epub 12/25/2005.

Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.

Kang N, Xu J, Xu Q, Nedergaard M, Kang J

Journal of neurophysiology.. 2005 December 94 (6):4121-30. Epub 09/14/2005.

Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells.

Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA

Experimental neurology.. 2005 December 196 (2):224-34. Epub 09/29/2005.

Receptor-mediated glutamate release from volume sensitive channels in astrocytes.

Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2005 November 8102 (45):16466-71. Epub 10/27/2005.

Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter.

Ballabh P, Hu F, Kumarasiri M, Braun A, Nedergaard M

Pediatric research.. 2005 October 58 (4):791-8. Epub 1900 01 01.

An astrocytic basis of epilepsy.

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M

Nature medicine.. 2005 September 11 (9):973-81. Epub 08/14/2005.

Role of glial cells in cerebral ischemia.

Nedergaard M, Dirnagl U

Glia.. 2005 June 50 (4):281-286. Epub 1900 01 01.

Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.

Xu J, Kang N, Jiang L, Nedergaard M, Kang J

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2005 February 1625 (7):1750-60. Epub 1900 01 01.

Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission.

Liu QS, Xu Q, Kang J, Nedergaard M

Neuron glia biology. 2004 November 1 (4):307-16. Epub 1900 01 01.

Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons.

Kang N, Jiang L, He W, Xu J, Nedergaard M, Kang J

Journal of neurophysiology.. 2004 August 92 (2):873-82. Epub 03/03/2004.

P2X7 receptor inhibition improves recovery after spinal cord injury.

Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M

Nature medicine.. 2004 August 10 (8):821-7. Epub 07/18/2004.

Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants.

Ballabh P, Braun A, Nedergaard M

Pediatric research.. 2004 July 56 (1):117-24. Epub 05/05/2004.

The blood-brain barrier: an overview: structure, regulation, and clinical implications.

Ballabh P, Braun A, Nedergaard M

Neurobiology of disease.. 2004 June 16 (1):1-13. Epub 1900 01 01.

Astrocyte-mediated activation of neuronal kainate receptors.

Liu QS, Xu Q, Arcuino G, Kang J, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2004 March 2101 (9):3172-7. Epub 02/06/2004.

Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.

Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA

Nature biotechnology.. 2004 March 22 (3):297-305. Epub 02/15/2004.

The neurobiology of glia in the context of water and ion homeostasis.

Simard M, Nedergaard M

Neuroscience.. 2004 129 (4):877-96. Epub 1900 01 01.

Signaling at the gliovascular interface.

Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 October 823 (27):9254-62. Epub 1900 01 01.

New roles for astrocytes (stars at last).

Ransom B, Behar T, Nedergaard M

Trends in neurosciences.. 2003 October 26 (10):520-2. Epub 1900 01 01.

New roles for astrocytes: redefining the functional architecture of the brain.

Nedergaard M, Ransom B, Goldman SA

Trends in neurosciences.. 2003 October 26 (10):523-30. Epub 1900 01 01.

Astrocyte-mediated control of cerebral microcirculation.

Anderson CM, Nedergaard M

Trends in neurosciences.. 2003 July 26 (7):340-4; author reply 344-5. Epub 1900 01 01.

Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain.

Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G, Jiang L, Kang J, Nedergaard M, Goldman SA

Nature medicine.. 2003 April 9 (4):439-47. Epub 03/10/2003.

Connexin mediates gap junction-independent resistance to cellular injury.

Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 January 1523 (2):430-41. Epub 1900 01 01.

Beyond the role of glutamate as a neurotransmitter.

Nedergaard M, Takano T, Hansen AJ

Nature reviews. Neuroscience.. 2002 September 3 (9):748-55. Epub 1900 01 01.

Erythropoietin strikes a new cord.

Goldman SA, Nedergaard M

Nature medicine.. 2002 August 8 (8):785-7. Epub 1900 01 01.

Intercellular calcium signaling mediated by point-source burst release of ATP.

Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2002 July 2399 (15):9840-5. Epub 07/03/2002.

Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.

Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 June 122 (11):4302-11. Epub 1900 01 01.

Astrocytes in the aging brain.

Cotrina ML, Nedergaard M

Journal of neuroscience research.. 2002 January 167 (1):1-10. Epub 1900 01 01.

Glutamate release promotes growth of malignant gliomas.

Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M

Nature medicine.. 2001 September 7 (9):1010-5. Epub 1900 01 01.

Expression and function of astrocytic gap junctions in aging.

Cotrina ML, Gao Q, Lin JH, Nedergaard M

Brain research.. 2001 May 18901 (1-2):55-61. Epub 1900 01 01.

A kainate receptor increases the efficacy of GABAergic synapses.

Jiang L, Xu J, Nedergaard M, Kang J

Neuron.. 2001 May 30 (2):503-13. Epub 1900 01 01.

Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells.

Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M

Cancer research.. 2000 October 160 (19):5395-400. Epub 1900 01 01.

ATP-mediated glia signaling.

Cotrina ML, Lin JH, López-García JC, Naus CC, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 April 1520 (8):2835-44. Epub 1900 01 01.

Perspectives on spreading depression.

Martins-Ferreira H, Nedergaard M, Nicholson C

Brain research. Brain research reviews. 2000 April 32 (1):215-34. Epub 1900 01 01.

Paired-pulse modulation at individual GABAergic synapses in rat hippocampus.

Jiang L, Sun S, Nedergaard M, Kang J

The Journal of physiology.. 2000 March 1523 Pt 2 :425-39. Epub 1900 01 01.

In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus.

Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA

Nature medicine.. 2000 March 6 (3):271-7. Epub 1900 01 01.

Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone.

Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA

Journal of neuroscience research.. 2000 February 159 (3):321-31. Epub 1900 01 01.

Meningeal cells can communicate with astrocytes by calcium signaling.

Grafstein B, Liu S, Cotrina ML, Goldman SA, Nedergaard M

Annals of neurology.. 2000 January 47 (1):18-25. Epub 1900 01 01.

ATP as a messenger in astrocyte-neuronal communication

Cotrina, M.; Nedergaard, M.

The Neuroscientist. 2000; 6(2): 120-126.

Glucocorticoids-potent modulators of astrocytic calcium signaling.

Simard M, Couldwell WT, Zhang W, Song H, Liu S, Cotrina ML, Goldman S, Nedergaard M

Glia.. 1999 October 28 (1):1-12. Epub 1900 01 01.

Direct gap junction communication between malignant glioma cells and astrocytes.

Zhang W, Couldwell WT, Simard MF, Song H, Lin JH, Nedergaard M

Cancer research.. 1999 April 1559 (8):1994-2003. Epub 1900 01 01.

Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain.

Williams S, Leventhal C, Lemmon V, Nedergaard M, Goldman SA

Molecular and cellular neurosciences.. 1999 January 13 (1):41-55. Epub 1900 01 01.

Connexins regulate calcium signaling by controlling ATP release.

Cotrina ML, Lin JH, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, Kang J, Naus CC, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 1998 December 2295 (26):15735-40. Epub 1900 01 01.

Astrocyte-mediated potentiation of inhibitory synaptic transmission.

Kang J, Jiang L, Goldman SA, Nedergaard M

Nature neuroscience.. 1998 December 1 (8):683-92. Epub 1900 01 01.

Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling.

Cotrina ML, Lin JH, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 November 118 (21):8794-804. Epub 1900 01 01.

Gap-junction-mediated propagation and amplification of cell injury.

Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M

Nature neuroscience.. 1998 October 1 (6):494-500. Epub 1900 01 01.

Fibroblast growth factor-2/brain-derived neurotrophic factor-associated maturation of new neurons generated from adult human subependymal cells.

Pincus DW, Keyoung HM, Harrison-Restelli C, Goodman RR, Fraser RA, Edgar M, Sakakibara S, Okano H, Nedergaard M, Goldman SA

Annals of neurology.. 1998 May 43 (5):576-85. Epub 1900 01 01.

Astrocytic gap junctions remain open during ischemic conditions.

Cotrina ML, Kang J, Lin JH, Bueno E, Hansen TW, He L, Liu Y, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 April 118 (7):2520-37. Epub 1900 01 01.

Neural stem and progenitor cells: a strategy for gene therapy and brain repair.

Pincus DW, Goodman RR, Fraser RA, Nedergaard M, Goldman SA

Neurosurgery.. 1998 April 42 (4):858-67; discussion 867-8. Epub 1900 01 01.

Neural precursors and neuronal production in the adult mammalian forebrain.

Goldman SA, Nedergaard M, Crystal RG, Fraser RA, Goodman R, Harrison-Restelli C, Jiang J, Keyoung HM, Leventhal C, Pincus DW, Shahar A, Wang S

Annals of the New York Academy of Sciences.. 1997 December 19835 :30-55. Epub 1900 01 01.

Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.

Rawanduzy A, Hansen A, Hansen TW, Nedergaard M

Journal of neurosurgery.. 1997 December 87 (6):916-20. Epub 1900 01 01.

Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes.

Wang Z, Tymianski M, Jones OT, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1997 October 117 (19):7359-71. Epub 1900 01 01.

Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.

Rawanduzy A, Hansen A, Hansen TW, Nedergaard M

Neurosurgical focus.. 1997 May 152 (5):E1; discussion 1 p following E1. Epub 1900 01 01.

In vitro neurogenesis by adult human epileptic temporal neocortex.

Pincus DW, Harrison-Restelli C, Barry J, Goodman RR, Fraser RA, Nedergaard M, Goldman SA

Clinical neurosurgery. 1997 44 :17-25. Epub 1900 01 01.

Transient coupling of Ng-CAM expression to NgCAM-dependent calcium signaling during migration of new neurons in the adult songbird brain.

Goldman SA, Williams S, Barami K, Lemmon V, Nedergaard M

Molecular and cellular neurosciences.. 1996 January 7 (1):29-45. Epub 1900 01 01.

Spreading depression as a contributor to ischemic brain damage.

Nedergaard M

Advances in neurology.. 1996 71 :75-83; discussion 83-4. Epub 1900 01 01.

Gap junctions are required for the propagation of spreading depression.

Nedergaard M, Cooper AJ, Goldman SA

Journal of neurobiology.. 1995 December 28 (4):433-44. Epub 1900 01 01.

Intracellular Ca2+ transients evoked by lactic acid in cultured mammalian neurons.

Nedergaard M

The American journal of physiology.. 1995 February 268 (2 Pt 2):R506-13. Epub 1900 01 01.

Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.

Nedergaard M

Science.. 1994 March 25263 (5154):1768-71. Epub 1900 01 01.

In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain.

Kirschenbaum,B., Nedergaard,M., Preuss,A., Barami,K., Fraser,R. A., Goldman,S. A.

Cereb. Cortex. 1994; 4: 576-589.

In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain.

Kirschenbaum B, Nedergaard M, Preuss A, Barami K, Fraser RA, Goldman SA

Cerebral cortex.. 1994 4 (6):576-89. Epub 1900 01 01.

Carrier-mediated transport of lactic acid in cultured neurons and astrocytes.

Nedergaard M, Goldman SA

The American journal of physiology.. 1993 August 265 (2 Pt 2):R282-9. Epub 1900 01 01.

Characterization of cortical depolarizations evoked in focal cerebral ischemia.

Nedergaard M, Hansen AJ

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 1993 July 13 (4):568-74. Epub 1900 01 01.

Newly generated neurons of the adult songbird brain become functionally active in long-term culture.

Goldman SA, Nedergaard M

Brain research. Developmental brain research.. 1992 August 2168 (2):217-23. Epub 1900 01 01.

Acid-induced death in neurons and glia.

Nedergaard M, Goldman SA, Desai S, Pulsinelli WA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1991 August 11 (8):2489-97. Epub 1900 01 01.

Dynamics of interstitial and intracellular pH in evolving brain infarct.

Nedergaard M, Kraig RP, Tanabe J, Pulsinelli WA

The American journal of physiology.. 1991 March 260 (3 Pt 2):R581-8. Epub 1900 01 01.

Dicarboxy-dichlorofluorescein: a new fluorescent probe for measuring acidic intracellular pH.

Nedergaard M, Desai S, Pulsinelli W

Analytical biochemistry.. 1990 May 15187 (1):109-14. Epub 1900 01 01.

Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats.

Jakobsen J, Nedergaard M, Aarslew-Jensen M, Diemer NH

Diabetes.. 1990 April 39 (4):437-40. Epub 1900 01 01.

Experimental cerebral ischemia: barbiturate resistant increase in regional glucose utilization.

Nedergaard M, Diemer NH

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 1988 October 8 (5):763-6. Epub 1900 01 01.

Spreading depression is not associated with neuronal injury in the normal brain.

Nedergaard M, Hansen AJ

Brain research.. 1988 May 24449 (1-2):395-8. Epub 1900 01 01.

Middle cerebral artery occlusion in presence of low perfusion pressure increases infarct size in rats.

Sillesen H, Nedergaard M, Schroeder T, Buchardt Hansen HJ

Neurological research.. 1988 March 10 (1):61-3. Epub 1900 01 01.

Mechanisms of brain damage in focal cerebral ischemia.

Nedergaard M

Acta neurologica Scandinavica.. 1988 February 77 (2):81-101. Epub 1900 01 01.

Autoradiographic determination of cerebral glucose content, blood flow, and glucose utilization in focal ischemia of the rat brain: influence of the plasma glucose concentration.

Nedergaard M, Jakobsen J, Diemer NH

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 1988 February 8 (1):100-8. Epub 1900 01 01.

Brain ion homeostasis in cerebral ischemia.

Hansen AJ, Nedergaard M

Neurochemical pathology. 1988 9 :195-209. Epub 1900 01 01.

Hyperglycaemia protects against neuronal injury around experimental brain infarcts.

Nedergaard M, Gjedde A, Diemer NH

Neurological research.. 1987 December 9 (4):241-4. Epub 1900 01 01.

Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction.

Nedergaard M

Brain research.. 1987 April 7408 (1-2):79-85. Epub 1900 01 01.

Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration.

Nedergaard M, Diemer NH

Acta neuropathologica.. 1987 73 (2):131-7. Epub 1900 01 01.

Neuronal injury in the infarct border: a neuropathological study in the rat.

Nedergaard M

Acta neuropathologica.. 1987 73 (3):267-74. Epub 1900 01 01.

Infarct rim: effect of hyperglycemia on direct current potential and [14C]2-deoxyglucose phosphorylation.

Nedergaard M, Astrup J

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 1986 October 6 (5):607-15. Epub 1900 01 01.

Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow.

Nedergaard M, Gjedde A, Diemer NH

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 1986 August 6 (4):414-24. Epub 1900 01 01.

Cell density in the border zone around old small human brain infarcts.

Nedergaard M, Vorstrup S, Astrup J

Stroke.. 1986 17 (6):1129-37. Epub 1900 01 01.

Irradiation protects against pancreatic islet degeneration and hyperglycaemia following streptozotocin treatment of mice.

Nedergaard M, Egeberg J, Kromann H

Diabetologia.. 1983 May 24 (5):382-6. Epub 1900 01 01.

Secondary brain stem hemorrhage in stroke.

Nedergaard M, Klinken L, Paulson OB

Stroke.. 1983 14 (4):501-5. Epub 1900 01 01.

The low dose streptozotocin murine model of type 1 (insulin-dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones.

Kromann H, Christy M, Lernmark A, Nedergaard M, Nerup J

Diabetologia.. 1982 March 22 (3):194-8. Epub 1900 01 01.

Books

Neuroglia (2012)

Chapter: Transcriptome Analysis of Astrocytes

Authors: Lovatt, D., Nedergaard, M.

Publisher: Oxford Univ. Press, New York 2012

Dynamic Brain Imaging (2009)

Chapter: Astrocytic Ca2+ Signaling: Mechanism and implications for functional brain imaging

Authors: Wang, X., Takano, T., Nedergaard, M.

Publisher: Humana Press 2009

Encyclopedia of Neuroscience (2008)

Chapter: Purinergic regulation of calcium waves

Authors: Cotrina, M., Nedergaard, M.

Publisher: Springer Berlin Heidelberg 2008

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces (2006)

Authors: Dermietzel, R.; Spray, D.C.; Nedergaard, M.;

Publisher: Wiley-VCH, Weinheim, Germany 2006

Imaging structure and function in the nervous system, 2th edition (2006)

Chapter: Imaging astrocytes in acute brain slices

Authors: Kang, J., Nedergaard, M.

Publisher: Cold Spring Harbor Laboratory Press 2006

Neuroglia (2005)

Chapter: Intracellular Calcium Control Mechanisms in Glia

Authors: Cotrina, M.L.; Nedergaard, M.

Publisher: Oxford University Press, New York 2005

Cerebrovascular Disease: 22nd Princeton Conference (2002)

Chapter: Astrocytes in ischemic stroke

Authors: Lin, J.; Nedergaard, M.

Publisher: Cambridge University Press, New York 2002

The Tripartite Synapse: Glia in Synaptic Transmission (2002)

Chapter: Astrocytes as an intermediary in activity-dependent modulation of inhibitory synaptic transmission in hippocampus

Authors: Kang, J.; Nedergaard, M.

Publisher: Oxford University Press, New York 2002

Imaging Structure and Function in the Nervous System (2000)

Chapter: Imaging Astrocytes in Acute Brain Slices

Authors: Kang, J.; Nedergaard, M.

Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 2000

Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (1998)

Chapter: Pathophysiology of Focal Stroke

Authors: Back, T.; Nedergaard M.; Ginsberg., M.D.

Publisher: Blackwell Science, Malden MA 1998

Clinical Neurosurgery: Proceedings of the Congress of Neurological Surgeons (1997)

Chapter: In Vitro Neurogenesis by Adult Human Epileptic Temporal Neocortex

Authors: Pincus, D.; Harrison, C.; Barry, J.; Goodman, R.; Fraser, R.; Nedergaard, M.; Goldman, S.A.

Publisher: Williams & Wilkins, Baltimore 1997

Advances in Neurology (1996)

Chapter: Spreading depression as a contributor to ischemic brain damage

Authors: Nedergaard, M.

Publisher: Lippincott-Raven, New York 1996

Gap Junctions in the Nervous System (1996)

Chapter: Spreading Depression- A Gap Junction Mediated Event?

Authors: Nedergaard M.; Goldman, S.A.

Publisher: R.G. Landes Company, Georgetown, TX 1996

Cerebrovascular Diseases (1989)

Chapter: Hypoglycemia Reduces Infarct Size in Experimental Focal Ischemia. The Influence of Plasma Glucose on Ischemic Brain Damage.

Authors: Nedergaard M.; Diemer, N. H.

Publisher: Raven Press, New York 1989

Brain Ischemia: Medical and Surgical Therapy and Rehabilitation (1985)

Chapter: Experimental Stroke: Effects of Hyperglycemia

Authors: Nedergaard, M.; Gjedde, A.; Diemer, N.H.

Publisher: Raven Press, New York 1985

Brain Ischemia: Medical and Surgical Therapy and Rehabilitation (1985)

Chapter: Is There Reduced Neuron Density in the CT Normal Borders of Chronic Brain Infarct

Authors: Nedergaard, M.; Klinken, L.; Astrup, J.

Publisher: Raven Press, New York 1985

Microsurgical Anastomosis for Cerebral Ischemia (1984)

Chapter: Cell Density in the Surroundings of Minor and Major Chronic Brain Infarcts

Authors: Nedergaard, M.; Klinken, L.; Astrup, J.

Publisher: Unknown 1984