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About Me

Faculty Appointments

Professor - Department of Environmental Medicine (SMD)

Dean's Professorship - Department of Environmental Medicine (SMD)

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD) - Joint

Professor - Department of Public Health Sciences (SMD) - Joint

Credentials

Awards

Senior Investigator Award: The Oxygen Club of California. 2006

Research

Oxidant and cigarette smoke-mediated lung inflammation.

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per ye...
Oxidant and cigarette smoke-mediated lung inflammation.

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants.

Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Publications

Journal Articles

Chemical and physiological interactions between e-liquid constituents: cause for concern?

Strongin RM, Sharma E, Erythropel HC, Kassem NOF, Noël A, Peyton DH, Rahman I

Tobacco control.. 2024 April 24 Epub 04/24/2024.

Vaping: Public Health, Social Media, and Toxicity.

Sun Y, Prabhu P, Li D, McIntosh S, Rahman I

Online journal of public health informatics.. 2024 April 1116 :e53245. Epub 04/11/2024.

Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: "What Are the Tools Needed for the Job?" and "Do We Have Them?".

Chandy M, Hill T, Jimenez-Tellez N, Wu JC, Sarles SE, Hensel E, Wang Q, Rahman I, Conklin DJ

Cardiovascular toxicology.. 2024 March 31 Epub 03/31/2024.

Emerging roles of senolytics/senomorphics in HIV-related co-morbidities.

Kaur G, Sohanur Rahman M, Shaikh S, Panda K, Chinnapaiyan S, Santiago Estevez M, Xia L, Unwalla H, Rahman I

Biochemical pharmacology.. 2024 March 29 :116179. Epub 03/29/2024.

Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis.

Wang Q, Goracci C, Sundar IK, Rahman I

Journal of inflammation.. 2024 March 2021 (1):9. Epub 03/20/2024.

Abnormal expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users.

Li D, Xie Z, Shaikh SB, Rahman I

Research square.. 2024 January 24 Epub 01/24/2024.

Tobacco-derived and tobacco-free nicotine cause differential inflammatory cell influx and MMP-9 in mouse lung.

Lamb T, Kaur G, Rahman I

Respiratory research.. 2024 January 2325 (1):51. Epub 01/23/2024.

Tobacco and menthol flavored nicotine-free electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium.

Wang Q, Lucas JH, Pang C, Zhao R, Rahman I

Respiratory research.. 2024 January 1025 (1):23. Epub 01/10/2024.

Development of a Vaping Cessation Text Messaging Intervention for Latino Young Adults: A Participatory Research Approach.

Orfin RH, Siddalingaiah S, Dontu V, Estrada B, Martinez C, Guerra D, Carrillo H, Cervantes-Díaz MJ, Rodríguez-Rojas DV, Rahman I, McIntosh S, Ossip DJ, Cupertino AP, Cartujano-Barrera F

Community health equity research & policy.. 2024 January 5 :2752535X231225928. Epub 01/05/2024.

Comparison of emissions across tobacco products: A slippery slope in tobacco control.

El-Hellani A, Adeniji A, Erythropel HC, Wang Q, Lamb T, Mikheev VB, Rahman I, Stepanov I, Strongin RM, Wagener TL, Brinkman MC

Tobacco induced diseases.. 2024 22 Epub 03/30/2024.

Recruiting Latino young adults into a vaping cessation study via social media: Feasibility and cost analysis.

Orfin RH, Uceda V, Gardner C, Estrada B, Tamayo E, Hernández-Torres R, Li D, Rahman I, McIntosh S, Ossip DJ, Cupertino AP, Cartujano-Barrera F

Tobacco prevention & cessation.. 2024 10 Epub 04/09/2024.

Corrigendum to "E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses" [Toxicol. Rep. 9 (2022) 1823-1830].

Manevski M, Yogeswaran S, Rahman I, Devadoss D, Chand HS

Toxicology reports.. 2023 December 11 :259-260. Epub 09/19/2023.

Tobacco-Derived and Tobacco-Free Nicotine cause differential inflammatory cell influx and MMP9 in mouse lung.

Lamb T, Kaur G, Rahman I

Research square.. 2023 November 28 Epub 11/28/2023.

Environmental tobacco smoke exposure exaggerates bleomycin- induced collagen overexpression during pulmonary fibrogenesis.

Wang Q, Goracci C, Sundar IK, Rahman I

Research square.. 2023 October 10 Epub 10/10/2023.

Tobacco and Menthol flavored electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium.

Wang Q, Lucas JH, Pang C, Zhao R, Rahman I

Research square.. 2023 June 12 Epub 06/12/2023.

Impact of aging on immune function in the pathogenesis of pulmonary diseases: Potential for therapeutic targets.

Shaikh SB, Goracci C, Tjitropranoto A, Rahman I

Expert review of respiratory medicine.. 2023 April 20 Epub 04/20/2023.

Clearance of senescent cells reverts the cigarette smoke-induced lung senescence and airspace enlargement in p16-3MR mice.

Kaur G, Muthumalage T, Rahman I

Aging cell.. 2023 April 20 :e13850. Epub 04/20/2023.

Pulmonary Immune Response Regulation, Genotoxicity, and Metabolic Reprogramming by Menthol and Tobacco Flavored E-Cigarette Exposures in Mice.

Muthumalage T, Rahman I

Toxicological sciences : an official journal of the Society of Toxicology.. 2023 April 13 Epub 04/13/2023.

An evaluation of statistical differential analysis methods in single-cell RNA-seq data.

Li D, Zand M, Dye T, Goniewicz M, Rahman I, Xie Z

Research square.. 2023 March 23 Epub 03/23/2023.

Circadian clock molecule REV-ERB? regulates lung fibrotic progression through collagen stabilization.

Wang Q, Sundar IK, Lucas JH, Park JG, Nogales A, Martinez-Sobrido L, Rahman I

Nature communications.. 2023 March 914 (1):1295. Epub 03/09/2023.

Classification, Perception, and Toxicity of Emerging Flavored Oral Nicotine Pouches.

Shaikh SB, Newton C, Tung WC, Sun Y, Li D, Ossip D, Rahman I

International journal of environmental research and public health.. 2023 March 320 (5)Epub 03/03/2023.

Emerging Oral Nicotine Products and Periodontal Diseases.

Ye D, Rahman I

International journal of dentistry.. 2023 2023 :9437475. Epub 02/10/2023.

Pro-inflammatory effects of aerosols from e-cigarette-derived flavoring chemicals on murine macrophages.

Lamb T, Rahman I

Toxicology reports.. 2023 10 :431-435. Epub 04/06/2023.

Potential Impact of the COVID-19 Pandemic on Public Perception of Water Pipes on Reddit: Observational Study.

Zheng Z, Xie Z, Goniewicz M, Rahman I, Li D

JMIR infodemiology.. 2023 3 :e40913. Epub 04/20/2023.

SARS-CoV-2 Covid-19 Infection During Pregnancy and Differential DNA Methylation in Human Cord Blood Cells From Term Neonates.

Urday P, Gayen Nee' Betal S, Sequeira Gomes R, Al-Kouatly HB, Solarin K, Chan JS, Li D, Rahman I, Addya S, Boelig RC, Aghai ZH

Epigenetics insights.. 2023 16 :25168657231184665. Epub 06/30/2023.

Circadian clock-based therapeutics in chronic pulmonary diseases.

Giri A, Rahman I, Sundar IK

Trends in pharmacological sciences.. 2022 October 24 Epub 10/24/2022.

Perfluorooctane sulfonic acid disrupts protective tight junction proteins via protein kinase D in airway epithelial cells.

Lucas JH, Wang Q, Rahman I

Toxicological sciences : an official journal of the Society of Toxicology.. 2022 September 15 Epub 09/15/2022.

Nose-Only Exposure to Cherry- and Tobacco-Flavored E-Cigarettes Induced Lung Inflammation in Mice in a Sex-Dependent Manner.

Lamb T, Muthumalage T, Meehan-Atrash J, Rahman I

Toxics.. 2022 August 1310 (8)Epub 08/13/2022.

Perceptions of Oral Nicotine Pouches on Reddit: Observational Study.

Shao Y, Zou J, Xie Z, Mayne RG, Ossip DJ, Rahman I, McIntosh S, Li D

Journal of medical Internet research.. 2022 July 1524 (7):e37071. Epub 07/15/2022.

Influence of E-Cigarette and Cannabis Vaping on Orthodontically Induced Tooth Movement and Periodontal Health in Patients Undergoing Orthodontic Therapy.

Michelogiannakis D, Rahman I

International journal of environmental research and public health.. 2022 May 2719 (11)Epub 05/27/2022.

Circadian molecular clock disruption in chronic pulmonary diseases.

Giri A, Wang Q, Rahman I, Sundar IK

Trends in molecular medicine.. 2022 May 1 Epub 05/01/2022.

Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study.

Podguski S, Kaur G, Muthumalage T, McGraw MD, Rahman I

ERJ open research.. 2022 April 8 (2)Epub 04/04/2022.

Reduced Plasma Phosphatidylethanolamines in E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI).

McGraw MD, Croft DP, Nacca NE, Rahman I

Pediatric pulmonology.. 2022 February 28 Epub 02/28/2022.

Increased Expression of lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia.

Manevski M, Devadoss D, Long C, Singh SP, Nasser MW, Borchert GM, Nair MN, Rahman I, Sopori M, Chand HS

Frontiers in immunology.. 2022 13 :803362. Epub 06/14/2022.

Corrigendum: Increased expression of LncRNA regulates the cigarette smoke and COPD associated airway inflammation and mucous cell hyperplasia.

Manevski M, Devadoss D, Long C, Singh SP, Nasser MW, Borchert GM, Nair MN, Rahman I, Sopori M, Chand HS

Frontiers in immunology.. 2022 13 :988069. Epub 08/08/2022.

An evaluation of RNA-seq differential analysis methods.

Li D, Zand MS, Dye TD, Goniewicz ML, Rahman I, Xie Z

PloS one.. 2022 17 (9):e0264246. Epub 09/16/2022.

Editorial: Insights in respiratory pharmacology: 2021.

Montuschi P, Rahman I

Frontiers in pharmacology.. 2022 13 :1052994. Epub 11/07/2022.

E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses.

Manevski M, Yogeswaran S, Rahman I, Devadoss D, Chand HS

Toxicology reports.. 2022 9 :1823-1830. Epub 09/20/2022.

The role of synthetic coolants, WS-3 and WS-23, in modulating E-cigarette-induced reactive oxygen species (ROS) in lung epithelial cells.

Yogeswaran S, Shaikh SB, Manevski M, Chand HS, Rahman I

Toxicology reports.. 2022 9 :1700-1709. Epub 08/19/2022.

Novel ?-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals.

Meehan-Atrash J, Rahman I

Chemical research in toxicology.. 2021 December 10 Epub 12/10/2021.

Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract.

Le HHT, Liu CW, Denaro P, Jousma J, Shao NY, Rahman I, Lee WH

Stem cell research & therapy.. 2021 December 412 (1):593. Epub 12/04/2021.

Epithelial Ablation of Miro1/Rhot1 GTPase Augments Lung Inflammation by Cigarette Smoke.

Sharma S, Wang Q, Muthumalage T, Rahman I

Pathophysiology : the official journal of the International Society for Pathophysiology. 2021 November 2628 (4):501-512. Epub 11/26/2021.

Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF Patients.

Kaur G, Maremanda KP, Campos M, Chand HS, Li F, Hirani N, Haseeb MA, Li D, Rahman I

International journal of molecular sciences.. 2021 October 3122 (21)Epub 10/31/2021.

Cannabis Vaping: Existing and Emerging Modalities, Chemistry, and Pulmonary Toxicology.

Meehan-Atrash J, Rahman I

Chemical research in toxicology.. 2021 October 8 Epub 10/08/2021.

SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism.

Kaur G, Ji X, Rahman I

Metabolites.. 2021 September 2811 (10)Epub 09/28/2021.

Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-?-mediated suppression of CFTR mRNA and function.

Dutta RK, Chinnapaiyan S, Santiago MJ, Rahman I, Unwalla HJ

Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.. 2021 August 27142 :112090. Epub 08/27/2021.

Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD.

Maremanda KP, Sundar IK, Rahman I

Redox biology.. 2021 June 2445 :102055. Epub 06/24/2021.

Multi-Walled Carbon Nanotubes (MWCNTs) Cause Cellular Senescence in TGF-? Stimulated Lung Epithelial Cells.

Lucas JH, Wang Q, Muthumalage T, Rahman I

Toxics.. 2021 June 199 (6)Epub 06/19/2021.

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.

Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B

American journal of respiratory and critical care medicine.. 2021 May 25 Epub 05/25/2021.

Molecular clock REV-ERB? regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal-transition.

Wang Q, Sundar IK, Lucas JH, Muthumalage T, Rahman I

JCI insight.. 2021 May 20 Epub 05/20/2021.

p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries.

Kaur G, Sundar IK, Rahman I

International journal of molecular sciences.. 2021 May 322 (9)Epub 05/03/2021.

Recent updates on biomarkers of exposure and systemic toxicity in e-cigarette users and EVALI.

McDonough SR, Rahman I, Sundar IK

American journal of physiology. Lung cellular and molecular physiology.. 2021 January 27 Epub 01/27/2021.

E-Cigarettes and Cardiopulmonary Health.

Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE

Function.. 2021 2 (2):zqab004. Epub 02/08/2021.

Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19.

Kaur G, Yogeswaran S, Muthumalage T, Rahman I

Frontiers in physiology.. 2021 12 :653045. Epub 05/28/2021.

Perspectives on Epigenetics Alterations Associated with Smoking and Vaping.

Xie Z, Rahman I, Goniewicz ML, Li D

Function.. 2021 2 (3):zqab022. Epub 04/23/2021.

Acute effects of heated tobacco product (IQOS) aerosol-inhalation on lung tissue damage and inflammatory changes in the lungs.

Bhat TA, Kalathil SG, Leigh N, Muthumalage T, Rahman I, Goniewicz ML, Thanavala YM

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2020 December 21 Epub 12/21/2020.

Cross-Sectional Association Between Exclusive and Concurrent Use of Cigarettes, ENDS, and Cigars, the Three Most Popular Tobacco Products, and Wheezing Symptoms Among U.S. Adults.

Schneller LM, Quiñones Tavárez Z, Goniewicz ML, Xie Z, McIntosh S, Rahman I, O'Connor RJ, Ossip DJ, Li D

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2020 December 1522 (Supplement_1):S76-S84. Epub 1900 01 01.

FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease.

Alderawi A, Caramori G, Baker EH, Hitchings AW, Rahman I, Rossios C, Adcock I, Cassolari P, Papi A, Ortega VE, Curtis JL, Dunmore S, Kirkham P

BMJ open respiratory research.. 2020 November 7 (1)Epub 1900 01 01.

Exosomal microRNAs are novel circulating biomarkers in cigarette, waterpipe smokers, E-cigarette users and dual smokers.

Singh KP, Maremanda KP, Li D, Rahman I

BMC medical genomics.. 2020 September 1013 (1):128. Epub 09/10/2020.

Flavor Inconsistencies between Flavored Tobacco Products among US Adults.

Schneller LM, Li D, Tavárez ZQ, Goniewicz ML, Quisenberry AJ, Xie Z, Rahman I, McIntosh S, O'Connor RJ, Ossip DJ

American journal of health behavior.. 2020 September 144 (5):617-630. Epub 1900 01 01.

Prenatal Exposure to E-Cigarette Aerosols Leads to Sex-dependent Pulmonary Extracellular Matrix Remodeling and Myogenesis in Offspring Mice.

Wang Q, Sundar IK, Blum JL, Ratner JR, Lucas JH, Chuang TD, Wang Y, Liu J, Rehan VK, Zelikoff JT, Rahman I

American journal of respiratory cell and molecular biology.. 2020 August 27 Epub 08/27/2020.

Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells.

Lamb T, Muthumalage T, Rahman I

Toxicology letters.. 2020 August 9 Epub 08/09/2020.

Home smoking and vaping policies among US adults: results from the Population Assessment of Tobacco and Health (PATH) study, wave 3.

Li D, Shi H, Xie Z, Rahman I, McIntosh S, Bansal-Travers M, Winickoff JP, Drehmer JE, Ossip DJ

Preventive medicine.. 2020 July 18 :106215. Epub 07/18/2020.

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR ?7 receptor: role of nAChR ?7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.

Wang Q, Sundar IK, Li D, Lucas JH, Muthumalage T, McDonough SR, Rahman I

Respiratory research.. 2020 June 1821 (1):154. Epub 06/18/2020.

Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN

Toxicology letters.. 2020 June 1325 :25-33. Epub 02/26/2020.

Cellular stress responses and dysfunctional Mitochondrial-cellular senescence, and therapeutics in chronic respiratory diseases.

Manevski M, Muthumalage T, Devadoss D, Sundar IK, Wang Q, Singh KP, Unwalla HJ, Chand HS, Rahman I

Redox biology.. 2020 June 33 :101443. Epub 01/25/2020.

E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR ?7 Receptor: Role of nAChR ?7 in ACE2 Covid-19 receptor regulation.

Wang Q, Sundar I, Li D, Lucas J, Muthumalage T, McDonough S, Rahman I

Research square.. 2020 May 18 Epub 05/18/2020.

Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.

Chinnapaiyan S, Dutta RK, Devadoss D, Chand HS, Rahman I, Unwalla HJ

International journal of molecular sciences.. 2020 April 2421 (8)Epub 04/24/2020.

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).

Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I

Toxics.. 2020 April 38 (2)Epub 04/03/2020.

Inflammatory Biomarkers and Growth Factors in Saliva and Gingival Crevicular Fluid of E-cigarette users, Cigarette smokers, and Dual smokers: A pilot study.

Ye D, Gajendra S, Lawyer G, Jadeja N, Pishey D, Pathagunti S, Lyons J, Veazie P, Watson G, McIntosh S, Rahman I

Journal of periodontology.. 2020 February 12 Epub 02/12/2020.

Flavor Preference and Systemic Immunoglobulin Responses in E-Cigarette Users and Waterpipe and Tobacco Smokers: A Pilot Study.

Jackson M, Singh KP, Lamb T, McIntosh S, Rahman I

International journal of environmental research and public health.. 2020 January 1917 (2)Epub 01/19/2020.

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping

Kaur, G.; Lungarella, G.; Rahman, I.

Journal of Inflammation. 2020; 17(28): 1-8.

E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR ?7 Receptor: Role of nAChR ?7 in ACE2 Covid-19 receptor regulation

Wang, Q.; Isaac Sundar, I.; Li, D.; Lucas, J.; Muthumalage, T.; McDonough, S.; Rahman, I.

Respiratory Research. 2020; .

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping.

Kaur G, Lungarella G, Rahman I

Journal of inflammation.. 2020 17 :21. Epub 06/10/2020.

DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis.

Fong G, Gayen Nee' Betal S, Murthy S, Favara M, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Li D, Rahman I, Aghai ZH

Frontiers in pediatrics.. 2020 8 :437. Epub 08/04/2020.

E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging.

Lucas JH, Muthumalage T, Wang Q, Friedman MR, Friedman AE, Rahman I

Frontiers in physiology.. 2020 11 :924. Epub 09/04/2020.

Association of flavored electronic nicotine delivery system (ENDS) use with self-reported chronic obstructive pulmonary disease (COPD): Results from the Population Assessment of Tobacco and Health (PATH) study, Wave 4.

Shi H, Tavárez ZQ, Xie Z, Schneller LM, Croft DP, Goniewicz ML, McIntosh S, O'Connor RJ, Ossip DJ, Rahman I, Li D

Tobacco induced diseases.. 2020 18 :82. Epub 10/01/2020.

Electronic cigarette use and subjective cognitive complaints in adults.

Xie Z, Ossip DJ, Rahman I, O'Connor RJ, Li D

PloS one.. 2020 15 (11):e0241599. Epub 11/02/2020.

Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers.

Kaur G, Singh K, Maremanda KP, Li D, Chand HS, Rahman I

PloS one.. 2020 15 (12):e0243065. Epub 12/08/2020.

Current Perspectives on Characteristics, Compositions, and Toxicological Effects of E-Cigarettes Containing Tobacco and Menthol/Mint Flavors.

Kaur G, Gaurav A, Lamb T, Perkins M, Muthumalage T, Rahman I

Frontiers in physiology.. 2020 11 :613948. Epub 11/19/2020.

The Interplay Between Respiratory Microbiota and Innate Immunity in Flavor E-Cigarette Vaping Induced Lung Dysfunction.

Quinones Tavarez Z, Li D, Croft DP, Gill SR, Ossip DJ, Rahman I

Frontiers in microbiology.. 2020 11 :589501. Epub 12/16/2020.

Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke.

Sundar IK, Maremanda KP, Rahman I

Toxicology letters.. 2019 December 15317 :92-101. Epub 10/05/2019.

E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes.

Muthumalage T, Lamb T, Friedman MR, Rahman I

Scientific reports.. 2019 December 139 (1):19035. Epub 12/13/2019.

Use of electronic cigarettes and self-reported COPD diagnosis in adults.

Xie Z, Ossip DJ, Rahman I, Li D

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2019 December 12 Epub 12/12/2019.

Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts.

Muthumalage T, Rahman I

Toxicology and applied pharmacology.. 2019 November 1382 :114713. Epub 08/19/2019.

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.

Maremanda KP, Sundar IK, Rahman I

Toxicology and applied pharmacology.. 2019 October 30 :114788. Epub 10/30/2019.

Tobacco-product usage as a risk factor for dental implants.

Javed F, Rahman I, Romanos GE

Periodontology 2000.. 2019 October 81 (1):48-56. Epub 1900 01 01.

Dysregulated repair and inflammatory responses by e-cigarette-derived inhaled nicotine and humectant propylene glycol in a sex-dependent manner in mouse lung.

Wang Q, Khan NA, Muthumalage T, Lawyer GR, McDonough SR, Chuang TD, Gong M, Sundar IK, Rehan VK, Rahman I

FASEB bioAdvances.. 2019 October 1 (10):609-623. Epub 08/23/2019.

Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries.

Singh KP, Lawyer G, Muthumalage T, Maremanda KP, Khan NA, McDonough SR, Ye D, McIntosh S, Rahman I

ERJ open research.. 2019 October 5 (4)Epub 12/23/2019.

Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers.

Khan NA, Lawyer G, McDonough S, Wang Q, Kassem NO, Kas-Petrus F, Ye D, Singh KP, Kassem NOF, Rahman I

Tobacco control.. 2019 September 7 Epub 09/07/2019.

Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.

Devadoss D, Long C, Langley RJ, Manevski M, Nair M, Campos MA, Borchert G, Rahman I, Chand HS

American journal of respiratory cell and molecular biology.. 2019 September 5 Epub 09/05/2019.

TGF-?1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cells.

Chinnapaiyan S, Dutta RK, Nair M, Chand HS, Rahman I, Unwalla HJ

Scientific reports.. 2019 August 299 (1):12552. Epub 08/29/2019.

Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers.

BinShabaib M, ALHarthi SS, Akram Z, Khan J, Rahman I, Romanos GE, Javed F

Archives of oral biology.. 2019 May 3102 :212-217. Epub 05/03/2019.

Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates.

Gayen Nee', Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH

Scientific reports.. 2019 April 109 (1):5862. Epub 04/10/2019.

Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs.

Khan NA, Yogeswaran S, Wang Q, Muthumalage T, Sundar IK, Rahman I

PloS one.. 2019 14 (2):e0211645. Epub 02/27/2019.

Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses.

Lawyer GR, Jackson M, Prinz M, Lamb T, Wang Q, Muthumalage T, Rahman I

PloS one.. 2019 14 (12):e0226066. Epub 12/11/2019.

Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury.

Chand HS, Muthumalage T, Maziak W, Rahman I

Frontiers in pharmacology.. 2019 10 :1619. Epub 01/14/2020.

Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: a prospective study.

ALHarthi SS, BinShabaib M, Akram Z, Rahman I, Romanos GE, Javed F

Clinical oral investigations.. 2018 October 26 Epub 10/26/2018.

Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.

Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 September 32 (9):4955-4971. Epub 04/09/2018.

Genetic Ablation of p16 Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema.

Sundar IK, Rashid K, Gerloff J, Li D, Rahman I

American journal of respiratory cell and molecular biology.. 2018 August 59 (2):189-199. Epub 1900 01 01.

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema.

Rashid K, Sundar IK, Gerloff J, Li D, Rahman I

Scientific reports.. 2018 June 138 (1):9023. Epub 06/13/2018.

Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies.

Javed F, Kellesarian SV, Abduljabbar T, Abduljabbar AT, Akram Z, Vohra F, Rahman I, Romanos GE

International journal of oral and maxillofacial surgery.. 2018 June 47 (6):764-772. Epub 12/09/2017.

Does E-cigarette Use at Baseline Influence Smoking Cessation Rates among 2-Year College Students?

Snow E, Johnson T, Ossip DJ, Williams GC, Ververs D, Rahman I, McIntosh S

Journal of smoking cessation.. 2018 June 13 (2):110-120. Epub 06/28/2017.

Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products.

Kaur G, Muthumalage T, Rahman I

Toxicology letters.. 2018 May 15288 :143-155. Epub 02/23/2018.

Redox regulation of circadian molecular clock in chronic airway diseases.

Sundar IK, Sellix MT, Rahman I

Free radical biology & medicine.. 2018 May 1119 :121-128. Epub 10/31/2017.

Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.

Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM

Scientific reports.. 2018 April 108 (1):5746. Epub 04/10/2018.

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.

Tang M, Ji C, Pallo S, Rahman I, Johnson GVW

Neurobiology of aging.. 2018 March 63 :128-139. Epub 12/09/2017.

Qualitative Analysis of E-Liquid Emissions as a Function of Flavor Additives Using Two Aerosol Capture Methods.

Eddingsaas N, Pagano T, Cummings C, Rahman I, Robinson R, Hensel E

International journal of environmental research and public health.. 2018 February 1315 (2)Epub 02/13/2018.

Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse.

Khan NA, Sundar IK, Rahman I

Physiological reports.. 2018 February 6 (3)Epub 1900 01 01.

Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling.

Lee H, Lee J, Hong SH, Rahman I, Yang SR

Frontiers in pharmacology.. 2018 9 :684. Epub 07/02/2018.

Tobacco use and chemosensory impairments among current adult tobacco users in the US: Data from NHANES 2013-2014.

Schneller LM, McIntosh S, Li D, Rahman I, Ossip D, Goniewicz M, O'Connor RJ

Tobacco induced diseases.. 2018 16 :43. Epub 09/18/2018.

The nuclear receptor and clock gene REV-ERB? regulates cigarette smoke-induced lung inflammation.

Sundar IK, Rashid K, Sellix MT, Rahman I

Biochemical and biophysical research communications.. 2017 December 2493 (4):1390-1395. Epub 09/30/2017.

Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues.

Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I

Oral diseases.. 2017 November 23 (8):1052-1057. Epub 03/30/2017.

Comparison of Periodontal Parameters and Self-Perceived Oral Symptoms Among Cigarette Smokers, Individuals Vaping Electronic Cigarettes, and Never-Smokers.

Javed F, Abduljabbar T, Vohra F, Malmstrom H, Rahman I, Romanos GE

Journal of periodontology.. 2017 October 88 (10):1059-1065. Epub 06/23/2017.

Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice.

Rahman I, De Cunto G, Sundar IK, Lungarella G

American journal of respiratory cell and molecular biology.. 2017 September 57 (3):270-271. Epub 1900 01 01.

Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system.

Javed F, ALHarthi SS, BinShabaib MS, Gajendra S, Romanos GE, Rahman I

Inhalation toxicology.. 2017 August 29 (9):389-396. Epub 10/17/2017.

In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use.

Behrsing H, Hill E, Raabe H, Tice R, Fitzpatrick S, Devlin R, Pinkerton K, Oberdörster G, Wright C, Wieczorek R, Aufderheide M, Steiner S, Krebs T, Asgharian B, Corley R, Oldham M, Adamson J, Li X, Rahman I, Grego S, Chu PH, McCullough S, Curren R

Alternatives to laboratory animals : ATLA.. 2017 July 45 (3):117-158. Epub 1900 01 01.

Blockade of RAGE ameliorates elastase-induced emphysema development and progression RAGE-DAMP signaling.

Lee H, Park JR, Kim WJ, Sundar IK, Rahman I, Park SM, Yang SR

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2017 May 31 (5):2076-2089. Epub 02/01/2017.

Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III.

Lei W, Lerner C, Sundar IK, Rahman I

Scientific reports.. 2017 March 37 :43213. Epub 03/03/2017.

Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts.

Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I

Applied in vitro toxicology.. 2017 March 13 (1):28-40. Epub 1900 01 01.

Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study.

Arbat S, Dave M, Niranjane V, Rahman I, Arbat A

Virusdisease.. 2017 March 28 (1):33-38. Epub 03/18/2017.

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.

Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I

American journal of respiratory cell and molecular biology.. 2017 January 56 (1):38-49. Epub 1900 01 01.

DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.

Sundar IK, Yin Q, Baier BS, Yan L, Mazur W, Li D, Susiarjo M, Rahman I

Clinical epigenetics.. 2017 9 :38. Epub 04/14/2017.

Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine.

Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I

Frontiers in physiology.. 2017 8 :1130. Epub 01/11/2018.

Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer.

Sundar IK, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2016 December 1311 (6):L1245-L1258. Epub 10/28/2016.

Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD.

Lerner CA, Sundar IK, Rahman I

The international journal of biochemistry & cell biology.. 2016 December 81 (Pt B):294-306. Epub 07/26/2016.

Redox regulation of inflammatory processes.

Valacchi G, Cervellati C, Evelson P, Rahman I

The international journal of biochemistry & cell biology.. 2016 December 81 (Pt B):234-235. Epub 11/03/2016.

E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts.

Sundar IK, Javed F, Romanos GE, Rahman I

Oncotarget.. 2016 November 227 (47):77196-77204. Epub 1900 01 01.

Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts.

Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I

Biochemical and biophysical research communications.. 2016 September 2477 (4):620-625. Epub 06/23/2016.

Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the United States by Gas Chromatography-Mass Spectrometry.

Pagano T, DiFrancesco AG, Smith SB, George J, Wink G, Rahman I, Robinson RJ

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2016 May 18 (5):700-7. Epub 06/04/2015.

Comparison of Clinical and Radiographic Periodontal Status Between Habitual Water-Pipe Smokers and Cigarette Smokers.

Javed F, Al-Kheraif AA, Rahman I, Millan-Luongo LT, Feng C, Yunker M, Malmstrom H, Romanos GE

Journal of periodontology.. 2016 February 87 (2):142-7. Epub 10/02/2015.

Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury.

Lerner CA, Lei W, Sundar IK, Rahman I

Frontiers in pharmacology.. 2016 7 :391. Epub 10/25/2016.

Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.

Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I

American journal of respiratory cell and molecular biology.. 2015 December 53 (6):782-92. Epub 1900 01 01.

Circadian molecular clock in lung pathophysiology.

Sundar IK, Yao H, Sellix MT, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2015 November 15309 (10):L1056-75. Epub 09/11/2015.

Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases.

Sundar IK, Yao H, Sellix MT, Rahman I

American journal of respiratory cell and molecular biology.. 2015 September 53 (3):285-90. Epub 1900 01 01.

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease.

Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2015 July 29 (7):2912-29. Epub 03/19/2015.

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.

Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I

Scientific reports.. 2015 April 294 :9927. Epub 04/29/2015.

Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols.

Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I

Environmental pollution.. 2015 March 198 :100-7. Epub 01/09/2015.

Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.

Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I

PloS one.. 2015 10 (2):e0116732. Epub 02/06/2015.

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2014 May 1306 (9):L816-28. Epub 03/14/2014.

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GV

Nature communications.. 2014 March 255 :3496. Epub 03/25/2014.

Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer.

Rahman I, Sundar IK, Nevid MZ, Friedman AE

Journal of proteome research.. 2014 February 713 (2):982-96. Epub 12/13/2013.

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.

Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2014 January 28 (1):176-94. Epub 09/11/2013.

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis.

Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I

PloS one.. 2014 9 (2):e87999. Epub 02/10/2014.

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.

Gilels F, Paquette ST, Zhang J, Rahman I, White PM

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 November 2033 (47):18409-24. Epub 1900 01 01.

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2013 November 1305 (9):L615-24. Epub 09/13/2013.

Redox regulation of SIRT1 in inflammation and cellular senescence.

Hwang JW, Yao H, Caito S, Sundar IK, Rahman I

Free radical biology & medicine.. 2013 August 61 :95-110. Epub 03/27/2013.

Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.

Sundar IK, Yao H, Rahman I

Antioxidants & redox signaling.. 2013 May 2018 (15):1956-71. Epub 11/06/2012.

Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.

Biswas S, Hwang JW, Kirkham PA, Rahman I

Current medicinal chemistry.. 2013 20 (12):1496-530. Epub 1900 01 01.

P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence.

Yao H, Sundar IK, Gorbunova V, Rahman I

PloS one.. 2013 8 (11):e80007. Epub 11/11/2013.

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.

Yao H, Rahman I

Biochemical pharmacology.. 2012 November 1584 (10):1332-9. Epub 07/14/2012.

Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD.

Yao H, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2012 October 1303 (7):L557-66. Epub 07/27/2012.

Antioxidant pharmacological therapies for COPD.

Rahman I, Macnee W

Current opinion in pharmacology.. 2012 June 12 (3):256-65. Epub 02/18/2012.

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I

The Journal of clinical investigation.. 2012 June 122 (6):2032-45. Epub 05/01/2012.

Pharmacological antioxidant strategies as therapeutic interventions for COPD.

Rahman I

Biochimica et biophysica acta.. 2012 May 1822 (5):714-28. Epub 11/09/2011.

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.

Rahman I, Kinnula VL, Gorbunova V, Yao H

Preventive medicine.. 2012 May 54 Suppl :S20-8. Epub 12/08/2011.

Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.

Rahman I, Kinnula VL

Expert review of clinical pharmacology.. 2012 May 5 (3):293-309. Epub 1900 01 01.

Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes.

Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I

PloS one.. 2012 7 (2):e31378. Epub 02/01/2012.

SIRT1-mediated acute cardioprotection.

Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente LP, Rahman I, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2011 October 301 (4):H1506-12. Epub 08/19/2011.

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.

Yao H, Rahman I

Toxicology and applied pharmacology.. 2011 July 15254 (2):72-85. Epub 02/04/2011.

FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 July 15187 (2):987-98. Epub 06/20/2011.

Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics.

Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I

Current opinion in pulmonary medicine.. 2011 July 17 (4):279-85. Epub 1900 01 01.

Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung.

Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I

Pediatric research.. 2011 May 69 (5 Pt 1):371-7. Epub 1900 01 01.

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation.

Sundar IK, Hwang JW, Wu S, Sun J, Rahman I

Biochemical and biophysical research communications.. 2011 March 4406 (1):127-33. Epub 02/12/2011.

Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.

Nadtochiy SM, Redman E, Rahman I, Brookes PS

Cardiovascular research.. 2011 February 1589 (3):643-9. Epub 09/07/2010.

NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I

PloS one.. 2011 6 (8):e23488. Epub 08/24/2011.

Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.

Sundar IK, Rahman I

Frontiers in pharmacology.. 2011 2 :50. Epub 08/30/2011.

Outcome of Smoking Cessation on Airway Remodeling and Pulmonary Inflammation in COPD Patients.

Mortaz E, Masjedi MR, Rahman I

Tanaffos.. 2011 10 (3):7-11. Epub 1900 01 01.

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction.

Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I

Biochemical and biophysical research communications.. 2010 December 17403 (3-4):452-6. Epub 11/19/2010.

Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury.

Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I

Experimental lung research.. 2010 October 36 (8):451-62. Epub 1900 01 01.

Regulation of SIRT1 in cellular functions: role of polyphenols.

Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I

Archives of biochemistry and biophysics.. 2010 September 1501 (1):79-90. Epub 05/05/2010.

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress.

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 September 24 (9):3145-59. Epub 04/12/2010.

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.

Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I

Proceedings of the National Academy of Sciences of the United States of America.. 2010 August 31107 (35):15571-6. Epub 08/16/2010.

Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I

Archives of biochemistry and biophysics.. 2010 August 15500 (2):203-9. Epub 05/20/2010.

Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.

Chung S, Sundar IK, Yao H, Ho YS, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2010 August 299 (2):L192-203. Epub 05/14/2010.

Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.

Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I

Journal of inflammation.. 2010 July 227 :34. Epub 07/22/2010.

Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells.

Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I

Antioxidants & redox signaling.. 2010 June 1512 (12):1355-69. Epub 1900 01 01.

Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke.

Rajendrasozhan S, Hwang JW, Yao H, Kishore N, Rahman I

Pulmonary pharmacology & therapeutics.. 2010 June 23 (3):172-81. Epub 01/18/2010.

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol.

Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I

Biochemical and biophysical research communications.. 2010 February 26393 (1):66-72. Epub 01/25/2010.

Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.

Yao H, Hwang J, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I

The Journal of biological chemistry.. 2010 February 19285 (8):5405-16. Epub 12/11/2009.

PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity.

Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I

Biochemical and biophysical research communications.. 2010 February 12392 (3):264-70. Epub 01/10/2010.

Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling.

Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2010 February 298 (2):L197-209. Epub 12/04/2009.

Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2.

Bancos S, Baglole CJ, Rahman I, Phipps RP

Cellular immunology.. 2010 262 (1):18-27. Epub 12/16/2009.

Dietary polyphenols, deacetylases and chromatin remodeling in inflammation.

Rahman I, Chung S

World review of nutrition and dietetics.. 2010 101 :84-94. Epub 04/30/2010.

Oxidative stress, thiol redox signaling methods in epigenetics.

Sundar IK, Caito S, Yao H, Rahman I

Methods in enzymology.. 2010 474 :213-44. Epub 06/20/2010.

Dietary polyphenols, deacetylases and chromatin remodeling in inflammation.

Rahman I, Chung S

Journal of nutrigenetics and nutrigenomics.. 2010 3 (4-6):220-30. Epub 04/06/2011.

Current concepts on the role of inflammation in COPD and lung cancer.

Yao H, Rahman I

Current opinion in pharmacology.. 2009 August 9 (4):375-83. Epub 07/15/2009.

Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD.

Rajendrasozhan S, Yao H, Rahman I

COPD.. 2009 August 6 (4):291-7. Epub 1900 01 01.

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke.

Adenuga D, Yao H, March TH, Seagrave J, Rahman I

American journal of respiratory cell and molecular biology.. 2009 April 40 (4):464-73. Epub 10/16/2008.

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I

American journal of respiratory cell and molecular biology.. 2009 February 40 (2):147-58. Epub 08/07/2008.

Cyp1A1, Cyp1A2 and Cyba gene polymorphisms associated with oxidative stress in COPD

Vibhuti A; Arif E; Deepak D; Singh B; Rahman I; Pasha MAQ.

Respir Res. 2009; .

Histone Deacetylase 2 is Phosphorylated, Ubiquitinated and Degraded by Cigarette Smoke

Adenuga D*; Yao H*; March TH; Seagrave J; Rahman I.

Am J Respir Cell Mol Biol. 2009; 40: 464-473.

RelB is differentially regulated by I{kappa}B-Kinase{alpha} in B Cells and Mouse Lung by Cigarette Smoke

Yang SR*; Yao H*; Rajendrasozhan S*; Chung S*; Edirisinghe I*; Valvo S*; Fromm G; McCabe Jr MJ; Sime PJ; Phipps RP; Li JD; Bulger M; Rahman I.

Am J Respir Cell Mol Biol. 2009; 40: 147-158.

Cigarette smoke regulates expression of TLR4 and IL-8 production by human macrophages: Crucial role for Reactive Oxygen Species

Sarir H; Mortaz E; Karimi K; Rahman I; Caldenhoven E; Nijkamp FP; Folkerts G.

Journal of Inflammation. 2009; 1(6): 12.

SIRT1 is an Redox Sensitive Deacetylase which is Post-translationally Modified by Oxidants and Carbonyl Stress

Caito S*; Rajendrasozhan S; Cook S; Chung S*; Yao H*; Brookes PS; Rahman I.

FASEB J. 2009; .

Anti-inflammatory effect of a selective IkB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke

Rajendrasozhan S*; Yao H*; Hwang J-W*; Kishore N; Rahman I.

Pulmonary Pharmacology and Therapeutics. 2009; .

Targeted disruption of NF-kB1 (p50) enhances cigarette smoke-mediated lung inflammation and emphysema in mice

Rajendrasozhan S*; Chung SW; Sundar IK;, Yao H;* Rahman I.

Am J Physiol: Lung Cell Mol Physiol. 2009; .

Disruption of PKCz attenuates cigarette smoke- and lipopolysaccharide-mediated lung inflammation and histone modifications

Yao H*; Hwang J*; Moscat J; Diaz-Meco MT; Leitges M; Kishore N; Li X; Rahman I.

J. Biol. Chem. 2009; .

CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2

Adenuga D*; Rahman I.

J Biol. Chem. 2009; .

Environmental toxicity, redox signaling and lung inflammation: the role of glutathione.

Biswas SK, Rahman I

Molecular aspects of medicine.. 2009 30 (1-2):60-76. Epub 08/08/2008.

Antioxidant therapeutic advances in COPD.

Rahman I

Therapeutic advances in respiratory disease.. 2008 December 2 (6):351-74. Epub 1900 01 01.

Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.

Biswas S, Rahman I

Molecular nutrition & food research.. 2008 September 52 (9):987-94. Epub 1900 01 01.

Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation.

Rahman I

Nutrition reviews.. 2008 August 66 Suppl 1 :S42-5. Epub 1900 01 01.

Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice.

Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O'Reilly MA, Rahman I

American journal of respiratory cell and molecular biology.. 2008 July 39 (1):7-18. Epub 01/31/2008.

IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung.

Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I

American journal of respiratory cell and molecular biology.. 2008 June 38 (6):689-98. Epub 01/31/2008.

Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice.

Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2008 June 294 (6):L1174-86. Epub 03/28/2008.

Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.

Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I

The American journal of pathology.. 2008 May 172 (5):1222-37. Epub 04/10/2008.

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I

American journal of respiratory and critical care medicine.. 2008 April 15177 (8):861-70. Epub 01/03/2008.

Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD.

Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I

Antioxidants & redox signaling.. 2008 April 10 (4):799-811. Epub 1900 01 01.

Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells.

Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP

Cancer immunology, immunotherapy : CII.. 2008 March 57 (3):347-58. Epub 08/01/2007.

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.

Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2008 March 294 (3):L478-88. Epub 12/27/2007.

Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages.

Caito S, Yang SR, Kode A, Edirisinghe I, Rajendrasozhan S, Phipps RP, Rahman I

Antioxidants & redox signaling.. 2008 February 10 (2):253-60. Epub 1900 01 01.

Ceramide inhibition of MMP-2 expression and human cancer bronchial cells invasiness involves decreased histone acetylation

Debret R; Brassart-Pasco S; Lorin J; Martoriati A; Deshorgue A; Maquart F-X; Hornebeck W; Rahman I; Antonicelli F.

Biochem Biophys Acta. 2008; 1783: 1718-1727.

Rosiglitazone and 15-Deoxy-Delta(12,14)-Prostaglandin J(2), PPARgamma Agonists, Differentially Regulate Cigarette Smoke-Mediated Pro-Inflammatory Cytokine Release in Monocytes/Macrophages

Caito S*; Yang SR*; Kode A*; Edirisinghe I*; Rajendrasozhan S*; Phipps RP; Rahman I.

Antioxid Redox Signal. 2008; 10: 253-260.

Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells

Ryan EP; Bushnell TP; Friedman AE; Rahman I; Phipps RP.

2008; 57: 347-358.

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

Meja, K.K; Rajendrasozhan S*; Adenuga D*; Kirkham, P.A.; G. Spooner, J.A.; Marwick, C.P.; Fletcher, P.; Whittaker, I.L.; Megson, Kirkham, P.A.; and I. Rahman.

Am J Respir Cell Mol Biol. 2008; 39: 312-323.

SIRT1, an Anti-Inflammatory and Anti-Aging Protein, is Decreased in Lungs of Patients with COPD

Rajendrasozhan S*; Yang SR*; Kinnula VL; Rahman I.

Am J Respir Crit Care Med. 2008; 177: 861-870.

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

Kode A*; Rajendrasozhan S*; Caito S*; Yang SR*; Megson IL; Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2008; 294: L478-L488.

Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice

Yao H*; Edirisinghe I*; Rajendrasozhan S*; Yang SR*; Caito S*; Adenuga D*; Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1174-L1186.

Targeted disruption of p21CIP1/WAF1/SDI1 attenuates lung oxidative stress and NF-_B activation in response to cigarette smoke and other inflammatory agents in mice (Selected for Faculty of 1000 Medicine)

Yao H*; Yang SR*; Edirisinghe I*; Rajendrasozhan S*; Caito S*; Adenuga D*; O'Reilly M; Rahman I.

Am J Respir Cell Mol Biol. 2008; 39: 7-18.

Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and injury in mice

Yao H*; Edirisinghe I*; Yang SR*; Rajendrasozhan S*; Kode A*; Caito S; Adenuga D*; Rahman I.

Am J. Pathol. 2008; 172: 1222-1237.

VEGFR2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction

Edirisinghe I*; Yang SR*; Hongwei Yao*; Rajendrasozhan S*; Caito S*; Adenuga D*; Wong C; Rahman A; Phipps RP; Jin ZG; Rahman I.

FASEB J. 2008; 22: 2297-22310.

IKKa causes chromatin modification on pro-inflammatory promoters by cigarette smoke in mouse lung

Yang SR*; Valvo S*; Yao H*; Kode A*; Rajendrasozhan S*; Edrisinghe I*; Caito S*; Adenuga D*; Henry R*; Fromm G; Maggirwar S; Li JD; Bulger MD; Rahman I.

Am J Respir Cell Mol Biol. 2008; : 698-698.

Targeting lung inflammation: novel therapies for the treatment of COPD.

Yao H, de Boer WI, Rahman I

Current respiratory medicine reviews. 2008 4 (1):57-68. Epub 1900 01 01.

Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling.

Yao H, Yang SR, Kode A, Rajendrasozhan S, Caito S, Adenuga D, Henry R, Edirisinghe I, Rahman I

Biochemical Society transactions.. 2007 November 35 (Pt 5):1151-5. Epub 1900 01 01.

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2007 February 292 (2):L567-76. Epub 10/13/2006.

Novel assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

Rahman, I.; Kode, A.; Biswas, S.K.

Nat. Protocol. 2007; 1: 3159-3165.

Sirtuin regulates cigarette smoke induced pro-inflammatory mediators release via acetylation of RelA/p65 NF-kB in macrophages in vitro and in vivo in rat lungs

Yang, S.R.; Wright, J.; Bauter, M.; Seweryniak, K.;, Kode, A.; Rahman, I.

Am. J. Physiol. Lung Cell Mol. Physiol. 2007; 292: 567-576.

Azithromycin Suppresses Activation of Nuclear Factor-kappaB and Synthesis of Pro-inflammatory Cytokines in Tracheal Aspirate Cells from Premature Infants

Aghai, Z.H.; Kode, A.; Salow, J.G.; Tarek Nakhla, T.; Stahl, G.E.; Eydelman, R.; Strande, L.; Leone, P.; Rahman, I.

Ped. Res. 2007; 62: 483-488.

Novel assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

Rahman, I.; Kode, A.; Biswas, S.K.

Nat. Protocol. 2007; 1: 3159-3165.

Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation

Stevenson CS; Docx C; Webster R; Battram C; Hynx D; Giddings J; Cooper PR; Chakravarty P; Rahman I; Marwick JA; Kirkham PA; Charman C; Richardson DL; Nirmala NR; Whittaker P; Bultler K.

Am J Physiol Lung Cell Mol Physiol. 2007; 293: L1183-93.

Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction: potential advantages of S-nitrosoglutathione supplementation

Tambyraja AL; Mitchell R; Driscoll PJ; Deans C; Parks RW; Rahman I; Megson IL.

Transplant Immunol. 2007; 18: 146-150.

Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants

Aghai ZH; Kode A*; Saslow JG; Nakhla T; Farhath S; Stahl GE; Eydelman R; Strande L; Leone P; Rahman I.

Pediatr Res. 2007; 62: 483-488.

Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone.

Morrison D, Rahman I, MacNee W

Respiratory medicine.. 2006 December 100 (12):2227-34. Epub 10/04/2006.

Regulation of inflammation and redox signaling by dietary polyphenols.

Rahman I, Biswas SK, Kirkham PA

Biochemical pharmacology.. 2006 November 3072 (11):1439-52. Epub 08/21/2006.

Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.

Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2006 July 291 (1):L19-29. Epub 01/27/2006.

Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2006 July 291 (1):L46-57. Epub 02/10/2006.

Oxidative stress and redox regulation of lung inflammation in COPD.

Rahman I, Adcock IM

The European respiratory journal.. 2006 July 28 (1):219-42. Epub 1900 01 01.

Dexamethasone suppresses expression of Nuclear Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress.

Aghai ZH, Kumar S, Farhath S, Kumar MA, Saslow J, Nakhla T, Eydelman R, Strande L, Stahl G, Hewitt C, Nesin M, Rahman I

Pediatric research.. 2006 June 59 (6):811-5. Epub 04/26/2006.

Antioxidant therapeutic targets in COPD.

Rahman I, Kilty I

Current drug targets.. 2006 June 7 (6):707-20. Epub 1900 01 01.

Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.

Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA

American journal of physiology. Lung cellular and molecular physiology.. 2006 May 290 (5):L897-908. Epub 12/16/2005.

Oxidant and antioxidant balance in the airways and airway diseases.

Rahman I, Biswas SK, Kode A

European journal of pharmacology.. 2006 March 8533 (1-3):222-39. Epub 02/28/2006.

Current concepts of redox signaling in the lungs.

Rahman I, Yang SR, Biswas SK

Antioxidants & redox signaling.. 2006 8 (3-4):681-9. Epub 1900 01 01.

Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method.

Rahman I, Kode A, Biswas SK

Nature protocols.. 2006 1 (6):3159-65. Epub 1900 01 01.

Antioxidant therapies in COPD.

Rahman I

International journal of chronic obstructive pulmonary disease.. 2006 1 (1):15-29. Epub 1900 01 01.

Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice.

Biswas SK, Newby DE, Rahman I, Megson IL

Biochemical and biophysical research communications.. 2005 December 23338 (3):1368-73. Epub 10/26/2005.

Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione.

Luppi F, Aarbiou J, van Wetering S, Rahman I, de Boer WI, Rabe KF, Hiemstra PS

Respiratory research.. 2005 November 256 :140. Epub 11/25/2005.

Regulation of glutathione in inflammation and chronic lung diseases.

Rahman I

Mutation research.. 2005 November 11579 (1-2):58-80. Epub 07/27/2005.

Effects of platelet-activating factor challenge on oxidant-antioxidant balance and exhaled nitric oxide in mild asthma

Echazarreta, A.L.; Rahman, I.; Sala, E.; Peinado, V.; Barbera, J.A.; MacNee, W.; Rodriguez-Roisin, R.

Respir. Med. 2005; 99: 510-523.

Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I

Antioxidants & redox signaling.. 2005 7 (1-2):32-41. Epub 1900 01 01.

Glutathione, stress responses, and redox signaling in lung inflammation.

Rahman I, Biswas SK, Jimenez LA, Torres M, Forman HJ

Antioxidants & redox signaling.. 2005 7 (1-2):42-59. Epub 1900 01 01.

The role of oxidative stress in the pathogenesis of COPD: implications for therapy.

Rahman I

Treatments in respiratory medicine. 2005 4 (3):175-200. Epub 1900 01 01.

Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms.

Rahman I

Cell biochemistry and biophysics.. 2005 43 (1):167-88. Epub 1900 01 01.

Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, Macnee W, Rahman I

American journal of respiratory cell and molecular biology.. 2004 December 31 (6):633-42. Epub 08/27/2004.

Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells.

Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2004 December 18 (15):1897-9. Epub 09/28/2004.

15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis.

Lim SY, Jang JH, Na HK, Lu SC, Rahman I, Surh YJ

The Journal of biological chemistry.. 2004 October 29279 (44):46263-70. Epub 08/19/2004.

Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression.

Rahman I, Marwick J, Kirkham P

Biochemical pharmacology.. 2004 September 1568 (6):1255-67. Epub 1900 01 01.

Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.

Antonicelli F, Brown D, Parmentier M, Drost EM, Hirani N, Rahman I, Donaldson K, MacNee W

American journal of physiology. Lung cellular and molecular physiology.. 2004 June 286 (6):L1319-27. Epub 1900 01 01.

Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products.

Kirkham PA, Spooner G, Rahman I, Rossi AG

Biochemical and biophysical research communications.. 2004 May 21318 (1):32-7. Epub 1900 01 01.

Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol anti-oxidant Nacystelyn

Antonicelli, F.; Parmentier, M.; Drost, E.M.; Hirani, N.; Rahman, I.; Donaldson, K.; MacNee, W.

Am. J. Physiol. Lung Cell Mol. Physiol,. 2004; 286: L1319-L1327.

Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues.

Rahman I, Biswas SK

Redox report : communications in free radical research.. 2004 9 (3):125-43. Epub 1900 01 01.

Biomarkers in breath condensate: a promising new non-invasive technique in free radical research.

Rahman I, Kelly F

Free radical research.. 2003 December 37 (12):1253-66. Epub 1900 01 01.

Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.

Wickenden JA, Clarke MC, Rossi AG, Rahman I, Faux SP, Donaldson K, MacNee W

American journal of respiratory cell and molecular biology.. 2003 November 29 (5):562-70. Epub 05/14/2003.

Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells.

Debret R, El Btaouri H, Duca L, Rahman I, Radke S, Haye B, Sallenave JM, Antonicelli F

FEBS letters.. 2003 July 10546 (2-3):195-202. Epub 1900 01 01.

Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).

Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RP, Knaapen AM, Rahman I, Faux SP, Brown DM, MacNee W

Free radical biology & medicine.. 2003 June 134 (11):1369-82. Epub 1900 01 01.

Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells.

Rahman I, Gilmour PS, Jimenez LA, Biswas SK, Antonicelli F, Aruoma OI

Biochemical and biophysical research communications.. 2003 March 21302 (4):860-4. Epub 1900 01 01.

Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles.

Gilmour PS, Rahman I, Donaldson K, MacNee W

American journal of physiology. Lung cellular and molecular physiology.. 2003 March 284 (3):L533-40. Epub 11/22/2002.

Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases.

Rahman I

Journal of biochemistry and molecular biology.. 2003 January 3136 (1):95-109. Epub 1900 01 01.

Environmental particle-mediated epithelial IL-8 release is regulated by histone acetylation

Gilmour, P.S.; Rahman, I.; Donaldson, K.; MacNee, W.

Am. J. Physiology. Lung Cell Mol. Physiol. 2003; 284: L533-L540.

Nitric oxide synthase type I (nNOS), vascular endothelial growth factor (VEGF) and myoglobin-like expression in skeletal muscle of Antarctic icefishes (Notothenioidei: Channichthyidae)

Busquets, X.; Morla, M.; Rahman, I.; Motterlini, R.; Saus, C.; Garcia, P.; Miralles, C.; Morales-Nin, B.; Agusti, A.G.N.

Polar Biol. 2003; 26: 458-462.

Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.

Marwick JA, Kirkham P, Gilmour PS, Donaldson K, MacNEE W, Rahman I

Annals of the New York Academy of Sciences.. 2002 November 973 :278-83. Epub 1900 01 01.

The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.

Deiana M, Dessi MA, Ke B, Liang YF, Higa T, Gilmour PS, Jen LS, Rahman I, Aruoma OI

Biochemical and biophysical research communications.. 2002 September 6296 (5):1148-51. Epub 1900 01 01.

Oxidative stress, transcription factors and chromatin remodelling in lung inflammation.

Rahman I

Biochemical pharmacology.. 2002 September 64 (5-6):935-42. Epub 1900 01 01.

Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets.

Rahman I

Current drug targets. Inflammation and allergy.. 2002 September 1 (3):291-315. Epub 1900 01 01.

4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease.

Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI

American journal of respiratory and critical care medicine.. 2002 August 15166 (4):490-5. Epub 1900 01 01.

Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke.

Kim HJ, Liu X, Wang H, Kohyama T, Kobayashi T, Wen FQ, Romberger DJ, Abe S, MacNee W, Rahman I, Rennard SI

American journal of physiology. Lung cellular and molecular physiology.. 2002 August 283 (2):L409-17. Epub 1900 01 01.

Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.

Jardine H, MacNee W, Donaldson K, Rahman I

The Journal of biological chemistry.. 2002 June 14277 (24):21158-66. Epub 03/23/2002.

Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.

Antonicelli F, Parmentier M, Drost EM, Hirani N, Rahman I, Donaldson K, MacNee W

Free radical biology & medicine.. 2002 March 1532 (6):492-502. Epub 1900 01 01.

Glutathione and p53 independently mediate responses against oxidative stress in ES cells.

Coe JP, Rahman I, Sphyris N, Clarke AR, Harrison DJ

Free radical biology & medicine.. 2002 January 1532 (2):187-96. Epub 1900 01 01.

PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha

Jimenez, L.A.; Drost, E.M.; Gilmour, P.; Rahman, I.; Antonicelli, F.; Ritche, H.; MacNee, W.; Donaldson, K.

Am. J. Physiol. 2002; 282: L237-L248.

PM10-mediated IL-8 release from epithelial cells involves histone acetylation

Gilmour, P.S.; Rahman, I.; Stone, V.; Donaldson, K.; MacNee, W.

Ann. Occup. Hyg. 2002; 46: 436-439.

Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation.

Rahman I, Gilmour PS, Jimenez LA, MacNee W

Molecular and cellular biochemistry.. 2002 234-235 (1-2):239-48. Epub 1900 01 01.

Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.

Rahman I, Mulier B, Gilmour PS, Watchorn T, Donaldson K, Jeffery PK, MacNee W

Biochemical pharmacology.. 2001 September 1562 (6):787-94. Epub 1900 01 01.

Adenoviral E1A renders alveolar epithelial cells susceptible to environmental particle-induced transcription of interleukin-8

Gilmour, P.S.; Rahman, I.; Hayashi, S.; Hogg, J.C.; Donaldson, K.; MacNee, W.

Am. J. Physiol. 2001; 281: L598-L606.

Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells.

Parmentier M, Hirani N, Rahman I, Donaldson K, MacNee W, Antonicelli F

The European respiratory journal.. 2000 November 16 (5):933-9. Epub 1900 01 01.

Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension.

Mantle D, Patel VB, Why HJ, Ahmed S, Rahman I, MacNee W, Wassif WS, Richardson PJ, Preedy VR

Clinica chimica acta; international journal of clinical chemistry.. 2000 September 299 (1-2):1-10. Epub 1900 01 01.

Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation.

Jiménez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, Drost EM, Hay RT, Donaldson K, MacNee W

Toxicology and applied pharmacology.. 2000 July 15166 (2):101-10. Epub 1900 01 01.

Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension.

Miralles C, Busquets X, Santos C, Togores B, Hussain S, Rahman I, MacNee W, Agustí AG

FEBS letters.. 2000 July 7476 (3):253-7. Epub 1900 01 01.

Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease.

Rahman I, van Schadewijk AA, Hiemstra PS, Stolk J, van Krieken JH, MacNee W, de Boer WI

Free radical biology & medicine.. 2000 March 1528 (6):920-5. Epub 1900 01 01.

Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism.

Ward C, Wong TH, Murray J, Rahman I, Haslett C, Chilvers ER, Rossi AG

Biochemical pharmacology.. 2000 February 159 (3):305-14. Epub 1900 01 01.

Antagonist G induces apoptosis in small cell lung cancer cells via ROS mechanisms

MacKinnon, A.C.; Rahman, I.; Hirani, N.; Haslett, C.; Sethi, T.

Br. J. Cancer Res. 2000; 83: 941-948.

Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.

Rahman I, MacNee W

American journal of physiology. Lung cellular and molecular physiology.. 1999 December 1277 (6):L1067-L1088. Epub 1900 01 01.

Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis.

Rahman I, Skwarska E, Henry M, Davis M, O'Connor CM, FitzGerald MX, Greening A, MacNee W

Free radical biology & medicine.. 1999 July 27 (1-2):60-8. Epub 1900 01 01.

Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers.

Morrison D, Rahman I, Lannan S, MacNee W

American journal of respiratory and critical care medicine.. 1999 February 159 (2):473-9. Epub 1900 01 01.

Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells.

Lapperre TS, Jimenez LA, Antonicelli F, Drost EM, Hiemstra PS, Stolk J, MacNee W, Rahman I

FEBS letters.. 1999 January 25443 (2):235-9. Epub 1900 01 01.

Molecular mechanism of the regulation of glutathione synthesis by tumour necrosis factor-a and dexamethasone in human alveolar epithelial cells

Rahman, I.; Antonicelli, F.; MacNee, W.

J. Biol. Chem. 1999; 274: 5988-5096.

Studies on pulmonary and systemic Aspergillus fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD)

Schmallenbach, K.S.; Rahman, I.; Sasse, H.H.L.; Dixon, P.M.; Halliwell, R.E.W.; McGorum, B.C.; Crameri, R.; Miller, H.R.P.

Vet. Immunol. Immunopath. 1999; 66: 245-256.

Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells.

Rahman I, Bel A, Mulier B, Donaldson K, MacNee W

American journal of physiology. Lung cellular and molecular physiology.. 1998 July 1275 (1):L80-L86. Epub 1900 01 01.

Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells.

Rahman I, Bel A, Mulier B, Donaldson K, MacNee W

The American journal of physiology.. 1998 July 275 (1):L80-6. Epub 1900 01 01.

Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

Rossi AG, Haslett C, Hirani N, Greening AP, Rahman I, Metz CN, Bucala R, Donnelly SC

The Journal of clinical investigation.. 1998 June 15101 (12):2869-74. Epub 1900 01 01.

Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH).

Mulier B, Rahman I, Watchorn T, Donaldson K, MacNee W, Jeffery PK

The European respiratory journal.. 1998 February 11 (2):384-91. Epub 1900 01 01.

Characterisation of g-glutamylcysteine synthetase-heavy subunit promoter : A critical role of AP-1

Rahman, I.; Smith, C.A.D.; Antonicelli, F.; MacNee, W.

FEBS Lett. 1998; 427: 120-133.

Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.

Gilmour PS, Brown DM, Beswick PH, MacNee W, Rahman I, Donaldson K

Environmental health perspectives.. 1997 September 105 Suppl 5 :1313-7. Epub 1900 01 01.

Cigarette smoke-induced oxidant/antioxidant imbalance and its role in increased epithelial permeability

MacNee,W.; Rahman, I.; Li, X.Y.; Morrison, D.; Donaldson, K.

Ann. Occup. Hyg. 1997; 41: 728-735.

Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells.

Rahman I, Bel A, Mulier B, Lawson MF, Harrison DJ, Macnee W, Smith CA

Biochemical and biophysical research communications.. 1996 December 24229 (3):832-7. Epub 1900 01 01.

Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells.

Rahman I, Smith CA, Lawson MF, Harrison DJ, MacNee W

FEBS letters.. 1996 October 28396 (1):21-5. Epub 1900 01 01.

Systemic oxidative stress in asthma, COPD, and smokers.

Rahman I, Morrison D, Donaldson K, MacNee W

American journal of respiratory and critical care medicine.. 1996 October 154 (4 Pt 1):1055-60. Epub 1900 01 01.

Mechanisms of cigarette smoke induced increased airspace permeability.

Li XY, Rahman I, Donaldson K, MacNee W

Thorax.. 1996 May 51 (5):465-71. Epub 1900 01 01.

Cigarette smoke and ozone-induced epithelial perturbation in vivo and in vitro. The role of glutathione.

MacNee W, Morrison D, Rahman I, Li XY, Donaldson K

Chest.. 1996 March 109 (3 Suppl):39S. Epub 1900 01 01.

Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress.

Rahman I, Li XY, Donaldson K, Harrison DJ, MacNee W

The American journal of physiology.. 1995 September 269 (3 Pt 1):L285-92. Epub 1900 01 01.

Hypoxia prolongs neutrophil survival in vitro

Hannah, S.; Mechlenburgh, K.; Rahman, I.; Bellingan, G.; Greening, A.; Hasslett, C.; Chilvers, E.

Am. J. Physiol. 1995; 372: 233-237.

Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs

Rahman, I.; Li, X.Y.; Donaldson, K.; MacNee, W.

Biochem. Soc. Trans. 1995; 23: 235S.

An investigation of the role of glutathione in the increased epithelial permeability induced by cigarette smoke in vivo and in vitro

Li, X.Y.; Donaldson, K.; Rahman, I.; MacNee, W.

Am. J. Resp. Cri. Care Med. 1994; 149: 1519-1525.

Membrane potentials and phagocytic indices of diabetic, arthritic and hypertensive PMN leukocytes

Rahman, I.; Upadhyay, A.; Tule, V.; Nath, N.

Indian J. Clin. Biochem. 1993; 8: 25-31.

Calcium homeostasis and its messenger systems of PMN leukocytes in essential hypertension

Rahman, I.; Nath, N.

Annals Natl. Acad. Med. Sci. (India). 1993; 29: 75-82.

Endotoxin treatment protects rats against ozone-induced lung edema: with evidence for the role of manganese superoxide dismutase.

Rahman I, Massaro D

Toxicology and applied pharmacology.. 1992 March 113 (1):13-8. Epub 1900 01 01.

Exposure of rats to ozone: evidence of damage to heart and brain.

Rahman I, Massaro GD, Massaro D

Free radical biology & medicine.. 1992 12 (4):323-6. Epub 1900 01 01.

Rat lung antioxidant enzyme induction by ozone.

Rahman I, Clerch LB, Massaro D

The American journal of physiology.. 1991 June 260 (6 Pt 1):L412-8. Epub 1900 01 01.

Peroxiredoxin 6 regulates cigarette smoke-mediated lung inflammatory response via up-regulation of antioxidant enzymes in mouse lung

Sundar IK; Chung S; Hwang J; Arunachalam G; Cook S; Yao H; Kinnula VL; Fisher AB; Rahman I.

Am J Physiol: Lung Cell Mol Physiol. .