Associate Professor - Department of Obstetrics and Gynecology (SMD)
Associate Professor - Department of Microbiology and Immunology (SMD) - Joint
Post-doctoral Training & Residency
Postdoctoral Fellow, Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 1989 - 1993
PhD | Duke University. Microbiology. 1989
BA | New College. Biology. 1983
3rd Annual Human Placenta Workshop Lecturer. 2008
Guest editor, special edition of Immunological Investigations on Reproductive Immunology. 2008
2nd Annual Human Placenta Workshop Lecturer. 2007
1st Annual Human Placenta Workshop Lecturer. 2006
Semi-finalist, Western New York Inventor of the Year 2002
Olympus Award for New Investigators, European Placenta Group Meeting, Schladming, Austria 1999
Best Student Poster Presentation, 17th Annual Southeastern Development Biology Conference, Columbia, SC 1984
Our recent studies demonstrated that responses of both human and mouse trophoblast cells to IFN-gamma are significantly reduced relative to other cell types, which correspond with both the inability to express MHC class II molecules, and resistance of trophoblast cells to IFN-gamma-mediated apoptosis and inhibition of cell proliferation. Based on the fact that a wide range of pathogens, including multiple viruses, bacteria and mycobacteria have evolved mechanisms for inhibiting cellular responses to IFN-gamma as an important mechanism of immunoevasion, we have proposed that trophoblastic suppression of IFN-gamma signaling is essential for successful pregnancy. Thus, we have been investigating how trophoblast cells inhibit IFN-gamma signaling.
Our laboratory is also examining the mechanisms accounting for loss of MHC class II antigen expression in human diffuse large B cell lymphoma (DLBLCL). Downregulation of MHC class II expression on DLBLCL is associated with significant decreases in patient survival. Our recent studies in collaboration with Dr. Lisa Rimsza's group demonstrate that the most common mechanism underlying MHC class II loss in DLBCL is silencing of CIITA expression. Thus, we are currently examining the molecular mechanisms responsible for silencing CIITA in DLBCL.
Uccello TP, Lesch ML, Kintzel SA, Gradzewicz LB, Lamrous L, Murphy SP, Fleming FJ, Mills BN, Murphy JD, Hughson A, Hannon G, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Keeley DC, Love TMT, Repasky EA, Lord EM, Linehan DC, Gerber SA
Cell death & disease.. 2023 July 2614 (7):470. Epub 07/26/2023.
Agbayani G, Clark K, Sad S, Murphy SP, Krishnan L
American journal of reproductive immunology : AJRI.. 2022 July 18 Epub 07/18/2022.
Murthy GG, Prideaux MA, Armstrong M, Kenney HM, Latchney SE, Susiarjo M, Murphy SP
Placenta.. 2021 September 14115 :129-138. Epub 09/14/2021.
Agbayani G, Clark K, Sandhu JK, Hewitt M, Sad S, Murphy SP, Krishnan L
American journal of reproductive immunology : AJRI.. 2021 May 15 :e13454. Epub 05/15/2021.
Perry ID, Nguyen T, Sherina V, Love TMT, Miller RK, Krishnan L, Murphy SP
Placenta.. 2019 August 83 :43-52. Epub 06/26/2019.
Agbayani G, Wachholz K, Murphy SP, Sad S, Krishnan L
American journal of reproductive immunology : AJRI.. 2019 January 81 (1):e13068. Epub 12/04/2018.
Perry ID, Krishnan L, Murphy SP
Placenta.. 2019 January 75 :23-26. Epub 11/22/2018.
Spinelli P, Latchney SE, Reed JM, Fields A, Baier BS, Lu X, McCall MN, Murphy SP, Mak W, Susiarjo M
Human molecular genetics.. 2018 November 7 Epub 11/07/2018.
Agbayani G, Wachholz K, Chattopadhyay A, Gurnani K, Murphy SP, Krishnan L
American journal of reproductive immunology : AJRI.. 2017 December 78 (6)Epub 10/09/2017.
Van Twisk D, Murphy SP, Thakar J
Immunology.. 2017 May 151 (1):71-80. Epub 02/09/2017.
Zozzaro-Smith PE, Bushway ME, Gerber SA, Hebert D, Pressman EK, Lord EM, Miller RK, Murphy SP
Placenta.. 2015 November 36 (11):1310-7. Epub 09/10/2015.
Gerber SA, Lim JY, Connolly KA, Sedlacek AL, Barlow ML, Murphy SP, Egilmez NK, Lord EM
International journal of cancer.. 2014 May 15134 (10):2383-92. Epub 11/11/2013.
Bushway ME, Gerber SA, Fenton BM, Miller RK, Lord EM, Murphy SP
Biology of reproduction.. 2014 May 90 (5):110. Epub 03/19/2014.
Lim JY, Gerber SA, Murphy SP, Lord EM
Cancer immunology, immunotherapy : CII.. 2014 March 63 (3):259-71. Epub 12/20/2013.
Cycon KA, Mulvaney K, Rimsza LM, Persky D, Murphy SP
Immunology.. 2013 October 140 (2):259-72. Epub 1900 01 01.
Gerber SA, Sedlacek AL, Cron KR, Murphy SP, Frelinger JG, Lord EM
The American journal of pathology.. 2013 June 182 (6):2345-54. Epub 04/12/2013.
Katzman PJ, Shawn M, Oble D
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2011 14 (4):284-93. Epub 02/23/2011.
Bushway M, Cycon KA, Mulvaney K, Murphy SP
Immunogenetics.. 2010 February 62 (2):109-16. Epub 12/19/2009.
Murphy SP, Tayade C, Ashkar AA, Hatta K, Zhang J, Croy BA
Biology of reproduction.. 2009 May 80 (5):848-59. Epub 01/21/2009.
Choi, J.C.; Holtz, R.; Murphy, S.P.
Histone deacetylases inhibit IFN-y-inducible
Human Leukocyte Antigen (HLA) expression by normal trophoblast cells and placental cell lines using a novel method to characterize allotype specificities of anti-HLA antibodies
Apps, R.A.; Murphy, S.P.; Fernando, R.; Gardner, L.; Ahad, T.; Moffett, A.
Immunology. 2009; 127(1): 26-39.
CIITA or RFX Coding Region Loss of Function Mutations Occur Rarely in Diffuse Large B Cell Lymphoma Cases and Cell Lines with Low Levels of Major Histocompatibility Complex Class II Expression.
Rimsza, L.M.; Chan, W.C.; Gascoyne, R.D.; Campo, E.; Jaffe, E.S.; Staudt, L.M.; Delabie, J.; Rosenwald, A.; Murphy S.P.
Haematologica. 2009; 94(4): 596-598.
Interferon-gamma in successful pregnancies
Murphy, S.P.; Tayade, C.; Ashkar, A.A.; Hattta, K.; Zhang, J.; Croy B.A.
Biol Reprod. 2009; 80(5): 848-859.
The immunogenicity of L1210 lymphoma clones correlates with the ability to function as antigen presenting cells
Cycon, K.; Clements, J; Holtz, R.; Fuji, H.; Murphy, S.P.
Immunology. 2009; 128: e641-651.
Alterations in CIITA constitute a common mechanism accounting for downregulation of MHC class II expression in diffuse large B cell lymphoma (DLBCL)
Cycon, K.; Rimsza, L.; Murphy, S.P.
Experimental Hematology. 2009; 37(2): 184-194.
Choi JC, Holtz R, Petroff MG, Alfaidy N, Murphy SP
The Journal of immunology : official journal of the American Association of Immunologists.. 2007 February 1178 (3):1598-607. Epub 1900 01 01.
Dampening of IFN-y-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway
Choi, J.C.; Petroff, M.G.; Holtz, R.; Alfaidy, N.; Challis, J.R.; Murphy, S.P.
J Immunol. 2007; 178(3): 1589-1607.
Murphy SP, Choi JC, Holtz R
Reproductive biology and endocrinology : RB&E.. 2004 July 52 :52. Epub 07/05/2004.
Chang CC, Murphy SP, Ferrone S
Human immunology.. 2003 November 64 (11):1057-63. Epub 1900 01 01.
Holtz R, Choi JC, Petroff MG, Piskurich JF, Murphy SP
Biology of reproduction.. 2003 September 69 (3):915-24. Epub 05/14/2003.
Murphy SP, Holtz R, Lewandowski N, Tomasi TB, Fuji H
The Journal of immunology : official journal of the American Association of Immunologists.. 2002 September 15169 (6):3085-93. Epub 1900 01 01.
Li LH, Sen A, Murphy SP, Jahreis GP, Fuji H, Hui SW
Experimental cell research.. 1999 December 15253 (2):541-50. Epub 1900 01 01.
Murphy SP, Tomasi TB
Molecular reproduction and development.. 1998 September 51 (1):1-12. Epub 1900 01 01.
Murphy SP, Gollnick SO, Pazmany T, Maier P, Elkin G, Tomasi TB
Molecular reproduction and development.. 1997 August 47 (4):390-403. Epub 1900 01 01.
Pazmany T, Murphy SP, Gollnick SO, Brooks SP, Tomasi TB
Experimental cell research.. 1995 November 221 (1):103-10. Epub 1900 01 01.
Bhattacharyya T, Karnezis AN, Murphy SP, Hoang T, Freeman BC, Phillips B, Morimoto RI
The Journal of biological chemistry.. 1995 January 27270 (4):1705-10. Epub 1900 01 01.
Mathur SK, Sistonen L, Brown IR, Murphy SP, Sarge KD, Morimoto RI
Proceedings of the National Academy of Sciences of the United States of America.. 1994 August 3091 (18):8695-9. Epub 1900 01 01.
Murphy SP, Gorzowski JJ, Sarge KD, Phillips B
Molecular and cellular biology.. 1994 August 14 (8):5309-17. Epub 1900 01 01.
Small subclass of olfactory neurons with specific bulbar projections reactive with monoclonal antibodies to the hsp70 heat shock protein.
Carr, V.M.; Murphy, S.P.; Morimoto, R.I.; Farbman, A.
Carr, V.M., Murphy, S.P., Morimoto, R.I. and Farbman, A. 1994; 348: 150-160.
Sarge, K.D.; Murphy, S.P.; Morimoto, R.I.
Activation of heat shock gene transcription of
Differential regulation of Heat shock gene transcription by a family of heat shock factors. (Review).
Kroeger, P.E.; Sarge, K.D.; Murphy, S.P.; Naki, A.; Morimoto, R.I.
J. Occup. Environ.
Abravaya K, Myers MP, Murphy SP, Morimoto RI
Genes & development.. 1992 July 6 (7):1153-64. Epub 1900 01 01.
Espeseth, A.; Murphy, S.P.; Linney, E.
Retinoic acid receptor expression vector inhibits
Murphy SP, Garbern J, Odenwald WF, Lazzarini RA, Linney E
Proceedings of the National Academy of Sciences of the United States of America.. 1988 August 85 (15):5587-91. Epub 1900 01 01.