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Takahiro Takano, Ph.D.

Takahiro Takano, Ph.D.

Contact

Office (585) 276-7837
Fax (585) 273-1237
Administrative (585) 273-5272

About Me

Faculty Appointments

Research Assistant Professor - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Post-Doctoral Fellow;
Center for Aging and Developmental Biology;
URMC;
Rochester, NY 2003 - 2006

Education

PhD | New York Medical College. Biology. 2003

MS | Fordham University. Biology. 1996

BS | York College, City University of New York. Biology. 1994

Research

Our laboratory is interested in developing alternative treatment strategies for chronic pain, with the focus on peripheral nervous system. Persistent pain causes the sensory nerves to transmit hyperalgesic signals, which contribute to the establishment of pathological condition in central nervous sy...
Our laboratory is interested in developing alternative treatment strategies for chronic pain, with the focus on peripheral nervous system. Persistent pain causes the sensory nerves to transmit hyperalgesic signals, which contribute to the establishment of pathological condition in central nervous system, manifested as chronic pain. Conversely, manipulation of peripheral signals can reverse the chronic pain condition in central nervous system and thus restore the normal sensory perception. In particular, we study both acute and long-term pain relief by pharmacologically or mechanically manipulating sensory inputs in both orofacial neuropathic and joint inflammatory chronic pain models.

Publications

Journal Articles

An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease.

Zhao N, Michelucci A, Pietrangelo L, Malik S, Groom L, Leigh J, O'Connor TN, Takano T, Kingsley PD, Palis J, Boncompagni S, Protasi F, Dirksen RT

The EMBO journal.. 2024 October 17 Epub 10/17/2024.

Dysregulated Ca signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren's disease.

Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U, Yule DI

eLife.. 2024 September 1113 Epub 09/11/2024.

Neuronal and hormonal control of Ca signalling in exocrine glands: insight from in vivo studies.

Takano T, Yule DI

The Journal of physiology.. 2024 July 602 (14):3341-3350. Epub 06/07/2024.

Dysregulated Ca signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren's syndrome.

Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U, Yule DI

bioRxiv : the preprint server for biology.. 2024 June 26 Epub 06/26/2024.

Pacing intracellular Ca signals in exocrine acinar cells.

Yule DI, Takano T

The Journal of physiology.. 2024 January 10 Epub 01/10/2024.

Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype.

Wahl AM, Takano T, Su S, Warner BM, Perez P, Sneyd J, Yule DI

The Journal of physiology.. 2023 October 601 (20):4539-4556. Epub 09/19/2023.

Targeting Synovial Lymphatic Function as a Novel Therapeutic Intervention for Age-Related Osteoarthritis in Mice.

Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L

Arthritis & rheumatology.. 2023 June 75 (6):923-936. Epub 04/17/2023.

Ca signals in pancreatic acinar cells in response to physiological stimulation in vivo.

Takano T, Yule DI

The Journal of physiology.. 2023 June 601 (12):2391-2405. Epub 03/25/2023.

Ca Imaging in Mouse Salivary Glands.

Takano T, Yule DI

Bio-protocol.. 2022 April 512 (7):e4380. Epub 04/05/2022.

Highly localized intracellular Ca signals promote optimal salivary gland fluid secretion.

Takano T, Wahl A, Huang KT, Narita T, Rugis J, Sneyd J, Yule DI

eLife.. 2021 July 910 Epub 07/09/2021.

Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice.

Michelucci A, Boncompagni S, Pietrangelo L, Takano T, Protasi F, Dirksen RT

The Journal of general physiology.. 2020 October 5152 (10)Epub 1900 01 01.

Transverse tubule remodeling enhances Orai1-dependent Ca entry in skeletal muscle.

Michelucci A, Boncompagni S, Pietrangelo L, García-Castañeda M, Takano T, Malik S, Dirksen RT, Protasi F

eLife.. 2019 October 288 Epub 10/28/2019.

Low Molecular Weight Supramolecular Hydrogels for Sustained and Localized Drug Delivery.

Raymond DM, Abraham BL, Fujita T, Watrous MJ, Toriki ES, Takano T, Nilsson BL

ACS applied bio materials.. 2019 April 42 (5):2116-2124. Epub 05/20/2019.

Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia.

Fujita T, Feng C, Takano T

Scientific reports.. 2017 June 137 (1):3397. Epub 06/13/2017.

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2017 January 1212 (1):3. Epub 01/12/2017.

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2016 December 811 (1):74. Epub 12/08/2016.

Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2016 September 36 (9):1537-52. Epub 10/14/2015.

Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2016 January 26113 (4):1074-9. Epub 01/11/2016.

156?Capillary-Level Control of Cerebrovascular Tone.

Wei HS, Rasheed ID, Takano T, Kang H, Reitz KM, Gershteyn A, Vates GE, Nedergaard M

Neurosurgery.. 2015 August 62 Suppl 1 :216-7. Epub 1900 01 01.

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M

Nature communications.. 2015 April 236 :6807. Epub 04/23/2015.

Neuronal transgene expression in dominant-negative SNARE mice.

Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 December 1034 (50):16594-604. Epub 1900 01 01.

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices.

Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M

Glia.. 2014 January 62 (1):78-95. Epub 11/06/2013.

Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.

Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 October 3033 (44):17404-12. Epub 1900 01 01.

Sleep drives metabolite clearance from the adult brain.

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M

Science.. 2013 October 18342 (6156):373-7. Epub 1900 01 01.

Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling.

Langevin H, Fujita T, Bouffard N, Takano T, Koptiuch C, Badger G, Nedergaard M

Journal of cellular physiology.. 2013 September 228 (9):1922-6. Epub 1900 01 01.

In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 July 33 (7):996-9. Epub 04/24/2013.

Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter.

Chen X, Yang J, Kress BT, Tong J, Liu H, Takano T, Zhao Y, Nedergaard M, Ren Z

Neuroscience.. 2013 June 25241 :89-99. Epub 03/19/2013.

Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.

Goldman N, Chandler-Militello D, Langevin HM, Nedergaard M, Takano T

Cell calcium.. 2013 April 53 (4):297-301. Epub 02/22/2013.

Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M

Cell stem cell.. 2013 March 712 (3):342-53. Epub 1900 01 01.

Traditional acupuncture triggers a local increase in adenosine in human subjects.

Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M

The journal of pain.. 2012 December 13 (12):1215-23. Epub 1900 01 01.

Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake.

Wang F, Xu Q, Wang W, Takano T, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 May 15109 (20):7911-6. Epub 04/30/2012.

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.

Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 April 17109 (16):6265-70. Epub 03/15/2012.

Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.

Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M

Science signaling.. 2012 April 35 (218):ra26. Epub 04/03/2012.

Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.

Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 March 732 (10):3333-8. Epub 1900 01 01.

Extracellular Ca²? acts as a mediator of communication from neurons to glia.

Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M

Science signaling.. 2012 January 245 (208):ra8. Epub 01/24/2012.

Cultured astrocytes do not release adenosine during hypoxic conditions.

Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2012 January 32 (1):e1-7. Epub 10/12/2011.

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA

Proceedings of the National Academy of Sciences of the United States of America.. 2011 January 11108 (2):846-51. Epub 12/27/2010.

Pericyte constriction after stroke: the jury is still out.

Vates GE, Takano T, Zlokovic B, Nedergaard M

Nature medicine.. 2010 September 16 (9):959; author reply 960. Epub 1900 01 01.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M

Nature neuroscience.. 2010 July 13 (7):883-8. Epub 05/30/2010.

TR(I)Pping towards treatment for ischemia.

Rempe DA, Takano T, Nedergaard M

Nature neuroscience.. 2009 October 12 (10):1215-6. Epub 1900 01 01.

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury.

Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2009 July 28106 (30):12489-93. Epub 07/27/2009.

Stereotactic radiosurgery for glioblastoma: retrospective analysis.

Biswas T, Okunieff P, Schell MC, Smudzin T, Pilcher WH, Bakos RS, Vates GE, Walter KA, Wensel A, Korones DN, Milano MT

Radiation oncology.. 2009 March 174 :11. Epub 03/17/2009.

Uniquely hominid features of adult human astrocytes.

Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 March 1129 (10):3276-87. Epub 1900 01 01.

Astrocytes and ischemic injury.

Takano T, Oberheim N, Cotrina ML, Nedergaard M

Stroke.. 2009 March 40 (3 Suppl):S8-12. Epub 12/08/2008.

Deciphering migraine.

Takano T, Nedergaard M

The Journal of clinical investigation.. 2009 January 119 (1):16-9. Epub 1900 01 01.

Astrocytic Ca2+ Signaling: Mechanism and implications for functional brain imaging

Wang X, Takano T, Nedergaard M.

Humana Press. 2009; .

Astrocytic calcium signaling: mechanism and implications for functional brain imaging.

Wang X, Takano T, Nedergaard M

Methods in molecular biology.. 2009 489 :93-109. Epub 1900 01 01.

Loss of astrocytic domain organization in the epileptic brain.

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 March 2628 (13):3264-76. Epub 1900 01 01.

A central role of connexin 43 in hypoxic preconditioning.

Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 January 1628 (3):681-95. Epub 1900 01 01.

Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor.

Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M

Nature medicine.. 2008 January 14 (1):75-80. Epub 12/23/2007.

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.

Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 November 727 (45):12255-66. Epub 1900 01 01.

Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes.

Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 August 28104 (35):14151-6. Epub 08/21/2007.

Cortical spreading depression causes and coincides with tissue hypoxia.

Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M

Nature neuroscience.. 2007 June 10 (6):754-62. Epub 04/29/2007.

DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+.

Takano T, Nedergaard M

Cell calcium.. 2007 May 41 (5):503-4. Epub 10/19/2006.

Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.

Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M

Developmental biology.. 2007 February 1302 (1):356-66. Epub 09/16/2006.

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.

Takano T, Han X, Deane R, Zlokovic B, Nedergaard M

Annals of the New York Academy of Sciences.. 2007 February 1097 :40-50. Epub 1900 01 01.

Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain.

Tian GF, Takano T, Lin JH, Wang X, Bekar L, Nedergaard M

Advanced drug delivery reviews.. 2006 September 1558 (7):773-87. Epub 08/04/2006.

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M

Nature neuroscience.. 2006 June 9 (6):816-23. Epub 05/14/2006.

Astrocyte-mediated control of cerebral blood flow.

Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M

Nature neuroscience.. 2006 February 9 (2):260-7. Epub 12/25/2005.

Receptor-mediated glutamate release from volume sensitive channels in astrocytes.

Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2005 November 8102 (45):16466-71. Epub 10/27/2005.

An astrocytic basis of epilepsy.

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M

Nature medicine.. 2005 September 11 (9):973-81. Epub 08/14/2005.

Receptor-mediated glutamate release from volume sensitive channels in astrocytes

Takano,T.; Kang,J.; Jaiswal,J. K.; Simon,S. M.; Lin,J. H.; Yu,Y.; Li,Y.; Yang,J.; Dienel,G.; Zielke,H. R.; Nedergaard,M.

Proceedings of the National Academy of Sciences, U.S.A. 2005; 102(45): 16466-16471.

P2X7 receptor inhibition improves recovery after spinal cord injury.

Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M

Nature medicine.. 2004 August 10 (8):821-7. Epub 07/18/2004.

P2X7 receptor inhibition improves recovery after spinal cord injury

Wang,X.; Arcuino,G.; Takano,T.; Lin,J.; Peng,W. G.; Wan,P.; Li,P.; Xu,Q.; Liu,Q. S.; Goldman,S. A.; Nedergaard,M.

Nature Medicine. 2004; 102(8): 821-827.

Signaling at the gliovascular interface.

Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 October 823 (27):9254-62. Epub 1900 01 01.

Connexin mediates gap junction-independent resistance to cellular injury.

Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 January 1523 (2):430-41. Epub 1900 01 01.

Beyond the role of glutamate as a neurotransmitter.

Nedergaard M, Takano T, Hansen AJ

Nature reviews. Neuroscience.. 2002 September 3 (9):748-55. Epub 1900 01 01.

Intercellular calcium signaling mediated by point-source burst release of ATP.

Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2002 July 2399 (15):9840-5. Epub 07/03/2002.

Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.

Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 June 122 (11):4302-11. Epub 1900 01 01.

Intercellular calcium signaling mediated by point-source burst release of ATP;

Arcuino,G.; Lin,J. H.; Takano,T.; Liu,C.; Jiang,L.; Gao,Q.; Kang,J.; Nedergaard,M.

Proceedings of the National Academy of Sciences, U.S.A. 2002; 99(15): 9840-9845.

Glutamate release promotes growth of malignant gliomas.

Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M

Nature medicine.. 2001 September 7 (9):1010-5. Epub 1900 01 01.

Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells.

Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M

Cancer research.. 2000 October 160 (19):5395-400. Epub 1900 01 01.