Research Assistant Professor - Department of Pediatrics, Neonatology (SMD)
Post-doctoral Training & Residency
Postdoctoral Research Fellow, Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, Dr. Lester F. Lau. 2004 - 2007
Ph.D. | Northwestern University. Molecular Biology and Genetics. 2004
BS | University of South Alabama. Biomedical Sciences. 1998
American Society for Cell Biology Pre-doctoral Travel Award. 1999
Biomedical Sciences Distinguished Achievement in Medical Microbiology. 1998
Alpha Chi National College Honor Scholarship Society. 1996
My research focuses on elucidating the mechanism(s) of cell death and survival of primary alveolar epithelial cells and lung fibroblasts in response to the extracellular matrix associated signaling molecule, CCN1/Cyr61. CCN1/Cyr61 is an extracellular matrix (ECM)-associated signaling molecule that functions to promote cell adhesion, migration, survival and differentiation in the context of vascular development. Most recently we have shown that CCN1/Cyr61 can also modulate cell death in certain cells and can promote cell death in response to TNFa. In the context of the lung, I have found that CCN1/Cyr61 together with TNFa causes apoptosis of alveolar epithelial cells and lung fibroblasts. Because CCN1/Cyr61 has been shown to be induced in the lungs of patients with COPD and ARDS, I hypothesize that CCN1/Cyr61, together with inflammatory mediators such as TNFa causes cell death of primary lung cells in vivo, thus contributing to lung injury. I have also found that CCN1/Cyr61 functional knock-out mice have greatly reduced pulmonary inflammation at early times (<24 hrs) after LPS treatment, suggesting that CCN1/Cyr61, in addition to playing a role in apoptosis and cell survival, is likely to be involved in the initial inflammatory response as well. My research goals include determining a role for CCN1/Cyr61 in lung injury and inflammation and defining the mechanism by which CCN1/Cyr61 and TNFa cause cell death of lung cells in vivo. The ultimate goal of these studies is to gain a better understanding of the complex pathology of lung diseases such as COPD and ARDS so that better treatments for these lung diseases can be developed.
Lin X, Barravecchia M, Kothari P, Young JL, Dean DA
Gene therapy.. 2016 June 23 (6):489-99. Epub 03/17/2016.
Emr BM, Roy S, Kollisch-Singule M, Gatto LA, Barravecchia M, Lin X, Young JL, Wang G, Liu J, Satalin J, Snyder K, Nieman GF, Dean DA
Shock.. 2015 January 43 (1):16-23. Epub 1900 01 01.
Albert S, Kubiak BD, Vieau CJ, Roy SK, DiRocco J, Gatto LA, Young JL, Tripathi S, Trikha G, Lopez C, Nieman GF
The Journal of surgical research.. 2011 March 166 (1):e71-81. Epub 11/12/2010.
Smooth muscle-specific gene delivery in the vasculature based on restriction of DNA nuclear import.
Young, J.L.; Zimmer, W.E.,; Dean, D.A.
Experimental Biology and Medicine Epub doi: 10.3181/0721-Rm-331. 2008; .
Zhou R, Norton JE, Dean DA
Methods in molecular biology.. 2008 423 :233-47. Epub 1900 01 01.
Chen CC, Young JL, Monzon RI, Chen N, Todorovi? V, Lau LF
The EMBO journal.. 2007 March 726 (5):1257-67. Epub 02/22/2007.
Machado-Aranda D, Adir Y, Young JL, Briva A, Budinger GR, Yeldandi AV, Sznajder JI, Dean DA
American journal of respiratory and critical care medicine.. 2005 February 1171 (3):204-11. Epub 10/29/2004.
Dean DA, Machado-Aranda D, Blair-Parks K, Yeldandi AV, Young JL
Gene therapy.. 2003 September 10 (18):1608-15. Epub 1900 01 01.
Young JL, Benoit JN, Dean DA
Gene therapy.. 2003 August 10 (17):1465-70. Epub 1900 01 01.
Shirasawa Y, Rutland TJ, Young JL, Dean DA, Joseph BN
Frontiers in bioscience : a journal and virtual library.. 2003 May 18 :a133-8. Epub 05/01/2003.
Non-viral gene transfer of the Na+,K+-ATPase (beta)1 subunit using electroporation increases lung liquid clearance in rats.
Machado-Aranda, D., Y. Adir, J. L. Young, A. V. Yeldandi, G. R. S. Budinger, J. I. Sznajder, and D. A. Dean.
Am J Resp Crit Care Med. 2003; 171: 204-211.
Martin JB, Young JL, Benoit JN, Dean DA
Journal of vascular research.. 2000 37 (5):372-80. Epub 1900 01 01.