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Gail V W Johnson, Ph.D.

Gail V W Johnson, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Anesthesiology and Perioperative Medicine, Research (SMD)

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Postdoctoral Research Fellow, Department of Pharmacology, University of Alabama at Birmingham (UAB), Birmingham, AL 1985 - 1988

Education

Ph.D. | University of Delaware. Physiology. 1984

M.S. | University of Massachusetts. Entomology. 1978

B.A. | Southampton College. Biology. 1976

Awards

Ruth K. Broad Biomedical Research Foundation, Inc. Awardee. 1994 - 1996

Ciba Foundation Fellow Sponsor. 1992

NIH First Award. 1989 - 1994

Research

THE MOLECULAR MECHANISMS OF NEURODEGENERATION
gail_johnsonvoll@urmc.rochester.edu
Our laboratory has a longstanding interest in the pathogenic processes in Alzheimer's disease (AD) and central nervous system (CNS) injury. For our studies we use a wide variety of different approaches from in ...
THE MOLECULAR MECHANISMS OF NEURODEGENERATION
gail_johnsonvoll@urmc.rochester.edu
Our laboratory has a longstanding interest in the pathogenic processes in Alzheimer's disease (AD) and central nervous system (CNS) injury. For our studies we use a wide variety of different approaches from in vitro enzyme assays with purified proteins, to studies in whole animals. This broad-based approach allows us to translate what we learn about a process or signaling pathway at the molecular level to the in vivo situation. Currently studies in our lab are focused in two areas: (1) on understanding the regulation and function of the protein in tau in the context of AD, and (2) on how a protein called transglutaminase 2 (TG2) differentially impacts the survival and function of neurons and astrocytes following CNS injury. Each of these two areas of research that are ongoing in our lab is discussed briefly below.
The neuronally enriched protein tau plays a primary role in the pathogenesis of AD. Indeed, abnormal accumulations of aberrantly modified forms of the protein, neurofibrillary tangles, are one of the defining hallmarks of the disease. However, why the levels of these pathogenic forms of tau increase in AD, and how they cause toxicity are questions that have not been satisfactorily answered. A major focus of our studies involves determining how a neuron recognizes tau that is abnormally modified or no longer functional, and targets it to the autophagy pathway for degradation. In particular our group is interested in determining if a complex containing the co-chaperone BAG3 and other interacting proteins plays a role in not only directing tau to autophagy, but also in mediating the autophagy process. Further, our lab is also investigating how pathologically relevant forms of tau impact mitochondrial biology and the general health/functioning of the neuron.
Our lab also has a well-established interest in understanding the regulation and function of TG2 in neuronal cell death and survival. We have found that in neurons TG2 localizes to the nucleus in response to stress and plays a protective role. Intriguingly the converse is true for TG2 in astrocytes where it plays a detrimental role. Knockdown or deletion of TG2 from astrocytes significantly increases survival after stress and significantly increases their ability to protein neurons from insults. Given these and other findings we are currently delineating the differential roles of TG2 in regulating gene expression profiles in neurons and astrocytes. We are also examining how selective deletion of astrocytic TG2 improves outcomes after spinal cord injury, as well as investigating selective TG2 inhibitors as possible therapeutic interventions in the treatment of spinal cord injury.
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Patents

TG2 Inhibitors Piperazine Compounds and Uses Thereof

Issue date: January 19, 2021

Patent #: 10,894,777

Country: United States

Inventors: Abdullah Akbar, Richard L Eckert, Matthew Fisher, Gail VW Johnson, Jeffrey W Keillor

Publications

Journal Articles

Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation.

Isei MO, Crockett M, Chen E, Rodwell-Bullock J, Caroll T, Girardi PA, Nehrke K, Johnson GV

bioRxiv : the preprint server for biology.. 2024 July 9 Epub 07/09/2024.

Site-specific phosphorylation of tau impacts mitochondrial function and response to stressors.

Isei MO, Girardi PA, Rodwell-Bullock J, Nehrke K, Johnson GVW

Journal of neurochemistry.. 2024 June 168 (6):1019-1029. Epub 10/03/2023.

Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging.

Olesen MA, Pradenas E, Villavicencio-Tejo F, Porter GA, Johnson GVW, Quintanilla RA

Free radical biology & medicine.. 2024 May 1217 :141-156. Epub 03/27/2024.

Stabilizing transglutaminase 2 in the open conformation results in reactive astrocytes being more neurosupportive.

Emerson J, Delgado T, Hong M, Keillor JW, Johnson GV

bioRxiv : the preprint server for biology.. 2024 April 19 Epub 04/19/2024.

Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore.

Pérez MJ, Ibarra-García-Padilla R, Tang M, Porter GA, Johnson GVW, Quintanilla RA

Biochimica et biophysica acta. Molecular basis of disease.. 2024 January 1870 (1):166898. Epub 09/28/2023.

Author Correction: All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ.

Koren SA, Ahmed Selim N, De la Rosa L, Horn J, Farooqi MA, Wei AY, Müller-Eigner A, Emerson J, Johnson GVW, Wojtovich AP

Nature communications.. 2023 December 1214 (1):8230. Epub 12/12/2023.

All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ.

Koren SA, Ahmed Selim N, De la Rosa L, Horn J, Farooqi MA, Wei AY, Müller-Eigner A, Emerson J, Johnson GVW, Wojtovich AP

Nature communications.. 2023 September 2714 (1):6036. Epub 09/27/2023.

Commentary: BAG3 as a Mediator of Endosome Function and Tau Clearance.

Lin H, Deaton CA, Johnson GVW

Neuroscience.. 2023 May 10518 :4-9. Epub 05/10/2022.

Deletion of Transglutaminase 2 from Mouse Astrocytes Significantly Improves Their Ability to Promote Neurite Outgrowth on an Inhibitory Matrix.

Emerson J, Delgado T, Girardi P, Johnson GVW

International journal of molecular sciences.. 2023 March 2324 (7)Epub 03/23/2023.

Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors.

Isei MO, Girardi PA, Rodwell-Bullock J, Nehrke K, Johnson GV

bioRxiv : the preprint server for biology.. 2023 February 19 Epub 02/19/2023.

BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.

Lin H, Sandkuhler S, Dunlea C, King DH, Johnson GVW

bioRxiv : the preprint server for biology.. 2023 February 9 Epub 02/09/2023.

Deletion of transglutaminase 2 from astrocytes significantly improves their ability to promote neurite outgrowth on an inhibitory matrix.

Emerson J, Delgado T, Girardi P, Johnson GV

bioRxiv : the preprint server for biology.. 2023 February 6 Epub 02/06/2023.

Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model.

Guha S, Cheng A, Carroll T, King D, Koren SA, Swords S, Nehrke K, Johnson GVW

Genetics.. 2022 August 30222 (1)Epub 1900 01 01.

BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.

Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, Johnson GVW

Biological psychiatry.. 2022 July 192 (1):10-24. Epub 11/10/2021.

The role of BAG3 in health and disease: A "Magic BAG of Tricks".

Lin H, Koren SA, Cvetojevic G, Girardi P, Johnson GVW

Journal of cellular biochemistry.. 2022 January 123 (1):4-21. Epub 05/14/2021.

Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury.

Elahi A, Emerson J, Rudlong J, Keillor JW, Salois G, Visca A, Girardi P, Johnson GVW, Pröschel C

Cells.. 2021 October 2910 (11)Epub 10/29/2021.

Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer's Disease.

Carroll T, Guha S, Nehrke K, Johnson GVW

Biology.. 2021 October 1510 (10)Epub 10/15/2021.

Transglutaminase 2 as a therapeutic target for neurological conditions.

Keillor JW, Johnson GVW

Expert opinion on therapeutic targets.. 2021 September 25 (9):721-731. Epub 10/15/2021.

The Crosstalk Between Pathological Tau Phosphorylation and Mitochondrial Dysfunction as a Key to Understanding and Treating Alzheimer's Disease.

Guha S, Johnson GVW, Nehrke K

Molecular neurobiology.. 2020 December 57 (12):5103-5120. Epub 08/26/2020.

Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model.

Guha S, Fischer S, Johnson GVW, Nehrke K

Molecular neurodegeneration.. 2020 November 915 (1):65. Epub 11/09/2020.

A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in touch neurons.

Guha S, Fischer S, Cheng A, Johnson GVW, Nehrke K

microPublication biology.. 2020 September 92020 Epub 09/09/2020.

The role of transglutaminase 2 in mediating glial cell function and pathophysiology in the central nervous system.

Rudlong J, Cheng A, Johnson GVW

Analytical biochemistry.. 2020 February 15591 :113556. Epub 12/19/2019.

Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer's Disease.

Deaton CA, Johnson GVW

Journal of Alzheimer's disease : JAD.. 2020 77 (3):961-977. Epub 1900 01 01.

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.

Ji C, Tang M, Zeidler C, Höhfeld J, Johnson GV

Autophagy.. 2019 July 15 (7):1199-1213. Epub 03/01/2019.

Tissue Transglutaminase-Mediated AT1 Receptor Sensitization Underlies Pro-inflammatory Cytokine LIGHT-Induced Hypertension.

Liu C, Luo R, Wang W, Peng Z, Johnson GVW, Kellems RE, Xia Y

American journal of hypertension.. 2019 April 2232 (5):476-485. Epub 1900 01 01.

It's all about tau.

Tapia-Rojas C, Cabezas-Opazo F, Deaton CA, Vergara EH, Johnson GVW, Quintanilla RA

Progress in neurobiology.. 2019 April 175 :54-76. Epub 12/31/2018.

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.

Fu H, Possenti A, Freer R, Nakano Y, Villegas NCH, Tang M, Cauhy PVM, Lassus BA, Chen S, Fowler SL, Figueroa HY, Huey ED, Johnson GVW, Vendruscolo M, Duff KE

Nature neuroscience.. 2019 January 22 (1):47-56. Epub 12/17/2018.

Tau Clearance Mechanisms.

Tang M, Harrison J, Deaton CA, Johnson GVW

Advances in experimental medicine and biology.. 2019 1184 :57-68. Epub 1900 01 01.

Nuclear transglutaminase 2 directly regulates expression of cathepsin S in rat cortical neurons.

Ji C, Tang M, Harrison J, Paciorkowski A, Johnson GV

The European journal of neuroscience.. 2018 November 48 (9):3043-3051. Epub 10/06/2018.

Depletion of astrocytic transglutaminase 2 improves injury outcomes.

Monteagudo A, Feola J, Natola H, Ji C, Pröschel C, Johnson GVW

Molecular and cellular neurosciences.. 2018 October 92 :128-136. Epub 06/30/2018.

Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes.

Quinn BR, Yunes-Medina L, Johnson GVW

Journal of neuroscience research.. 2018 July 96 (7):1150-1158. Epub 03/23/2018.

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.

Tang M, Ji C, Pallo S, Rahman I, Johnson GVW

Neurobiology of aging.. 2018 March 63 :128-139. Epub 12/09/2017.

Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability.

Yunes-Medina L, Paciorkowski A, Nuzbrokh Y, Johnson GVW

Molecular and cellular neurosciences.. 2018 January 86 :72-80. Epub 11/29/2017.

Subcellular localization patterns of transglutaminase 2 in astrocytes and neurons are differentially altered by hypoxia.

Yunes-Medina L, Feola J, Johnson GVW

Neuroreport.. 2017 December 1328 (18):1208-1214. Epub 1900 01 01.

Transglutaminase 2 modulation of NF-?B signaling in astrocytes is independent of its ability to mediate astrocytic viability in ischemic injury.

Feola J, Barton A, Akbar A, Keillor J, Johnson GVW

Brain research.. 2017 August 11668 :1-11. Epub 05/15/2017.

The complex role of transglutaminase 2 in glioblastoma proliferation.

Gundemir S, Monteagudo A, Akbar A, Keillor JW, Johnson GV

Neuro-oncology.. 2017 February 119 (2):208-218. Epub 1900 01 01.

Inhibition or ablation of transglutaminase 2 impairs astrocyte migration.

Monteagudo A, Ji C, Akbar A, Keillor JW, Johnson GV

Biochemical and biophysical research communications.. 2017 January 22482 (4):942-947. Epub 11/27/2016.

Assessing the degradation of tau in primary neurons: The role of autophagy.

Ji C, Tang M, Johnson GVW

Methods in cell biology.. 2017 141 :229-244. Epub 07/31/2017.

Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.

Lin CH, Chen J, Zhang Z, Johnson GV, Cooper AJ, Feola J, Bank A, Shein J, Ruotsalainen HJ, Pihlajaniemi TA, Goligorsky MS

Kidney international.. 2016 June 89 (6):1281-92. Epub 04/14/2016.

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors.

Kim S, Choi KJ, Cho SJ, Yun SM, Jeon JP, Koh YH, Song J, Johnson GV, Jo C

Scientific reports.. 2016 April 266 :24933. Epub 04/26/2016.

Mechanisms of tau and A?-induced excitotoxicity.

Pallo SP, DiMaio J, Cook A, Nilsson B, Johnson GV

Brain research.. 2016 March 11634 :119-131. Epub 12/28/2015.

Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.

Chesser AS, Ganeshan V, Yang J, Johnson GV

Nutritional neuroscience.. 2016 19 (1):21-31. Epub 07/24/2015.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM, Doran KS, D'Orazi G, Dorn GW, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, 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Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.

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FEBS letters.. 2011 November 4585 (21):3424-9. Epub 10/05/2011.

Transglutaminase 2 and its role in pulmonary fibrosis.

Olsen KC, Sapinoro RE, Kottman RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ

American journal of respiratory and critical care medicine.. 2011 September 15184 (6):699-707. Epub 06/23/2011.

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics.

Pritchard SM, Dolan PJ, Vitkus A, Johnson GV

Journal of cellular and molecular medicine.. 2011 August 15 (8):1621-35. Epub 1900 01 01.

The application of permanent middle cerebral artery ligation in the mouse.

Colak G, Filiano AJ, Johnson GV

Journal of visualized experiments : JoVE.. 2011 July 25 (53)Epub 07/25/2011.

Influence of Methylobacterium on iron translocation in plants.

Bishop YM, Barton LL, Johnson GV

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.. 2011 June 24 (3):575-80. Epub 01/15/2011.

Suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau.

Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.. 2011 April 15 (2):107-14. Epub 04/30/2011.

Split GFP complementation assay for quantitative measurement of tau aggregation in situ.

Chun W, Waldo GS, Johnson GV

Methods in molecular biology.. 2011 670 :109-23. Epub 1900 01 01.

AES/GRG5: more than just a dominant-negative TLE/GRG family member.

Beagle B, Johnson GV

Developmental dynamics : an official publication of the American Association of Anatomists.. 2010 November 239 (11):2795-805. Epub 1900 01 01.

Transglutaminase 2 protects against ischemic stroke.

Filiano AJ, Tucholski J, Dolan PJ, Colak G, Johnson GV

Neurobiology of disease.. 2010 September 39 (3):334-43. Epub 05/06/2010.

The role of tau kinases in Alzheimer's disease.

Dolan PJ, Johnson GV

Current opinion in drug discovery & development.. 2010 September 13 (5):595-603. Epub 1900 01 01.

Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.

Beagle B, Johnson GV

PloS one.. 2010 July 285 (7):e11821. Epub 07/28/2010.

A caspase cleaved form of tau is preferentially degraded through the autophagy pathway.

Dolan PJ, Johnson GV

The Journal of biological chemistry.. 2010 July 16285 (29):21978-87. Epub 05/13/2010.

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease.

Jin YN, Johnson GV

Journal of bioenergetics and biomembranes.. 2010 June 42 (3):199-205. Epub 1900 01 01.

Development of a rapid, high-efficiency, scalable refold for neurotrophin-4.

Buckley JJ, Hoeltzli SD, Johnson GV

Biotechnology and applied biochemistry.. 2010 May 1956 (1):27-34. Epub 05/19/2010.

Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity.

Beagle B, Mi K, Johnson GV

Journal of cellular biochemistry.. 2009 November 1108 (4):886-95. Epub 1900 01 01.

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease.

Quintanilla RA, Johnson GV

Brain research bulletin.. 2009 October 2880 (4-5):242-7. Epub 07/19/2009.

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease.

Quintanilla RA, Matthews-Roberson TA, Dolan PJ, Johnson GV

The Journal of biological chemistry.. 2009 July 10284 (28):18754-66. Epub 04/23/2009.

Intracellular localization and conformational state of transglutaminase 2: implications for cell death.

Gundemir S, Johnson GV

PloS one.. 2009 July 14 (7):e6123. Epub 07/01/2009.

Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line.

Kong PJ, Kil MO, Lee H, Kim SS, Johnson GV, Chun W

Neurological research.. 2009 February 31 (1):77-83. Epub 08/07/2008.

Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death.

Matthews-Roberson TA, Quintanilla RA, Ding H, Johnson GV

Brain research.. 2008 October 91234 :206-12. Epub 08/07/2008.

Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease.

Quintanilla RA, Jin YN, Fuenzalida K, Bronfman M, Johnson GV

The Journal of biological chemistry.. 2008 September 12283 (37):25628-25637. Epub 07/18/2008.

Histone deacetylase 6 interacts with the microtubule-associated protein tau.

Ding H, Dolan PJ, Johnson GV

Journal of neurochemistry.. 2008 September 106 (5):2119-30. Epub 07/12/2008.

Use of cyclohexanedimethanol as a nonflammable organic solvent for industrial scale reversed phase chromatography.

Hunter AK, Hoeltzli SD, Johnson GV, Gustafson ME, Ho SV

Journal of chromatography. A.. 2008 August 151202 (1):107-10. Epub 07/01/2008.

Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.

Filiano AJ, Bailey CD, Tucholski J, Gundemir S, Johnson GV

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 August 22 (8):2662-75. Epub 03/28/2008.

New application of beta-galactosidase complementation to monitor tau self-association.

Ding H, Johnson GV

Journal of neurochemistry.. 2008 August 106 (4):1545-51. Epub 06/28/2008.

The last tangle of tau.

Ding H, Johnson GV

Journal of Alzheimer's disease : JAD.. 2008 August 14 (4):441-7. Epub 1900 01 01.

Evaluation of refolding conditions for a human recombinant fusion cytokine protein, promegapoietin-1a.

Boyle DM, Johnson GV, Heeren RA, Shell RE, Banerjee A, Gustafson ME

Biotechnology and applied biochemistry.. 2008 January 49 (Pt 1):73-83. Epub 1900 01 01.

The differential effects of R580A mutation on transamidation and GTP binding activity of rat and human type transglutaminase

Ruan, Q., Tucholski, J., Gundemir, S. and Johnson Voll, G.V.W.

International Journal of Clinical and Experimental Medicine. 2008; : 248-259.

Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.

Mookherjee P, Quintanilla R, Roh MS, Zmijewska AA, Jope RS, Johnson GV

Journal of cellular biochemistry.. 2007 September 1102 (1):196-210. Epub 1900 01 01.

Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy.

Chun W, Johnson GV

The Journal of biological chemistry.. 2007 August 10282 (32):23410-7. Epub 06/12/2007.

Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin.

Ruan Q, Quintanilla RA, Johnson GV

Journal of neurochemistry.. 2007 July 102 (1):25-36. Epub 03/30/2007.

Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease.

Hunter JM, Lesort M, Johnson GV

Journal of neuroscience research.. 2007 June 85 (8):1774-88. Epub 1900 01 01.

Inhibition of iron deficiency stress response in cucumber by rare earth elements.

Johnson GV, Barton LL

Plant physiology and biochemistry : PPB. 2007 May 45 (5):302-8. Epub 03/15/2007.

Regulated proteolytic processing of LRP6 results in release of its intracellular domain.

Mi K, Johnson GV

Journal of neurochemistry.. 2007 April 101 (2):517-29. Epub 02/26/2007.

The role of tau phosphorylation and cleavage in neuronal cell death.

Chun W, Johnson GV

Frontiers in bioscience : a journal and virtual library.. 2007 January 112 :733-56. Epub 01/01/2007.

Transglutaminase 2 in neurodegenerative disorders.

Ruan Q, Johnson GV

Frontiers in bioscience : a journal and virtual library.. 2007 January 112 :891-904. Epub 01/01/2007.

Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency.

Clodfelder-Miller BJ, Zmijewska AA, Johnson GV, Jope RS

Diabetes.. 2006 December 55 (12):3320-5. Epub 1900 01 01.

The role of tau phosphorylation in the pathogenesis of Alzheimer's disease.

Mi K, Johnson GV

Current Alzheimer research.. 2006 December 3 (5):449-63. Epub 1900 01 01.

Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences.

Milakovic T, Quintanilla RA, Johnson GV

The Journal of biological chemistry.. 2006 November 17281 (46):34785-95. Epub 09/13/2006.

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.

Ding H, Matthews TA, Johnson GV

The Journal of biological chemistry.. 2006 July 14281 (28):19107-14. Epub 05/10/2006.

[Abdominal hernias resulting from abdominal flap harvest].

Germann G, Sauerbier M, Unglaub F

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.. 2006 May 77 (5):424-31. Epub 1900 01 01.

Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage.

Tucholski J, Roth KA, Johnson GV

Journal of neurochemistry.. 2006 April 97 (2):582-94. Epub 03/15/2006.

The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.

Mi K, Dolan PJ, Johnson GV

The Journal of biological chemistry.. 2006 February 24281 (8):4787-94. Epub 12/19/2005.

Tau phosphorylation and proteolysis: insights and perspectives.

Johnson GV

Journal of Alzheimer's disease : JAD.. 2006 9 (3 Suppl):243-50. Epub 1900 01 01.

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR

Journal of neurochemistry.. 2005 October 95 (1):210-20. Epub 1900 01 01.

Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington's disease mouse model.

Choo YS, Mao Z, Johnson GV, Lesort M

Neuroscience letters.. 2005 September 23386 (1):63-8. Epub 1900 01 01.

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin.

Milakovic T, Johnson GV

The Journal of biological chemistry.. 2005 September 2280 (35):30773-82. Epub 06/27/2005.

14-3-3Zeta does not increase GSK3beta-mediated tau phosphorylation in cell culture models.

Matthews TA, Johnson GV

Neuroscience letters.. 2005 August 26384 (3):211-6. Epub 1900 01 01.

Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway.

Mi K, Johnson GV

Journal of cellular biochemistry.. 2005 May 1595 (2):328-38. Epub 1900 01 01.

Verification of somatic CAG repeat expansion by pre-PCR fractionation.

Hunter JM, Crouse AB, Lesort M, Johnson GV, Detloff PJ

Journal of neuroscience methods.. 2005 May 15144 (1):11-7. Epub 11/28/2004.

FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.

Stoothoff WH, Cho JH, McDonald RP, Johnson GV

The Journal of biological chemistry.. 2005 January 7280 (1):270-6. Epub 11/01/2004.

Tau phosphorylation: physiological and pathological consequences.

Stoothoff WH, Johnson GV

Biochimica et biophysica acta.. 2005 January 31739 (2-3):280-97. Epub 1900 01 01.

Transglutaminases in neurodegenerative disorders.

Bailey CD, Tucholski J, Johnson GV

Progress in experimental tumor research. Fortschritte der

Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ.

Cho JH, Johnson GV

The Journal of biological chemistry.. 2004 December 24279 (52):54716-23. Epub 10/19/2004.

Developmental regulation of tissue transglutaminase in the mouse forebrain.

Bailey CD, Johnson GV

Journal of neurochemistry.. 2004 December 91 (6):1369-79. Epub 1900 01 01.

Tau phosphorylation in neuronal cell function and dysfunction.

Johnson GV, Stoothoff WH

Journal of cell science.. 2004 November 15117 (Pt 24):5721-9. Epub 1900 01 01.

Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.

Suh MD, Park CH, Kim SS, Kil MO, Lee GH, Johnson GV, Chun W

Archives of pharmacal research.. 2004 August 27 (8):850-6. Epub 1900 01 01.

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release.

Choo YS, Johnson GV, MacDonald M, Detloff PJ, Lesort M

Human molecular genetics.. 2004 July 1513 (14):1407-20. Epub 05/26/2004.

Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis.

Robitaille K, Daviau A, Tucholski J, Johnson GV, Rancourt C, Blouin R

Cell death and differentiation.. 2004 May 11 (5):542-9. Epub 1900 01 01.

Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway.

Ruan Q, Lesort M, MacDonald ME, Johnson GV

Human molecular genetics.. 2004 April 113 (7):669-81. Epub 02/12/2004.

Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells.

Shelton SB, Krishnamurthy P, Johnson GV

Journal of neuroscience research.. 2004 April 176 (1):110-20. Epub 1900 01 01.

Intracellular localization and activity state of tissue transglutaminase differentially impacts cell death.

Milakovic T, Tucholski J, McCoy E, Johnson GV

The Journal of biological chemistry.. 2004 March 5279 (10):8715-22. Epub 12/11/2003.

Cyclin-dependent kinase-5 in neurodegeneration.

Shelton SB, Johnson GV

Journal of neurochemistry.. 2004 March 88 (6):1313-26. Epub 1900 01 01.

Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases.

Bailey CD, Graham RM, Nanda N, Davies PJ, Johnson GV

Molecular and cellular neurosciences.. 2004 March 25 (3):493-503. Epub 1900 01 01.

Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model.

Krishnamurthy PK, Johnson GV

The Journal of biological chemistry.. 2004 February 27279 (9):7893-900. Epub 12/02/2003.

The glamour and gloom of glycogen synthase kinase-3.

Jope RS, Johnson GV

Trends in biochemical sciences.. 2004 February 29 (2):95-102. Epub 1900 01 01.

The p38 MAP kinase signaling pathway in Alzheimer's disease.

Johnson GV, Bailey CD

Experimental neurology.. 2003 October 183 (2):263-8. Epub 1900 01 01.

Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation.

Tucholski J, Johnson GV

The Journal of biological chemistry.. 2003 July 18278 (29):26838-43. Epub 05/12/2003.

Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders.

Lesort M, Lee M, Tucholski J, Johnson GV

The Journal of biological chemistry.. 2003 February 7278 (6):3825-30. Epub 11/27/2002.

Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding.

Cho JH, Johnson GV

The Journal of biological chemistry.. 2003 January 3278 (1):187-93. Epub 10/29/2002.

Transient osmotic stress facilitates mutant huntingtin aggregation.

Chun W, Lesort M, Lee M, Johnson GV

Neuroreport.. 2002 December 2013 (18):2543-6. Epub 1900 01 01.

Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta.

Stoothoff WH, Bailey CD, Mi K, Lin SC, Johnson GV

Journal of neurochemistry.. 2002 November 83 (4):904-13. Epub 1900 01 01.

Tau, where are we now?

Johnson GV, Bailey CD

Journal of Alzheimer's disease : JAD.. 2002 October 4 (5):375-98. Epub 1900 01 01.

Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling.

Zhang J, Luan CH, Chou KC, Johnson GV

Proteins.. 2002 August 1548 (3):447-53. Epub 1900 01 01.

Multifocal osteonecrosis -- a case report.

Rehman HU, Johnson GV, Taylor AD, Doherty SM

Clinical rheumatology.. 2002 August 21 (4):322-3. Epub 1900 01 01.

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage.

Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GV, Jope RS

Proceedings of the National Academy of Sciences of the United States of America.. 2002 June 1199 (12):7951-5. Epub 06/04/2002.

Ten to fourteen year survival and functional analysis of the AGC total knee replacement system.

Worland RL, Johnson GV, Alemparte J, Jessup DE, Keenan J, Norambuena N, Johnson G

The Knee.. 2002 May 9 (2):133-7. Epub 1900 01 01.

Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner.

Tucholski J, Johnson GV

Journal of neurochemistry.. 2002 May 81 (4):780-91. Epub 1900 01 01.

Cdk5 phosphorylates p53 and regulates its activity.

Zhang J, Krishnamurthy PK, Johnson GV

Journal of neurochemistry.. 2002 April 81 (2):307-13. Epub 1900 01 01.

Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors.

Chun W, Lesort M, Lee M, Johnson GV

FEBS letters.. 2002 March 27515 (1-3):61-5. Epub 1900 01 01.

Does tissue transglutaminase play a role in Huntington's disease?

Lesort M, Chun W, Tucholski J, Johnson GV

Neurochemistry international.. 2002 January 40 (1):37-52. Epub 1900 01 01.

Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells.

Mookherjee P, Johnson GV

Brain research.. 2001 December 7921 (1-2):31-43. Epub 1900 01 01.

Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells.

Shelton SB, Johnson GV

Journal of neuroscience research.. 2001 October 1566 (2):203-13. Epub 1900 01 01.

Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells.

Stoothoff WH, Johnson GV

Journal of neuroscience research.. 2001 September 1565 (6):573-82. Epub 1900 01 01.

Complement activation by neurofibrillary tangles in Alzheimer's disease.

Shen Y, Lue L, Yang L, Roher A, Kuo Y, Strohmeyer R, Goux WJ, Lee V, Johnson GV, Webster SD, Cooper NR, Bradt B, Rogers J

Neuroscience letters.. 2001 June 15305 (3):165-8. Epub 1900 01 01.

Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1.

De Sarno P, Lesort M, Bijur GN, Johnson GV, Jope RS

Brain research.. 2001 June 8903 (1-2):226-30. Epub 1900 01 01.

Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.

Hartigan JA, Xiong WC, Johnson GV

Biochemical and biophysical research communications.. 2001 June 8284 (2):485-9. Epub 1900 01 01.

Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells.

Chun W, Lesort M, Tucholski J, Faber PW, MacDonald ME, Ross CA, Johnson GV

Neurobiology of disease.. 2001 June 8 (3):391-404. Epub 1900 01 01.

Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates.

Chun W, Lesort M, Tucholski J, Ross CA, Johnson GV

The Journal of cell biology.. 2001 April 2153 (1):25-34. Epub 1900 01 01.

Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase.

Grierson AJ, Johnson GV, Miller CC

Neuroscience letters.. 2001 January 26298 (1):9-12. Epub 1900 01 01.

Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells.

Tucholski J, Lesort M, Johnson GV

Neuroscience.. 2001 102 (2):481-91. Epub 1900 01 01.

Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells.

Zhang J, Johnson GV

Journal of neurochemistry.. 2000 December 75 (6):2346-57. Epub 1900 01 01.

Impaired mitochondrial function results in increased tissue transglutaminase activity in situ.

Lesort M, Tucholski J, Zhang J, Johnson GV

Journal of neurochemistry.. 2000 November 75 (5):1951-61. Epub 1900 01 01.

Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis.

Krishnamurthy PK, Mays JL, Bijur GN, Johnson GV

Journal of neuroscience research.. 2000 September 161 (5):515-23. Epub 1900 01 01.

Tissue transglutaminase: a possible role in neurodegenerative diseases.

Lesort M, Tucholski J, Miller ML, Johnson GV

Progress in neurobiology.. 2000 August 61 (5):439-63. Epub 1900 01 01.

Modulation of tau phosphorylation and intracellular localization by cellular stress.

Jenkins SM, Zinnerman M, Garner C, Johnson GV

The Biochemical journal.. 2000 January 15345 Pt 2 (Pt 2):263-70. Epub 1900 01 01.

Osmotic stress increases tau phosphorylation independent of stress-activated protein kinase activation

Jenkins, S.M., Zinnerman, M., Garner, C. and Johnson, G.V.W.

Biochemical Journal. 2000; 345: 263-270.

Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau as substrates.

Guttmann RP, Johnson GV

Methods in molecular biology.. 2000 144 :143-50. Epub 1900 01 01.

The microtubule binding of Tau and high molecular weight Tau in apoptotic PC12 cells is impaired because of altered phosphorylation.

Davis PK, Johnson GV

The Journal of biological chemistry.. 1999 December 10274 (50):35686-92. Epub 1900 01 01.

Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling.

Zhang J, Tucholski J, Lesort M, Jope RS, Johnson GV

The Biochemical journal.. 1999 November 1343 Pt 3 (Pt 3):541-9. Epub 1900 01 01.

Modulation of tau phosphorylation within its microtubule-binding domain by cellular thiols.

Jenkins SM, Johnson GV

Journal of neurochemistry.. 1999 November 73 (5):1843-50. Epub 1900 01 01.

Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination.

Tucholski J, Kuret J, Johnson GV

Journal of neurochemistry.. 1999 November 73 (5):1871-80. Epub 1900 01 01.

Tissue transglutaminase is increased in Huntington's disease brain.

Lesort M, Chun W, Johnson GV, Ferrante RJ

Journal of neurochemistry.. 1999 November 73 (5):2018-27. Epub 1900 01 01.

Tau protein in normal and Alzheimer's disease brain.

Johnson GV, Jenkins SM

Journal of Alzheimer's disease : JAD.. 1999 November 1 (4-5):307-28. Epub 1900 01 01.

Tau protein in normal and Alzheimer's disease brain: an update.

Johnson GV, Hartigan JA

Journal of Alzheimer's disease : JAD.. 1999 November 1 (4-5):329-51. Epub 1900 01 01.

Endoscopically-assisted excision of scapular osteochondroma.

Kumar N, Ramakrishnan V, Johnson GV, Southern S

Acta orthopaedica Scandinavica.. 1999 August 70 (4):394-6. Epub 1900 01 01.

p38 kinase is activated in the Alzheimer's disease brain.

Hensley K, Floyd RA, Zheng NY, Nael R, Robinson KA, Nguyen X, Pye QN, Stewart CA, Geddes J, Markesbery WR, Patel E, Johnson GV, Bing G

Journal of neurochemistry.. 1999 May 72 (5):2053-8. Epub 1900 01 01.

Altered protein kinase C activation of Na/Caexchange in mesangial cells from salt-sensitive rats.

Mashburn NA, Unlap MT, Runquist J, Alderman A, Johnson GVW, Bell PD

American journal of physiology. Renal physiology.. 1999 April 1276 (4):F574-F580. Epub 1900 01 01.

Altered protein kinase C activation of Na+/Ca2+ exchange in mesangial cells from salt-sensitive rats.

Mashburn NA, Unlap MT, Runquist J, Alderman A, Johnson GV, Bell PD

The American journal of physiology.. 1999 April 276 (4):F574-80. Epub 1900 01 01.

Hippocampal microtubule-associated protein-2 alterations with contextual memory.

Woolf NJ, Zinnerman MD, Johnson GV

Brain research.. 1999 March 6821 (1):241-9. Epub 1900 01 01.

Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase.

Lesort M, Jope RS, Johnson GV

Journal of neurochemistry.. 1999 February 72 (2):576-84. Epub 1900 01 01.

kinase is activated in Alzheimer's Disease brain

Hensley, K; Floyd, RA; Zheng, N-Y; Nael, R; Robinson, K; Nguyen, X; Pye, QN; Stewart, CA; Geddes, J; Markesbery, WR; Patel, E; Johnson, GVW; Bing, G.

Journal of Neurochemistry. 1999; 72: 2047-2052.

"Calpain-mediated proteolysis of neuronal structural proteins".

Guttmann, RP; Johnson, GVW.

The Pharmacology and Toxicology of Calpain. 1999; : 229-249.

Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain.

Lesort M, Greendorfer A, Stockmeier C, Johnson GV, Jope RS

Journal of neural transmission.. 1999 106 (11-12):1217-22. Epub 1900 01 01.

Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2.

Spear N, Estévez AG, Johnson GV, Bredesen DE, Thompson JA, Beckman JS

Archives of biochemistry and biophysics.. 1998 August 1356 (1):41-5. Epub 1900 01 01.

Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells.

Xie HQ, Johnson GV

Journal of neuroscience research.. 1998 July 1553 (2):153-64. Epub 1900 01 01.

The interrelationship between selective tau phosphorylation and microtubule association.

Xie H, Litersky JM, Hartigan JA, Jope RS, Johnson GV

Brain research.. 1998 July 6798 (1-2):173-83. Epub 1900 01 01.

Tissue transglutaminase is an in situ substrate of calpain: regulation of activity.

Zhang J, Guttmann RP, Johnson GV

Journal of neurochemistry.. 1998 July 71 (1):240-7. Epub 1900 01 01.

Oxidative stress inhibits calpain activity in situ.

Guttmann RP, Johnson GV

The Journal of biological chemistry.. 1998 May 22273 (21):13331-8. Epub 1900 01 01.

Distinct nuclear localization and activity of tissue transglutaminase.

Lesort M, Attanavanich K, Zhang J, Johnson GV

The Journal of biological chemistry.. 1998 May 15273 (20):11991-4. Epub 1900 01 01.

Modulation of the in situ activity of tissue transglutaminase by calcium and GTP.

Zhang J, Lesort M, Guttmann RP, Johnson GV

The Journal of biological chemistry.. 1998 January 23273 (4):2288-95. Epub 1900 01 01.

Tau complexes with phospholipase C-gamma in situ.

Jenkins SM, Johnson GV

Neuroreport.. 1998 January 59 (1):67-71. Epub 1900 01 01.

Calpains: intact and active?

Johnson GV, Guttmann RP

BioEssays : news and reviews in molecular, cellular and developmental biology.. 1997 November 19 (11):1011-8. Epub 1900 01 01.

Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase.

Jenkins SM, Johnson GV

Brain research.. 1997 September 5767 (2):305-13. Epub 1900 01 01.

Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.

Xie H, Johnson GV

Journal of neurochemistry.. 1997 September 69 (3):1020-30. Epub 1900 01 01.

Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase.

Spear N, Estévez AG, Barbeito L, Beckman JS, Johnson GV

Journal of neurochemistry.. 1997 July 69 (1):53-9. Epub 1900 01 01.

Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells.

Davis PK, Dudek SM, Johnson GV

Journal of neurochemistry.. 1997 June 68 (6):2338-47. Epub 1900 01 01.

Transglutaminase activity is increased in Alzheimer's disease brain.

Johnson GV, Cox TM, Lockhart JP, Zinnerman MD, Miller ML, Powers RE

Brain research.. 1997 March 21751 (2):323-9. Epub 1900 01 01.

Large-scale production and characterization of Bacillus thuringiensis subsp. tenebrionis insecticidal protein from Escherichia coli.

Gustafson ME, Clayton RA, Lavrik PB, Johnson GV, Leimgruber RM, Sims SR, Bartnicki DE

Applied microbiology and biotechnology.. 1997 March 47 (3):255-61. Epub 1900 01 01.

Oxidation inhibits substrate proteolysis by calpain I but not autolysis.

Guttmann RP, Elce JS, Bell PD, Isbell JC, Johnson GV

The Journal of biological chemistry.. 1997 January 17272 (3):2005-12. Epub 1900 01 01.

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments.

Johnson GV, Seubert P, Cox TM, Motter R, Brown JP, Galasko D

Journal of neurochemistry.. 1997 January 68 (1):430-3. Epub 1900 01 01.

Involvement of the low-affinity neurotrophin receptor (p75NTR) in apoptosis of differentiated PC12 cells

Jenkins, SM; Johnson, GVW.

Neuroscience Research Communications. 1997; 20: 137-146.

Analysis of the phosphorylation state of tau in situ

Johnson, G.V.W. and Fleming, L.M.

Function and Malfunction of the Tau Proteins: Concepts and Approaches. 1997; : 313-329.

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine.

Arnold CS, Johnson GV, Cole RN, Dong DL, Lee M, Hart GW

The Journal of biological chemistry.. 1996 November 15271 (46):28741-4. Epub 1900 01 01.

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

Litersky JM, Johnson GV, Jakes R, Goedert M, Lee M, Seubert P

The Biochemical journal.. 1996 June 1316 ( Pt 2) (Pt 2):655-60. Epub 1900 01 01.

Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins.

Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV

Experimental neurology.. 1996 April 138 (2):252-60. Epub 1900 01 01.

Tau protein in normal and Alzheimer's disease brain

Johnson, GVW; Jenkins, SM.

Alzheimer's Disease Reviews

Postnatal changes in serine/threonine protein phosphatases and their association with the microtubules.

Dudek SM, Johnson GV

Brain research. Developmental brain research.. 1995 December 2190 (1-2):54-61. Epub 1900 01 01.

Localization and in situ phosphorylation state of nuclear tau.

Greenwood JA, Johnson GV

Experimental cell research.. 1995 October 220 (2):332-7. Epub 1900 01 01.

Transglutaminase cross-linking of the tau protein.

Miller ML, Johnson GV

Journal of neurochemistry.. 1995 October 65 (4):1760-70. Epub 1900 01 01.

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GV, Litersky JM, Schenk D, Lieberburg I, Trojanowski JQ

The Journal of biological chemistry.. 1995 August 11270 (32):18917-22. Epub 1900 01 01.

Phosphorylation of tau in situ: inhibition of calcium-dependent proteolysis.

Litersky JM, Johnson GV

Journal of neurochemistry.. 1995 August 65 (2):903-11. Epub 1900 01 01.

Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP.

Fleming LM, Johnson GV

The Biochemical journal.. 1995 July 1309 ( Pt 1) (Pt 1):41-7. Epub 1900 01 01.

Metal-catalyzed oxidation of bovine neurofilaments in vitro.

Troncoso JC, Costello AC, Kim JH, Johnson GV

Free radical biology & medicine.. 1995 May 18 (5):891-9. Epub 1900 01 01.

Tau self-association: stabilization with a chemical cross-linker and modulation by phosphorylation and oxidation state.

Guttmann RP, Erickson AC, Johnson GV

Journal of neurochemistry.. 1995 March 64 (3):1209-15. Epub 1900 01 01.

Understanding the hyperphosphorylation of tau in Alzheimer's disease: Importance of examining site-specific phosphorylation in non-disease system

Johnson, GVW; Greenwood, JA.

Neurobiology of Aging. 1995; 16: 371-374.

Monoclonal antibody Alz-50 reacts with bovine and human serum albumin.

Davis PK, Johnson GV

Journal of neuroscience research.. 1994 December 139 (5):589-94. Epub 1900 01 01.

Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide.

Dudek SM, Johnson GV

Brain research.. 1994 July 18651 (1-2):129-33. Epub 1900 01 01.

Pavlovian conditioning alters cortical microtubule-associated protein-2.

Woolf NJ, Young SL, Johnson GV, Fanselow MS

Neuroreport.. 1994 May 95 (9):1045-8. Epub 1900 01 01.

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

Greenwood JA, Scott CW, Spreen RC, Caputo CB, Johnson GV

The Journal of biological chemistry.. 1994 February 11269 (6):4373-80. Epub 1900 01 01.

Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of tau.

Dudek SM, Johnson GV

Journal of neurochemistry.. 1993 September 61 (3):1159-62. Epub 1900 01 01.

Phosphorylation modulates calpain-mediated proteolysis and calmodulin binding of the 200-kDa and 160-kDa neurofilament proteins.

Greenwood JA, Troncoso JC, Costello AC, Johnson GV

Journal of neurochemistry.. 1993 July 61 (1):191-9. Epub 1900 01 01.

In vitro polymerization of oxidized tau into filaments.

Troncoso JC, Costello A, Watson AL, Johnson GV

Brain research.. 1993 June 11613 (2):313-6. Epub 1900 01 01.

Metal (Fe3+) affinity chromatography: differential adsorption of tau phosphoproteins.

Erickson AC, Johnson GV

Journal of neuroscience methods.. 1993 March 46 (3):245-9. Epub 1900 01 01.

Phosphorylation, calpain proteolysis and tubulin binding of recombinant human tau isoforms.

Litersky JM, Scott CW, Johnson GV

Brain research.. 1993 February 26604 (1-2):32-40. Epub 1900 01 01.

The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration.

Johnson GV, Jope RS

Journal of neuroscience research.. 1992 December 33 (4):505-12. Epub 1900 01 01.

Brain casein kinase 2: affinity purification procedure using immobilized polyethylenimine.

Khilko S, Greenwood JA, Johnson GV

Protein expression and purification.. 1992 October 3 (5):355-61. Epub 1900 01 01.

The Scott wiring technique for direct repair of lumbar spondylolysis.

Johnson GV, Thompson AG

The Journal of bone and joint surgery. British volume.. 1992 May 74 (3):426-30. Epub 1900 01 01.

Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain.

Litersky JM, Johnson GV

The Journal of biological chemistry.. 1992 January 25267 (3):1563-8. Epub 1900 01 01.

Alterations of choline acetyltransferase, phosphoinositide hydrolysis, and cytoskeletal proteins in rat brain in response to colchicine administration.

Kolasa K, Jope RS, Baird MS, Johnson GV

Experimental brain research.. 1992 89 (3):496-500. Epub 1900 01 01.

Dietary aluminum selectively decreases MAP-2 in brains of developing and adult rats.

Johnson GV, Watson AL, Lartius R, Uemura E, Jope RS

Neurotoxicology.. 1992 13 (2):463-74. Epub 1900 01 01.

Neurotoxic effects of dietary aluminium.

Jope RS, Johnson GV

Ciba Foundation symposium.. 1992 169 :254-62; discussion 262-7. Epub 1900 01 01.

Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D.

Johnson GV, Litersky JM, Whitaker JN

Journal of neurochemistry.. 1991 November 57 (5):1577-83. Epub 1900 01 01.

The regulatory role of calmodulin in the proteolysis of individual neurofilament proteins by calpain.

Johnson GV, Greenwood JA, Costello AC, Troncoso JC

Neurochemical research.. 1991 August 16 (8):869-73. Epub 1900 01 01.

Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study.

Johnson GV, Litersky JM, Jope RS

Journal of neurochemistry.. 1991 May 56 (5):1630-8. Epub 1900 01 01.

Seizure-induced protein tyrosine phosphorylation in rat brain regions.

Jope RS, Johnson GV, Baird MS

Epilepsia.. 1991 32 (6):755-60. Epub 1900 01 01.

Oral aluminum alters in vitro protein phosphorylation and kinase activities in rat brain.

Johnson GV, Cogdill KW, Jope RS

Neurobiology of aging.. 1990 11 (3):209-16. Epub 1900 01 01.

Proteolysis of tau by calpain.

Johnson GV, Jope RS, Binder LI

Biochemical and biophysical research communications.. 1989 September 29163 (3):1505-11. Epub 1900 01 01.

Aluminum increases agonist-stimulated cyclic AMP production in rat cerebral cortical slices.

Johnson GV, Li XH, Jope RS

Journal of neurochemistry.. 1989 July 53 (1):258-63. Epub 1900 01 01.

Changes in protein kinase activities following aluminum administration to aged rats

Caputo, CB; Sygowski, LA; Scott, CW; Johnson, GVW; Brunner, WF; Salama, AI.

Brain Dysfunction. 1989; : 297-309.

Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum.

Johnson GV, Jope RS

Brain research.. 1988 July 19456 (1):95-103. Epub 1900 01 01.

Modulation of carbachol-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.

Jope RS, Casebolt TL, Johnson GV

Neurochemical research.. 1987 August 12 (8):693-700. Epub 1900 01 01.

In vitro measurements of cholinergic activity in brain regions of hibernating ground squirrels.

Stanton TL, Johnson GV

Brain research bulletin.. 1987 May 18 (5):663-7. Epub 1900 01 01.

Aluminum alters cyclic AMP and cyclic GMP levels but not presynaptic cholinergic markers in rat brain in vivo.

Johnson GV, Jope RS

Brain research.. 1987 February 10403 (1):1-6. Epub 1900 01 01.

Management of severely displaced medial epicondyle fractures.

Dias JJ, Johnson GV, Hoskinson J, Sulaiman K

Journal of orthopaedic trauma.. 1987 1 (1):59-62. Epub 1900 01 01.

Aluminum increases cyclic AMP in rat cerebral cortex in vivo.

Johnson GV, Jope RS

Life sciences.. 1986 October 639 (14):1301-5. Epub 1900 01 01.

Aluminum impairs glucose utilization and cholinergic activity in rat brain in vitro.

Johnson GV, Jope RS

Toxicology.. 1986 July 40 (1):93-102. Epub 1900 01 01.

Increased aerobic glucose oxidation by cAMP in cultured regenerated skeletal myotubes.

Freerksen DL, Schroedl NA, Johnson GV, Hartzell CR

The American journal of physiology.. 1986 May 250 (5 Pt 1):C713-9. Epub 1900 01 01.

Quinacrine and 2-(4-phenylpiperidino)cyclohexanol (AH5183) inhibit acetylcholine release and synthesis in rat brain slices.

Jope RS, Johnson GV

Molecular pharmacology.. 1986 January 29 (1):45-51. Epub 1900 01 01.

Halothane-induced alterations of glucose and pyruvate metabolism in rat cerebra synaptosomes.

Johnson GV, Hartzell CR

Journal of neurochemistry.. 1985 June 44 (6):1838-44. Epub 1900 01 01.

Choline uptake, acetylcholine synthesis and release, and halothane effects in synaptosomes.

Johnson GV, Hartzell CR

Anesthesia and analgesia.. 1985 April 64 (4):395-9. Epub 1900 01 01.

In vivo MAC values and in vitro experimentation.

Hartzell CR, Johnson GV

Anesthesia and analgesia.. 1985 April 64 (4):386-7. Epub 1900 01 01.

Teaching self-feeding to children with cerebral palsy.

JOHNSON GV

Public health nursing. 1947 June 39 (6):310. Epub 1900 01 01.

Books

Transglutaminase: Fundamentals and Applications (2023)

Chapter: Transglutaminase 2 in Neurological Conditions,

Authors: Delgado, T. and Johnson, G.V.W

Publisher: ELSEVIER / Academic Press 2023

Tau Biology, Advances in Experimental Medicine and Biology (2019)

Chapter: Tau Clearance Mechanisms

Authors: Tang, M., Harrison, J., Deaton, C. A. and Johnson G.V.W.

Publisher: Springer Nature, Singapore 2019

Methods in Cell Biology (2017)

Chapter: Assessing the degradation of tau in primary neurons: the role of autophagy

Authors: Ji, C., Tang, M. and Johnson G.V.W.

Publisher: Elsevier, Oxford, England 2017

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges (2016)

Chapter: Stimulation of Tau Degradation

Authors: Quintanilla, R.A., Cabezas-Opazo, F., Pallo, S.P., Chesser, A.S. and Johnson, G.V.W.

Publisher: Elsevier Publishing, Waltham, MA. 2016

Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery (2015)

Chapter: Transglutaminases and Neurological Diseases

Authors: Feola, J., Monteagudo, A., Yunes-Medina, L. and Johnson, G.V.W.

Publisher: Springer Publishing 2015

Alzheimer's Disease and Frontotemporal Dementia: Methods in Molecular Biology (2011)

Chapter: Split GFP complementation assay for quantitative measurement of tau aggregation in situ

Authors: Chun, W., Waldo, G.S. and Johnson, G.V.W.

Publisher: The Humana Press Inc 2011

The Ubiquitin Proteasome System in the Central Nervous System: From Physiology To Pathology - 2008 update (2008)

Chapter: The role of the ubiquitin proteasome system in the pathogenesis of Huntington's disease and other polyglutamine disorders

Authors: Lesort, M. and Johnson, G.V.W

Publisher: Nova Biomedical Books 2008

Transglutaminases: the family of enzymes with diverse functions Progress in Expe (2005)

Chapter: Transglutaminases in neurodegenerative disorders

Authors: Bailey, CDC; Tucholski, J; Johnson, GVW

Publisher: Karger Publishers 2005

The Pharmacology and Toxicology of Calpain (1999)

Chapter: Calpain-mediated proteolysis of neuronal structural proteins

Authors: Guttmann, RP; Johnson, GVW

Publisher: Taylor and Francis Publishers, NY 1999

Calpain Methods & Protocols: Methods in Molecular Biology (1999)

Chapter: Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau protein as substrates

Authors: Guttmann, RP; Johnson, GVW

Publisher: Humana Press, Inc., Totowa, NJ 1999

Calpain Methods & Protocols: Methods in Molecular Biology (1999)

Chapter: "Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau protein as substrates".

Authors: Guttmann, RP; Johnson, GVW

Publisher: Calpain Methods & Protocols: Methods in Molecular Biology 1999

Neuromethods, General Techniques In Vitro, Molecular (1998)

Chapter: Protein phosphorylation

Authors: Johnson, GVW; Davis, PK

Publisher: Humana Press, Inc, Totowa, NJ 1998

Function and Malfunction of the Tau Proteins: Concepts and Approaches (1997)

Chapter: Analysis of the phosphorylation state of tau in situ

Authors: Johnson, GVW; Fleming, LM

Publisher: Harwood Academic Publishers, Amsterdam, The Netherlands 1997