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Hongmei Yang, Ph.D.

Hongmei Yang, Ph.D.

Contact

Office (585) 275-0411
Fax (585) 273-1031

About Me

Professional Background

Education
Ph.D. in Statistics, Aug, 2007 --North Carolina State Univ., Raleigh, NC
M.S in Statistics, May, 2003-- Univ. of Toledo, Toledo, OH
B.S in Mathematics, July, 1997--Central China Normal Univ.,Wuhan, P.R.C.

Academic Appointments
Research Associate Professor, Department of ...
Education
Ph.D. in Statistics, Aug, 2007 --North Carolina State Univ., Raleigh, NC
M.S in Statistics, May, 2003-- Univ. of Toledo, Toledo, OH
B.S in Mathematics, July, 1997--Central China Normal Univ.,Wuhan, P.R.C.

Academic Appointments
Research Associate Professor, Department of Biostatistics & Computational Biology, Univ. of Rochester

Faculty Appointments

Research Associate Professor - Department of Biostatistics and Computational Biology (SMD)

Credentials

Education

PhD | N Carolina St Univ at Raleigh. Statistics. 2007

MS | Univ of Toledo. Statistics. 2003

BS | China-Central China Normal Univ/HuaZhong Normal. Mathematics. 1997

Research

Longitudinal Data Analysis
Mixed-effect Models, including LMM, GLMM, NLME and NPME
Dimensional Reduction
Statistical Processing and Analysis of Limiting Dilution Data

Publications

Journal Articles

Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model.

Yang H, Holden-Wiltse J, Topham DJ, Treanor J

Journal of biopharmaceutical statistics.. 2018 28 (3):492-500. Epub 09/05/2017.

Viral Respiratory Infections in Preterm Infants during and after Hospitalization.

Caserta MT, Yang H, Gill SR, Holden-Wiltse J, Pryhuber G

The Journal of pediatrics.. 2017 March 182 :53-58.e3. Epub 12/30/2016.

Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection.

Antwi S, Yang H, Enimil A, Sarfo AM, Gillani FS, Ansong D, Dompreh A, Orstin A, Opoku T, Bosomtwe D, Wiesner L, Norman J, Peloquin CA, Kwara A

Antimicrobial agents and chemotherapy.. 2017 February 61 (2)Epub 01/24/2017.

Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection.

Kwara A, Enimil A, Gillani FS, Yang H, Sarfo AM, Dompreh A, Ortsin A, Osei-Tutu L, Kwarteng Owusu S, Wiesner L, Norman J, Kurpewski J, Peloquin CA, Ansong D, Antwi S

Journal of the Pediatric Infectious Diseases Society.. 2016 December 5 (4):356-365. Epub 05/26/2015.

Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection.

DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ

Immunology.. 2016 June 148 (2):160-73. Epub 03/30/2016.

Enhancing physical function in HIV-infected older adults: A randomized controlled clinical trial.

Shah KN, Majeed Z, Yoruk YB, Yang H, Hilton TN, McMahon JM, Hall WJ, Walck D, Luque AE, Ryan RM

Health psychology : official journal of the Division of Health Psychology, American Psychological Association.. 2016 June 35 (6):563-73. Epub 02/11/2016.

Proportion and factors associated with Hepatitis B viremia in antiretroviral treatment naïve and experienced HIV co-infected Ghanaian patients.

Archampong TN, Lartey M, Sagoe KW, Obo-Akwa A, Kenu E, Gillani FS, Yang H, Boamah I, Flanigan T, Kwara A

BMC infectious diseases.. 2016 January 1316 :14. Epub 01/13/2016.

An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein.

Yang H, Baker SF, González ME, Topham DJ, Martínez-Sobrido L, Zand M, Holden-Wiltse J, Wu H

Journal of biopharmaceutical statistics.. 2016 26 (3):409-20. Epub 05/26/2015.

Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.

Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS

Clinical immunology : the official journal of the Clinical Immunology Society.. 2015 December 161 (2):65-74. Epub 07/29/2015.

High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine.

Halliley JL, Khurana S, Krammer F, Fitzgerald T, Coyle EM, Chung KY, Baker SF, Yang H, Martínez-Sobrido L, Treanor JJ, Subbarao K, Golding H, Topham DJ, Sangster MY

The Journal of infectious diseases.. 2015 October 15212 (8):1270-8. Epub 04/02/2015.

Images of a Healthy Worksite: A Group-Randomized Trial for Worksite Weight Gain Prevention With Employee Participation in Intervention Design.

Fernandez ID, Chin NP, Devine CM, Dozier AM, Martina CA, McIntosh S, Thevenet-Morrison K, Yang H

American journal of public health.. 2015 October 105 (10):2167-74. Epub 03/19/2015.

Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses.

Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ

The Journal of infectious diseases.. 2015 May 1211 (9):1408-17. Epub 11/06/2014.

An Improved Method for Estimating Antibody Titers in Microneutralization Assay Using Green Fluorescent Protein

Yang, H.; Baker, S.F.; González, M.E.; Topham, D.J.; Martínez-Sobrido, L.; Zand, M.; Holden-Wiltse, J; Wu, H.

Journal of Biopharmaceutical Statistics. 2015; .

High Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine after Priming with Live Attenuated Influenza Vaccine

Halliley, J.L.; Khurana, S.; Krammer, F.; Fitzgerald, T.; Coyle, E.M.; Chung, K.Y.; Baker, S.F.; Yang, H.; Martínez-Sobrido, L.; Treanor, J.J.; Subbarao, K.; Golding, H.; Topham, D.J.; Sangster, M.

Journal of Infectious Diseases. 2015; .

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent.

Lerman YV, Lim K, Hyun YM, Falkner KL, Yang H, Pietropaoli AP, Sonnenberg A, Sarangi PP, Kim M

Blood.. 2014 December 4124 (24):3515-23. Epub 10/02/2014.

Adapting the pregnancy risk assessment monitoring survey to enhance locally available data: methods.

Dozier AM, Brownell E, Guido J, Yang H, Howard CA, Doniger A, Ossip D, Lawrence R

Maternal and child health journal.. 2014 July 18 (5):1196-204. Epub 1900 01 01.

Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance.

Kwara A, Cao L, Yang H, Poethke P, Kurpewski J, Tashima KT, Mahjoub BD, Court MH, Peloquin CA

Pharmacotherapy.. 2014 March 34 (3):265-71. Epub 01/13/2014.

Hearing function in patients living with HIV/AIDS.

Luque AE, Orlando MS, Leong UC, Allen PD, Guido JJ, Yang H, Wu H

Ear and hearing.. 2014 35 (6):e282-90. Epub 1900 01 01.

L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness.

Wang J, Li D, Bambara RA, Yang H, Dykes C

The Journal of general virology.. 2013 July 94 (Pt 7):1597-607. Epub 03/27/2013.

B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination.

Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K

Clinical and vaccine immunology : CVI.. 2013 June 20 (6):867-76. Epub 04/10/2013.

CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine.

Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ

The Journal of infectious diseases.. 2013 January 15207 (2):297-305. Epub 11/12/2012.

Increase in IFN?(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza.

Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR

PloS one.. 2013 8 (3):e57275. Epub 03/20/2013.

Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays.

Yang H, Topham DJ, Holden-Wiltse J, Wu H

Journal of biopharmaceutical statistics.. 2013 23 (4):921-36. Epub 1900 01 01.

High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature.

Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS

Scientific reports.. 2013 3 :2327. Epub 1900 01 01.

Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults.

Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, Dewhurst S, Shah K

Aging and disease.. 2013 4 (6):311-9. Epub 08/27/2013.

Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.

Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY

PloS one.. 2012 7 (3):e34377. Epub 03/23/2012.

Functionally Distinct Subpopulations of CpG-Activated Memory B Cells.

Henn AD, Laski M, Yang H, Welle S, Qiu X, Miao H, Barry CT, Wu H, Zand MS

Scientific reports.. 2012 2 :345. Epub 03/30/2012.

Community participatory research with deaf sign language users to identify health inequities.

Barnett S, Klein JD, Pollard Jr RQ, Samar V, Schlehofer D, Starr M, Sutter E, Yang H, Pearson TA

American journal of public health.. 2011 December 101 (12):2235-8. Epub 10/20/2011.

Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.

Quách TD, Manjarrez-Orduño N, Adlowitz DG, Silver L, Yang H, Wei C, Milner EC, Sanz I

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 April 15186 (8):4640-8. Epub 03/11/2011.

Viral decay rates are similar in HIV-infected patients with and without TB coinfection during treatment with an Efavirenz-based regimen.

Lartey M, Sagoe KW, Yang H, Kenu E, Xexemeku F, Oliver-Commey J, Boima V, Seshie M, Sagoe A, Mingle JA, Flanigan TP, Wu H, Kwara A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2011 February 1552 (4):547-50. Epub 01/20/2011.

B Cell Responses to H5 Influenza HA in Human Subjects Vaccinated with Drifted Variants

Baer, J.; Santiago, F.; Yang, H.; Wu, H.; Holden-Wiltse, J.; Treanor, J.; Topham, D.J.

Vaccine. 2010; 28(4): 907-915.

Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells.

Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE

Journal of immunological methods.. 2009 January 1340 (1):42-7. Epub 11/06/2008.