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Sergiy Nadtochiy, Ph.D.

Sergiy Nadtochiy, Ph.D.


Call Center (585) 276-3000

About Me

Faculty Appointments

Assistant Professor - Department of Anesthesiology and Perioperative Medicine (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint


Journal Articles

High-Dose Dabigatran Is an Effective Anticoagulant for Simulated Cardiopulmonary Bypass Using Human Blood.

Nadtochiy, SM; Baldzizhar, A; Stefanos, T; et al.

Anesth Analg. 2021; 132(2): 566-574.

Nadtochiy, SM; Ngai, M; Brookes, PS.

Modified Blue Native Gel Approach for Analysis of Respiratory

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.

Kulkarni, CA; Nadtochiy, SM; Kennedy, L; Brookes, PS; et al.

Elife. 2020; 9.

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS

Journal of molecular and cellular cardiology.. 2018 August 121 :155-162. Epub 06/26/2018.

Cardiac metabolic effects of K1.2 channel deletion and evidence for its mitochondrial localization.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 June 4 :fj201800139R. Epub 06/04/2018.

Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.

Peoples JNR, Maxmillian T, Le Q, Nadtochiy SM, Brookes PS, Porter GA, Davidson VL, Ebert SN

The Journal of biological chemistry.. 2018 May 4293 (18):6925-6941. Epub 03/14/2018.

Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS

The Biochemical journal.. 2017 August 10474 (16):2829-2839. Epub 08/10/2017.

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS

The Journal of biological chemistry.. 2016 September 16291 (38):20188-97. Epub 08/10/2016.

The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy.

Zhang J, Nadtochiy SM, Urciuoli WR, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2016 January 1310 (1):H29-38. Epub 10/30/2015.

Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH, Eliseev RA

PloS one.. 2016 11 (5):e0155709. Epub 05/16/2016.


Free Radical Effects on Membranes (2008)

Chapter: The Interaction of Mitochondrial Membranes with Reactive Oxygen and Nitrogen Species

Authors: Paul Brookes, Andrew Wojtovich, Lindsay Burwell, Davide Hoffman and Sergiy Nadtochiy

Publisher: Academic Press, New York 2008