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Patricia M. White, Ph.D.

Patricia M. White, Ph.D.

Contact

About Me

Faculty Appointments

Associate Professor - Department of Neuroscience (SMD)

Associate Professor - Department of Otolaryngology (SMD) - Joint

Credentials

Residency & Fellowship

House Ear Institute, Los Angeles, CA 2000 - 2009

Education

PhD | California Inst of Tech. Developmental Biology. 2000

BS | California Inst of Tech. Biology. 1989

Awards

ARCS Scholar.

Hearst Scholar.

Research

Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseas...
Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.

Publications

Journal Articles

Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.

Vaara ST, Serpa Neto A, Bellomo R, Adhikari NKJ, Dreyfuss D, Gallagher M, Gaudry S, Hoste E, Joannidis M, Pettilä V, Wang AY, Kashani K, Wald R, Bagshaw SM, Ostermann M, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Liu KD, McAuley DF, McGuinness SP, Nichol AD, Ostermann M, Palevsky PM, Qiu H, Pettilä V, Schneider AG, Smith OM, Vaara ST, Weir M, Bellomo R, Eastwood GM, Peck L, Young H, Kruger P, Laurie G, Saylor E, Meyer J, Venz E, Wetzig K, French C, McGain F, Mulder J, Fennessy G, Koottayi S, Bates S, Towns M, Morgan R, Tippett A, Udy A, Mason C, Licari E, Gantner D, McClure J, Nichol A, McCracken P, Board J, Martin E, Vallance S, Young M, Vladic C, McGloughlin S, Gattas D, Buhr H, Coles J, Hutch D, Wun J, Cole L, Whitehead C, Lowrey J, Masters K, Gresham R, Campbell V, Gutierrez D, Brailsford J, Forbes L, Murray L, Maguire T, NiChonghaile M, Orford N, Bone A, Elderkin T, Salerno T, Chimunda T, Fletcher J, Broadfield E, Porwal S, Knott C, Boschert C, Smith J, Richardson A, Hill D, Duke G, Oziemski P, Cegarra S, Chan P, Welsh D, Hunter S, Roodenburg O, Dyett J, Kokotsis N, Moser M, Yang Y, Padayachee L, Vetro J, Gangopadhyay H, Kaufman M, Ghosh A, Said S, Patel A, Bihari S, Matheson E, Jin X, Shrestha T, Schwartz K, Gallagher MP, Cross R, Cheung W, Wong H, Kol M, Shah A, Wang AY, Endre Z, Bradford C, Janin P, Finfer S, Diel N, Gatward J, Hammond N, Delaney A, Bass F, Yarad E, Buscher H, Reynolds C, Baker N, Joannidis M, Bellmann R, Peer A, Hasslacher J, Koglberger P, Klein S, Zotter K, Brandtner A, Finkenstedt A, Ditlbacher A, Hartig F, Fries D, Bachler M, Schenk B, Wagner M, Staudinger T, Tiller E, Schellongowski P, Bojic A, Hoste EA, Bracke S, De Crop L, Vermeiren D, Thome F, Chiella B, Fendt L, Antunes V, Maisonneuve-Rosemont , Lafrance JP, Lamontagne F, D'Aragon F, St-Arnaud C, Mayette M, Carbonnaeu É, Marchand J, Masse MH, Ladouceur M, Turgeon AF, Lauzier F, Bellemare D, Langis Francoeur C, LeBlanc G, Guilbault G, Grenier S, Cloutier E, Boivin A, Delisle-Thibault C, Giannakouros P, Costerousse O, Cailhier JF, Carrier FM, Ghamraoui A, Lebrasseur M, Benettaib F, Salamé M, Boumahni D, Tung Sia Y, Naud JF, Roy I, Stelfox HT, Ruddell S, Manns BJ, Duggan S, Carney D, Barchard J, Whitlock RP, Belley-Cote E, Savija N, Sabev A, Campbell T, Creary T, Devereaux K, Brodutch S, Rigatto C, Paunovic B, Mooney O, Glybina A, Harasemiw O, Di Nella M, Harmon J, Mehta N, Lakatos L, Haslam N, Lellouche F, Simon M, Tung Y, Lizotte P, Bourchard PA, Rochwerg B, Karachi T, Millen T, Muscedere J, Maslove D, Gordon Boyd J, Sibley S, Drover J, Hunt M, Georgescu I, Wax R, Lenga I, Sridhar K, Steele A, Fusco K, Ghate T, Tolibas M, Robinson H, Weir MA, Taneja R, Ball IM, Garg A, Campbell E, Ovsenek A, Bagshaw SM, van Diepen S, Baig N, Magder S, Yao H, Alam A, Campisi J, MacIntyre E, Rokosh E, Scherr K, Lapinsky S, Mehta S, Shah S, Niven DJ, Stelfox HT, Ruddell S, Russell M, Jim K, Brown G, Oxtoby K, Hall A, Benoit L, Sokolowski C, Prasad B, Rao J, Giebel S, Kutsogiannis DJ, Thompson P, Thompson T, Cirone R, Kavikondala K, Soth M, Clarke F, Takaoka A, Wald R, Mazer D, Burns K, Friedrich J, Klein D, Sandhu G, Santos M, Khalid I, Hodder J, Dodek P, Ayas N, Alcuaz V, Suen G, Rewa O, Singh G, Norris S, Gibson N, Arias C, Shami A, Pelletier C, Adhikari NKJ, Zahirieh A, Amaral A, Marinoff N, Kaur N, Perez A, Wang J, Haljan G, Condin C, McIntyre L, Gomes B, Porteous R, Watpool I, Hiremath S, Clark E, Herridge MS, Backhouse F, Elizabeth Wilcox M, Walczak K, Ki V, Sharman A, Romano M, Bagshaw SM, Noel Gibney RT, Romanovsky AS, Rewa O, McCoshen L, Baig N, Wood G, Ovakim D, Auld F, Carney G, Duan M, Ji X, Guo D, Qi Z, Lin J, Zhang M, Dong L, Liu J, Liu P, Zhi D, Bai G, Qiu Y, Yang Z, Bai J, Liu Z, Zhuang H, Wang H, Li J, Zhao M, Zhou X, Shi X, Ye B, Liu M, Wu J, Fu Y, Long D, Pan Y, Wang J, Mei H, Zhang S, Wen M, Yang E, Mu S, Li J, Hu T, Qin B, Li M, Wang C, Dong X, Wang K, Wang H, Yang J, Du B, Wang C, Wang D, Li N, Yu Z, Xu S, Yao L, Hou G, Liu Z, Lu L, Lian Y, Wang C, Zhang J, Ding R, Qi G, Wang Q, Wang P, Meng Z, Chen M, Hu X, He X, Zhao S, Hang L, Li R, Qin S, Lu K, Dun S, Liu C, Zhou Q, Chen Z, Mei J, Zhang M, Xu H, Lin J, Shi Q, Fu L, Zeng Q, Ma H, Yan J, Gao L, Liu H, Zhang L, Li H, He X, Fan J, Guo L, Liu Y, Wang X, Sun J, Liu Z, Yang J, Ding L, Sheng L, Liu X, Yan J, Wang Q, Wang Y, Zhao D, Zhao S, Hu C, Li J, Deng F, Qiu H, Yang Y, Mo M, Pan C, Wu C, Huang Y, Huang L, Liu A, Pettilä V, Vaara ST, Korhonen AM, Törnblom S, Sutinen S, Pettilä L, Heinonen J, Lappi E, Suhonen T, Karlsson S, Hoppu S, Jalkanen V, Kuitunen A, Levoranta M, Långsjö J, Ristimäki S, Malila K, Wootten A, Varila S, Järvisalo MJ, Inkinen O, Kentala S, Leivo K, Haltia P, Dreyfuss D, Ricard JD, Messika J, Tiagarajah A, Emery M, Dechanet A, Gernez C, Roux D, Martin-Lefevre L, Fiancette M, Vinatier I, Claude Lacherade J, Colin G, Lebert C, Azais MA, Yehia A, Pouplet C, Henry-Lagarrigue M, Seguin A, Crosby L, Maizel J, Titeca-Beauport D, Combes A, Nieszkowska A, Masi P, Demoule A, Mayaux J, Dres M, Morawiec E, Decalvele M, Demiri S, Faure M, Marios C, Mallet M, Amélie Ordon M, Morizot L, Cantien M, Pousset F, Gaudry S, Poirson F, Cohen Y, Argaud L, Cour M, Bitker L, Simon M, Hernu R, Baudry T, De La Salle S, Robine A, Sedillot N, Tchenio X, Bouisse C, Roux S, Barbar D, Trusson R, Tamion F, Grangé S, Carpentier D, Chevrel G, Ensenyat-Martin L, Marque S, Quenot JP, Andreu P, Dargent A, Large A, Chudeau N, Landais M, Derrien B, Christophe Callahan J, Guitton C, Le Moal C, Robert A, Asehnoune K, Cinotti R, Grillot N, Demeure D, Vinsonneau C, Rahmani I, Marzouk M, Dekeyser T, Sejourne C, Verlay M, Thevenin F, Delecolle L, Didier Thevenin L, Souweine B, Coupez E, Adda M, Eraldi JP, Marchalot A, De Prost N, Mekontso Dessap A, Razazi K, Meziani F, Boisrame-Helms J, Clere-Jehl R, Delabranche X, Kummerlen C, Merdji H, Monnier A, Rabouel Y, Rahmani H, Allam H, Chenaf S, Franja V, Pons B, Carles M, Martino F, Richard R, Zuber B, Lacave G, Lakhal K, Rozec B, Dang Van H, Boulet É, Dubos R, Fadel F, Cleophax C, Dufour N, Grant C, Thuong M, Reignier J, Canet E, Nicolet L, Boulain T, Nay MA, Benzekri D, Barbier F, Bretagnol A, Kamel T, Mathonnet A, Muller G, Skarzynski M, Rossi J, Pradet A, Dos Santos S, Guery A, Muller L, Felix L, Bohé J, Thiéry G, Aissaoui N, Vimpere D, Commeureuc M, Diehl JL, Guerot E, Liangos O, Wittig M, Zarbock A, Küllmar M, van Waegeningh T, Rosenow N, Nichol AD, Brickell K, Doran P, Murray PT, Landoni G, Lembo R, Zangrillo A, Monti G, Tozzi M, Marzaroli M, Lombardi G, Paternoster G, Vitiello M, McGuinness S, Parke R, Butler M, Gilder E, Cowdrey KA, Wallace S, Hallion J, Woolett M, Neal P, Duffy K, Long S, McArthur C, Simmonds C, Chen Y, McConnochie R, Newby L, Knight D, Henderson S, Mehrtens J, Morgan S, Morris A, Vander Hayden K, Burke T, Bailey M, Freebairn R, Chadwick L, Park P, Rolls C, Thomas L, Buehner U, Williams E, Albrett J, Kirkham S, Jackson C, Browne T, Goodson J, Jackson D, Houghton J, Callender O, Higson V, Keet O, Dominy C, Young P, Hunt A, Judd H, Lawrence C, Olatunji S, Robertson Y, Latimer-Bell C, Hendry D, Mckay-Vucago A, Beehre N, Lesona E, Navarra L, Robinson C, Jang R, Junge A, Lambert B, Schneider AG, Thibault M, Eckert P, Kissling S, Polychronopoulos E, Poli E, Altarelli M, Schnorf M, Abed Mallaird S, Heidegger C, Perret A, Montillier P, Sangla F, Neils S, De Watteville A, Phull MK, George A, Hussain N, Pogreban T, Lobaz S, Daniels A, Cunningham M, Kerr D, Nicholson A, Shanmugasundaram P, Abrams J, Manso K, Hambrook G, McKerrow E, Salva J, Foulkes S, Wise M, Morgan M, Brooks J, Cole J, Michelle Davies T, Hill H, Thomas E, Vizcaychipi M, Baharlo B, Carungcong J, Costa P, Martins L, Kapoor R, Hazelton T, Moon A, Musselwhite J, Shelley B, McCall P, Ostermann M, Arbane G, Bociek A, Marotti M, Lim R, Campos S, Grau Novellas N, Cennamo A, Slack A, Wyncoll D, Camporota L, Sparkes S, Tilley R, Rattray A, Moreland G, Duffy J, McGonigal E, Hopkins P, Finney C, Smith J, Noble H, Watson H, Harris CL, Clarey E, Corcoran E, Beck J, Howcroft C, Youngs N, Wilby E, Ogg B, Wolverson A, Lee S, Butler S, Okubanjo M, Hindle J, Welters I, Williams K, Johnson E, Patrick-Heselton J, Shaw D, Waugh V, Stewart R, Mwaura E, Wren L, Mew L, Sutherland SB, Adderley J, Ruddy J, Harkins M, Kaye C, Scott T, Mitchell W, Anderson F, Willox F, Jagannathan V, Clark M, Purv S, Sharman A, Meredith M, Ryan L, Conner L, Peters C, Harvey D, Roshdy A, Collins A, Sim M, Henderson S, Chee N, Pitts S, Bowman K, Dilawershah M, Vamplew L, Howe E, Rogers P, Hernandez C, Prendergast C, Benton J, Rosenberg A, Forni LG, Grant A, Carvelli P, Raithatha A, Bird S, Richardson M, Needham M, Hirst C, Ball J, Leaver S, Howlett L, Castro Delgado C, Farnell-Ward S, Farrah H, Gray G, Joseph G, Robinson F, Tridente A, Harrop C, Shuker K, McLaughlan D, Ramsey J, Meehan S, Oliver Rose B, Reece-Anthony R, Gurung B, Whitehouse T, Snelson C, Veenith T, Johnston A, Cooper L, Carrera R, Ellis K, Fellows E, Harkett S, Bergin C, Spruce E, Despy L, Goundry S, Dooley N, Mason T, Clark A, Dignam G, Ward G, Attwood B, Parsons P, Mason S, Margarson M, Lord J, McGlone P, Hodgson LE, Chadbourn I, Gomez R, Margalef J, Pretorius R, Hamshere A, Carter J, Cahill H, Grainger L, Howard K, Forshaw G, Guy Z, Kashani KB, Albright RC, Amsbaugh A, Stoltenberg A, Niven AS, Lynch M, O'Mara A, Naeem S, Sharif S, McKenney Goulart J, Lynch M, O'Mara A, Naeem S, Sharif S, McKenney Goulart J, Tolwani A, Lyas C, Latta L, Bihorac A, Hashemighouchani H, Efron P, Ruppert M, Cupka J, Kiley S, Carson J, White P, Omalay G, Brown S, Velez L, Marceron A, Neyra JA, Carlos Aycinena J, Elias M, Ortiz-Soriano VM, Hauschild C, Dorfman R

Critical care explorations.. 2024 February 6 (2):e1053. Epub 02/19/2024.

Corrigendum: Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation.

Piekna-Przybylska D, Na D, Zhang J, Baker C, Ashton JM, White PM

Frontiers in cellular neuroscience.. 2024 18 :1428589. Epub 05/24/2024.

Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.

Na D, Zhang J, Beaulac HJ, Piekna-Przybylska D, Nicklas PR, Kiernan AE, White PM

Frontiers in neuroscience.. 2023 17 :1106570. Epub 05/26/2023.

Corrigendum: Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.

Na D, Zhang J, Beaulac HJ, Piekna-Przybylska D, Nicklas PR, Kiernan AE, White PM

Frontiers in neuroscience.. 2023 17 :1250244. Epub 07/18/2023.

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R.

Na D, White PM

Journal of visualized experiments : JoVE.. 2022 December 9 (190)Epub 12/09/2022.

Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss.

Gilels FA, Wang J, Bullen A, White PM, Kiernan AE

Cell death & disease.. 2022 November 1813 (11):971. Epub 11/18/2022.

Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation.

Piekna-Przybylska D, Na D, Zhang J, Baker C, Ashton JM, White PM

Frontiers in cellular neuroscience.. 2022 16 :1096872. Epub 01/06/2023.

Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice.

Beaulac HJ, Gilels F, Zhang J, Jeoung S, White PM

Cell death & disease.. 2021 July 712 (7):682. Epub 07/07/2021.

SIRT3 promotes auditory function in young adult FVB/nJ mice but is dispensable for hearing recovery after noise exposure.

Patel S, Shah L, Dang N, Tan X, Almudevar A, White PM

PloS one.. 2020 15 (7):e0235491. Epub 07/13/2020.

ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea.

Zhang J, Wang Q, Abdul-Aziz D, Mattiacio J, Edge ASB, White PM

The European journal of neuroscience.. 2018 November 48 (10):3299-3316. Epub 10/24/2018.

Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.

Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM

Scientific reports.. 2018 April 108 (1):5746. Epub 04/10/2018.

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure.

Gilels F, Paquette ST, Beaulac HJ, Bullen A, White PM

Scientific reports.. 2017 April 217 (1):1054. Epub 04/21/2017.

Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse.

Paquette ST, Gilels F, White PM

Scientific reports.. 2016 May 106 :25056. Epub 05/10/2016.

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.

Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE

PloS one.. 2014 9 (9):e108160. Epub 09/29/2014.

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.

Gilels F, Paquette ST, Zhang J, Rahman I, White PM

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 November 2033 (47):18409-24. Epub 1900 01 01.

EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.

White PM, Stone JS, Groves AK, Segil N

Developmental biology.. 2012 March 1363 (1):191-200. Epub 01/02/2012.

Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells.

White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N

Nature.. 2006 June 22441 (7096):984-7. Epub 1900 01 01.

Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea.

Doetzlhofer A, White P, Lee YS, Groves A, Segil N

Brain research.. 2006 May 261091 (1):282-8. Epub 04/17/2006.

In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme.

Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK

Developmental biology.. 2004 August 15272 (2):432-47. Epub 1900 01 01.

Math1-driven GFP expression in the developing nervous system of transgenic mice.

Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N, Johnson JE

Gene expression patterns : GEP.. 2003 August 3 (4):389-95. Epub 1900 01 01.

Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals.

White PM, Morrison SJ, Orimoto K, Kubu CJ, Verdi JM, Anderson DJ

Neuron.. 2001 January 29 (1):57-71. Epub 1900 01 01.

In vivo transplantation of mammalian neural crest cells into chick hosts reveals a new autonomic sublineage restriction.

White PM, Anderson DJ

Development.. 1999 October 126 (19):4351-63. Epub 1900 01 01.

Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells.

Morrison SJ, White PM, Zock C, Anderson DJ

Cell.. 1999 March 596 (5):737-49. Epub 1900 01 01.

Regulatory anatomy of the murine interleukin-2 gene.

Novak TJ, White PM, Rothenberg EV

Nucleic acids research.. 1990 August 1118 (15):4523-33. Epub 1900 01 01.