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Ying Chuech Tsai, M.S.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Associate - Department of Radiation Oncology (SMD)

Credentials

Education

MS | National Taiwan University. Biochemical Science & Technology. 1979

BS | National Taiwan University. Biochemical Science & Technology. 1976

Research

Patents

Human Heme-Regulated Initiation Factor 2.Alpha Kinase

Issue date: May 13, 2003

Patent #: 6,562,571

Country: United States

Inventors: Yi-Guang Chen, Athanassios Mantalaris, Takeshi Omasa, Ying-Chuech Tsai, J.H. David Wu

Human Heme-Regulated Initiation Factor 2-Alpha Kinase

Issue date: June 26, 2007

Patent #: 7,235,636

Country: United States

Inventors: Yi-Guang Chen, Athanassios Mantalaris, Takeshi Omasa, Ying-Chuech Tsai, J.H. David Wu

Publications

Journal Articles

KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses

Sun Y; Tsai Y; Wood R; Shen B; Chen J; Zhou Z; Zeng G; Marples B; Kerns S; Chen Y.

Int J Radiat Oncol Biol Phys. 2024; 119(1): 251-260.

NF?B and TNF? as individual key molecules associated with the cisplatin-resistance and radioresistance of lung cancer.

Zhu R, Xue X, Shen M, Tsai Y, Keng PC, Chen Y, Lee SO, Chen Y

Experimental cell research.. 2019 January 1374 (1):181-188. Epub 12/01/2018.

Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer.

Zhu R, Yang X, Xue X, Shen M, Chen F, Chen X, Tsai Y, Keng PC, Chen Y, Lee SO, Chen Y

Biochimica et biophysica acta. Molecular cell research.. 2018 December 1865 (12):1878-1890. Epub 09/15/2018.

Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells.

Shen M, Chen Y, Xu L, Zhu R, Xue X, Tsai Y, Keng PC, Lee SO, Chen Y

International journal of oncology.. 2018 July 53 (1):317-328. Epub 05/04/2018.

Adipocytes affect castration-resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD-L1/NKG2D ligand levels in tumor cells.

Xu L, Shen M, Chen X, Zhu R, Yang DR, Tsai Y, Keng PC, Chen Y, Lee SO

The Prostate.. 2018 April 78 (5):353-364. Epub 01/12/2018.

In vitro-induced M2 type macrophages induces the resistance of prostate cancer cells to cytotoxic action of NK cells.

Xu L, Shen M, Chen X, Yang DR, Tsai Y, Keng PC, Lee SO, Chen Y

Experimental cell research.. 2018 March 1364 (1):113-123. Epub 02/01/2018.

Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels.

Xu L, Chen X, Shen M, Yang DR, Fang L, Weng G, Tsai Y, Keng PC, Chen Y, Lee SO

Molecular oncology.. 2018 March 12 (3):269-286. Epub 01/24/2018.

FASN-TGF-?1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells.

Shen M, Tsai Y, Zhu R, Keng PC, Chen Y, Chen Y, Lee SO

Biochimica et biophysica acta. Molecular and cell biology of lipids.. 2018 March 1863 (3):313-322. Epub 01/03/2018.

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway.

Shen MJ, Xu LJ, Yang L, Tsai Y, Keng PC, Chen Y, Lee SO, Chen Y

Oncotarget.. 2017 October 68 (46):80506-80520. Epub 07/12/2017.

Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition.

Yang L, Shen M, Xu LJ, Yang X, Tsai Y, Keng PC, Chen Y, Lee SO

Scientific reports.. 2017 August 117 (1):7958. Epub 08/11/2017.

Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer.

Zhang F, Shen M, Yang L, Yang X, Tsai Y, Keng PC, Chen Y, Lee SO, Chen Y

Cancer biology & therapy.. 2017 August 318 (8):606-615. Epub 07/07/2017.

IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell Lung Cancer.

Wang X, Yang X, Tsai Y, Yang L, Chuang KH, Keng PC, Lee SO, Chen Y

Radiation research.. 2017 January 187 (1):50-59. Epub 01/05/2017.

Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer.

Zhang F, Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y

Cancer science.. 2016 June 107 (6):746-54. Epub 05/03/2016.

IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer.

Lee SO, Yang X, Duan S, Tsai Y, Strojny LR, Keng P, Chen Y

Oncotarget.. 2016 February 97 (6):6626-38. Epub 1900 01 01.

Yang L; Zhang F; Wang X; Tsai Y; Chuang KH; Keng PC; Lee SO; Chen Y.

A FASN-TGF-?1-FASN regulatory loop contributes to high EMT/

IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation.

Chen Y, Zhang F, Tsai Y, Yang X, Yang L, Duan S, Wang X, Keng P, Lee SO

Radiation oncology.. 2015 November 1410 :227. Epub 11/14/2015.

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules.

Duan S, Tsai Y, Keng P, Chen Y, Lee SO, Chen Y

Oncotarget.. 2015 September 296 (29):27651-60. Epub 1900 01 01.

Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis

Sun H; Tsai Y; Nowak I; Liesveld J; Chen Y.

Stem Cell Research. 2012; .

Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture.

Sun H, Tsai Y, Nowak I, Dertinger SD, Wu JH, Chen Y

Mutation research.. 2011 January 10718 (1-2):38-43. Epub 11/04/2010.

Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model.

Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD

Health physics.. 2010 February 98 (2):218-27. Epub 1900 01 01.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.

Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y

Mutation research.. 2009 April 30675 (1-2):77-80. Epub 02/11/2009.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.

Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y

Mutation research.. 2007 December 1634 (1-2):119-25. Epub 07/05/2007.

Effects of nitrogen dioxide exposure on human host defense

Azadniv M; Gibb FR; Morrow PE; Nichols J; Roberts Jr., NJ; Speers DM; Torres A; Tsai Y; Utell MJ; Voter KZ; Frampton MW.

Inhalation Toxicology. 1998; 10: 586-601.

Effects of inhaled sulfuric acid aerosols on pulmonary immunocompetence: a comparative study in humans and animals

Zelikoff JT; Frampton MW; Cohen MD; Morrow PE; Sisco M; Tsai Y; Utell MJ; Schlesinger RB.

Inhalation Toxicology. 1997; 9: 731-752.

Airway inflammation in smokers and nonsmokers with varying responses to ozone

Torres A; Voter KZ; Whitin JC; Cox C; Looney RJ; Speers RM; Tsai Y; Frampton MW.

Am J Respir Crit Care Med. 1997; 156: 728-736.

Expression of membrane antigens on human alveolar macrophages after exposure to nitrogen dioxide

Gavras JB; Frampton MW; Ryan DH; Levy PC; Cox C; Morrow PE; Utell MJ with technical assistance from Tsai Y.

Inhalation Toxicol. 1994; 6: 633-646.

Effects of H2SO4 aerosol exposure in humans assessed by bronchoalveolar lavage

Frampton MW; Voter KZ; Morrow PE; Roberts Jr., NJ; Culp DJ; Cox C; Utell MJ with technical assistance from Beiter H; Gibb FR; Nichols J; Speers D; Tsai Y.

Am Rev Respir Dis. 1992; 146: 626-632.

Absence of significant cellular activity in microbial flora of the female genital tract

Garland S; Tsai YC; Kendrick MI; Kass EH.

Infect Immunol. 1987; 155: 414-419.

Interaction of magnesium ion, oxygen tension and temperature in the production of Toxic-Shock Syndrome Toxin-1 (TSST-1) by Staphylococcus aureus

Kass EH; Kendrick MI; Tsai YC; Parsonnet J.

J Infect Dis. 1987; 155: 812-815.

Control of production of Toxic-Shock Syndrome Toxin-1 (TSST-1) by magnesium ion

Mills JT; Parsonnet J; Tsai YC; Kendrick MI; Hickman RK; Kass EH.

J Infect Dis. 1985; 151: 1158-1161.